Abstract: Methods and formulations are provided for treating spinobulbar muscular atrophy in a subject in need thereof. By administering a therapeutically effective amount of a selective androgen receptor modulator or a small molecule such as 1-[2-(4-methylphenoxy)ethyl]-2-[(2-phenoxyethyl)sulfanyl]-1H-benzimidazole or a derivative, prodrug, or pharmaceutically acceptable salt thereof, one or more symptoms of spinobulbar muscular atrophy can be ameliorated. The effective amount can be effective to prevent or delay loss of body weight, a loss of mobility, and/or a loss of physical strength in the subject; to prevent or delay neurogenic atrophy and/or to prevent a loss of spinal cord motor neurons in the subject; to restore the frequency of type I myofibers to normal levels for a healthy subject; and/or to reverse testicular atrophy in the subject.

Abstract: A coil assembly is provided, comprising: a direct expansion (DX) coil circulating refrigerant and cooling supply air passing over the DX coil by heat exchange to generate dehumidified air; a reheat coil circulating the refrigerant and heating the dehumidified air by heat exchange to generate output air; a first horizontal drain pan below the DX and reheat coils in a first horizontal position; a second horizontal drain pan below the DX and reheat coils in a second horizontal position; a first vertical drain pan below the DX and reheat coils in a vertical position, wherein the first and second horizontal drain pans are connected to the first vertical drain pan, the reheat coil is secured between the first and second horizontal drain pans, and the first horizontal drain pan is on an opposite side of the DX coil and the reheat coil from the second horizontal drain pan.

Abstract: A transmission includes an input shaft coupled to a prime mover, a countershaft, main shaft, and an output shaft, with gears between the countershaft and the main shaft. A shift actuator selectively couples the input shaft to the main shaft by rotatably coupling gears between the countershaft and the main shaft. The shift actuator is mounted on an exterior wall of a housing including the countershaft and the main shaft. A controller controls the shift actuator utilizing an actuating pulse and an opposing pulse.

Abstract: A coil assembly is provided, comprising: a direct expansion (DX) coil circulating refrigerant and cooling supply air passing over the DX coil by heat exchange to generate dehumidified air; a reheat coil circulating the refrigerant and heating the dehumidified air by heat exchange to generate output air; a first horizontal drain pan below the DX and reheat coils in a first horizontal position; a second horizontal drain pan below the DX and reheat coils in a second horizontal position; a first vertical drain pan below the DX and reheat coils in a vertical position, wherein the first and second horizontal drain pans are connected to the first vertical drain pan, the reheat coil is secured between the first and second horizontal drain pans, and the first horizontal drain pan is on an opposite side of the DX coil and the reheat coil from the second horizontal drain pan.

Abstract: Surgical instruments and methods for using and manufacturing the same are provided. The surgical instrument includes a combination of serrated forceps and non-serrated forceps, the serrated forceps and the non-serrated forceps being operable independently of each other. A method of using the instrument includes using the serrated forceps of the instrument to grasp a tissue and using the non-serrated forceps of the instrument to pull a surgical needle through the tissue.

Abstract: A utility loader incorporating a boom of adjustable length. The boom includes either or both of a left and right arm assembly, with each lift arm assembly including a rear lift arm telescopingly engaged with a front lift arm. Each lift arm assembly also includes an extension actuator adapted to variably extend and retract the front lift arm relative to the rear lift arm. The lift arm assembly includes a connection point to, e.g., receive a tool assembly, and the motion of the lift arm assembly is synchronized to move the connection point along a predetermined path. In one or more embodiments, the predetermined path includes moving along a direction that is normal to the ground surface.

Abstract: Disclosed are techniques for two-way synchronization of infrastructure-as-code templates and instances, including a method comprising detecting changes to a run-time state of a system and, in response to detecting a change, triggering an update of a current run-time state model. The method may further comprise, in response to updating the run-time state model, comparing the updated model to a current model using a template in a local repository instantiated as the current model. The method may further comprise, in response to the comparison determining a structural difference between the updated model and the current model, merging the updated model and the current model into a new model; and updating a local clone of a repository of the template with the new model. The method may further comprise, in response to the comparison determining no structural difference between the updated model and the current model, pushing changes to a remote repository.

Abstract: A mobility device configurable in a first walk configuration and a second stair-climb configuration, including a frame with movable front leg portions, a leg-actuation system connected to the front leg portions and a safety-control device mounted to the frame. The safety-control device includes a configuration selector, and a lever connected to the leg-actuation system and configured to actuate the cable actuation system so as to cause the first and second movable leg portions to move from a first position to a second position. The lever remains locked in a first lever position such that the lever cannot be moved unless the configuration selector is in a depressed position, thereby preventing inadvertent movement of the leg portion.

Abstract: A multiple lumen central venous catheter with the lumens exit ports on the distal sides of the catheter; enclosed in a separate casing that has exit ports in the walls at its distal end; that allows the enclosed catheter to rotate in the casing, allowing the exit ports in the catheter to align or non-align to open and close the individual lumens at the distal end.

Abstract: A cloud configuration, including public and private clouds, is organized hierarchically, with a top level and any number of lower levels. A parent level cloud receives resource workload metrics from respective child level cloud(s), makes predictions, based in part on the metrics, as to future resource needs at the child level. The parent level sets up runtime-modifiable business rules and scaling plans based on the predictions. The parent level cloud sends the scaling plans to respective child level(s). The parent level automatically triggers a scaling plan at a child level, if conditions written into the business rules are satisfied. Resources are scaled upward or downward automatically as needed to maintain optimal resource usage.

Abstract: A system is disclosed that monitors endpoints such as video cameras and audio devices for malfunction through a novel TDMA device allocation format. The system isolates and analyzes a set of groups of video streams in a rotating and recurring fashion and generates alerts and remedial commands based on the analysis. The system also provides endpoint management functions such as password analysis and firewall functions.

Abstract: The present invention provides a modified human cancer cell comprising a recombinant polynucleotide encoding an allele of a human leukocyte antigen gene. The present invention also provides methods for selecting a whole-cell cancer vaccine for a subject having cancer and methods of treating cancer using whole-cell cancer vaccines of the present invention. In addition, the present invention provides a method of determining the HER2 status of a cell. Compositions and kits are also provided herein.

Abstract: A transmission includes an input shaft coupled to a prime mover, a countershaft, main shaft, and an output shaft, with gears between the countershaft and the main shaft. A shift actuator selectively couples the input shaft to the main shaft by rotatably coupling gears between the countershaft and the main shaft. The shift actuator is mounted on an exterior wall of a housing including the countershaft and the main shaft. A controller controls the shift actuator utilizing an actuating pulse and an opposing pulse.

Abstract: A social networking system that allows a user to host a page for a pre-launch product that transitions to a post launch page. In some cases, the pre-launch page may be accessible to the users of the social networking system to provide information and data associated with the pre-launch product. In some cases, the pre-launch page may be configurable such that when the product launches, the page converts to a post launch page at which the product may be purchased.

Abstract: Disclosed are devices, systems, and methods of a wearable compression control system for actively controlling an applied pressure against an extremity to restrict blood flow along the extremity of a user performing an exercise or undergoing a therapy. In some embodiments, the system can include an inflatable band that extends circumferentially around the extremity. The inflatable band can include a bladder having an expandable inner volume for receiving fluid to cause the inflatable band to increase in thickness and increase an applied pressure against the extremity. The system can further include a controller that releasably couples to the inflatable band and includes a processor having a programmed pressure range. The processor can be configured to actively maintain the applied pressure within the programmed pressure range throughout the user performing the exercise or the user undergoing the therapy.

Abstract: A shape-memory alloy orthopedic implant includes a bridge having a curved longitudinal axis, a first end, and a second end opposite the first end. The bridge has a radially outer surface extending axially from the first end to the second end. In addition, the orthopedic implant includes a first leg extending from the first end of the bridge. The first leg has a central axis, a fixed end fixably attached to the bridge, a free end distal the bridge, and a radially outer surface extending axially from the fixed end of the first leg to the free end of the first leg. Further, the orthopedic implant includes a second leg extending from the second end of the bridge. The second leg has a central axis, a fixed end fixably attached to the bridge, a free end distal the bridge, and a radially outer surface extending axially from the fixed end of the second leg to the free end of the second leg.