Abstract: A computer-implemented method for transmitting electronic query data related to various types of information or resources may include detecting user input on a website or other platform indicating permission to receive electronic data, causing display a widget or other user interface element that pre-fills the user input with query criteria, and requesting additional query criteria from the user to generate a complete query. The method may also include receiving available data including corresponding location or other relevant data for each available resource, determining a subset of data including recommended resources for the user based on the query location or other parameters, the initial query criteria, and the additional query criteria, and transmitting the subset of data to a graphical user interface on the user's device or other platform.

Abstract: Embodiments of the disclosure provide a structure with a guard ring between the terminals of a single photon avalanche diode photodetector (SPAD), and related methods. A structure according to the disclosure includes a SPAD with an anode within a doped well and a cathode within the doped well. A guard ring includes a semiconductor material within the doped well. The semiconductor material and the doped well have opposite doping polarities.

Abstract: The present disclosure relates to anti-glyco-LAMP1 antibodies and antigen binding fragments thereof that specifically bind to a cancer-specific glycosylation variant of LAMP1 and related fusion proteins and antibody-drug conjugates, as well as nucleic acids encoding such biomolecules. The present disclosure further relates to use of the antibodies, antigen-binding fragments, fusion proteins, antibody-drug conjugates and nucleic acids for cancer therapy.

Abstract: Regulating downhole fluid flow through a plurality of valves to treat wellbore sections while also allowing for production to continue. If it is determined that fluid flow through a valve of a plurality of valves is below a threshold, maintaining fluid flow through the below threshold valve may be maintained while restricting fluid flow through other valves of the plurality. This restriction fluidly isolates a section of a well from other sections of the well. Once isolated, a treatment substance may be injected through the below threshold valve into the isolated section of well. Afterwards, the closed valves may be reopened while restricting fluid flow through the treated section valve for a threshold period of time, the treated section valve may then be reopened after the threshold period of time.

Abstract: A method of scattering-type scanning near-field optical microscopy (s-SNOM) comprises placing an s-SNOM tip 11 at a near-field distance from a sample 1 and subjecting the s-SNOM tip 11 to a mechanical oscillation, which provides a primary modulation, illuminating the oscillating s-SNOM tip 11 with a sequence of illumination light pulses, wherein each of the illumination light pulses hits the s-SNOM tip 11 at a specific s-SNOM tip modulation phase ?i of the mechanical oscillation, collecting scattering light pulse amplitudes Si, each being created by scattering one of the illumination light pulses at the s-SNOM tip 11, using a scattering light detector device 30, collecting the s-SNOM tip modulation phase i associated to each of the collected scattering light pulse amplitudes Si, using a mechanical oscillation detector device 40, and calculating an s-SNOM near-field signal by demodulating a scattering light function S(?i) of the scattering light pulse amplitudes Si in dependency on the s-SNOM tip modulation ph

Abstract: The invention relates to a turf transport and presentation apparatus, system and method for pet toiletry and a container blank configured to form the apparatus. The apparatus includes a first container portion and a second container portion and a joining portion connecting the first and second container portions together, wherein the container portions are configured to open and close in the manner of a clam-shell. In a closed condition the container portions form a cavity for holding a rolled or folded turf sheet for storage and/or transport and in an open condition, the apparatus forms a tray for supporting a turf sheet in a lay-flat condition.

Abstract: Pressure-sensitive adhesive compound containing: a) at least 28% by weight and at most 60% by weight of an elastomer component, wherein i. the elastomer component contains at least 60% by weight and preferably at most 90% by weight, based in each case on the elastomer component, of at least one hydrogenated polyvinylaromatic-polydiene block copolymer having a polyvinylaromatic fraction of at least 18% by weight and a peak molecular weight of 100,000 to 500,000 g/mol, determined according to GPC (Test i), ii. the polydiene blocks are substantially fully hydrogenated, iii. the hydrogenated polyvinylaromatic-polydiene block copolymer has an ABA structure, (AB)nZ structure with n=2 or radial (AB)n structure or radial (AB)n?Z structure with n?3, wherein A=polyvinylaromatic, B=ethylene and butylene or ethylene and propylene and Z=derivative of a coupling substance, and wherein the ethylene fraction in the B blocks is preferably at least 50% by weight, and iv.

Abstract: The disclosure relates to determining information about a target structure formed on a substrate using a lithographic process. In one arrangement, a cantilever probe is provided having a cantilever arm and a probe element. The probe element extends from the cantilever arm towards the target structure. Ultrasonic waves are generated in the cantilever probe. The ultrasonic waves propagate through the probe element into the target structure and reflect back from the target structure into the probe element or into a further probe element extending from the cantilever arm. The reflected ultrasonic waves are detected and used to determine information about the target structure.

Abstract: The present invention relates to s solvent composition for natural material extraction, which is harmless to and safe for the human body, has excellent antibacterial activity, and can extract an effect substance from a natural material at improved yield. Containing 2,3-butanediol, the solvent composition for natural material extraction according to the present invention is harmless to and safe for the human body, has excellent antibacterial activity, and exhibits an improved yield in extracting an effective substance from a natural material. In addition, the solvent composition for natural material extraction contains 2,3-butanediol produced from biomass and thus does not cause the emission of greenhouse gases (CO2).

Abstract: A food with an extended shelf-life and a method of extending shelf-life of food is provided herein. The extended shelf-life is provided by treating the food with isothiocyanate, a non-aromatic cyclic ketone, a boronic acid, a ligand and their precursors.

Abstract: Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Abstract: Hand held and portable disinfection units for use with patients having indwelling catheters or are hospitalized or under care in an intensive care unit.

Abstract: A 3D printed, complex polymer structure can include a seed layer on the polymer structure. A thin film can be disposed on the seed layer. The seed layer can be an oxide, a nitride, or an oxynitride. The thin film can be an oxide, dielectric, semiconductor, or conductor. The polymer structure can be a lattice structure, cantilever, beam, or other shapes.

Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein a, b, c, d, G1, G2, L1, L2, R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8 and X are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, nanoparticles comprising the compounds and methods for their use and preparation are also provided.

Abstract: A transfer device (2) and a method for transferring at least one functional element (3) into a process chamber (4) are provided, wherein the at least one functional element (3) is arranged interchangeably on an element carrier (5) and the element carrier (5) is transferable from a starting position (6) into an end or working position (7), wherein, in the end or working position (7), the at least one functional element (3) is arranged partly in the process chamber (4) and partly outside the process chamber (4). The invention is therefore particularly suitable for aseptic processes in the pharmaceutical industry, but is not limited to this sphere.

Abstract: A method is disclosed of predicting cancer patient response to immune checkpoint inhibitors, e.g., an antibody drug blocking ligand activation of programmed cell death 1 (PD-1) or CTLA4. The method includes obtaining mass spectrometry data from a blood-based sample of the patient, obtaining integrated intensity values in the mass spectrometry data of a multitude of pre-determined mass-spectral features; and operating on the mass spectral data with a programmed computer implementing a classifier. The classifier compares the integrated intensity values with feature values of a training set of class-labeled mass spectral data obtained from a multitude of melanoma patients with a classification algorithm and generates a class label for the sample. A class label “early” or the equivalent predicts the patient is likely to obtain relatively less benefit from the antibody drug and the class label “late” or the equivalent indicates the patient is likely to obtain relatively greater benefit from the antibody drug.

Abstract: One example method includes performing, in a global environment that includes a central node and edge nodes that are able to communicate with each other, by the central node, operations including: sampling optimal information from the edge nodes concerning a state of the global environment, the edge nodes being grouped into a plurality of cluster structures based on the optimal information, updating a global map of the global environment, based on the optimal information, updating an information retrieval cost, using the state of the global environment to orchestrate placement and execution of one or more tasks and actions in the global environment, using the updated global map, information retrieval cost, tasks and actions to update an attention mechanism operable to control retrieval of next optimal information, and selecting next optimal information for retrieval.