Patents by Inventor Julie A. Thompson
Julie A. Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240142466Abstract: Method for detecting a urinary tract infection (UTI) in a subject comprising determining levels of one or more biomarkers selected from MMP8, HNE, Cystatin C, MMP9, HSA, IL-8, interleukin-6 (IL-6), interleukin-1 beta (IL-1b), fibrinogen, RBP4, active MMP9 and MMP2, NGAL, Desmosine, MPO and CRP in a urine sample obtained from the subject. The determined levels may then be compared with a threshold level, wherein increased levels of at least one of the biomarkers in the urine sample relative to the threshold level is indicative of the presence of a urinary tract infection. Methods for monitoring a UTI and monitoring treatment of a UTI are also provided as are companion systems or test kits.Type: ApplicationFiled: January 9, 2024Publication date: May 2, 2024Applicant: Mologic LimitedInventors: Gita Parekh, Paul Davis, Julie Thompson, Annelyse Duvoix
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Publication number: 20230380772Abstract: Systems and methods are described for subject rehospitalization management. In an example, multiple physiologic signals can be obtained from a subject using multiple sensors. In response to a hospitalization event, pre-hospitalization characteristics of the multiple physiologic signals can be identified. Post-hospitalization characteristics of the multiple physiologic signals can be identified, including characteristics that differ from their corresponding pre-hospitalization characteristics. Later subsequent physiologic signals can be further monitored after the hospitalization event, such as using the same multiple sensors, and subsequent physiologic signal characteristics can be identified. In an example, a heart failure diagnostic indication can be determined using information about the pre-hospitalization characteristics, the post-hospitalization characteristics, and the subsequent characteristics.Type: ApplicationFiled: July 10, 2023Publication date: November 30, 2023Inventors: Pramodsingh Hirasingh Thakur, Qi An, Barun Maskara, Julie A. Thompson
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Patent number: 11723544Abstract: A hospitalization management system including a heart failure analyzer that receives diagnostic data including at least sensor data representative of one or more physiological signals sensed from a hospitalized patient using one or more sensors and assesses risk of rehospitalization for the patient using the diagnostic data. The outcome of the risk assessment is used during and following the patient's hospitalization for reducing the risk of rehospitalization.Type: GrantFiled: September 30, 2019Date of Patent: August 15, 2023Assignee: Cardiac Pacemakers, Inc.Inventors: Ramesh Wariar, Jeffrey E. Stahmann, Julie A. Thompson, Helen L. Reeve-Stoffer
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Patent number: 11723605Abstract: Systems and methods are described for subject rehospitalization management. In an example, multiple physiologic signals can be obtained from a subject using multiple sensors. In response to a hospitalization event, pre-hospitalization characteristics of the multiple physiologic signals can be identified. Post-hospitalization characteristics of the multiple physiologic signals can be identified, including characteristics that differ from their corresponding pre-hospitalization characteristics. Later subsequent physiologic signals can be further monitored after the hospitalization event, such as using the same multiple sensors, and subsequent physiologic signal characteristics can be identified. In an example, a heart failure diagnostic indication can be determined using information about the pre-hospitalization characteristics, the post-hospitalization characteristics, and the subsequent characteristics.Type: GrantFiled: May 26, 2022Date of Patent: August 15, 2023Assignee: Cardiac Pacemakers, Inc.Inventors: Pramodsingh Hirasingh Thakur, Qi An, Barun Maskara, Julie A. Thompson
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Publication number: 20230148970Abstract: Systems and methods for monitoring patients with multiple chronic diseases are described. A system may include a health status monitor that receives diagnostic data including physiological signals sensed from a patient. The system may produce at least a first risk indication of the patient developing a first disease and a second risk indication of the patient developing a different second disease. The system may detect the first and second diseases from the physiological signals, and generate a composite health status indicator using the detections of the first and second diseases and the first and second risk indications. An alert of worsening health status may be generated if the composite detection score exceeds an alert threshold.Type: ApplicationFiled: January 16, 2023Publication date: May 18, 2023Inventors: Qi An, Pramodsingh Hirasingh Thakur, Viktoria A. Averina, Julie A. Thompson
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Publication number: 20230097649Abstract: Systems and methods for monitoring patients with a chronic disease are described. A patient management system may sense physiological signals from a patient using one or more implantable or other ambulatory sensors, and generate from the physiological signals a chronobiological rhythm indicator (CRI) such as indicating a circadian rhythm. A reference CRI associated with a prior hospital admission event of the patient may be provided to the patient management system, which compares the CRI to the reference CRI and generates a readmission risk score indicating the patient's risk of subsequent hospital readmission due to a worsened condition of the chronic disease. The readmission risk score may be provided to a user or a process, or used to initiate or adjust a therapy delivered to the patient.Type: ApplicationFiled: December 6, 2022Publication date: March 30, 2023Inventors: Qi An, Viktoria A. Averina, Julie A. Thompson, Pramodsingh Hirasingh Thakur
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Patent number: 11576620Abstract: Systems and methods for monitoring patients with multiple chronic diseases are described. A system may include a health status monitor that receives diagnostic data including physiological signals sensed from a patient. The system may produce at least a first risk indication of the patient developing a first disease and a second risk indication of the patient developing a different second disease. The system may detect the first and second diseases from the physiological signals, and generate a composite health status indicator using the detections of the first and second diseases and the first and second risk indications. An alert of worsening health status may be generated if the composite detection score exceeds an alert threshold.Type: GrantFiled: March 28, 2017Date of Patent: February 14, 2023Assignee: Cardiac Pacemakers, Inc.Inventors: Qi An, Pramodsingh Hirasingh Thakur, Viktoria A. Averina, Julie A. Thompson
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Patent number: 11534113Abstract: Systems and methods for monitoring patients with a chronic disease are described. A patient management system may sense physiological signals from a patient using one or more implantable or other ambulatory sensors, and generate from the physiological signals a chronobiological rhythm indicator (CRI) such as indicating a circadian rhythm. A reference CRI associated with a prior hospital admission event of the patient may be provided to the patient management system, which compares the CRI to the reference CRI and generates a readmission risk score indicating the patient's risk of subsequent hospital readmission due to a worsened condition of the chronic disease. The readmission risk score may be provided to a user or a process, or used to initiate or adjust a therapy delivered to the patient.Type: GrantFiled: October 15, 2019Date of Patent: December 27, 2022Assignee: Cardiac Pacemakers, Inc.Inventors: Qi An, Viktoria A. Averina, Julie A. Thompson, Pramodsingh Hirasingh Thakur
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Publication number: 20220280123Abstract: Systems and methods are described for subject rehospitalization management. In an example, multiple physiologic signals can be obtained from a subject using multiple sensors. In response to a hospitalization event, pre-hospitalization characteristics of the multiple physiologic signals can be identified. Post-hospitalization characteristics of the multiple physiologic signals can be identified, including characteristics that differ from their corresponding pre-hospitalization characteristics. Later subsequent physiologic signals can be further monitored after the hospitalization event, such as using the same multiple sensors, and subsequent physiologic signal characteristics can be identified. In an example, a heart failure diagnostic indication can be determined using information about the pre-hospitalization characteristics, the post-hospitalization characteristics, and the subsequent characteristics.Type: ApplicationFiled: May 26, 2022Publication date: September 8, 2022Inventors: Pramodsingh Hirasingh Thakur, Qi An, Barun Maskara, Julie A. Thompson
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Patent number: 11363993Abstract: Systems and methods are described for subject rehospitalization management. In an example, multiple physiologic signals can be obtained from a subject using multiple sensors. In response to a hospitalization event, pre-hospitalization characteristics of the multiple physiologic signals can be identified. Post-hospitalization characteristics of the multiple physiologic signals can be identified, including characteristics that differ from their corresponding pre-hospitalization characteristics. Later subsequent physiologic signals can be further monitored after the hospitalization event, such as using the same multiple sensors, and subsequent physiologic signal characteristics can be identified. In an example, a heart failure diagnostic indication can be determined using information about the pre-hospitalization characteristics, the post-hospitalization characteristics, and the subsequent characteristics.Type: GrantFiled: December 18, 2018Date of Patent: June 21, 2022Assignee: Cardiac Pacemakers, Inc.Inventors: Pramodsingh Hirasingh Thakur, Qi An, Barun Maskara, Julie A. Thompson
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Patent number: 11173310Abstract: Devices and methods for improving device therapy such as cardiac resynchronization therapy by determining a value for a device parameter are described. An ambulatory medical device (AMD) can include a sensor circuit to sense a physiological signal and generate two or more signal metrics, and detect an event of worsening cardiac condition using the two or more signal metrics. In response to the detection of worsening cardiac condition, the AMD can determine, for a stimulator, a value of at least one stimulation parameter based on temporal responses of two or more signal metrics. The temporal responses include near-term and long-term responses to the stimulation. The AMD can program the stimulator with the determined parameter value, and generate stimulation according to the determined parameter value to stimulate target tissue.Type: GrantFiled: May 30, 2019Date of Patent: November 16, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: Qi An, Julie A. Thompson, Yinghong Yu, Yi Zhang, Pramodsingh Hirasingh Thakur
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Patent number: 10912520Abstract: In one example, a method of monitoring a sustained activity of a human or animal subject for the purpose of determining a risk group includes detecting a physical activity signal from the subject, determining a magnitude of the detected physical activity signal, initiating a timer in response to determining the magnitude of the physical activity signal exceeding an activity level threshold, triggering storing at least one value associated with the physical activity signal only when the magnitude of the physical activity signal exceeds the activity level threshold and the timer is greater than a duration threshold, and determining, using the processor circuit, an indication of the subject's cardiovascular disease based on the stored value.Type: GrantFiled: July 28, 2015Date of Patent: February 9, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: Qi An, Pramodsingh Hirasingh Thakur, Viktoria A. Averina, Yi Zhang, Julie A. Thompson
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Publication number: 20200264195Abstract: Method for detecting a urinary tract infection (UTI) in a subject comprising determining levels of one or more biomarkers selected from MMP8, HNE, Cystatin C, MMP9, HSA, IL-8, interleukin-6 (IL-6), interleukin-1 beta (IL-1b), fibrinogen, RBP4, active MMP9 and MMP2, NGAL, Desmosine, MPO and CRP in a urine sample obtained from the subject. The determined levels may then be compared with a threshold level, wherein increased levels of at least one of the biomarkers in the urine sample relative to the threshold level is indicative of the presence of a urinary tract infection. Methods for monitoring a UTI and monitoring treatment of a UTI are also provided as are companion systems or test kits.Type: ApplicationFiled: March 1, 2018Publication date: August 20, 2020Applicant: Mologic LimitedInventors: Gita Parekh, Paul Davis, Julie Thompson, Annelyse Duvoix
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Publication number: 20200046299Abstract: Systems and methods for monitoring patients with a chronic disease are described. A patient management system may sense physiological signals from a patient using one or more implantable or other ambulatory sensors, and generate from the physiological signals a chronobiological rhythm indicator (CRI) such as indicating a circadian rhythm. A reference CRI associated with a prior hospital admission event of the patient may be provided to the patient management system, which compares the CRI to the reference CRI and generates a readmission risk score indicating the patient's risk of subsequent hospital readmission due to a worsened condition of the chronic disease. The readmission risk score may be provided to a user or a process, or used to initiate or adjust a therapy delivered to the patient.Type: ApplicationFiled: October 15, 2019Publication date: February 13, 2020Inventors: Qi An, Viktoria A. Averina, Julie A. Thompson, Pramodsingh Hirasingh Thakur
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Publication number: 20200022588Abstract: A hospitalization management system including a heart failure analyzer that receives diagnostic data including at least sensor data representative of one or more physiological signals sensed from a hospitalized patient using one or more sensors and assesses risk of rehospitalization for the patient using the diagnostic data. The outcome of the risk assessment is used during and following the patient's hospitalization for reducing the risk of rehospitalization.Type: ApplicationFiled: September 30, 2019Publication date: January 23, 2020Inventors: Ramesh Wariar, Jeffrey E. Stahmann, Julie A. Thompson, Helen L. Reeve-Stoffer
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Patent number: 10537281Abstract: Assessing decongestive therapy delivered to a heart failure patient involves use of an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status and a processor coupled to the implantable sensor. The sensor may comprise a thoracic fluid sensor, a heart sounds sensor, a cardiac chamber or arterial pressure sensor, a respiration sensor, or a blood chemistry sensor, for example. The processor is configured to determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient, and to produce an output in response to determining that the target level of patient diuresis has been achieved. The processor may be disposed in an implantable housing, in a patient-external housing, or in a network server system.Type: GrantFiled: March 1, 2017Date of Patent: January 21, 2020Assignee: Cardiac Pacemakers, Inc.Inventors: Julie A. Thompson, Yousufali H. Dalal
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Patent number: 10506987Abstract: Systems and methods for monitoring patients with a chronic disease are described. A patient management system may sense physiological signals from a patient using one or more implantable or other ambulatory sensors, and generate from the physiological signals a chronobiological rhythm indicator (CRI) such as indicating a circadian rhythm. A reference CRI associated with a prior hospital admission event of the patient may be provided to the patient management system, which compares the CRI to the reference CRI and generates a readmission risk score indicating the patient's risk of subsequent hospital readmission due to a worsened condition of the chronic disease. The readmission risk score may be provided to a user or a process, or used to initiate or adjust a therapy delivered to the patient.Type: GrantFiled: June 26, 2017Date of Patent: December 17, 2019Assignee: Cardiac Pacemakers, Inc.Inventors: Qi An, Viktoria A. Averina, Julie A. Thompson, Pramodsingh Hirasingh Thakur
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Patent number: 10456049Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.Type: GrantFiled: February 23, 2017Date of Patent: October 29, 2019Assignee: Cardiac Pacemakers, Inc.Inventors: Yi Zhang, Jeffrey E. Stahmann, Krzysztof Z. Siejko, Ramesh Wariar, Julie A. Thompson, John D. Hatlestad, Kenneth C. Beck
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Patent number: 10441179Abstract: A hospitalization management system including a heart failure analyzer that receives diagnostic data including at least sensor data representative of one or more physiological signals sensed from a hospitalized patient using one or more sensors and assesses risk of rehospitalization for the patient using the diagnostic data. The outcome of the risk assessment is used during and following the patient's hospitalization for reducing the risk of rehospitalization.Type: GrantFiled: July 11, 2017Date of Patent: October 15, 2019Assignee: Cardiac Pacemakers, Inc.Inventors: Ramesh Wariar, Jeffrey E. Stahmann, Julie A. Thompson, Helen L. Reeve-Stoffer
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Publication number: 20190275338Abstract: Devices and methods for improving device therapy such as cardiac resynchronization therapy by determining a value for a device parameter are described. An ambulatory medical device (AMD) can include a sensor circuit to sense a physiological signal and generate two or more signal metrics, and detect an event of worsening cardiac condition using the two or more signal metrics. In response to the detection of worsening cardiac condition, the AMD can determine, for a stimulator, a value of at least one stimulation parameter based on temporal responses of two or more signal metrics. The temporal responses include near-term and long-term responses to the stimulation. The AMD can program the stimulator with the determined parameter value, and generate stimulation according to the determined parameter value to stimulate target tissue.Type: ApplicationFiled: May 30, 2019Publication date: September 12, 2019Inventors: Qi An, Julie A. Thompson, Yinghong Yu, Yi Zhang, Pramodsingh Hirasingh Thakur