Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: In some aspects, the disclosure relates to methods for improving titer and yield of viral vector production. In some embodiments, the methods comprise transient silencing of transgene expression during packaging of a viral vector.

Abstract: In some aspects, the disclosure relates to compositions and methods for treating fibrodysplasia ossificans progressiva (FOP) in a subject. In some aspects, the disclosure provides isolated nucleic acids, and vectors such as rAAV vectors, configured to express transgenes that inhibit (e.g., decrease) expression of mutated AVCR1 gene in muscle cells or connective tissues.

Abstract: Disclosed is a method for producing biogas from a waste liquid/residue after diosgenin extraction by aluminum chloride. Specifically, in a fermentation vessel, an anaerobic sludge and a waste residue from diosgenin extraction by aluminum chloride are added at a volatile solids ratio of (1-3):(1-2), or a seeding sludge and a diosgenin waste liquid are added with an organic loading having a VS:COD ratio of (1-2):(1-2); and then the above components are fermented at 35-37° C. for 5-25 d such that biogas is produced. According to the method of the present invention, the maximum cumulative biogas production rates are 255.4 mL/g VS for waste residue and 326.9 mL/g COD for waste liquid, and throughout the fermentation period, ammoniacal nitrogen values are below 1500 mg/L and pH variation is within the normal range, and the COD removal rate for the fermentation broth is 91.11%.

Abstract: The present application discloses a pellet flue gas circulation and waste heat utilization process and a system thereof, which relates to the technical field of flue gas treatment. The system includes a grate, a rotary kiln, an annular cooler, and ducts connecting each part. On the basis of not changing the existing process a flue gas circulation unit and intelligent control equipment are arranged additionally in the present application. The process is simple, and not only can ensure the parameter stability of the production system such as temperature, gas flow or gas pressure, but also can make full use of the low and medium temperature flue gas components and the waste heat, so as to achieve net zero waste gas discharging, energy saving and emission reduction.

Abstract: Embodiments of this application include an information conversion method for translating source information. The source information is encoded to obtain a first code. A preset conversion condition is obtained. The preset conversion condition indicates a mapping relationship between the source information and a conversion result. The first code is decoded according to the source information, the preset conversion condition, and translated information to obtain target information. The target information and the source information are in different languages. Further, the translated information includes a word obtained through conversion of the source information into a language of the target information.

Abstract: Provided herein, inter alia, are methods of treating cancer or cutaneous T-cell lymphoma (CTCL) using compounds of the invention.

Abstract: In some aspects, the disclosure relates to compositions and methods for treating fibrodysplasia ossificans progressiva (FOP) in a subject. In some aspects, the disclosure provides isolated nucleic acids, and vectors such as rAAV vectors, configured to express transgenes that inhibit (e.g., decrease) expression of mutated AVCR1 gene in muscle cells or connective tissues.

Abstract: A one-time programmable (OTP) memory has a plurality of pages. A predefined section of each page is configured to store error policy bits. When an indicator in a first predefined location has a first value, the page is configured to store data with error correction code (ECC) bits, and when the indicator has a second value, at least a portion of the page is configured to store data with redundancy. Address translation circuitry is configured to, in response to receiving an access address, use a second predefined location of an accessed page of the plurality of pages accessed by the access address to determine a physical address in the accessed page which corresponds to the access address.

Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

Abstract: Provided herein are methods for treating metastatic prostate cancer using anti-androgen compounds and radionuclide-labeled androgens.

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

Abstract: In some aspects the disclosure provides compositions and methods for promoting expression of functional Thymine Kinase 2 (TK2) protein in a subject. In some embodiments, the disclosure provides methods of treating a subject having TK2 deficiency, for example a subject having mitochondrial DNA depletion syndrome.

Abstract: A circuit design includes a flexible film, an electrode pattern, and a connecting circuit. The flexible film has a visible area and a bending area and includes an external conductive connection. The electrode pattern is disposed in the visible area of the flexible film. The connecting circuit is electrically connected to the electrode pattern and disposed in the bending area of the flexible film. The bending area has a first portion and a second portion. The first portion is located between the visible area and the second portion. A width of one end of the second portion connected to the first portion is smaller than a width of the first portion. The external conductive connection is electrically connected to the connecting circuit and located at another end of the second portion.

Abstract: An electronic device includes an integrated circuit and a smart film layer. Integrated circuit is configured to output a control signal. Smart film layer is coupled to integrated circuit and includes a first substrate, a second substrate, a liquid crystal layer, a transparent glue layer, a cover, and at least one touch electrode layer. Second substrate is located on first substrate. Liquid crystal layer is located between first substrate and second substrate. Transparent glue layer is located on second substrate. Cover is located on transparent glue layer. At least one touch electrode layer is located between two of first substrate, second substrate, liquid crystal layer, transparent glue layer, or cover. At least one touch electrode layer is configured to transmit a touch signal or at least one touch electrode layer is configured to control liquid crystal layer to present in transparent states according to control signal of integrated circuit.

Abstract: Provided, inter alia, are methods and compositions for treating FTO-mediated cancer.

Abstract: A hierarchical system firewall, comprising a root security manager, secondary security managers, a firewall controller, and firewalls. The root security manager designates a secondary security manager and allocates a system resource for each domain cluster, and provides firewall configuration schemes between the domain clusters. The secondary security managers add domain identifiers for hosts and devices of domain clusters, and provides a firewall configuration scheme for each domain. The firewall controller adds domain cluster identifiers for the hosts and devices in the system, and adds identification for the secondary security managers; allocates domain identification for a host and a device of a current domain cluster; and configures access permissions for the firewall of each device in the current domain cluster. The firewalls perform permissions control for access to a current device by hosts from different domains or different domain clusters.

Abstract: A magnetoresistive random access memory (MRAM), including a bottom electrode layer on a substrate, a magnetic tunnel junction stack on the bottom electrode layer, a top electrode layer on the magnetic tunnel junction stack, and a hard mask layer on said top electrode layer, wherein the material of top electrode layer is titanium nitride, a material of said hard mask layer is tantalum or tantalum nitride, and the percentage of nitrogen in the titanium nitride gradually decreases from the top surface of top electrode layer to the bottom surface of top electrode layer.

Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.

Abstract: The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention, methods and compositions for treating cholesterol related disorders are provided. In one aspect of the invention, miRNA inhibitors against miR-122 and rAAV-based compositions comprising the same are provided.