Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.

Abstract: A moderate-strength steel rail is provided. The chemical composition of the moderate-strength steel rail in weight percentages includes carbon 0.70-0.90 wt %, silicon 0.08-0.65 wt %, manganese 0.69-1.31 wt %, chromium 0.10-0.25 wt %, phosphorus ?0.020 wt %, sulfur ?0.020 wt %, and iron 96.85-98.41 wt %. According to a production method for the moderate-strength steel rail of the present invention, the moderate-strength steel rail produced has a rail hardness of 350-370 HB, a wear amount of ?0.40 g, a contact fatigue life of ?50,000 times, and a 610 mm steel rail waist opening ?3.0 mm/400 mm.

Abstract: The invention discloses a high strength fireproof board, which has two structures. The first structure is a three-layer hot pressed composite structure, which is composed of fiber layer, foaming fiber layer and fiber layer respectively from top to bottom, and the second structure is composed of hot-pressed fiber layer. The invention also discloses a wear resistant fireproof decorative panel consisting of a high strength fireproof board which is hot pressed at one time, or can be hot pressed twice, or composite molded after glue coated. The invention also discloses a manufacturing method for high strength fireproof board and wear resistant decorative panel based on high strength fireproof base board. The stated high strength fireproof board and wear resistant decorative panel are made of thermosetting resin and have the characteristics of flame retardant, wear resistant, high, and low temperature resistant, sound absorbing and antistatic.

Abstract: To provide plate-like alumina particles that are less likely to wear apparatuses. Plate-like alumina particles containing germanium or a germanium compound. The plate-like alumina particles preferably have a molar ratio of Ge to Al, [Ge]/[Al], of 0.08 or more as determined in an XPS analysis. The plate-like alumina particles preferably contain the germanium or germanium compound in a surface layer. The plate-like alumina particles preferably have a density of 3.7 g/cm3 or more and 4.1 g/cm3 or less. The plate-like alumina particles preferably have a molar ratio of Ge to Al, [Ge]/[Al], of 0.08 or less as determined in an XRF analysis.

Abstract: This application discloses a time of flight (TOF) apparatus and an electronic device comprising the TOF apparatus. The TOF apparatus includes a transmitter and a receiver, and both the transmitter and the receiver are divided into a plurality of regions. The TOF apparatus can capture a plurality of local 3D images corresponding to different regions of a target object in a manner in which the transmitter performs region-based turning-on and the receiver performs region-based detection, and then the electronic device splices the plurality of local 3D images, to obtain a 3D image of the target object.

Abstract: A novel method for service based network resource allocation is disclosed. In one embodiment, a method is disclosed comprising receiving from a UE at a base station over a Primary Cell (PCell), a request message to perform an action with respect to a Secondary Cell (SCell), the request message including service information. The method then determines a specific action to be performed with respect to the SCell based on the service information. Finally, the method performs the specific action with respect to the SCell at the base station and transmits a connection reconfiguration message to the UE to direct the UE to perform the specific action based on a service to be supported.

Abstract: A method, apparatus, system for managing a maintenance for a component in a vehicle. Sensor data is received for the vehicle. Target parameters are predicted using behavior machine learning models trained using first training data to predict the target parameters for a normal behavior of the component operating in a tolerance, wherein the target parameters characterize behavior of the component. Prediction metrics are determined from predicted values for the target parameters predicted by behavior machine learning models and actual values for the target parameters. Whether the component will fall out of the tolerance after a time period is predicted using the prediction metrics and a maintenance machine learning model trained using second training data to predict whether the maintenance is needed for the component, wherein the second training data comprises historical prediction metrics determined for the target parameters.

Abstract: An e-cigarette cartridge includes a housing with an air inlet and an air outlet; and the housing is provided with a liquid storage cavity, a porous body, a vaporization cavity, a heating element, a support frame, and a vapor output channel, where the vaporization cavity is in airflow communication with the air inlet; the support frame is constructed to provide the porous body with support and holding; and the vapor output channel includes a first channel part and a second channel part that are formed on the support frame and extend in a width direction of the housing. One end of the first channel part is in communication with the vaporization cavity and the other end is in communication with the air outlet; one end of the second channel part is in airflow communication with the vaporization cavity and the other end is in airflow communication with the air outlet.

Abstract: An improved cellular network communications scheme enables synchronization of end-to-end session parameters between a radio access network and user equipment. In one embodiment, a method is disclosed comprising receiving, at an access point, a first notification from user equipment (UE), the first notification including data representing a capability of the UE; receiving, at the access point, a second notification from the UE, the second notification including data representing a negotiated session parameter; detecting, by the access point, a change in quality of a network link associated with the UE; and disabling, by the access point, a transmission of a recommendation to the UE based on the negotiated session parameter.

Abstract: A method and an apparatus for cloud service management, and a readable storage medium are disclosed. The method includes steps of: by a service management module in response to receipt of a work order of an application request, splitting the work order, creating a department and a virtual data center (VDC), creating a user, and binding the user to the department and the VDC, where the work order comprises a resource creation request and a resource parameter; by a resource management module, sending the resource parameter to an underlying resource pool through an interface; by the resource management module, sending a first notification to a software defined network (SDN) controller, where the first notification is a notification requesting to send a flow table; and by the SDN controller, sending the flow table to gateway device according to the first notification.

Abstract: An electronic cigarette, an electronic cigarette atomizer and an atomization assembly. The electronic cigarette atomizer comprises: an e-liquid storage chamber (12), which stores an e-liquid matrix; a porous body (30), which is in fluid communication with the e-liquid storage chamber (12) to absorb the e-liquid matrix; and a heating element (40), which comprises a first electrode connection part (41), a second electrode connection part (42), and a resistance heating track (43) extending between the first electrode connection part (41) and the second electrode connection part (42), wherein the curvature of any position of a part of the resistance heating track (43) that is close to and is connected to the first electrode connection part (41) and/or the second electrode connection part (42) is not zero.

Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.

Abstract: Systems and methods described herein enable user-aware and application-aware dynamic slicing for mobile networks. A network device in a provider network receives a dynamic slice request from a client application. The dynamic slice request includes authorization credentials and a quality of service (QoS) indication for the client application. In response to the dynamic slice request, the network device generates a traffic descriptor value. The traffic descriptor value includes an access token that indicates the QoS authorized for the client application. The network device pushes updated UE Route Selection Policy (URSP) rules to a modem of the UE device, and also separately directs the traffic descriptor value to the client application. The network device receives, from the UE device, a protocol data unit (PDU) session establishment request that includes network slice selection information based on the traffic descriptor value.

Abstract: In some implementations, a device may receive file location information identifying a file to be transferred to a user device associated with the first network provider, wherein the file location information identifies a domain name associated with a second network provider. The device may provide, based on the file location information, a request to obtain one or more records associated with the domain name. The device may receive the one or more records based on the request. The device may selectively obtain, based on the one or more records, the file from a first content device associated with the second network provider or from a second content device associated with a third-party provider. The device may provide the file to the user device.

Abstract: A user equipment transmits user equipment information, associated with a communication of the user equipment, to permit a base station to select a first bandwidth part, a second bandwidth part, or a third bandwidth part. The user equipment is configured to communicate by the first bandwidth part, the second bandwidth part, and the third bandwidth part. The user equipment receives, from the base station, an instruction to monitor the first bandwidth part, the second bandwidth part, or the third bandwidth part. The instruction is selected based on the user equipment information. The user equipment monitors, based on the instruction, the first bandwidth part, the second bandwidth part, or the third bandwidth part.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: Prognostication and amelioration of gas ingress in hydraulic systems can be provided by identifying a stable reading window when operating a carrying system comprising a hydraulic system; collecting a set of fluid level readings of a hydraulic fluid in the hydraulic system during a plurality of stable reading windows across a corresponding plurality of operational instances of the carrying system; calculating median fluid levels in each stable reading window of the plurality of stable reading windows; identifying an increasing trend in the median fluid levels when analyzed as time series data that satisfies a trend threshold of at least a predefined number successive indications of increased fluid levels in the hydraulic fluid within an analysis window; and generating an alert of gas ingress to the hydraulic system.

Abstract: The invention relates to a turnout rail production technology, in particular to a deeply-hardened-surface turnout rail with high degree of undercooling and the preparation method thereof. The invention aims to solve the technical problem by providing a deeply-hardened-surface turnout rail with high degree of undercooling featured in even hardness distribution and a deeply hardened surface layer and the preparation method thereof. The method is described as follows: feeding molten iron for converter smelting?furnace rear argon blowing station?LF refining?RH vacuumization?casting steel blanks?slow cooling in the slow cooling pit?austenitic homogenization?rail rolling?heat treatment; in the converter smelting process, adding 0.2-0.3% Cr, 0.04-0.06 V and 0.75-0.80% C; the heat treatment process is divided into two cooling stages.

Abstract: Provided is a molybdenum sulfide that is ribbon-shaped and particularly suitable for a hydrogen generation catalyst. Disclosed are a ribbon-shaped molybdenum sulfide, in which 50 particles as measured by observation with a scanning electron microscope (SEM) have a shape of, on average, 500 to 10000 nm in length, 10 to 1000 nm in width, and 3 to 200 nm in thickness; a method for producing the ribbon-shaped molybdenum sulfide, including: (1) heating a molybdenum oxide at a temperature of 200 to 1000° C. in the presence of a sulfur source; or (2) heating a molybdenum oxide at a temperature of 100 to 800° C. in the absence of a sulfur source, and then heating the molybdenum oxide at a temperature of 200 to 1000° C. in the presence of a sulfur source; and a hydrogen generation catalyst including the ribbon-shaped molybdenum sulfide.

Abstract: A multimedia information display method is provided. The method includes: obtaining to-be-displayed multimedia information, where the to-be-displayed multimedia information includes main multimedia information and at least one piece of additional multimedia information having an association relationship; displaying the main multimedia information on a display interface; determining a cover for the at least one piece of additional multimedia information when the main multimedia information is displayed for a preset time period, and displaying the main multimedia information and the cover on the display interface; and switching, in response to a clicking operation on the cover, the main multimedia information displayed on the display interface into the additional multimedia information corresponding to the clicking operation.