Patents by Inventor Jun O. Liu

Jun O. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS
    Publication number: 20110124649
    Abstract: Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject.
    Type: Application
    Filed: November 10, 2008
    Publication date: May 26, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jun O. Liu, Xiaoyi Hu, Xiaochun Chen, Dawei Ma, Shridhar Bhat
  • MEHODS AND COMPOSITIONS FOR INHIBITING IMPDH-1 ISOFORM 1
    Publication number: 20100330148
    Abstract: Described herein are methods of inhibiting IMPDH type 1, and treating or preventing a disease or disorder (or symptoms thereof) associated with IMPDH type 1, wherein an IMPDH type 1 inhibitor compound is administered to a subject.
    Type: Application
    Filed: March 20, 2007
    Publication date: December 30, 2010
    Applicant: The Johns Hopkins University
    Inventors: Jun O. Liu, Curtis Robert Chong, David J. Sullivan
  • PHENAZINE DERIVATIVES AND USES THEREOF
    Publication number: 20100330156
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: March 22, 2010
    Publication date: December 30, 2010
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jun O. LIU, Yunzhao REN, Fan PAN, Curtis R. CHONG, Reinhold PENNER, Jonathan R. BEHR
  • Hedgehog pathway antagonists to treat disease
    Publication number: 20090203713
    Abstract: Compounds, compositions, kits and methods for modulating hedgehog pathway activity, and treating conditions related to abnormal or aberrant hedgehog pathway activity, are disclosed.
    Type: Application
    Filed: August 22, 2006
    Publication date: August 13, 2009
    Inventors: Philip A. Beachy, Jun O. Liu
  • Immunosuppressive agents that inhibit calcineurin function and uses of these agents
    Patent number: 6686450
    Abstract: The present invention provides novel immunosuppressive agents. In particular, the invention provides immunosuppressive agents that bind calcineurin and/or that inhibit interaction between calcineurin and NF-AT. The invention also provides analogs of these agents, nucleic acids encoding the agents and/or their analogs, gene therapy vectors, etc., and methods of making and using them.
    Type: Grant
    Filed: June 17, 1999
    Date of Patent: February 3, 2004
    Assignee: Massachusetts Institute of Technology
    Inventors: Jun O. Liu, Luo Sun, Hong-Duk Youn
  • Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof
    Patent number: 6566541
    Abstract: Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: May 20, 2003
    Assignee: Massachusetts Institute of Technology
    Inventors: Jun O. Liu, Eric C. Griffith, Zhuang Su
  • Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof
    Publication number: 20010034455
    Abstract: Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.
    Type: Application
    Filed: March 21, 2001
    Publication date: October 25, 2001
    Inventors: Jun O. Liu, Eric C. Griffith, Zhuang Su
  • Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof
    Patent number: 6207704
    Abstract: Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: March 27, 2001
    Assignee: Massachusetts Institute of Technology
    Inventors: Jun O. Liu, Eric C. Griffith, Zhuang Su