Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.

Abstract: The present disclosure relates to an end tool of a surgical instrument and a surgical instrument including the same, and more particularly, to an end tool of a surgical instrument that may be mounted on a robotic arm or operable manually to be used in laparoscopic surgery or other various surgeries, wherein the end tool is rotatable in two or more directions and is moved in a way that intuitively matches a motion of a manipulation part, and a surgical instrument including the same.

Abstract: Provided are a substrate processing apparatus and a substrate processing method, and more specifically, a substrate processing apparatus and a substrate processing method for easily cleaning an unnecessary thin film deposited on a lower surface and edge area of a substrate without inverting the substrate.

Abstract: A cooling system of an agricultural work vehicle includes a cooling unit including a radiator and configured to perform cooling operation, and a coupling unit rotatably coupling the cooling unit to an inner side wall of an engine room. The coupling unit comprises a hinge part provided on a first side surface of the cooling unit and rotatably coupled to a first inner side wall of the engine room; and a locking part provided on a second side surface of the cooling unit and separably coupled to a second inner side wall of the engine room, wherein when the locking part is separated from the second inner side wall of the engine room, the cooling unit is rotatable on the hinge part.

Abstract: A cathode active material for a lithium secondary battery includes a lithium-transition metal oxide including nickel (Ni), cobalt (Co), manganese (Mn), strontium (Sr) and sulfur (S). A mole fraction of nickel based on the total number of moles of nickel, cobalt and manganese in the lithium-transition metal oxide is 0.9 or more. A molar ratio of cobalt relative to manganese in the lithium-transition metal oxide is in a range from 0.9 to 1.5. A molar ratio of strontium (Sr) relative to sulfur (S) in the lithium-transition metal oxide is greater than 0, and 4 or less.

Abstract: A display device may include a pixel defining layer defining subpixels, a pixel electrode of each subpixel disposed in an opening of the pixel defining layer, a trench formed by etching a portion of the pixel defining layer and surrounding a portion of each of the subpixels, heating wires disposed on the pixel defining layer and spaced apart from each other with the trench between the heating wires, a first organic material covering a first pixel electrode of a first subpixel and a portion of the pixel defining layer surrounding the first pixel electrode, a second organic material covering a second pixel electrode of a second subpixel and a portion of the pixel defining layer surrounding the second pixel electrode, and a third organic material covering a third pixel electrode of a third subpixel and a portion of the pixel defining layer surrounding the third pixel electrode.

Abstract: The present invention relates to a pharmaceutical composition including vitrified periodontal tissue-derived mesenchymal stem cells for prevention or treatment of male infertility. The pharmaceutical composition for prevention or treatment of male infertility according to the present invention recovers sex hormone levels in seminiferous tubules of atrophic testes and blood to normal levels through improvement in the activity of lipid metabolism enzymes in the liver, thereby exhibiting remarkable prophylactic and therapeutic effects on male infertility. In addition, the periodontal tissue-derived mesenchymal stem cells which are an active ingredient in the present invention can be obtained in the most non-invasive manner and as such, are expected to be advantageously used as a cell therapy product for male infertility.

Abstract: Provided herein are novel compounds, e.g., those of Formula (I), as GCN2 inhibitors. Also provided are pharmaceutical compositions including one or more of the novel compounds, and pharmaceutical uses thereof. Compounds provided herein can typically inhibit an activity of a GCN2 and thus can be used for treating or preventing diseases related thereto.

Abstract: A light-emitting element includes a light-emitting element core extending in a direction and including a first semiconductor layer, a second semiconductor layer disposed on the first semiconductor layer, and a device active layer disposed between the first semiconductor layer and the second semiconductor layer, a device insulating film surrounding a lateral surface of the light-emitting element core, and a reflective film disposed on an outer lateral surface of the device insulating film and surrounding at least a lateral surface of the device active layer.

Abstract: Provided are an anti-4-1BB/anti-HER2 bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.

Abstract: The present invention relates to a polypropylene-based composite, including (A) polypropylene, and (B) an olefin-based polymer satisfying the following conditions: (1) a melt index (MI, 190° C., 2.16 kg load conditions) is from 0.1 g/10 min to 10.0 g/10 min, (2) a density (d) is from 0.860 g/cc to 0.880 g/cc, and (3) T(90)-T(50)?50 and T(95)-T(90)?10 are satisfied, wherein T(50), T(90) and T(95) are temperatures at which 50%, 90%, and 95% are melted, respectively, when fractionating a temperature-heat capacity curve from measurement results by the differential scanning calorimetry precise measurement method (SSA). The polypropylene-based composite of the present invention may show excellent impact strength.

Abstract: A display device includes: a substrate; a transistor disposed on the substrate; a first electrode connected to the transistor; an emission layer disposed on the first electrode; a second electrode disposed on the emission layer; a common voltage line connected to the second electrode; and a third electrode and a fourth electrode disposed between the common voltage line and the second electrode.

Abstract: An image sensor according to the present disclosure includes: a first pixel group, which includes a first pixel unit corresponding to a first color, and a plurality of first pixels arranged with an m×n form. The image sensor further includes a second pixel unit, which corresponds to a second color, and a plurality of second pixels arranged with the m×n form. The image sensor further includes a third pixel unit, which corresponds to a third color, and a plurality of third pixels arranged with the m×n form, and m and n are natural numbers greater than or equal to 3. A first micro lens is formed on the first pixel unit and shared by at least two adjacent first pixels in a first direction among the plurality of first pixels.

Abstract: The present invention relates to a composition for an encapsulant film, including an ethylene/alpha-olefin copolymer having high volume resistance and light transmittance, and an encapsulant film using the same.

Abstract: A three-dimensional AND flash memory device includes a gate stack structure, a charge storage structure, a first conductive pillar and a second conductive pillar, an insulating pillar, and a channel pillar. The gate stack structure includes gate layers and insulating layers stacked alternately with each other. The first and second conductive pillars extend through the gate stack structure. The channel pillar extends through the gate stack structure. The charge storage structure is disposed between the gate stack structure and the channel pillar. The channel pillar includes: a first part and a second part connected each other. The first part is located between the charge storage structure and the insulating pillar. The second part includes a first region electrically connected to the first conductive pillar, and a second region electrically connected to the second conductive pillar. A curvature of the first part is smaller than a curvature of the second part.

Abstract: A thermally adhesive fiber web implemented by including the steps of: (1) preparing respectively a first spinning solution in which a support component and a second spinning solution in which a thermally adhesive component; (2) performing electrospinning such that the first spinning solution is discharged to a portion of the end surface of a discharge port and the second spinning solution is discharged to the remaining portion, thereby accumulating side-by-side type thermally adhesive composite fibers having a diameter of less than 1 ?m; and (3) applying heat to the accumulated side-by-side type thermally adhesive composite fibers. The thermally adhesive fiber web enables easy interfacial bonding to a heterogeneous material with a different material and structural specification and prevents pores formed in an initial stage from being closed during thermal bonding.

Abstract: A nasal dilator for treating breathing problem is provided, which includes a hollow nasal dilator body and a one-way flow resistance unit. The hollow nasal dilator body has a first end opening and a second end opening opposing the first end opening. The hollow nasal dilator body longitudinally extends from the first end opening to the second end opening and being adapted for insertion into a user's nostril with the second end opening placed within the user's nasal passage so that the hollow nasal dilator body supports and dilates the nasal passage. The one-way flow resistance unit is assembled to the hollow nasal dilator body and in proximity to the first end opening and away from the second end opening. The one-way flow resistance unit creates an exhalation flow resistance higher than an inhalation flow resistance such that an expiratory positive airway pressure is generated within the nasal passage.