Abstract: One embodiment is a method of treating cancer. The method includes administering a therapeutically effective amount of a compound to a patient.

Abstract: One embodiment relates to a method of treating cancer by administering a compound of Formula I to a patient.

Abstract: A refrigeration device, including a cabinet, a door body, a drawer, a first snap assembly, and a second snap assembly. The door body is provided to the cabinet in a drawable manner; the drawer is detachably provided to the door body, the first snap assembly is adapted to limit the door body at a first position where the door body can be fixed to the cabinet, the second snap assembly is adapted to limit the door body at a second position where the door body can be fixed to the cabinet, during the process that the door body is pulled out of the cabinet, the door body passes through the first position and the second position in sequence, when the first snap assembly fails, the drawer is adapted to be taken out of the door body, and when the second snap assembly fails, the door body is adapted to be separated from the cabinet.

Abstract: One embodiment is a method of treating cancer. The method includes administering a therapeutically effective amount of a compound to a patient.

Abstract: The present disclosure provides a door opening and closing device, and a refrigerator. A door of the refrigerator is rotatably connected to a refrigerator body by means of a rotating shaft, wherein the rotating shaft is fixedly connected to the door, the door opening and closing device includes a connecting rod, a first drive means, a second drive means and an elastic member. The connecting rod is arranged on the door, and the connecting rod includes a first end and a second end that matches a shaft hole. The first drive means is connected to the connecting rod and is configured to drive the connecting rod to rotate. The second drive means is configured to drive the connecting rod to move towards the shaft hole, and cause the second end of the connecting rod to be inserted into the shaft hole.

Abstract: This invention generally relates to interference mitigation, and more specifically to interference mitigation in wireless communications networks. The proposed solution takes advantage of the clear channel assessment (CCA) function used by WLAN networks. Hence, by jamming the interfering WLAN channel during a predetermined time period, the interfering WLAN network is forced to withhold transmissions on the WLAN interfering channel during a backoff period of time. The solution of the subject application makes use of this backoff period to enable a WPAN network to transmit critical information such as, but not limited to, a request for changing the current working frequency.

Abstract: A power converter for converting an input power at an input of the converter to an output power at an output of the converter includes a power conversion circuit and a snubber circuit coupled to the power conversion circuit. The power conversion circuit includes a switching device coupled to a reference potential, and an inductance coupled to the switching device. The snubber circuit includes a snubber switching device, a capacitance coupled to the snubber switching device, and an auxiliary inductance coupled to the inductance of the power conversion circuit and the snubber switching device. The snubber switching device and the capacitance are coupled across the switching device of the power conversion circuit. The capacitance is adapted to store leakage energy output from the power conversion circuit and discharge at least a portion of the stored leakage energy via the snubber switching device. Other example power converters are also disclosed.

Abstract: One embodiment is a method of treating cancer. The method includes administering a therapeutically effective amount of a compound to a patient.

Abstract: A refrigeration device, including a cabinet, a door body, a drawer, a first snap assembly, and a second snap assembly. The door body is provided to the cabinet in a drawable manner; the drawer is detachably provided to the door body, the first snap assembly is adapted to limit the door body at a first position where the door body can be fixed to the cabinet, the second snap assembly is adapted to limit the door body at a second position where the door body can be fixed to the cabinet, during the process that the door body is pulled out of the cabinet, the door body passes through the first position and the second position in sequence, when the first snap assembly fails, the drawer is adapted to be taken out of the door body, and when the second snap assembly fails, the door body is adapted to be separated from the cabinet.

Abstract: A service processing method includes determining, by a first local terminal, whether a service needs to be roamed, and when the service needs to be roamed, transferring, by the first local terminal, the service to a second local terminal, where the second local terminal is in communication with the first local terminal using a first network. Local terminals in the first network are interconnected, such that service roaming can be implemented. The first network is a locally interconnected network, roaming does not need to be controlled by an operator network, and the local terminal can control the roaming.

Abstract: A method of identifying a gene associated with a disease or pathological condition of the disease includes: a) obtaining a first group of exome sequences from a first population suffering from the disease or pathological condition and a second group of exome sequences from a second population not having the disease or pathological condition; b) identifying one or more variants in the first group by comparing it with the second group, and optionally with a public database, to generate a first set of variant data; c) applying a variant quality score calibration tool with a truth sensitivity threshold to remove false-positive variants having a sensitivity lower than the threshold and background variants from the first set of variant data so as to obtain a second set of variant data; d) removing synonymous variants from the second set of variant data to obtain a third set of variant data; and e) identifying one or more deleterious variants from the third set of variant data using a gene burden analysis, optionall

Abstract: A position locating method and apparatus are applied to the electronic information field, so that shifting an indication cursor in a wide range using a wireless indication device can be avoided, and a user operation can be simplified. The method comprises detecting a line-of-sight orientation of a user, and obtaining a line-of-sight orientation parameter of the user; detecting a line-of-sight source of the user, and obtaining a line-of-sight source position of the user; obtaining a position of a screen, and obtaining a screen position of a line of sight according to the line-of-sight orientation parameter, the position of the screen, and the line-of-sight source position; and receiving an adjustment signal, adjusting, according to the adjustment signal, the position displayed on the screen, and displaying an adjusted position on the screen.

Abstract: A power converter for converting an input power at an input of the converter to an output power at an output of the converter includes a power conversion circuit and a snubber circuit coupled to the power conversion circuit. The power conversion circuit includes a switching device coupled to a reference potential, and an inductance coupled to the switching device. The snubber circuit includes a snubber switching device, a capacitance coupled to the snubber switching device, and an auxiliary inductance coupled to the inductance of the power conversion circuit and the snubber switching device. The snubber switching device and the capacitance are coupled across the switching device of the power conversion circuit. The capacitance is adapted to store leakage energy output from the power conversion circuit and discharge at least a portion of the stored leakage energy via the snubber switching device. Other example power converters are also disclosed.

Abstract: One example embodiment is a lignanamide that includes a benzo-angular triquinane skeleton. The lignanamide is represented by formula (I) and any derivative of the formula (I), in which R is represented by —OH or —OCH3. Another example embodiment relates to a method of treating neurodegenerative disease by administering the lignanamide of the formula (I) to a person in need thereof.

Abstract: A method of treating a subject, in particular a human, suffering from non-small cell lung cancer includes administering a bufadienolide to the subject. A method of inhibiting the proliferation and inducing the cell death of non-small cell lung cancer cells, a method of inhibiting the Epidermal growth factor receptor (EGFR) kinase activity in non-small cell lung cancer cells harboring an abnormality in the EGFR gene, and a method of inhibiting Na+/K+-ATPase in non-small cell lung cancer cells includes contacting those cells with a bufadienolide. Proscillaridin A as bufadienolide, with the structure of Formula (III) has advantageously high cytotoxicity against EGFR-dependent non-small cell lung cancer at nano-molar levels while having low toxicity to normal lung cells.

Abstract: The present invention generally relates to injectable electronics. In some aspects, the present invention is generally directed to systems and methods for interfacing an electrical cable with electrical elements, such as nanoscale wires, that are injected or otherwise introduced into a subject. The subject may be living or non-living. In one set of embodiments, electrical elements introduced within a subject may be placed in electrical communication to a circuit board using a plurality of electrically isolated contacts that the circuit board can clamp or otherwise connect to. The electrical contacts may be in electrical communication with the electrical elements using a joining portion. The circuit board can also be connected to an electrical cable that can be attached, for example, to a computer. In some cases, the electrical cable can be attached or detached to or from the circuit board, e.g.

Abstract: A service processing method includes determining, by a first local terminal, whether a service needs to be roamed, and when it is determined that the service needs to be roamed, transferring, by the first local terminal, the service to a second local terminal, where the second local terminal is connected to the first local terminal using a first network. Local terminals in the first network are interconnected, such that service roaming can be implemented. The first network is a locally interconnected network, roaming does not need to be controlled by an operator network, and the local terminal can control the roaming.

Abstract: A compound for treating a disease, in particular cancer like non-small cell lung cancer, exceptionally inhibits activity of oncogenic ALK kinase. Compositions, particularly pharmaceutical compositions, are provided comprising this compound. Methods for targeting cancer cells harboring an abnormality in the ALK gene are also The compound for treating a disease has certain structural elements, namely a tricyclic, more specifically heterocyclic, backbone as the core part of the compound at least one highly electronegative atom in form of a tertiary amine attached to the backbone via an at most 6-membered linking group with a terminal highly electronegative atom in form of a nitrogen as secondary amine, and a further hydrophobic moiety fused to the backbone. The structural components allow for an advantageous interaction with the ALK kinase domain. The compound therefor represents a highly promising treatment option for patients in particular those bearing ALK-dependent non-small cell lung cancer.

Abstract: The provided are method and device for processing information interaction, the offloading processing method and device, a base station, an RNC and UE. The method for processing information interaction includes that: a target side network element for handover of UE receives at least one of the following source side information sent by a source side network element: WLAN auxiliary information, offloading rule information, WLAN measurement report information, offloading decision information and information indicating a capability in supporting interoperation with a WLAN; and/or, the target side network element sends at least one of the following target side information to the source side network element: WLAN auxiliary information, load information, offloading rule information, measurement configuration information, offloading decision information and information indicating a capability in supporting interoperation with the WLAN.