Abstract: The present invention provides a compound having a new structure as a PDE4B inhibitor, a preparation method for the compound, and a use of the compound in treating PDE4B-mediated diseases. Experiments confirm that the compound has a strong inhibitory effect on PDE4B enzyme and can be used as a promising compound for treating PDE4B-mediated diseases.

Abstract: This disclosure provides isolated antibodies, for example, monoclonal antibodies, that specifically bind to the C-C Motif Chemokine Receptor 8 (CCR8) expressed on the surface of a cell and mediate depletion of the CCR8-expressing cell by antibody-dependent cellular cytotoxicity (ADCC). The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CCR8 antibody as monotherapy or in combination with an anti-cancer agent such as an immune checkpoint inhibitor, for example, an anti-PD-1 or anti-PD-L1 antibody.

Abstract: A battery cell fault identification method for an energy storage system and an energy storage system are provided. The battery cell fault identification method for the energy storage system includes: setting an upper threshold for a cell voltage deviation; acquiring a cell voltage V_n_i of each battery cell, wherein n denotes a number of battery modules, and i denotes an index of the battery cells within a battery module; performing a horizontal comparison on the battery cells to acquire a deviation ?V_n_i of the cell voltage of each of battery cells relative to an average cell voltage within a same battery module; and performing a vertical comparison on the battery cells, calculating a difference between the deviations of battery cells with a same index within each battery module and a median value of the deviations of the battery cells with the same index.

Abstract: Provided herein are modified hemoglobin (Hb) comprising at least two subunits of a Hb intramolecularly crosslinked with a compound of formula (I), or salt, stereoisomer, or deuterated form thereof, wherein X, R1, and R2 are defined herein. The modified Hb can further comprise residues functionalized with reactive groups. Also provided herein are multimerized hemoglobin (Hb) compositions comprising a reaction product of: the modified Hb comprising a residue functionalized with one or more first reactive groups for click reaction and a reactant molecule comprising second reactive groups complementary to the first reactive group for the click reaction.

Abstract: The invention provides a class of compounds represented by Formula (I), and pharmaceutically acceptable salts thereof. The compounds of the invention have strong inhibitory activity against Lp(a) assembly and can be used to treat cardiovascular diseases (CVDs).

Abstract: A method for identifying an internal resistance consistency fault in an energy storage battery and an energy storage system are provided.

Abstract: An active fault detection method of an energy storage system, and the energy storage system are provided. The active fault detection method of the energy storage system includes: a step of causing the state of charge of an energy storage battery to reach a first preset value; a discharge time acquisition step of causing the energy storage battery to discharge at constant current a until the state of charge thereof reaches a second preset value, stopping discharging, and acquiring a discharge time T, wherein the second preset value is less than the first preset value; and judging whether the discharge time T is less than or equal to a preset discharge time t, if so, judging that the energy storage battery has a hidden fault or the service life thereof is seriously shortened, and if not, judging that the energy storage battery is normal.

Abstract: Disclosed are a power control method and apparatus, an energy storage system, and a nonvolatile storage medium. The method includes: acquiring a State of Charge (SOC) of each of a plurality of battery cells in the energy storage system, and a power direction and a power level of a microgrid connected to the energy storage system; determining, according to the SOC of each of the plurality of battery cells and the power direction of the microgrid, an optimal cell power and a maximum cell power of each of the plurality of battery cells matching the power direction; determining total optimal power and total maximum power of the plurality of battery cells according to the optimal cell power and the maximum cell power; and determining an actual cell power of each of the plurality of battery cells according to the total optimal power, the total maximum power, and the power level.

Abstract: A data processing method, apparatus and device are provided. The data processing method includes: obtaining application requirement information according to function requirement information and preset template information; performing resource exploration according to the application requirement information; when a result of the resource exploration indicates that a target application is allowed to operate, according to the application requirement information, allocating, from target operation platform resource, application resource to the target application, and creating an operation environment for the target application; deploying and releasing the target application according to the application resource and the operation environment; wherein the target application is an application program corresponding to the application requirement information.

Abstract: Provided herein are compounds of formula (I), or salt, stereoisomer, or deuterated form thereof, wherein X, R1, and R2 are defined herein. Also provided herein are conjugated compositions comprising reacted units of a molecule (e.g., a protein) and a compound of formula (I), or salt, stereoisomer, or deuterated form thereof.

Abstract: Disclosed herein are compounds having the structure of Formula (I): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein A, Q1, R2, R3, Q4, R5, R6, R7, R and n are as defined herein. Pharmaceutical compositions comprising them, processes for preparing them and uses of them to treat or prevent diseases, disorders and conditions are also provided. The compounds are inhibitors of ENPP1 and are useful in the treatment of diseases, disorders and conditions related to ENPP1 activity. In particular, the compounds are useful for treating a disease or condition selected from an infection (including but not limited to bacterial infections and viral infections), proliferative disorders (such as cancer or a tumor), cardiovascular disease (including cardiac injury), diabetes or insulin resistance, chondrocalcinosis, calcium pyrophosphate deposition disorder (pseudogout), or hypophosphatasia.

Abstract: An antenna includes a plurality of antenna elements each respectively operable as a radiator of electromagnetic waves, and a decoupler arrangement operably coupled with the plurality of antenna elements. The decoupler arrangement is configured to prevent, reduce, or substantially eliminate mutual coupling of at least two of the plurality of antenna elements when at least one of the plurality of antenna elements is operated as radiator.

Abstract: This disclosure provides isolated antibodies that specifically bind to the C-C Motif Chemokine Receptor 8 (CCR8) expressed on the surface of a cell and exhibit various functional properties, including properties that are desirable in a diagnostic antibody. These properties include binding with high affinity and specificity to CCR8-expressing cells, such as tumor-infiltrating, activated CD4+FOXP3high Tregs, and binding to a human CCR8 (hCCR8) epitope outside the N-terminal domain of hCCR8 to which most therapeutic anti-CCR8 antibodies bind.

Abstract: A digital road network traffic state reckoning method includes: S1, acquiring traffic weight coefficients of vehicles; S2, calculating traffic weight coefficients of evaluation objects in the road network at different spatial scales; S3, reckoning traffic operation indexes of the different evaluation objects in the road network; S4, reckoning delay time indexes and average delay times of the different evaluation objects in the road network; S5, reckoning indexes of the numbers of times of stopping and average numbers of times of stopping of the different evaluation objects in the road network; and S6, reckoning indexes of mileages of congested roads and proportions of mileages of heavily congested roads of the different evaluation objects in the road network by using the mileages of the heavily congested roads and the traffic weight coefficients of the vehicles.

Abstract: A substrate-integrated dielectric resonator, which includes a first substrate layer having a first dielectric constant, and a plurality of metallic patches on a first side of the first substrate layer. The plurality of metallic patches is separated from each other, and is shorted to ground. A dielectric resonator antenna incorporating such a resonator is also described. The DRA has a low profile with an enhanced gain. The DRA can be easily fabricated using low-cost PCB technology. By adding shorted metallic patches to the DR without increasing the antenna size, the gain of DRA is obviously increased.

Abstract: Provided herein are modified hemoglobin (Hb) comprising at least two subunits of a Hb intramolecularly crosslinked with a compound of formula (I), or salt, stereoisomer, or deuterated form thereof, wherein X, R1, and R2 are defined herein. The modified Hb can further comprise residues functionalized with reactive groups. Also provided herein are multimerized hemoglobin (Hb) compositions comprising a reaction product of: the modified Hb comprising a residue functionalized with one or more first reactive groups for click reaction and a reactant molecule comprising second reactive groups complementary to the first reactive group for the click reaction.

Abstract: An on-chip dual-mode transmission line with an spoof surface plasmon based on a balun includes a dual-mode transmission line located in the intermediate, the balun structures symmetrically located at both terminals of the dual-mode transmission line, and pad structures and excitation portions located outside the balun structures. The dual-mode transmission line comprises two metal strip lines that are the same in structure and parallel to each other, and the branches located between the two metal strip lines. The dual-mode transmission line can simultaneously support the transmissions of the odd-mode spoof surface plasmon signal and the even-mode spoof surface plasmon signal, and is not only suitable for III-V chips such as gallium arsenide and silicon nitride, but also suitable for technologies such as other chips and printed circuit boards.

Abstract: A display panel and a display device are provided. The display panel includes a display substrate including a first display region and a second display region adjacent to the first display region, n rows of first pixel driving circuits located in the first display region and m rows of second pixel driving circuits located in the second display region, a plurality of reset signal lines including n first reset signal lines corresponding to the n rows of the first pixel driving circuits; wherein one terminal of each of the first reset signal lines is electrically connected to the corresponding first pixel driving circuits, and another terminal of one of any two adjacent first reset signal lines is electrically connected to the corresponding second pixel driving circuits. The display device includes the display panel.

Abstract: A multi-slot antenna includes a ground plane, a driven slot, a first parasitic slot, a second parasitic slot, a third parasitic slot, and a fourth parasitic slot. The driven slot is positioned on the ground plane and extends along a first direction. The first, second, third, fourth parasitic slots are positioned on the ground plane, and each of them extends along the first direction and a second direction different than the first direction. The first parasitic slot and the third parasitic slot symmetrical about the driven slot. The fourth parasitic slot is positioned on the ground plane and at the second side of the driven slot. The second parasitic slot and the fourth parasitic slot are symmetrical about the driven slot.