Abstract: Post quantum secure network communication is provided. The process comprises sending, by a client in a first computing cluster, an outbound message to a quantum safe cryptographic (QSC) proxy server in the first computing cluster, wherein the outbound message is addressed to a target server in a second computing cluster. The QSC proxy server initiates a QSC transport layer security (TLS) connection with an ingress controller in the second computing cluster, wherein the ingress controller comprises a QSC algorithm. The QSC proxy server transfers the message to the ingress controller via the QSC TLS connection, and the ingress controller routes the message to the target server in the second computing cluster via a non-QSC connection.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.

Abstract: Hybrid encryption of imported key material is provided. A request to import key material is received from a user system. In response to the request, two public keys are sent to the user system. The two public keys include a classical cryptography (CC) public key and a quantum-safe cryptography (QSC) public key. At least one public key of the two public keys is retrieved from a hardware security module (HSM). Hybrid-encrypted key material is received from the user system. The hybrid-encrypted key material is key material that has been encrypted using the two public keys. The key material, at least partially encrypted by the at least one public key, is sent to the HSM.

Abstract: The instant disclosure provides (among other things) novel water-soluble polymer reagents capable of selective conjugation to histidine residues. e.g., in peptides and proteins, as well the resulting conjugates and related compositions. In addition, provided are methods of preparing the polymer reagents, as well as methods for conjugating the polymer reagents to active agents and other substances, pharmaceutical compositions, and methods for administering the conjugates.

Abstract: Provided is a method of administering to a patient having cancer: (a) a 4-1BB agonist; (b) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and/or (c) a toll-like receptor agonist, as well as related compositions, kits and compositions.

Abstract: Disclosed herein are methods in the field of cancer immunotherapy that involve the treatment of a subject having cancer by administering to the subject a toll-like receptor 7/8 (TLR7/8) agonist in combination with a long-acting IL-2R?-biased agonist and a programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) axis inhibitor, and related compositions, dosage forms, and kits.

Abstract: Microfluidic devices and methods that utilize ion concentration polarization within nanoliter scale droplets for concentration enrichment, separation, and substitution of charges species are disclosed. Such devices and methods can be used for separation of multiple species by mobility of each species and for the alteration and manipulation of the droplet composition by ion exchange.

Abstract: Systems and methods for enforcing durability of second level encryption keys by a key management system (KMS) are provided. In embodiment, a method includes: receiving a first request to encrypt a first level key, the request including the first level key and a second level key identification associated with a stored encrypted second level key; determining that a durability check of the encrypted second level key is required based on the request; determining a durability status of the encrypted second level key by comparing actual storage of the encrypted second level key in one or more storage locations with predetermined storage rules for a durability level of the encrypted second level key, wherein the durability status indicates that the storage of the encrypted second level key complies with the durability level; and sending a notification regarding the durability status to the data storage service.

Abstract: Microfluidic devices and methods that utilize ion concentration polarization within water-in-oil nanoliter scale droplets for concentration enrichment, separation, and substitution of charges species are disclosed. Such devices and methods can be used for separation of multiple species by mobility of each species and for the alteration and manipulation of the droplet composition by ion exchange.

Abstract: High-throughput microfluidic devices comprising one or more fluidic microchannels each with at least one flow-through 3D structure comprising a 3D electrode, or alternatively a 3D permselective structure, and optional secondary bead bed(s) are disclosed. Such devices can be used for counter-flow focusing of charged species via ion concentration polarization and in situ quantification of electrokinetically enriched charged species from an ionically conductive solution by both optical and electrical detection.

Abstract: Microfluidic devices and methods that introduce ions into, and extract ions from, water-in-oil nanoliter scale droplets are disclosed. The droplets are in simultaneous contact with both an anion-permselective membrane and a cation-permselective membrane at opposing sides. When a voltage bias is applied across the system, anions and cations migrate across the respective permselective membranes and either into or out of the droplet.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: RQ-POLY-Xr-TLR7/8 AG)q??Formula I or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist.

Abstract: Hybrid encryption of imported key material is provided. A request to import key material is received from a user system. In response to the request, two public keys are sent to the user system. The two public keys include a classical cryptography (CC) public key and a quantum-safe cryptography (QSC) public key. At least one public key of the two public keys is retrieved from a hardware security module (HSM). Hybrid-encrypted key material is received from the user system. The hybrid-encrypted key material is key material that has been encrypted using the two public keys. The key material, at least partially encrypted by the at least one public key, is sent to the HSM.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.

Abstract: A microfluidic device comprising one or more fluidic microchannels and one or more arrays of cell assay units is disclosed. Each cell assay unit in turn comprises at one bipolar electrode, micropocket, reaction chamber, and leak channel. In some embodiments, the cell assay unit further comprises two or more split BPEs inside the reaction chamber. The disclosed microfluidic device can be used to separate cells, especially rare cells, from its biological matrix and then analyze the isolated cell inside the reaction chamber. The disclosed device can isolate and analyze cells in a high-throughput fashion and without any modification or labelling to the cells. Cells isolated using the disclosed devices does not lose their vitality.

Abstract: Post quantum secure network communication is provided. The process comprises sending, by a client in a first computing cluster, an outbound message to a quantum safe cryptographic (QSC) proxy server in the first computing cluster, wherein the outbound message is addressed to a target server in a second computing cluster. The QSC proxy server initiates a QSC transport layer security (TLS) connection with an ingress controller in the second computing cluster, wherein the ingress controller comprises a QSC algorithm. The QSC proxy server transfers the message to the ingress controller via the QSC TLS connection, and the ingress controller routes the message to the target server in the second computing cluster via a non-QSC connection.

Abstract: Methods and systems for unified HSM and key management services are disclosed. According to certain embodiments, an encryption service request is issued by a client instance to a key management service (KMS) logic in a KMS cloud instance. The KMS logic parses the request to verify authorization for the request, identify the instance ID, and provide additional information to the request needed by hardware security management (HSM) middleware and hardware. A router receives the request from the KMS logic and routes the request to a service based on the instance ID, that transfers the request to HSM middleware. The HSM middleware parses HSM type from the request, translates the request to HSM vendor-specific instructions and routes the translated request to an HSM. The HSM according to certain embodiments is in a cloud computing environment separate from the KMS cloud instance, and in some embodiments the HSM is on-prem at a physical client site.

Abstract: Methods and systems for unified HSM and key management services are disclosed. According to certain embodiments, an encryption service request is issued by a client instance to a key management service (KMS) logic in a KMS cloud instance. The KMS logic parses the request to verify authorization for the request, identify the instance ID, and provide additional information to the request needed by hardware security management (HSM) middleware and hardware. A router receives the request from the KMS logic and routes the request to a service based on the instance ID, that transfers the request to HSM middleware. The HSM middleware parses HSM type from the request, translates the request to HSM vendor-specific instructions and routes the translated request to an HSM. The HSM according to certain embodiments is in a cloud computing environment separate from the KMS cloud instance, and in some embodiments the HSM is on-prem at a physical client site.

Abstract: Systems and methods for enforcing durability of second level encryption keys by a key management system (KMS) are provided. In embodiment, a method includes: receiving a first request to encrypt a first level key, the request including the first level key and a second level key identification associated with a stored encrypted second level key; determining that a durability check of the encrypted second level key is required based on the request; determining a durability status of the encrypted second level key by comparing actual storage of the encrypted second level key in one or more storage locations with predetermined storage rules for a durability level of the encrypted second level key, wherein the durability status indicates that the storage of the encrypted second level key complies with the durability level; and sending a notification regarding the durability status to the data storage service.

Abstract: The instant disclosure provides novel adenosine receptor antagonist compounds, compositions, methods of making and methods of using. In a further aspect, a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of any one or more of the compounds described herein. In some embodiments, the subject has cancer and the method is a method of treating cancer.