Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for optimizing digital components. In one aspect, the system includes a digital component server that identifies a digital component to be presented in an electronic document. The system also includes a digital component distribution server that interacts with the digital component server to determine that the electronic document includes a particular item that identifies a same entity as the digital component that was identified to be presented in the electronic document. The system combines at least a portion of the digital component with content from the particular item to form an optimized digital component. The optimized digital component is integrated into the electronic document rather than presenting either of the particular item or the digital component individually.

Abstract: Methods, systems, and apparatus include computer programs encoded on a computer-readable storage medium, including a method for providing content. Data specifying a post-install activity is received from a provider of an application. An opportunity is identified to provide third-party content to a user. A likelihood is determined that the user will perform the specified post-install activity based on one or more attributes of the user and attributes of users that have previously performed the specified post-install activity in the application. A selection value is adjusted for third-party content that identifies the application based on the determined likelihood, wherein the selection value increases as the likelihood increases. The third-party content identifying the application is selected based on the adjusted selection value. The third-party content identifying the application is distributed to a client device of the user.

Abstract: In general, the invention is directed to a technique for percutaneously introducing a stimulation lead into a target stimulation site via the epidural region proximate the spine of a patient. The process of introducing the stimulation lead may include the use of a hollow stimulation lead introducer, which comprises an elongated sheath and an elongated dilator. The dilator fits within the sheath and serves to widen a path through the epidural region for the introduction of a stimulation lead. At least a portion of the stimulation lead introducer has an oblong cross-section, allowing passage of stimulation leads such as paddle leads. The stimulation lead introducer may enter the epidural region proximate a spine of a patient via a guidewire. The stimulation lead introducer provides a path through the epidural region of a patient to a target stimulation site. A stimulation lead may travel through the path to reach the target stimulation site where it may provide therapy to the patient.

Abstract: In general, the invention is directed to a technique for percutaneously introducing a stimulation lead into a target stimulation site via the epidural region proximate the spine of a patient. The process of introducing the stimulation lead may include the use of a hollow stimulation lead introducer, which comprises an elongated sheath and an elongated dilator. The dilator fits within the sheath and serves to widen a path through the epidural region for the introduction of a stimulation lead. At least a portion of the stimulation lead introducer has an oblong cross-section, allowing passage of stimulation leads such as paddle leads. The stimulation lead introducer may enter the epidural region proximate a spine of a patient via a guidewire. The stimulation lead introducer provides a path through the epidural region of a patient to a target stimulation site. A stimulation lead may travel through the path to reach the target stimulation site where it may provide therapy to the patient.

Abstract: Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodengroglial and neuronal cell types.

Abstract: In general, implementations of the present invention include devices, systems, and components for mounting and/or displaying panels and panel structures with one or more post modules. The post modules, according to the present invention, can include a post, which can secure one or more panels, and covers that can conceal the post from view. Additionally, the post modules can have hollow channels between the covers and the post, which can house wires, cords, lighting elements, and other components.

Abstract: Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodendroglial and neuronal cell types.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for ranking content items. In one aspect, a method includes identifying, for a content item, a bid value specifying an amount a content item provider is willing to pay for user interaction with the content item. A predicted performance measure is identified for the content item. The predicted performance measure is adjusted based on a weighting factor for the content item. The weighting factor for the content item is indicative of confidence that the predicted performance measure will match an actual performance measure for the content item and can be different than a weighting factor for another content item identified for inclusion in a ranking with the content item. A rank score is determined for the content item using the bid value and adjusted predicted performance measure. The content item is provided based on the rank score.

Abstract: The invention relates to a cable-actuated disc brake for a bicycle. The cable-actuated disc brake has a lever with dual, opposing piston assemblies that limit the movement of brake pads in relation to a brake disc of the bicycle. The lever includes symmetrical lever arms respectively engaged with symmetrical piston assemblies that are axially spaced, coaxially aligned and rotate about a pivot axis to selectively engage brake pads with a brake disc of the bicycle.

Abstract: A method and system a method for compressing and searching a plurality of strings. The method includes inputting a plurality of strings into a compression engine. The method also includes converting each of the plurality of strings into a new, prefix-preserving compressed string, using the compression engine. For every string P that is a strict prefix of a string S, P's resulting compressed string is a strict prefix of S's resulting compressed string.

Abstract: InAs based core-shell particles which leads to tunable, narrow emitting semiconductor nanocrystals with a very high quantum yield which can be preserved in physiological buffers with long stability can used for short wavelength infrared (SWIR) imaging. Increased resolution with reduced read time and increased imaging frequency can provide advantages in in vivo applications.

Abstract: In general, implementations of the present invention include devices, systems, and components for mounting and/or displaying panels and panel structures with one or more post modules. The post modules, according to the present invention, can include a post, which can secure one or more panels, and covers that can conceal the post from view. Additionally, the post modules can have hollow channels between the covers and the post, which can house wires, cords, lighting elements, and other components.

Abstract: Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodengroglial and neuronal cell types.

Abstract: In general, the invention is directed to a technique for percutaneously introducing a stimulation lead into a target stimulation site via the epidural region proximate the spine of a patient. The process of introducing the stimulation lead may include the use of a hollow stimulation lead introducer, which comprises an elongated sheath and an elongated dilator. The dilator fits within the sheath and serves to widen a path through the epidural region for the introduction of a stimulation lead. At least a portion of the stimulation lead introducer has an oblong cross-section, allowing passage of stimulation leads such as paddle leads. The stimulation lead introducer may enter the epidural region proximate a spine of a patient via a guidewire. The stimulation lead introducer provides a path through the epidural region of a patient to a target stimulation site. A stimulation lead may travel through the path to reach the target stimulation site where it may provide therapy to the patient.

Abstract: Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodengroglial and neuronal cell types.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for ranking content items. In one aspect, a method includes identifying, for a content item, a bid value specifying an amount a content item provider is willing to pay for user interaction with the content item. A predicted performance measure is identified for the content item. The predicted performance measure is adjusted based on a weighting factor for the content item. The weighting factor for the content item is indicative of confidence that the predicted performance measure will match an actual performance measure for the content item and can be different than a weighting factor for another content item identified for inclusion in a ranking with the content item. A rank score is determined for the content item using the bid value and adjusted predicted performance measure. The content item is provided based on the rank score.

Abstract: A population of semiconductor nanocrystals can include cores including a II-V semiconductor material, e.g., Cd3As2. The population can be monodisperse and can have a quantum yield of 20% or greater. A size-series of populations can have emission wavelengths falling in the range of about 530 nm to about 2000 nm.

Abstract: In general, the invention is directed to a technique for percutaneously introducing a stimulation lead into a target stimulation site via the epidural region proximate the spine of a patient. The process of introducing the stimulation lead may include the use of a hollow stimulation lead introducer, which comprises an elongated sheath and an elongated dilator. The dilator fits within the sheath and serves to widen a path through the epidural region for the introduction of a stimulation lead. At least a portion of the stimulation lead introducer has an oblong cross-section, allowing passage of stimulation leads such as paddle leads. The stimulation lead introducer may enter the epidural region proximate a spine of a patient via a guidewire. The stimulation lead introducer provides a path through the epidural region of a patient to a target stimulation site. A stimulation lead may travel through the path to reach the target stimulation site where it may provide therapy to the patient.

Abstract: A method and system for controlling access to an Internet resource is disclosed herein. When a request for an Internet resource, such as a Web site, is transmitted by an end-user of a LAN, a security appliance for the LAN analyzes a reputation index for the Internet resource before transmitting the request over the Internet. The reputation index is based on a reputation vector which includes a plurality of factors for the Internet resource such as country of domain registration, country of service hosting, country of an internet protocol address block, age of a domain registration, popularity rank, internet protocol address, number of hosts, to-level domain, a plurality of run-time behaviors, JavaScript block count, picture count, immediate redirect and response latency. If the reputation index for the Internet resource is at or above a threshold value established for the LAN, then access to the Internet resource is permitted.

Abstract: The invention relates to a cable-actuated disc brake for a bicycle. The cable-actuated disc brake has a lever with dual, opposing piston assemblies that limit the movement of brake pads in relation to a brake disc of the bicycle. The lever includes symmetrical lever arms respectively engaged with symmetrical piston assemblies that are axially spaced, coaxially aligned and rotate about a pivot axis to selectively engage brake pads with a brake disc of the bicycle.