Abstract: Mechanisms are provided for dynamically adjusting assignment of software threads to hardware threads in virtual machine (VM) environments. The mechanisms receive, by a virtual machine manager (VMM), an indication of workload priority from a plurality of VMs. The indication indicates a priority of a workload executing on each VM in the plurality of VMs. The mechanisms provide, by the VMM, an indication of physical resource usage to each VM. The indication of physical resource usage is an indication of physical resource usage across all VMs in the plurality of VMs. The mechanisms automatically adjust, by each VM, assignment of corresponding software threads to hardware threads based on the indication of physical resource usage and a priority of a workload executing on the VM to achieve a balance of usage of hardware threads across all VMs in the plurality of VMs.

Abstract: Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

Abstract: The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.

Abstract: Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

Abstract: The invention relates to (among other things) oligomer-containing benzamide-based compound compounds. A compound of the invention exhibits one or more advantages over corresponding compounds lacking the oligomer.

Abstract: The invention relates to (among other things) oligomer-containing benzamide-based compounds. A compound of the invention exhibits one or more advantages over corresponding compounds lacking the oligomer.

Abstract: Techniques for estimating processor load by using queue depth information of a peripheral adapter provides processor loading information that can be used to adapt interrupt latency to improve performance in a processing system. A mathematical function of the depth of one or more queues of the adapter is compared to its historical value in order to provide an estimate of processor load. The estimated processor load can then be used to set a parameter that controls the frequency of an interrupt generator. The mathematical function may be the ratio of the transmit queue depth to the receive queue depth and the historical value may be predetermined, user-settable, obtained during a calibration interval or obtained by taking a long-term average of the mathematical function of the queue depths.

Abstract: The present disclosure provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. The compounds are generally of formula (I): Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include “spectrum selective” kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR. Also disclosed are methods of making compounds for formula 8: comprising introducing group E2 into a compound of formula 7: wherein Ar, Z, P, and E2 are defined herein.

Abstract: Provided are compounds of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds of Formula I described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

Abstract: The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include “spectrum selective” kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.

Abstract: According to one aspect of the present disclosure, a method and technique for hybrid virtual machine configuration management is disclosed. The method includes: assigning to a first set of virtual resources associated with entitled resources of a virtual machine a first priority; assigning to a second set of virtual resources associated with the virtual machine a second priority lower than the first priority, wherein the first and seconds sets when combined exceed the entitled resources for the virtual machine; mapping the first set of virtual resources to a first physical resource of a pool of shared physical resources allocatable to the first and second sets of virtual resources, wherein the first physical resource comprises a desired affinity level to a second physical resource allocated to the virtual machine; and preferentially allocating the first physical resource to the first set of virtual resources.

Abstract: A technique for determining placement fitness for partitions under a hypervisor in a host computing system having non-uniform memory access (NUMA) nodes. In an embodiment, a partition resource specification is received from a partition score requester. The partition resource specification identifies a set of computing resources needed for a virtual machine partition to be created by a hypervisor in the host computing system. Resource availability within the NUMA nodes of the host computing system is assessed to determine possible partition placement options. A partition fitness score of a most suitable one of the partition placement options is calculated. The partition fitness score is reported to the partition score requester.

Abstract: According to one aspect of the present disclosure, a method and technique for hybrid virtual machine configuration management is disclosed. The method includes: assigning to a first set of virtual resources associated with entitled resources of a virtual machine a first priority; assigning to a second set of virtual resources associated with the virtual machine a second priority lower than the first priority, wherein the first and seconds sets when combined exceed the entitled resources for the virtual machine; mapping the first set of virtual resources to a first physical resource of a pool of shared physical resources allocatable to the first and second sets of virtual resources, wherein the first physical resource comprises a desired affinity level to a second physical resource allocated to the virtual machine; and preferentially allocating the first physical resource to the first set of virtual resources.

Abstract: A technique for determining placement fitness for partitions under a hypervisor in a host computing system having non-uniform memory access (NUMA) nodes. In an embodiment, a partition resource specification is received from a partition score requester. The partition resource specification identifies a set of computing resources needed for a virtual machine partition to be created by a hypervisor in the host computing system. Resource availability within the NUMA nodes of the host computing system is assessed to determine possible partition placement options. A partition fitness score of a most suitable one of the partition placement options is calculated. The partition fitness score is reported to the partition score requester.

Abstract: The present disclosure provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. The compounds are generally of formula (I): Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include “spectrum selective” kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR. Also disclosed are methods of making compounds for formula 8: comprising introducing group E2 into a compound of formula 7: wherein Ar, Z, P, and E2 are defined herein.

Abstract: Methods of bit manipulation within a computer processor are disclosed. Improved flexibility in bit manipulation proves helpful in computing elementary functions critical to the performance of many programs and for other applications. In one embodiment, a unit of input data is shifted/rotated and multiple non-contiguous bit fields from the unit of input data are inserted in an output register. In another embodiment, one of two units of input data is optionally shifted or rotated, the two units of input data are partitioned into a plurality of bit fields, bitwise operations are performed on each bit field, and pairs of bit fields are combined with either an AND or an OR bitwise operation. Embodiments are also disclosed to simultaneously perform these processes on multiple units and pairs of units of input data in a Single Input, Multiple Data processing environment capable of performing logical operations on floating point data.

Abstract: The invention relates to (among other things) oligomer-containing benzamide-based compounds. A compound of the invention exhibits one or more advantages over corresponding compounds lacking the oligomer.

Abstract: A technique for determining placement fitness for partitions under a hypervisor in a host computing system having non-uniform memory access (NUMA) nodes. In an embodiment, a partition resource specification is received from a partition score requester. The partition resource specification identifies a set of computing resources needed for a virtual machine partition to be created by a hypervisor in the host computing system. Resource availability within the NUMA nodes of the host computing system is assessed to determine possible partition placement options. A partition fitness score of a most suitable one of the partition placement options is calculated. The partition fitness score is reported to the partition score requester.

Abstract: Mechanisms are provided for dynamically adjusting assignment of software threads to hardware threads in virtual machine (VM) environments. The mechanisms receive, by a virtual machine manager (VMM), an indication of workload priority from a plurality of VMs. The indication indicates a priority of a workload executing on each VM in the plurality of VMs. The mechanisms provide, by the VMM, an indication of physical resource usage to each VM. The indication of physical resource usage is an indication of physical resource usage across all VMs in the plurality of VMs. The mechanisms automatically adjust, by each VM, assignment of corresponding software threads to hardware threads based on the indication of physical resource usage and a priority of a workload executing on the VM to achieve a balance of usage of hardware threads across all VMs in the plurality of VMs.

Abstract: Mechanisms are provided for dynamically adjusting assignment of software threads to hardware threads in virtual machine (VM) environments. The mechanisms receive, by a virtual machine manager (VMM), an indication of workload priority from a plurality of VMs. The indication indicates a priority of a workload executing on each VM in the plurality of VMs. The mechanisms provide, by the VMM, an indication of physical resource usage to each VM. The indication of physical resource usage is an indication of physical resource usage across all VMs in the plurality of VMs. The mechanisms automatically adjust, by each VM, assignment of corresponding software threads to hardware threads based on the indication of physical resource usage and a priority of a workload executing on the VM to achieve a balance of usage of hardware threads across all VMs in the plurality of VMs.