Patents by Inventor Jun O. Liu

Jun O. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200138821
    Abstract: Aryl hydrocarbon receptor (AHR) agonists and their use for treating, preventing, or reducing the risk of necrotizing enterocolitis in premature infants are disclosed.
    Type: Application
    Filed: May 25, 2018
    Publication date: May 7, 2020
    Inventors: David Hackam, Peng Lu, Chhinder P. Sodhi, Jun O. Liu
  • Publication number: 20190389911
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Application
    Filed: September 6, 2019
    Publication date: December 26, 2019
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Patent number: 10472315
    Abstract: The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using various naphthoquinone, hydroxyquinonline, and naphthothiazole compounds.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: November 12, 2019
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jun O. Liu, Omonike Arike Olaleye, Shridhar Bhat
  • Patent number: 10414801
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: September 17, 2019
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Publication number: 20190040046
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: October 4, 2018
    Publication date: February 7, 2019
    Inventors: Jun O. Liu, Yingjun Li, Kalyan Kumar Pasunooti, Wukun Liu, Wei Shi, Ruojing Li, Sarah Head
  • Publication number: 20180222942
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Application
    Filed: October 9, 2017
    Publication date: August 9, 2018
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Publication number: 20170304288
    Abstract: Provided herein are formulations and co-solvent formulations and methods for treating an infectious disease utilizing the same. The formulations and co-solvent formulations may comprise a hydroxyquinoline analog or its pharmaceutically acceptable salt, a solvent and at least two surfactants. Also provided are methods of quantitating a hydroxyquinoline analog in a sample via chromatographic/spectrometric measurements.
    Type: Application
    Filed: June 29, 2017
    Publication date: October 26, 2017
    Applicant: Texas Southern University
    Inventors: Omonike A. Olaleye, Jun O. Liu
  • Patent number: 9783577
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: October 10, 2017
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Publication number: 20170202985
    Abstract: The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.
    Type: Application
    Filed: April 4, 2017
    Publication date: July 20, 2017
    Inventors: Martin G. Pomper, Richard F. Ambinder, Jun O. Liu, Curtis R. Chong, Jianmeng Chen
  • Publication number: 20170071940
    Abstract: The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Applicants: Texas Southern University, The Board of Regents of the University of Texas System
    Inventors: Omonike Arike Olaleye, Sarah Finney John, Janice Endsley, Jun O. Liu, Rosa Maldonado
  • Publication number: 20170071948
    Abstract: The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Applicants: Texas Southern University, The Board of Regents of the University of Texas System
    Inventors: Omonike Arike Olaleye, Sarah Finney John, Janice Endsley, Jun O. Liu, Rosa Maldonado
  • Publication number: 20170071951
    Abstract: The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof.
    Type: Application
    Filed: December 1, 2016
    Publication date: March 16, 2017
    Applicant: Texas Southern University
    Inventors: Omonike Arike Olaleye, Jun O. Liu, Sarah Finney John, Adaugo Chimzurum Isichei
  • Publication number: 20160354498
    Abstract: The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.
    Type: Application
    Filed: March 17, 2016
    Publication date: December 8, 2016
    Inventors: Martin G. Pomper, Richard Ambinder, Jun O. Liu, Curtis R. Chong, Jianmeng Chen
  • Publication number: 20160264556
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: May 23, 2016
    Publication date: September 15, 2016
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti
  • Patent number: 9346791
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: May 24, 2016
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti
  • Publication number: 20160115203
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Application
    Filed: January 4, 2016
    Publication date: April 28, 2016
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Patent number: 9250237
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: February 2, 2016
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Patent number: 9095589
    Abstract: Described herein are methods of inhibiting angiogenesis, and treating and preventing disorders associated with angiogenesis by administering anti-angiogenesis compounds to a subject.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: August 4, 2015
    Assignee: Johns Hopkins University
    Inventors: Jun O. Liu, Curtis R. Chong, Jing Xu, Jun Lu, Shridhar Bhat, Wie Shi
  • Publication number: 20150141415
    Abstract: The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivatives thereof or a pharmaceutical salts thereof.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 21, 2015
    Inventors: Omonike Arike Olaleye, Sarah Finney John, Adaugo Chimzurum Isichei, Jun O Liu, Rosa Maldonado, Janice Endsley
  • Publication number: 20140221393
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: September 7, 2012
    Publication date: August 7, 2014
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti