Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: An image sensor and a manufacturing method thereof are provided. The image sensor includes a pixel sensing circuit, a pixel electrode, and an opto-electrical conversion layer. The pixel sensing circuit is corresponding to a plurality of pixel regions. The pixel electrode is disposed on the pixel sensing circuit. The pixel electrode includes a first electrode and a second electrode and is electrically connected to the pixel sensing circuit. The first electrode and the second electrode are coplanar, and have different polarities. The opto-electrical conversion layer is disposed on the pixel sensing circuit. The opto-electrical conversion layer includes a plurality of opto-electrical conversion portions, each of the opto-electrical conversion portions is corresponding to each of the pixel regions, and the opto-electrical conversion portions are separated from each other by a pixel isolation trench.

Abstract: An image sensor and a manufacturing method thereof are provided. The image sensor includes a pixel sensing circuit, a pixel electrode, and an opto-electrical conversion layer. The pixel sensing circuit is corresponding to a plurality of pixel regions. The pixel electrode is disposed on the pixel sensing circuit. The pixel electrode includes a first electrode and a second electrode and is electrically connected to the pixel sensing circuit. The first electrode and the second electrode are coplanar, and have different polarities. The opto-electrical conversion layer is disposed on the pixel sensing circuit. The opto-electrical conversion layer includes a plurality of opto-electrical conversion portions, each of the opto-electrical conversion portions is corresponding to each of the pixel regions, and the opto-electrical conversion portions are separated from each other by a pixel isolation trench.

Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.

Abstract: A semiconductor memory device includes a semiconductor substrate, a first support layer, a first electrode, a capacitor dielectric layer, and a second electrode. The first support layer is disposed on the semiconductor substrate. The first electrode is disposed on the semiconductor substrate and penetrates the first support layer. The capacitor dielectric layer is disposed on the first electrode. The second electrode is disposed on the semiconductor substrate, and at least a part of the capacitor dielectric layer is disposed between the first electrode and the second electrode. The first support layer includes a carbon doped nitride layer, and a carbon concentration of a bottom portion of the first support layer is higher than a carbon concentration of a top portion of the first support layer.

Abstract: An oral dilator includes a first body, a second body, a rotary member, and a positioning member. The first body includes a housing and a first duckbilled element. The second body includes a second duckbilled element corresponding to the first duckbilled element. The rotary member drives the second body to rotate. The positioning member is on the first body and selectively locks or unlocks the relative position between the first duckbilled element and the second duckbilled element when the second duckbilled element is driven to rotate by the rotary member.

Abstract: A dynamic random access memory (DRAM) includes a first bit line extending along a first direction, a first buried word line extending along a second direction, and an active region overlapping part of the first bit line and part of the first buried word line. Preferably, the active region comprises a V-shape. Moreover, the DRAM also includes at least a storage node contact overlapping one end of the active region, in which the storage node contact includes an ellipse.

Abstract: A trocar includes a puncturing device and a sleeving component. The puncturing device includes a base and a puncturing portion. The puncturing portion includes a bump and a tip. The bump extends from an outer surface of the puncturing portion radially. The sleeving component includes a gas pressure base, a first tube assembly, a second tube assembly, and a fixation base. The second tube assembly is retractable. The fixation base is fixed to the second sleeving end and includes a guiding groove and a key groove. The guiding groove communicates the key groove. While the bump of the puncturing device is entered through the guiding groove, and the puncturing device is rotated to have the bump be in the key groove, the puncturing device is secured to the fixation base, and the puncturing device drives the fixation base to move along an elongated direction of the puncturing device.

Abstract: A trocar set includes a handle portion, a first sleeve, a second sleeve, and a gasbag. The handle portion includes a grip, a connection part, and a first gas valve. The connection part extends from the grip and includes an assembling channel. The first gas valve is connected to the connection part and communicates with the assembling channel. An assembling end of the first sleeve is assembled to the connection portion. A sleeving end of the first sleeve is provided with a first opening. The second sleeve is retractably connected to the sleeving end of the first sleeve. A sleeve wall of the second sleeve is provided with a second opening. The gasbag is connected to an end of the second sleeve away from the sleeving end and corresponds to the second opening. The design of the retractable sleeves is benefit to perform operation.

Abstract: A semiconductor device and a method of forming the same are provided. A substrate is provided. A trench is formed in the substrate and a conductive material is formed filling the trench. A portion of the conductive material filling an upper portion of the trench is removed to expose an upper surface of the substrate and an upper corner and an upper sidewall of the trench. A doping process is performed to form a doped region in the substrate along the exposed upper surface of the substrate and the exposed upper corner and upper sidewall of the trench. The doped region has an upside-down L shape.

Abstract: A trocar set includes a handle portion, a first sleeve, a second sleeve, and a gas tight assembly. The handle portion includes a grip, a connection part, and a second gas valve. The connection part extends from the grip and includes an assembling channel. The second gas valve is connected to the connection part and communicates with the assembling channel. An assembling end of the first sleeve is assembled to the connection part. The second sleeve includes a receiving end, wherein the sleeving end is inserted into the receiving end. The gas tight assembly is fixed to the second sleeve and includes a gas tight sleeve and a gas tight ring. The gas tight sleeve encloses the receiving end, and the gas tight ring is pressed by the gas tight sleeve to be tightly attached to the first sleeve.

Abstract: A semiconductor memory device includes a semiconductor substrate, a first support layer, a first electrode, a capacitor dielectric layer, and a second electrode. The first support layer is disposed on the semiconductor substrate. The first electrode is disposed on the semiconductor substrate and penetrates the first support layer. The capacitor dielectric layer is disposed on the first electrode. The second electrode is disposed on the semiconductor substrate, and at least a part of the capacitor dielectric layer is disposed between the first electrode and the second electrode. The first support layer includes a carbon doped nitride layer, and a carbon concentration of a bottom portion of the first support layer is higher than a carbon concentration of a top portion of the first support layer.

Abstract: Disclosed herein is a method of determining whether a subject has or is at risk of developing a cancer. The method comprises, obtaining a sample from the subject; determining the levels of at least two target polypeptides, which are selected from the group consisting of, ANXA2, HSPA5, KNG1 and MMP1; and assessing whether the subject has or is at risk of developing the cancer based on the levels of target polypeptides. The present method provides a potential means to diagnose and predict the occurrence of oral squamous cell carcinoma, and accordingly, the subject in need thereof could receive a suitable therapeutic regimen in time.

Abstract: A trocar set includes a handle portion, a first sleeve, a second sleeve, and a gasbag. The handle portion includes a grip, a connection part, and a first gas valve. The connection part extends from the grip and includes an assembling channel. The first gas valve is connected to the connection part and communicates with the assembling channel. An assembling end of the first sleeve is assembled to the connection portion. A sleeving end of the first sleeve is provided with a first opening. The second sleeve is retractably connected to the sleeving end of the first sleeve. A sleeve wall of the second sleeve is provided with a second opening. The gasbag is connected to an end of the second sleeve away from the sleeving end and corresponds to the second opening. The design of the retractable sleeves is benefit to perform operation.

Abstract: A card gaming method and a card gaming system are provided. The card gaming method is adapted for the card gaming system including at least one deck of playing cards and a dedicated gaming table. The dedicated gaming table is designed to include an ante area, a play area and a revenge area. The ante area accepts an ante wager being not less than a minimum ante. The card gaming method includes: dealing initial two cards to a player side in response to an ante wager being placed in the ante area by the player side; dealing a third card to the player side in response to a play wager being placed in the play area by the player side when a player score of the initial two cards on the player side is less than a play threshold; dealing a fourth card to the player side in response to a revenge wager being placed in the revenge area by the player side when a player score of the three cards on the player side is less than a revenge threshold.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: A semiconductor device includes a substrate, plural active areas, plural bit lines and plural dummy bit lines. The substrate includes a cell region and a periphery region, and the active areas are defined on the substrate. The bit lines are disposed on the substrate, within the cell region and across the active areas. The dummy bit lines are disposed at a side of the bit lines, wherein the dummy bit lines are in contact with each other and have different pitches therebetween.

Abstract: An electrostatic discharge (ESD) protection circuit is coupled between first and second power supply buses. The ESD protection circuit includes a detection circuit; a pull-up circuit, coupled to the detection circuit, comprising at least a first n-type transistor; a pull-down circuit, coupled to the pull-up circuit, comprising at least a second n-type transistor; and a bypass circuit, coupled to the pull-up and pull-down circuits, wherein the detection circuit is configured to detect whether an ESD event is present on either the first or the second bus so as to cause the pull-up and pull-down circuits to selectively enable the bypass circuit for providing a discharging path between the first and second power supply buses.

Abstract: A method for forming patterns of semiconductor device is provided in the present invention, with steps of filling up first self-assembly material in first openings in a dielectric layer, phase-separating the first self-assembly material to form a first portion and a second portion surrounding the first portion, removing the first portion and performing a first etch process to form a first mask pattern in a mask layer, forming a second dielectric layer and repeating the above steps to form a second mask pattern in the mask layer, wherein the second mask pattern is aligned with the first mask pattern to form a common mask pattern.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).