Abstract: The present invention provides methods for treatment of a RAS-positive disease, in particular KRAS-positive non-small cell lung cancer as well as a method for potentiating the apoptotic activity of a PDE? inhibitor by combining the PDE? inhibitor with a direct autophagy inhibitor. The PDE? inhibitor is preferably, but not exclusively, deltarasin, and the direct autophagy inhibitor is in particular 3-methyladenine. Further provided by the present invention are a kit and a pharmaceutical composition comprising the PDE? inhibitor and a direct autophagy inhibitor. The methods of the present invention in particular provide a new treatment option for RAS-positive diseases such as KRAS-positive non-small cell lung cancer allowing for an increased apoptotic activity of the PDE? inhibitor by simultaneously blocking its “tumor protective” autophagy.

Abstract: A location system provides a location service for determining a location of a mobile device. A node of the location system comprises: a signal processing module, and a wireless interface which communicates wirelessly according to a standardized wireless networking protocol. The protocol defines a request message for sending a request from the mobile device to the node, the request message having a network ID field for specifying a network to which the request is directed. The wireless interface receives, from the mobile device, an instance of the request message including an ID of the location service, this being carried in the network ID field. The signal processing module detects the ID of the location service in this field, and in response captures a measurement of the received instance of the request, for use in determining the location of the mobile device in conjunction with measurements from other nodes.

Abstract: For logical multicasting in overlay networks, at a data processing system, an original unicast packet is received from a first component in a first computing node in an overlay network. To cause multicasting in the overlay network the received original unicast packet was unicast by the first computing node only to the data processing system, and a multicast data structure for the overlay network is maintained only by the data processing system, the multicast data structure containing information of each receiver that is configured to receive unicast packets during logical multicasting in the overlay network. From a set of subscriber receivers in the multicast data structure, a subset of the subscriber receivers is selected. A copy of the original unicast packet is unicast to each subscriber receiver in the subset.

Abstract: One example embodiment relates to a method of treating lung cancer by administering a compound of formula I to a subject in need thereof. Another embodiment relates to a method to treat Non-Small Cell Lung Cancer (NSCLC) by administering the compound of formula I to a patient.

Abstract: An imaging method comprises the steps of: putting an object in a detection region, and biasing a detector (1-8) relative to the object; moving an imaging system along a longitudinal Z axis, enabling a ray source (1-7) and the detector (1-8) to synchronously perform circular movement around the object, performing scanning and data collection, and supplementing the data; and reconstructing the collected data to obtain a complete object image. The imaging method combines detector biasing and spiral scanning, solves the problem that an image splicing method used in conventional CT imaging generates artifacts, reduces the usage area of the detector, and reduces system cost.

Abstract: The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is nobiletin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.

Abstract: A manual ice maker and a refrigerator comprising the same are provided. The manual ice maker comprises: an ice making body being a frame formed with an opening, and provided with a first positioning hole in a front wall thereof, a second positioning hole in a rear wall thereof and a first limiting protrusion on an inner surface of the rear wall thereof; an ice making tray provided with a first shaft at a front end thereof and a second shaft at a rear end thereof, the first shaft rotatably supported in and extended out of the first positioning hole, the second shaft rotatably supported in the second positioning hole; and an ice removing assembly. The ice removing assembly comprises: a twisting member provided with a gear; and a press member movable between a first position and a second position in a vertical direction to drive the gear to rotate.

Abstract: The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is tangeretin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.

Abstract: For logical multicasting in overlay networks, at a data processing system, an original unicast packet is received from a first component in a first computing node in an overlay network. To cause multicasting in the overlay network the received original unicast packet was unicast by the first computing node only to the data processing system, and a multicast data structure for the overlay network is maintained only by the data processing system, the multicast data structure containing information of each receiver that is configured to receive unicast packets during logical multicasting in the overlay network. From a set of subscriber receivers in the multicast data structure, a subset of the subscriber receivers is selected. A copy of the original unicast packet is unicast to each subscriber receiver in the subset.

Abstract: A compound suitable for treating cancer, in particular NSCLC, inhibits activity of oncogenic ROS1 kinase and ALK kinase. The compound has certain structural components such as a quinoline moiety in the backbone and at least one phenyl-containing moiety in a side chain with a hydrophobic substituent attached to the backbone via an up to 6-membered linking group as well as a further hydrophobic moiety. The presence of the structural components allows for an advantageous interaction with the ROS1 kinase domain and, further, with the ALK kinase domain. Hence, said compound represents a highly promising opportunity for patients bearing ROS1- or ALK-dependent cancer. A composition, in particular a pharmaceutical composition, includes the compound. A method for targeting cancer cells harboring an abnormality in ROS1 gene or ALK gene includes contacting a cell with the compound.

Abstract: This invention provides a method of treating lung cancer including administering a therapeutically effective amount of a compound of 0089-0022 formula I to a subject in need thereof. The compound activates pyruvate kinase M2 isoform (PKM2) to treat the lung cancer. In one example, the lung cancer is Non-Small Cell Lung Cancer (NSCLC).

Abstract: A touch panel having a cover plate, a sensor electrode layer, an insulating layer and a jumper layer is provided. The sensor electrode layer has first axis electrodes, second axis electrodes, bonding pads and first periphery traces. Each first axis electrode has first electrode blocks that are electrically connected to each other. Each second axis electrode has second electrode blocks that are electrically isolated from each other. The bonding pads are disposed on the periphery region of the cover plate. The first periphery traces are electrically connected to the bonding pads and the first axis electrodes or the second axis electrodes respectively. The insulating layer has first via holes and second via holes. The jumper layer has jumper traces and second periphery traces, wherein the second periphery traces are electrically connected to the first axis electrodes or the second axis electrodes through the first via holes.

Abstract: Systems and methods disclosed herein relate to reducing the losses associated with processing payments using credit card payment processing gateways. Payment processing gateways have different deposit success rates due to the gateways' varying arrangements with acquiring banks and the ability to process certain types of payments. A payment request related to a user may be received, wherein the request specifies a particular type of credit card, a transaction currency, and an amount. A payment application then routes, via a payment agent, the payment request to an adaptive gateway switching system (AGSS) in an attempt to complete a payment transaction. If in learning mode, the AGSS may randomly choose a payment processing gateway. Or the AGSS may choose the gateway based upon a learned gateway status based upon results learned through reinforcement learning. Upon receiving the result of a transaction attempt from the gateway, the agent reports the result to the AGSS.

Abstract: This invention generally relates to interference mitigation, and more specifically to interference mitigation in wireless communications networks. The proposed solution takes advantage of the clear channel assessment (CCA) function used by WLAN networks. Hence, by jamming the interfering WLAN channel during a predetermined time period, the interfering WLAN network is forced to withhold transmissions on the WLAN interfering channel during a backoff period of time. The solution of the subject application makes use of this backoff period to enable a WPAN network to transmit critical information such as, but not limited to, a request for changing the current working frequency.

Abstract: A coating device for coating a coating liquid onto a substrate includes: a coating head having a coating-liquid outlet, adapted to move with respect to the substrate along a first axial direction and capable of coating the substrate with coating liquid through the coating-liquid outlet; and adjustment unit connected to the coating head and including a movable pad disposed proximal to the coating-liquid outlet and adapted to move along a second axial direction for adjusting the size of the opening of the coating-liquid outlet; and a drive assembly connected to the adjustment unit for controlling the adjustment unit to move along the second axial direction. Additionally a coating method is provided.

Abstract: A manufacturing method of a touch panel is provided. The method comprises the following procedures: forming a sensing electrode layer on a cover plate, wherein the sensing electrode layer comprises a plurality of first axis electrodes, a plurality of second axis electrodes, a plurality of bonding pads and a plurality of first periphery traces; forming a insulating layer on the sensing electrode layer, wherein a plurality of first via holes and a plurality of second via holes are formed on the insulating layer; forming a jumper layer on the insulating layer, wherein the jumper layer comprises a plurality of jumper traces and a plurality of second periphery traces. Moreover, the sensing electrode layer, the insulating layer and the jumper layer are formed through a printing process, a photo etching process, a spraying process, a slit coating process, a laser scribing process, a laminating process or any combination thereof.

Abstract: A method and device for making a decision about interoperation with a Wireless Local Area Network (WLAN) during cell handover of a terminal are provided. The method includes that: if User Equipment (UE) determines that a condition of offloading to the WLAN is met according to a WLAN interoperation decision criterion configured by a network side, then offloading to the WLAN is delayed or cancelled; and if a reporting condition of a measurement report about offloading to the WLAN is met, then reporting of the measurement report about offloading to the WLAN is delayed or cancelled.

Abstract: The present invention discloses a method for processing non-unicast routes information in a TRILL network and a corresponding RBridge, wherein the RBridge has a neighbor relation with a plurality of other RBridges in the TRILL network, and the RBridge is the RBridge which computes non-unicast routes information in the neighbor relation, and in the method, the RBridge executes steps of: sending an acknowledgement message to the plurality of other RBridges, wherein the acknowledgement message acknowledges that the RBridge is the RBridge which computes the non-unicast routes information; obtaining a network topology related to the non-unicast routes information in the TRILL network; computing the non-unicast routes information based on the network topology; and distributing the computed non-unicast routes information to the plurality of other RBridges. The method and the corresponding RBridge are capable of reducing consumption of CPU resource of RBridges in the TRILL network.

Abstract: The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is nobiletin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.

Abstract: The present invention relates to the administration of a novel compound advantageously efficacious as PDE? inhibitor and its effects on subjects with cancer. More specifically, the present invention is directed to a method for administering a compound having favorable geometric properties for interacting with the PDE? prenyl-binding pocket, namely has certain structural components such as a three-cyclic backbone and at least one benzoyl-moiety in a side chain having at least two substituents containing highly electronegative atoms and being linked to the backbone via an aliphatic chain, for treating a subject suffering from a disease such as cancer, in particular non-small-cell lung cancer. The presence of said structural components particularly contributes to an advantageous interaction with PDE?, in particular with amino acids deep in the binding pocket.