Abstract: An electrostatic discharge (ESD) protection circuit is coupled between first and second power supply buses. The ESD protection circuit includes a detection circuit; a pull-up circuit, coupled to the detection circuit, comprising at least a first n-type transistor; a pull-down circuit, coupled to the pull-up circuit, comprising at least a second n-type transistor; and a bypass circuit, coupled to the pull-up and pull-down circuits, wherein the detection circuit is configured to detect whether an ESD event is present on either the first or the second bus so as to cause the pull-up and pull-down circuits to selectively enable the bypass circuit for providing a discharging path between the first and second power supply buses.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: Techniques are provided for generating feature-level recommendations for content items. One method comprises obtaining feature values related to a content item; applying the feature values to a trained engagement prediction model that generates an influence score for each feature value, wherein the influence score for each feature value indicates an influence of each respective feature value on a performance indicator associated with the content item; generating a recommendation for improving the performance indicator using the influence score for each feature value; and initiating a modification of the content item using the recommendation. Features can be selected using an artificial intelligence technique that performs a sub-image analysis on historical content items to evaluate an area of influence for a region of the historical content items when a feature value of a feature is changed. An automated feature extraction process may extract feature values using machine learning model.

Abstract: A method includes generating a first bitmap for a cell. The first bitmap is indicative of mapping constraints of the cell. The method also includes generating a second bitmap for a PSC filler cell. The second bitmap is indicative of the mapping constraints of the PSC filler cell. The method also includes a bitwise logical operation between a portion of the first bitmap and a respective portion of the second bitmap and determining a compatibility between the cell and the PSC filler cell based on at least a result of the bitwise logical operation.

Abstract: An electrostatic discharge (ESD) protection circuit is coupled between first and second power supply buses. The ESD protection circuit includes a detection circuit; a pull-up circuit, coupled to the detection circuit, comprising at least a first n-type transistor; a pull-down circuit, coupled to the pull-up circuit, comprising at least a second n-type transistor; and a bypass circuit, coupled to the pull-up and pull-down circuits, wherein the detection circuit is configured to detect whether an ESD event is present on either the first or the second bus so as to cause the pull-up and pull-down circuits to selectively enable the bypass circuit for providing a discharging path between the first and second power supply buses.

Abstract: A method of decreasing height differences of STIs includes providing a substrate comprising a peripheral circuit region. The peripheral circuit region includes a P-type transistor region and an N-type transistor region. A first STI and a third STI are respectively disposed within the N-type transistor region and the P-type transistor region. Later, a first mask is formed to cover the N-type transistor region. Then, an N-type well is formed in the P-type transistor region and part of the third STI is removed by taking the first mask as a mask. Next, the first mask is removed. After that, a second mask is formed to cover the P-type transistor region. Subsequently, a P-type well is formed in the N-type transistor region and part of the first STI is removed by taking the second mask as a mask. Finally, the second mask is removed.

Abstract: A voice wake-up device includes a microphone module, an electrical connector, and a microcontroller unit. The microcontroller unit includes at least one microcontroller and a memory for storing microcontroller-executable instructions. The microcontroller-executable instructions enable the microcontroller unit to execute multiple tasks including detecting whether a sound signal is in ambient sounds received by the microphone module, and generating an input sound signal according to the sound signal; determining whether the input sound signal includes a predetermined wake-up voice; and confirming the predetermined wake-up voice is comprised in the input sound signal and outputting a wake-up instruction to wake up the electronic device entering the non-hibernation mode from the hibernation mode.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: A method of decreasing height differences of STIs includes providing a substrate comprising a peripheral circuit region. The peripheral circuit region includes a P-type transistor region and an N-type transistor region. A first STI and a third STI are respectively disposed within the N-type transistor region and the P-type transistor region. Later, a first mask is formed to cover the N-type transistor region. Then, an N-type well is formed in the P-type transistor region and part of the third STI is removed by taking the first mask as a mask. Next, the first mask is removed. After that, a second mask is formed to cover the P-type transistor region. Subsequently, a P-type well is formed in the N-type transistor region and part of the first STI is removed by taking the second mask as a mask. Finally, the second mask is removed.

Abstract: Provided herein is a method for treating an oral cancer in a subject. According to embodiments of the present disclosure, the method comprises respectively obtaining a first and a second biological samples from a lesion site and a non-lesion site of the subject; respectively measuring the expression levels of CHEK1, PIK3CA, or PIK3CD in both biological samples by qRT-PCR thereby obtaining a first and a second expression level; determining the ratio of the first to the second expression level; and administering to the subject an effective amount of a checkpoint kinase 1 inhibitor when the ratio for CHEK1 is at least 1.7 or a phosphatidylinositol 3-kinase inhibitor when the ratio for PIK3CA is at least 2.4, or when the ratio for PIK3CD is at least 3.1.

Abstract: An existing design of an integrated circuit includes existing cells that have already been placed and routed. An engineering change order (ECO) specifies additional new cells (ECO cells) to be inserted into the existing design. The ECO cells are also associated with target locations for their placement among the existing cells, but these target locations may violate design rules. The feasibility of “legalizing” the placement of the ECO cells within the existing design is assessed as follows. The ECO cells are clustered into clusters based on their target locations. Clusters are assessed by determining an ECO placement impact (EPI) index for individual clusters. The EPI index is a measure of the feasibility for legalizing the placement of the ECO cells in that cluster.

Abstract: A three-dimension measurement device includes a moving device, a projecting device, a surface-type image-capturing device and a processing device. The moving device carries an object, and moves the object to a plurality of positions. The projecting device generates a first light to the object. The surface-type image-capturing device senses a second light generated by the object in response to the first light to generate a phase image on each of the positions. The processing device is coupled to the surface-type image-capturing device and receives the phase images. The processing device performs a region-of-interest (ROI) operation for the phase images to generate a plurality of ROI images. The processing device performs a multi-step phase-shifting operation for the ROI images to calculate the surface height distribution of the object.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: Disclosed herein is a method of determining whether a subject has or is at risk of developing a cancer. The method comprises, obtaining a sample from the subject; determining the levels of at least two target polypeptides, which are selected from the group consisting of, ANXA2, HSPA5, KNG1 and MMP1; and assessing whether the subject has or is at risk of developing the cancer based on the levels of target polypeptides. The present method provides a potential means to diagnose and predict the occurrence of oral squamous cell carcinoma, and accordingly, the subject in need thereof could receive a suitable therapeutic regimen in time.

Abstract: Provided herein is a method for treating an oral cancer in a subject. According to embodiments of the present disclosure, the method comprises respectively obtaining a first and a second biological samples from a lesion site and a non-lesion site of the subject; respectively measuring the expression levels of CHEK1, PIK3CA, or PIK3CD in both biological samples by qRT-PCR thereby obtaining a first and a second expression level; determining the ratio of the first to the second expression level; and administering to the subject an effective amount of a checkpoint kinase 1 inhibitor when the ratio for CHEK1 is at least 1.7 or a phosphatidylinositol 3-kinase inhibitor when the ratio for PIK3CA is at least 2.4, or when the ratio for PIK3CD is at least 3.1.

Abstract: A method including creating a first bus guide and a second bus guide of a plurality of bus guides for an integrated circuit is disclosed. The method includes routing the first bus guide and the second bus guide through a plurality of layout blocks of the integrated circuit. The method includes annotating the first bus guide or the second bus guide to identify a plurality of areas for placing a plurality of repeaters within the first bus guide or the second bus guide. The method includes, based on the annotated first bus guide and the second bus guide, generating, by at least one processor, a plurality of guidance directories corresponding to a plurality of routes through the plurality of layout blocks for placing the plurality of repeaters at the plurality of layout blocks on the identified plurality of areas on the first bus guide or the second bus guide.

Abstract: Route segments of a set of nets may be grouped into route groups. Terminals of the set of nets may be grouped into terminal groups. For each net in the set of nets, a net signature may be determined based on route groups associated with the net and terminal groups associated with the net. The set of nets may be grouped into net groups based on the net signatures.

Abstract: A computerized system is disclosed. The computerized system may include one or more processors configured to perform the operations stored in a memory. The operations may include creating a plurality of library (lib) cells for a directional routing layer, and determining a lib cell of the plurality of lib cells for placement of at least one repeater for the directional routing layer. The operations may also include determining a route touch region corresponding to a pin region of the lib cell through which a route is going through and inserting the at least one repeater at the route touch region. The operations may also include swapping the at least one inserted repeater to at least one target lib cell of the plurality of lib cells.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: An overhead transport vehicle is described for association with an Automated Material Handling System (AMHS). The overhead transport vehicle provides features to the AMHS by which the AMHS is able to reduce a number of manual urgent lot rescues by the fab operator when a logistic algorithm controlling traffic in the AMHS is unable to transport the front opening unified pods (FOUP) from one tool to the subsequent tool in the sequence of the process steps within the q-time due to unexpected problems. An indicator on the overhead transport vehicle which helps the fab operator with spotting a lot in trouble is described. A backup power source on the overhead transport vehicle used in case of a main power failure is also described.