Abstract: Methods are provided for treating COVID-19 patients to facilitate their recovery from the disease as well as for prognosis of severity of COVID-19 among patients who have been infected by SARS-CoV-2. Also provided are kits and compositions for use in these methods.

Abstract: The present invention provides for compositions and methods for treating long COVID symptoms or reducing the risk of developing such symptoms.

Abstract: Certain microorganism species in a composition for use in fecal microbiota transplantation (FMT), including fecal material obtained from an FMT donor, can affect the outcome of FMT treatment such as regulating the bodyweight and cholesterol level in FMT recipients. Thus, methods are provided for identifying subjects as suitable donor to optimize FMT outcome and for pretreating donors and/or recipients for optimized FMT outcome. Also provided are kits and compositions for improving FMT outcome, including for bodyweight and/or cholesterol reduction.

Abstract: Polypeptides useful for treating and/or imaging latent membrane protein 1 positive cells, such as cells infected with Epstein-Barr virus and Epstein-Barr virus-associated cancers, pharmaceutical compositions comprising the same, and methods of use thereof.

Abstract: The present disclosure provides EBNA1 and LMP1 dual-targeting peptides and upconversion nanoparticles conjugates comprising the same useful as therapeutic and theranostic agents capable of targeting EBNA1 and LMP1 proteins present in Epstein-Barr virus infected cells, such as cancer.

Abstract: Provided herein are porphyrinato-lanthanide complexes useful as theranostic agents and methods of preparation and use thereof. The porphyrinato-lanthanide complexes are useful in the treatment and imaging of cancer.

Abstract: The disclosed systems and methods are directed to generating cache IDs for each of a plurality of AI training pipelines, accessing training data elements included in a training data set, generating IDs corresponding to the training data elements, receiving the data IDs and an associated cache ID, randomizing the data IDs, selecting a subset of the randomized data IDs, fetching the training data elements previously cached by a cache node, receiving a portion of the training data elements present in the caching server corresponding to the subset of randomized data IDs, forwarding the portion of the training data elements present in the caching server to at least one consumer node, fetching the remaining training data elements associated with the subset of randomized data IDs from the training data set, and forwarding the remaining training data elements to at least one transformation node for training the neural network.

Abstract: Disclosed is a computer implemented method for time stamping and transferring intellectual property right, including the following steps: enrolling plurality of corresponding nodes to a platform; wherein the corresponding nodes include administration node, a public node, super node, child node, independent individual professor node and a service node; uploading information and document of the intellectual property right to the platform by independent individual professor node, super node or child node; wherein the information and document upon uploaded to the platform is time stamped; searching relevant intellectual property right on the platform; negotiating on the platform; composing a customized digital agreement on the platform by selecting, amending and/or adding on a relevant module clause; wherein the customized digital agreement has smart contract functions for automating execution; signing the agreement digitally by corresponding parties; blocking the intellectual property right automatically for fur

Abstract: The invention provides luminescent lanthanide nanoparticles having simultaneously an improved brightness and an increased lifetime of the excited-state. These nanoparticles comprise terbium ions and ions of a second lanthanide, preferentially europium, and are coated with molecules of chromophore ligand bonded to the surface of the nanoparticle. The ligand is an organic molecule comprising at least one chromophore radical of formula (I) or of formula (II): wherein R is selected from H, CN group or COOH group. The phosphorescence excited-state lifetime is improved by energy transfer from surface terbium ions to core ions of the second lanthanide The nanoparticle may further comprise a carrier molecule of analytical interest covalently attached to at least one ligand molecule.

Abstract: The present disclosure relates to compounds useful in the treatment, imaging, and/or diagnosis of Epstein-Barr virus (EBV)-positive cells, such as cancer.

Abstract: The present invention provides methods for assessing the likelihood of effectiveness of aspirin-based chemoprotection against colorectal cancer among individuals as well as methods for improving aspirin-based chemoprotection against colorectal cancer. Kits useful for such methods are also provided.

Abstract: A reforming reactor and process of using same in which a flow distributor distributes the process gas circumferentially to the reactive zone. Feed is injected into the reactor into a non-reactive zone. The non-reactive zone has two portions, a first portion receiving the feed, and a second portion receiving a purge gas. The purge gas will flow from the second portion to the first portion to prevent flow of the feed from the first portion to the second portion. The combined gas may be passed to a reaction zone for catalytic reforming. The first portion and the second portion may be separated by a flow distributor having two horizontal portions connected to opposite ends of a vertical portion.

Abstract: A reforming reactor and process of using same in which a flow distributor distributes the process gas circumferentially to the reactive zone. Feed is injected into the reactor into a non-reactive zone. The non-reactive zone has two portions, a first portion receiving the feed, and a second portion receiving a purge gas. The purge gas will flow from the second portion to the first portion to prevent flow of the feed from the first portion to the second portion. The combined gas may be passed to a reaction zone for catalytic reforming. The first portion and the second portion may be separated by a flow distributor having two horizontal portions connected to opposite ends of a vertical portion.

Abstract: The present disclosure relates to the technical field of small household appliances and discloses a separable evacuation device. The separable evacuation device includes an evacuation module. The evacuation module includes a base, which is connected to an opening of a to-be-evacuated container; a vacuum pump, which is disposed on the base and configured to vacuum the to-be-evacuated container; a power supply assembly, which is connected to the vacuum pump and configured to supply power to the vacuum pump; and a control assembly, which is connected to the power supply assembly and the vacuum pump and includes a vacuum pressure switch. The vacuum pressure switch is configured to detect an air pressure value in the to-be-evacuated container and control the power supply assembly to perform one of supplying power to the vacuum pump or powering off the vacuum pump.

Abstract: Methods are provided for identifying subjects as suitable donor or recipients for FMT, for assessing the likelihood of FMT treatment success, and for enhancing FMT treatment efficacy. Also provided are kits and compositions for FMT with enhanced efficacy.

Abstract: A control system for use in controlling operation of an electrical appliance, the system including: a processor module disposed inside of a housing of the electrical appliance, the processor module including at least one contactless-type sensor operably-connected with the processor module; an input control module including: an attachment element configured for releasably attaching the input control module to an outer surface of the housing; and at least one sensor-readable element configured for contactless-interaction with the contactless-type sensor.

Abstract: The present disclosure provides peptides useful as inhibitors of the dimerization interface of EBNA1. The present disclosure also provides methods for treating and imaging EBV-associated cancers.

Abstract: Luminescent lanthanide complexes comprising a triazine-based ligand capable of selective detection of urinary polyamines and their methods of use in detecting and quantifying urinary polyamines as well as prostate cancer biomarkers, such as spermine. The detection of the urinary polyamines can be accomplished using colorimetric methods such as, with an ultraviolet-visible spectrometer.

Abstract: Provided herein are lanthanide complexes that exhibit specific subcellular localization to primary cilium. The lanthanide complexes provided herein are useful for imaging, tagging, and pull down of binding targets located in primary cilium.

Abstract: This invention is about an improved garage door opener system, with design features for preventing garage door break-in from outside of the garage using an object such as a hanger. Typically, a person pulls down a cord connected to a release handle to release emergency release of a garage door opener, allowing the door to be manually open or closed. An unauthorized person may attempt to pull down the cord using a hanger from outside the garage or to pull or push down the release handle, to open the door from outside and gain unauthorized entrance. The improved garage door opener system provides a mechanism to reverse the pulling direction of the cord and also protects release handle from being accessed from outside the garage, for increased security.