Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments, including those where a Fab-binding molecule (Fab binding moiety) linked to a steric hindering molecule (steric hindering chemical moiety) is mechanically interlocked (e.g., through noncovalent conjugation) with the antibody or antibody fragment. Also provided are compositions that form highly stable and versatile drug delivery and diagnostic compositions.

Abstract: Provided herein are, inter alia, methods of treating cancer using compounds of the invention.

Abstract: A method of preparing lithium nickel manganese cobalt oxide high-nickel single-crystal positive electrode material comprises the following steps: mixing and ball milling nickel cobalt manganese hydroxide with a lithium source, zirconium oxide, tungsten oxide, and sodium carbonate, then performing primary sintering, pulverizing, and then obtaining an lithium nickel manganese cobalt oxide high-nickel single-crystal positive electrode material intermediate, the temperature of the primary sintering being 50-150° C. higher than a normal sintering temperature; and evenly mixing the lithium nickel manganese cobalt oxide high-nickel single-crystal positive electrode material intermediate and a coating agent, and then performing secondary sintering to obtain the lithium nickel manganese cobalt oxide high-nickel single-crystal positive electrode material.

Abstract: The present disclosure relates to the field of rAAV delivery of transgenes. In some aspects, the disclosure relates to RNAi. Provided herein are recombinant adeno-associated virus (rAAV) vectors comprising modified ITRs. In some embodiments, the modified ITRs comprise a sequence encoding a shRNA, miRNA, or AmiRNA.

Abstract: A push-bending forming device for titanium alloy tubes is provided, which includes a die main body, a plurality of filling balls, a differential temperature assembly and a punch. The filling balls are configured to be filled in a tube blank, and are made of a metal material, with a heat-resistance temperature over 500° C. A diameter of the filling ball is less than an inner diameter of the tube blank. The punch includes a first pushing part and a second pushing part. A push-bending forming method using such device is also provided.

Abstract: A method of fabricating magnetoresistive random access memory, including providing a substrate, forming a bottom electrode layer, a magnetic tunnel junction stack, a top electrode layer and a hard mask layer sequentially on the substrate, wherein a material of the top electrode layer is titanium nitride, a material of the hard mask layer is tantalum or tantalum nitride, and a percentage of nitrogen in the titanium nitride gradually decreases from a top surface of top electrode layer to a bottom surface of top electrode layer, and patterning the bottom electrode layer, the magnetic tunnel junction stack, the top electrode layer and the hard mask layer into multiple magnetoresistive random access memory cells.

Abstract: An aerosol generation system is provided, including an aerosol generator, a primary separation assembly, and a secondary separation assembly, the primary separation assembly includes a primary separation chamber and a pair of electrode plates, an inlet of the primary separation chamber is connected to an outlet of the aerosol generator, and a channel is formed between the pair of the electrode plates for aerosol particles to pass through; the secondary separation assembly comprises a secondary separation chamber, and an inlet of the secondary separation chamber is connected to an outlet of the primary separation chamber. The present disclosure achieves the requirements of different standard particle sizes for filter material testing equipment, the output of aerosols with different particle sizes and concentrations can be achieved by adjusting the voltage and length of the electrode plates, or the size and distance of the mechanical separation plate.

Abstract: The present disclosure relates to the field of rAAV delivery of transgenes. In some aspects, the disclosure relates to RNAi. Provided herein are recombinant adeno-associated virus (rAAV) vectors comprising modified ITRs. In some embodiments, the modified ITRs comprise a sequence encoding a shRNA, miRNA, or AmiRNA.

Abstract: Described herein, inter alia, is a method of conjugating of human serum Albumin (HSA) to SN38.

Abstract: A machine translation method includes: receiving a sentence, the sentence including a plurality of words; calling a machine translation model obtained through training, the machine translation model including a partitioning model and a translation model; partitioning the sentence based on the partitioning model and according to word vectors of the words, to obtain to-be-translated blocks, each to-be-translated block including at least one of the words; and translating the sentence based on the translation model and the to-be-translated blocks, to obtain a translation result.

Abstract: The present disclosure relates to the technical field of agricultural microorganisms and crop cultivation and more specifically relates to a compound mycorrhizal fungus growth promoting agent and an agricultural-photovoltaic complementary planting method for Dioscorea composita. The compound mycorrhizal fungus growth promoting agent for Dioscorea composita includes Glomus mosseae, Streptomyces chartreusis and plant growth promoting rhizobacteria, and can greatly improve photosynthesis of Dioscorea composita under a photovoltaic panel and promote growth and development of Dioscorea composita. The compound mycorrhizal fungus growth promoting agent is used, an unoccupied land under a solar photovoltaic panel is utilized, and a high-ridge close planting method is used to combine a solar photovoltaic industry and Dioscorea composita planting. The whole planting process is easy to operate, the cost is low, and three-dimensional value-added utilization of land is achieved.

Abstract: An air valve structure arranged on a base comprises an air plug and a state-switching component. The air plug is arranged in an air chamber in an axial direction. The air plug includes a closing state to close the air hole, and an opening state to open the air hole. The state-switching component comprises a driving member that links the air plug, a shape-memory alloy (SMA) wire connected with the driving member, and at least one conductive member connected with the SMA wire. The driving member exerts an acting force to the air plug based on a condition of electricity provided by the conductive member for the SMA wire. The direction of the acting force is non-parallel with the axial direction and the air plug is moved and changed between the closing state and the opening state by the acting force.

Abstract: Disclosed are a hoisting path planning model construction method, a hoisting path planning method and a crane. The hoisting path planning model construction method includes: building a crane model; constructing a hoisting system configuration space model based on a current operation scenario and the crane model, and the hoisting system configuration space model includes upper vehicle body data of a crane and lower vehicle body data of the crane; aiming at the hoisting system configuration space model and the upper vehicle body data, generating upper vehicle body raster graphic data of the crane; and aiming at the hoisting system configuration space model and the lower vehicle body data, generating lower vehicle body raster graphic data of the crane; and using an A-star algorithm and combining the upper vehicle body raster graphic data and the lower vehicle body raster graphic data to construct a hoisting path planning model.

Abstract: Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML.

Abstract: A sample to be measured is placed in a medium solution between two circular magnets to ensure that the sample to be measured is levitated in a set circular area between the two circular magnets, and a levitation position of the sample to be measured in the magnetic field is measured. The density of the sample is calculated according to formula (I): ? s = ? m + ? m - ? s g ? ? 0 ? ( B r ? ? B z ? r + B z ? ? B z ? z ) . Compared to the prior art, the method of the present disclosure provides a novel method for measuring a density of a substance, in which the involved device is easy to operate and has low cost, and the measurement results are easy to observe and have high accuracy.

Abstract: A method for constructing a multistage network includes: deploying a plurality of nodes; constructing the upper network with at least one node of the plurality of nodes; and in response to determining there is an isolated node, determining an intermediate node for the isolated node and adding the isolated node into the upper network or one of the at least one sub-network according to the intermediate node.

Abstract: An air valve with a SMA wire for switching is located in an air chamber in which at least two air holes are formed. The air valve comprises a base, an air piston, a driving component, and the SMA wire. The base is provided with two supporting blocks, and two conduction components near one of the two supporting blocks. The air piston determines a ventilation state of one of the two air holes. The air piston comprises a rod body on the two supporting blocks and with a first triggering part, and a spring sleeved on the rod body. The driving component is sleeved on the rod body and with a second triggering part matched with the first triggering part. The SMA wire is connected with the two conduction components and the driving component, and is turned by the supporting block opposite to the two conduction components.

Abstract: A downhole throttling device based on wireless control includes an inlet nozzle, a throttling assembly, an electrical sealing cylinder, a gas guide cylinder, a lower adapter sleeve, an end socket, a female sleeve, and electrical components. The inlet nozzle is connected to the throttling assembly, the throttling assembly is connected to the electrical sealing cylinder and the gas guide cylinder, the electrical sealing cylinder and the gas guide cylinder are both connected to the lower adapter sleeve, the lower adapter sleeve is respectively connected to the end socket and the female sleeve, and the electrical components are arranged in the electrical sealing cylinder. A throttling effect is achieved by detecting the temperature and pressure in a tube by a temperature/pressure sensor in the electrical components and controlling a motor to rotate a movable valve in the throttling assembly by a circuit control assembly, thereby achieving wireless control over downhole throttling.

Abstract: Disclosed is a method for producing biogas from a waste liquid/residue after diosgenin extraction by aluminum chloride. Specifically, in a fermentation vessel, an anaerobic sludge and a waste residue from diosgenin extraction by aluminum chloride are added at a volatile solids ratio of (1-3):(1-2), or a seeding sludge and a diosgenin waste liquid are added with an organic loading having a VS:COD ratio of (1-2):(1-2); and then the above components are fermented at 35-37° C. for 5-25 d such that biogas is produced. According to the method of the present invention, the maximum cumulative biogas production rates are 255.4 mL/g VS for waste residue and 326.9 mL/g COD for waste liquid, and throughout the fermentation period, ammoniacal nitrogen values are below 1500 mg/L and pH variation is within the normal range, and the COD removal rate for the fermentation broth is 91.11%.