Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract: A wire rope formed from a resin core and six strands, the resin core having an inner core with a circular cross section and an outer layer built up on the periphery thereof. The outer layer has a melting temperature lower than that of the inner core. The six strands are twisted together helically on the periphery of the resin core in an intertwining die in such a state that gaps are assured between the strands. The resulting wire rope is heated in a heating unit at a temperature higher than the melting temperature of the outer layer but lower than the melting temperature of the inner core. The wire rope is formed by subsequently compressing the six strands from the periphery thereof in a compressing die. The molten outer layer is hardened by natural cooling, after which the wire rope is taken up.

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract: A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases

Abstract: A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases

Abstract: A compound represented by general formula (I) and having a quinoline skeleton has a strong Axl inhibitory activity, and therefore the compound can be an agent for treating Axl-related diseases, for example, cancer such as acute myeloid leukemia, chronic myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.

Abstract: A water electrolysis system is equipped with a water electrolysis device, a water supply passage, a hydrogen supply passage, a gas-liquid separator, a first water drainage passage, a first water drainage valve, a second water drainage valve, a determination unit, and a valve control unit. In a method of stopping operation of the water electrolysis system, in a water drainage step, in the case that the determination unit determines that operation of the water electrolysis device has been stopped, the first water drainage valve is controlled to be placed in a valve open state, thereby draining liquid water from the gas-liquid separator into the first water drainage passage.

Abstract: A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract: A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract: In a water electrolysis system and a method of controlling the water electrolysis system, a control device places a high pressure water discharge solenoid valve, a depressurizing solenoid valve, and a low pressure water discharge solenoid valve in the closed state. Further, a pressure acquisition unit obtains the electrolysis time pressure as a pressure in the low pressure water sealing container during production of hydrogen by a water electrolyzer. Further, the control device determines the occurrence of hydrogen leakage in a depressurizing line based on at least the electrolysis time pressure.

Abstract: A method for extracting a lead compound from a plurality of compounds against a drug discovery target, includes the steps of creating a scatter diagram for a plurality of compounds by disposing symbols representing the compounds according to a plurality of features of the compounds and extracting a lead compound from the compounds represented by the symbols disposed in a predetermined region of the scatter diagram. The locations of the symbols to be disposed on the scatter diagram are determined according to first and second features (for example, selectivity and activity) of the respective compounds, and attributes (for example, color and size) of the symbols are determined according to third and fourth features (for example, molecular weight and ligand efficiency) of the respective compounds.

Abstract: A compound represented by general formula (I) and having a quinoline skeleton has a strong Axl inhibitory activity, and therefore the compound can be an agent for treating Axl-related diseases, for example, cancer such as acute myeloid leukemia, chronic myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract: A water electrolysis system includes a water electrolyzer, a water supply pipe, a water supply pipe, a water discharge pipe, and a first and second temperature sensors. The water electrolyzer includes a water supply port and a water discharge port. The water supply pipe is connected to the water supply port. The water is to be supplied to the water electrolyzer via the water supply pipe. The water discharge pipe is connected to the water discharge port. The water is to be discharged from the water electrolyzer via the water discharge pipe. The first temperature sensor is provided at the water supply pipe between a cooling apparatus and the water supply port to detect a temperature of the water in the water supply pipe. The second temperature sensor is provided at the water discharge pipe to detect a temperature of the water in the water discharge pipe.

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract: In order to provide a prophylactic and/or therapeutic agent for Trk-related diseases, the present invention provides a compound which has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and in addition thereto, is excellent in solubility and absorbability against free bases. The compound of the present invention has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and is excellent in solubility and absorbability against free bases, and is therefore useful as a prophylactic and/or therapeutic agent for Trk-related diseases.

Abstract: An exercise presenting apparatus, an exercise presenting method, and an exercise presenting program present effective exercise. The exercise presenting apparatus includes a purpose acquiring section (an information acquiring section) that acquires an input purpose of exercise, an exercise setting section that sets exercise intensity and an exercise time corresponding to the acquire purpose of exercise, a presentation-information generating section that generates presentation information including at least one of the set exercise intensity and an exercise type corresponding to the exercise intensity and the exercise time, and a presenting section that presents the generated presentation information.

Abstract: A water electrolysis system includes a water electrolysis apparatus, an electric component, and a casing. The electric component is to operate the water electrolysis apparatus. The casing includes a housing chamber, an electric component chamber, and a buffering chamber. The housing chamber has a first ventilation air inlet to introduce external air into the housing chamber and houses the water electrolysis apparatus. The electric component chamber has a second ventilation air inlet to introduce the external air into the electric component chamber and houses the electric component. The first ventilation air inlet and the second ventilation air inlet are separate from each other. The buffering chamber is in communication with the first ventilation air inlet and the second ventilation air inlet. An air pressure in the buffering chamber is to be maintained at atmospheric pressure.