Abstract: Provided herein are genetically modified T cells that exhibit increased proliferation compared to wild-type T cells when stimulated, methods of generating such T cells, and methods of using the T cells for the treatment of a disease such as cancer.

Abstract: Disclosed herein are biomarkers that correlate with responses to an anti-ILT4 and anti-PD-1 combination therapy. A biomarker that can differentiate responders from non-responders to this combination therapy can potentially be used to select human subjects who have a higher probability to benefit from such a combination therapy. In one embodiment, a combined positive score (CPS) for PD-L 1 expression in a tumor sample from a human subject is used as a biomarker to differentiate a responder from a non-responder to an anti-ILT4 and anti-PD-1 combination therapy. In another embodiment, a T-cell-inflamed gene expression profile (TcellinfGEP) score is used as a biomarker to differentiate a responder from a non-responder to an anti-ILT4 and anti-PD-1 combination therapy.

Abstract: Oral care compositions and methods for treating, preventing, or inhibiting dry mouth and/or inflammation of the oral cavity or a surface thereof are disclosed. Oral care compositions for improving oral care by treating, preventing, or otherwise inhibiting discomfort, irritation, or gum pain of the oral cavity are also disclosed. The oral care composition may include an orally acceptable vehicle, hyaluronic acid, and one or more benefit agents. The method for treating, preventing, or inhibiting dry mouth and/or inflammation of the oral cavity or a surface thereof may include contacting the oral cavity or the surface thereof with the oral care compositions.

Abstract: Methods, computer readable media, and apparatuses are provided herein for enhancement of document metadata processing and marking capability across cloud platforms. A data streaming pipeline may be configured between a cloud document storage platform and a cloud platform. A metadata processing server may detect a document manipulation event associated with a document stored in the cloud document storage platform. The metadata processing server may determine a triggering rule associated with the document corresponding to the document manipulation event, and cause a resultant document action in the cloud document storage platform.

Abstract: The invention provides a system for machine-learning assisted real-time video editing and playback. Users select content, and the system uses machine learning to analyze preferences and edit the content in real time. The system is distinguished by its ability to process real-time user commands (via text or voice) during playback, adjusting the video dynamically. Personalized versions of movies, shows, or other video content are then generated and played back to the user, based on preferences provided or inferred through the system.

Abstract: A brake lever end cap includes an elongated leg portion in which at least a portion of the brake lever is seated, and a foot portion joined to the leg portion and an end of the leg portion. The leg portion has a lower durometer value that the foot portion to help absorb the energy of an impact and prevent the end of the brake lever from passing through the foot portion.

Abstract: The disclosure relates to an absorbent article including a main portion defining a front and rear regions, and a crotch region located between the front and rear regions, the article including a pocket member attached to the rear region to form a closed faeces boundary with an opening towards the crotch region of, the pocket member including a plurality of elastic members providing the pocket member with elastic characteristics along the width direction, the elastic members being distributed over the pocket length (Lp) to form a first, second and intermediate elastic zones, wherein an average distribution of the elastic members in the intermediate zone being less than 0.5 elastic members per cm as seen in the length direction, and an average distribution of the elastic members in each of the first and second elastic zones being greater than the average distribution of elastic members in the intermediate zone.

Abstract: The disclosure provides anti-Siglec-9 antibodies and bispecific and multispecific antibodies that target Siglec-9 and Siglec-7, and therapeutic methods comprising administering such antibodies to a cancer patient or a patient having an autoimmune disease or other disorder in which it is desirable to inhibit an immune response.

Abstract: The present invention relates to an isolated antibody or antigen-binding fragment thereof that binds to human A2AP. The isolated antibody or antigen-binding fragment according to the present invention i) cross-reacts with rabbit and/or cynomolgus A2AP, ii) does not inhibit human plasmin activity, and iii) increases plasmin mediated clot lysis in the presence of A2AP.

Abstract: A method for evaluating gesture input comprises receiving input data for sequential data frames, including hand tracking data for hands of a user. A first neural network is trained to recognize features indicative of subsequent gesture interactions and configured to evaluate input data for a sequence of data frames and to output an indication of a likelihood of the user performing gesture interactions during a predetermined window of data frames. A second neural network is trained to recognize features indicative of whether the user is currently performing one or more gesture interactions and configured to adjust parameters for gesture interaction recognition during the predetermined window based on the indicated likelihood. The second neural network evaluates the predetermined window for performed gesture interactions based on the adjusted parameters, and outputs a signal as to whether the user is performing one or more gesture interactions during the predetermined window.

Abstract: This specification generally discloses technology for optimizing the loading of pallets on trucks and other sorts of vehicles. A pallet loading technique includes receiving pallet information for a shipment, the pallet information describing pallets to be included in the shipment, receiving vehicle constraint information for a vehicle, the vehicle constraint information describing rules for loading pallets on the vehicle, and determining candidate solutions for loading the pallets on the vehicle, each candidate solution (i) satisfying the rules for loading pallets on the vehicle, and (ii) defining, for each pallet to be included in the shipment, a respective position and orientation of the pallet on the vehicle. At least some of the candidate solutions are evaluated, one of the candidate solutions is selected, and the vehicle is loaded according to the selected candidate solution.

Abstract: A method of obtaining a doped semiconductor layer, including the successive steps of: a) performing, in a first single-crystal layer made of a semiconductor alloy of at least a first element A1 and a second element A2, an ion implantation of a first element B which is a dopant for the alloy and of a second element C which is not a dopant for the alloy, to make an upper portion of the first layer amorphous and to preserve the crystal structure of a lower portion of the first layer; and b) performing a solid phase recrystallization anneal of the upper portion of the first layer, resulting in transforming the upper portion of the first layer into a doped single-crystal layer of the alloy.

Abstract: The present disclosure relates to methods and systems for sharing with a plurality of users a chat session that uses large language models to provide responses for input messages received for the chat session. The methods and systems provide access to the chat session to the users and update the chat session in response to any changes made to the chat session by any of the users. The methods and systems allow the users to resume the chat session at a future time using the chat session history.

Abstract: Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

Abstract: An automatic transmission (1) includes a transmission housing, a hydrodynamic torque converter (5), a first brake, a second brake, an intermediate plate (6) fixedly connected to the transmission housing and with ducts for supplying the hydrodynamic torque converter (5) and the two brakes (A, B) with oil. An oil guide shell (7) is arranged between the hydrodynamic torque converter (5) and the intermediate plate (6). Oil coming from the two brakes sinks via oil ducts (39.1, 39.2, 39.3) in the transmission housing and the intermediate plate (6) via the inflow opening (40) in the oil guide shell (7). The hydrodynamic torque converter (5), via rotation, conveys the oil to the elevated oil ejection opening in the oil guide shell (7), from where the oil sinks into the tank (8) via a gap (52) delimited by the oil guide shell (7) and the intermediate plate (6).

Abstract: The present technology pertains to restoring a directory to a state prior to a past synchronization event. A content management system can present an interface including history of synchronization events for a directory, and a user can select to restore a directory to a state prior to any one of the past synchronization events.

Abstract: A method of locating a second V2X-capable vehicle by a first V2X-capable vehicle is described. A request is transmitted from the first vehicle to the second vehicle via a V2X communication connection, sensor data from at least one sensor of the second vehicle are received by the first vehicle via the V2X communication connection and are evaluated. At least one action is carried out by the first vehicle, the second vehicle is located relative to the first vehicle if the at least one action by the first vehicle is detected on the basis of the received sensor data from the at least one sensor of the second vehicle. A system is also described.

Abstract: A novel maize variety designated 1PHSZ12 and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety 1PHSZ12 with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into 1PHSZ12 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety 1PHSZ12 or a locus conversion of 1PHSZ12 with another maize variety.

Abstract: The invention relates to a method for testing an electrode arrangement (1) for generating a non-thermal plasma, having the following steps: determining at least one power parameter which characterizes a plasma power of the electrode arrangement (1); comparing the at least one power parameter with at least one predetermined target parameter value, and obtaining a comparison result; assessing the functionality of the electrode arrangement (1) on the basis of the comparison result, and preferably selecting at least one action according to the comparison result.

Abstract: An insulating tab attached to an electronic device driven by a battery includes a first insulating layer, a first wiring that extends in a first direction along the first insulating layer, the first wiring including a first electrode on one end thereof and a second electrode on the other end thereof, and a second wiring that extends in the first direction along the first insulating layer, the second wiring including a third electrode on one end thereof and a fourth electrode on the other end thereof. The first and third electrodes are disposed on opposite sides of the first insulating layer at a first location of the first insulating layer along the first direction.