Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: The production of multicomponent parts (4) which include a functional part (3), in particular a hollow needle, onto which a plastic molding (2), in particular a syringe barrel (2), is molded. In order to be able to convert the injection molding device quickly and conveniently, the device has a changing device (11), by which it is possible optionally to move functional part holders (7, 8, 9), matched to different types of functional parts, and/or a functional part holder (8) and a placeholder element (10) into the use position thereof in front of a mold cavity (6) of the injection mold (5) of the injection molding device (1).

Abstract: Provided are compounds of Formula (I?) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R8, R9, R11A, R11B, R12, Ri, Rii, A1, A2, Q1, Q2, Q3, X, W, and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.

Abstract: Provided are compounds of Formula (I): Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, A1, B1, B2, Q1 and Q2 are as defined herein; and methods for their use and production.

Abstract: Provided are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein ring A, R3, R4, R5, R6, A1, B1, B2, Q1 and Q2 are as defined herein; and methods for their use and production.

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: The production of multicomponent parts (4) which include a functional part (3), in particular a hollow needle, onto which a plastic molding (2), in particular a syringe barrel (2), is molded. In order to be able to convert the injection molding device quickly and conveniently, the device has a changing device (11), by which it is possible optionally to move functional part holders (7, 8, 9), matched to different types of functional parts, and/or a functional part holder (8) and a placeholder element (10) into the use position thereof in front of a mold cavity (6) of the injection mold (5) of the injection molding device (1).

Abstract: A winged visor stiffener for a hat's bill. A flat horizontal front section is connected to two angled offset sections. Two flat horizontal wings are connected to the two angled offset sections. The winged visor stiffener is sewn into the hat's bill via a plurality of rows of tight stitching. The winged visor stiffener provides protection to the wearer's face from the sun while optimizing peripheral vision and prevents the bill from flopping up or down in wet and windy conditions.

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: A directory structure that may allow concurrent processing of write-back and clean victimization requests is disclosed. The directory structure may include a memory configured to store a plurality of entries, where each entry may include information indicative of a status of a respective entry in a cache memory. Update requests for the entries in the memory may be received and stored. A subset of previously stored update requests may be selected. Each update request of the subset of the previously stored update requests may then be processed concurrently.

Abstract: A winged visor stiffener for a hat's brim. A flat horizontal front section is connected to two angled offset sections. Two flat horizontal wings are connected to the two angled offset sections. Two temple brace sections are each formed into the two flat horizontal wings. The temple brace sections function to brace the winged visor against the wearer's head to prevent the brim from flopping up and down, The winged visor stiffener is sewn into the hat's brim via a plurality of rows of tight stitching. The winged visor stiffener provides protection to the wearer's face from the sun while optimizing peripheral vision and prevents the bill from flopping up or down in wet and windy conditions.

Abstract: A hat having a removable chin strap for the hat's brim. The flexible strap has end pieces connected to its ends. The strap also has a strap position lock device. Additionally, the strap includes an attachment clip that can be utilized for connecting the strap to the wearer's clothing. In one preferred embodiment the attachment clip is an alligator clip. In another preferred embodiment the attachment clip is a hook clip. Also, in a preferred embodiment the hat's brim includes a plurality of slots and the flexible strap is inserted through the slots and retained to the brim by the end pieces.

Abstract: The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Abstract: A metal-ceramic substrate having at least one ceramic layer (2), which is provided on a first surface side (2a) with at least one first metallization (3) and on a second surface side (2b), opposite from the first surface side (2a), with a second metallization (4), wherein the first metallization (3) is formed by a film or layer of copper or a copper alloy and is connected to the first surface side (2a) of the ceramic layer (2) with the aid of a “direct copper bonding” process. The second metallization (4) is formed by a layer of aluminum or an aluminum alloy.

Abstract: The invention relates to a centrifuge for separating a sample into at least two components, comprising a chamber for receiving a sample to be centrifuged. According to the invention, the centrifuge further comprises a means for controlling the progress of the sample separation is located at the chamber.

Abstract: A system, comprising: a first local controller (LC) having a first position in a ring network and comprising a first LC cycle counter; a second LC having a second position in the ring network and comprising a second LC cycle counter; and a central controller (CC) connected to the ring network and comprising: a data structure linking the first LC to the first position and linking the second LC to the second position; and a CC cycle counter.

Abstract: A winged visor stiffener for a hat's bill. A flat horizontal front section is connected to two angled offset sections. Two flat horizontal wings are connected to the two angled offset sections. The winged visor stiffener is sewn into the hat's bill via a plurality of rows of tight stitching. The winged visor stiffener provides protection to the wearer's face from the sun while optimizing peripheral vision and prevents the bill from flopping up or down in wet and windy conditions.

Abstract: The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.