Abstract: Systems for performing cellular analysis and related devices for conditioning environments adjacent chips in such systems. A device for conditioning an environment adjacent a chip in a system for performing cellular analysis, the device includes a cover for being disposed adjacent the chip and comprising a planar body having a top surface, a bottom surface, and an outer edge surface. The cover includes a central opening extending between the top surface and the bottom surface and bounded by an inner edge surface of the cover. The cover also includes a fluid inlet extending into the body from the outer edge surface between the top surface and the bottom surface the fluid inlet arranged to accept a gas to be delivered to the central opening. The cover also includes a plurality of fluid outlets defined in the inner edge surface and in fluid communication with the fluid inlet. The plurality of fluid outlets are arranged to receive the gas from the fluid inlet and exhaust the gas into the central opening.

Abstract: Devices and methods for treatment of bodily lumens and sphincters are disclosed. Some embodiments include methods and devices for inducing an inflammatory response and development of fibrosis, collagen, and/or scar tissue. In some embodiments, scaffolds may be composed of a matrix of filaments. Application of the methods and devices disclosed herein to treat Gastroesophageal Reflux Disease (GERD) and other sphincter disorders are discussed. Biodegradable scaffolds configured to induce an inflammatory response are also disclosed.

Abstract: An implantable fixation device for rejoining opposed portions of a separated bone. The device including two corresponding plates that are configured to be aligned and coupled to a bone, such as a sternum, pre-resection of the bone or prior to cutting/separating the bone. The placement of the corresponding plates provides a gap between the edges of the plates that face one another allowing for and guiding a cutting tool for separating the bone. After the bone has been cut and the desired surgical procedure performed, the plates also assist in realigning and fixation of the bone portions. At least one plate includes a ratchet mechanism that is configured to tighten a locking element and draw the two plates together and into alignment with one another.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing colorectal cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens, and/or (iv) express one or more tumor fitness advantage mutations, including but not limited to driver mutations. Also provided herein are methods of making and preparing the colorectal cancer vaccine compositions and methods of use thereof.

Abstract: Systems and methods include a controller that compares an indoor temperature with a dead-band range having a heating setpoint and a cooling setpoint and that operates an HVAC system in an economizer mode to cool an indoor building space by introducing outside air to the indoor building space, prior to a call for cooling being received, in response to the indoor temperature being within the dead-band range and increasing.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing breast cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens, and/or (iv) express one or more tumor fitness advantage mutations, including but not limited to driver mutations. Also provided herein are methods of making and preparing the breast cancer vaccine compositions and methods of use thereof.

Abstract: A device for positioning an orthopaedic fixation device includes: a compression attachment mechanism; a fastener guide coupled to the compression attachment mechanism; and a spring member disposed in the fastener guide.

Abstract: A mattress encasement assembly an outer cover for an interior cushioning system of a mattress. The outer cover includes an upper section including a top wall having a top perimeter edge. An upper perimeter wall is coextensive with and extends downwardly from the top perimeter edge. A lower section includes a bottom wall having a bottom perimeter edge. A lower perimeter wall is coextensive with and extends upwardly from the bottom perimeter edge. A coupler is attached to the upper and lower sections to releasably secure the upper perimeter wall and the lower perimeter wall together such that the upper and lower sections encase a plurality of cushioning panels. The coupler allows a height between the top and bottom walls to be adjusted.

Abstract: An implantable fixation device for rejoining opposed portions of a separated bone. The device including two corresponding plates that are configured to be aligned and coupled to a bone, such as a sternum, pre-resection of the bone or prior to cutting/separating the bone. The placement of the corresponding plates provides a gap between the edges of the plates that face one another allowing for and guiding a cutting tool for separating the bone. After the bone has been cut and the desired surgical procedure performed, the plates also assist in realigning and fixation of the bone portions. At least one plate includes a ratchet mechanism that is configured to tighten a locking element and draw the two plates together and into alignment with one another.

Abstract: A ratchet fastener includes a base including a fastening portion including threads and a ratchet portion including teeth and a ratchet wheel disposed in mating arrangement with the teeth. The ratchet fastener is configured to receive a tether. The ratchet wheel is configured to be rotated to tighten the tether.

Abstract: A system and method for advanced digital economization for an HVAC system having an economizer. A digital processing unit is configured to open a damper of an economizer within a dead-band range that allows for preemptive cooling prior to a call for cooling. This economization strategy allows for free cooling (outside air) without having to pay energy costs for cooled (air-conditioned) air. The system and method can be used with or without demand control ventilation (DCV). The method also includes a “self-learning” strategy with outside air and return air sensor to regularly sense past economizer damper modifications and average out recent readings to help set the dead-band range. The method can include the ability to work in conjunction with a variable supply fan speed control, provide fault detection, self-correct, auto-configure, and report system status.

Abstract: An implant positioning device including a guide and holder for fasteners used in orthopaedic fixation for use in affixing a plate-like member to a bone or other part of a patient. The guide and holder includes a base adapted to align with the plate in a manner to orient fasteners with the plate for fixation. A plurality of fastener holders are on the base and adapted to releasably hold a fastener in a manner where the fastener is exposed at a proximal end for access by a fastener driver and aligned at a distal end with an aperture on the plate through which the fastener is to be driven.

Abstract: Treatment actions can be taken based on an analysis of the ability of a recipient of an auditory prosthesis to perceive musical activities. The occurrence of musical activities and the recipients response thereto can be determined based on transducers. The recipients musical perception can be determined by analyzing the signals from the transducers as stand-alone measures or by comparing the signals against known music. The treatment actions can relate to the treatment of a hearing-impairment of the recipient of the auditory prosthesis, such as by modifying the settings of the auditory prosthesis to affect the ongoing operation of the auditory prosthesis.

Abstract: Disclosed herein are methods, systems, and apparatuses to enable subscribers of mobile wireless communication devices to view, research, select and customize service plans; to create and manage device groups, share and set permission controls for service plans among devices in device groups; to manage communication services through graphical user interfaces; to sponsor and promote service plans; and to design, manage, and control communication services through application programming interfaces.

Abstract: Embodiments described herein are directed to a graphical user interface (GUI) for efficiently managing and organizing data items. The GUI utilizes machine learning-based clustering techniques that cluster data items into different clusters. The GUI displays each cluster as a user-selectable UI element. Each UI element displays keywords that are representative of the associated data items. The GUI enables the user to merge clusters together by interacting with the UI elements. For instance, the user may drag and drop one UI element over another UI element to combine the associated clusters. The GUI also enables a user to selectively associate certain Web pages of one cluster with another cluster. For instance, the GUI enables the user to move a keyword from one UI element to another UI element. The data items associated with that keyword are moved to the cluster represented by the other UI element.