Abstract: Contemplated compositions and methods comprise chimeric molecule complexes that advantageously provide activating signaling to immune competent cells when bound to ALL cells. Furthermore, chimeric molecule complexes include an Fc portion to extend serum half live time and facilitate purification.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: A vibration system which does not rely on adhesive assembly includes a first bracket and a vibration assembly. The vibration assembly includes a voice coil portion and a first diaphragm portion. The voice coil portion includes a mounting base and a voice coil body. The voice coil body surrounds an outer surface of the mounting base. Through holes define in one end of the mounting base. The through holes penetrate the base. The first diaphragm portion includes two connecting portions and a diaphragm body between the two connecting portions. A first connecting portion connects the first bracket. A second connecting portion surrounds an end of the mounting base away from the voice coil body, and the second connecting portion inserts into the through hole. The disclosure further provides a loudspeaker and a method for manufacturing the vibration system.

Abstract: A three-dimension measurement device includes a moving device, a projecting device, a surface-type image-capturing device and a processing device. The moving device carries an object, and moves the object to a plurality of positions. The projecting device generates a first light to the object. The surface-type image-capturing device senses a second light generated by the object in response to the first light to generate a phase image on each of the positions. The processing device is coupled to the surface-type image-capturing device and receives the phase images. The processing device performs a region-of-interest (ROI) operation for the phase images to generate a plurality of ROI images. The processing device performs a multi-step phase-shifting operation for the ROI images to calculate the surface height distribution of the object.

Abstract: An electrostatic discharge (ESD) protection circuit is coupled between first and second power supply buses. The ESD protection circuit includes a detection circuit; a pull-up circuit, coupled to the detection circuit, comprising at least a first n-type transistor; a pull-down circuit, coupled to the pull-up circuit, comprising at least a second n-type transistor; and a bypass circuit, coupled to the pull-up and pull-down circuits, wherein the detection circuit is configured to detect whether an ESD event is present on either the first or the second bus so as to cause the pull-up and pull-down circuits to selectively enable the bypass circuit for providing a discharging path between the first and second power supply buses.

Abstract: A vibration system which does not rely on adhesive assembly includes a first bracket and a vibration assembly. The vibration assembly includes a voice coil portion and a first diaphragm portion. The voice coil portion includes a mounting base and a voice coil body. The voice coil body surrounds an outer surface of the mounting base. Through holes define in one end of the mounting base. The through holes penetrate the base. The first diaphragm portion includes two connecting portions and a diaphragm body between the two connecting portions. A first connecting portion connects the first bracket. A second connecting portion surrounds an end of the mounting base away from the voice coil body, and the second connecting portion inserts into the through hole. The disclosure further provides a loudspeaker and a method for manufacturing the vibration system.

Abstract: A method includes generating a first bitmap for a cell. The first bitmap is indicative of mapping constraints of the cell. The method also includes generating a second bitmap for a PSC filler cell. The second bitmap is indicative of the mapping constraints of the PSC filler cell. The method also includes a bitwise logical operation between a portion of the first bitmap and a respective portion of the second bitmap and determining a compatibility between the cell and the PSC filler cell based on at least a result of the bitwise logical operation.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: Techniques and systems for inserting repeaters in an integrated circuit (IC) design are described. Some embodiments can place a snapping region in the IC design, wherein the snapping region includes a predetermined arrangement of feasible grid regions and blocked grid regions, and wherein repeaters are allowed to be placed in feasible grid regions but not in blocked grid regions. Next, the embodiments can iteratively perform a set of operations, comprising: selecting a net from a set of nets; determining an initial location for inserting a repeater in the net; identifying an unoccupied feasible grid region in the first snapping region that is closest to the initial location; and inserting a repeater in the net in the unoccupied feasible grid region.

Abstract: An electrostatic discharge (ESD) protection circuit is coupled between first and second power supply buses. The ESD protection circuit includes a detection circuit; a pull-up circuit, coupled to the detection circuit, comprising at least a first n-type transistor; a pull-down circuit, coupled to the pull-up circuit, comprising at least a second n-type transistor; and a bypass circuit, coupled to the pull-up and pull-down circuits, wherein the detection circuit is configured to detect whether an ESD event is present on either the first or the second bus so as to cause the pull-up and pull-down circuits to selectively enable the bypass circuit for providing a discharging path between the first and second power supply buses.

Abstract: A vibration system which does not rely on adhesive assembly includes a first bracket and a vibration assembly. The vibration assembly includes a voice coil portion and a first diaphragm portion. The voice coil portion includes a mounting base and a voice coil body. The voice coil body surrounds an outer surface of the mounting base. Through holes define in one end of the mounting base. The through holes penetrate the base. The first diaphragm portion includes two connecting portions and a diaphragm body between the two connecting portions. A first connecting portion connects the first bracket. A second connecting portion surrounds an end of the mounting base away from the voice coil body, and the second connecting portion inserts into the through hole. The disclosure further provides a loudspeaker and a method for manufacturing the vibration system.

Abstract: A trocar includes a puncturing device and a sleeving component. The puncturing device includes a base and a puncturing portion. The puncturing portion includes a bump and a tip. The bump extends from an outer surface of the puncturing portion radially. The sleeving component includes a gas pressure base, a first tube assembly, a second tube assembly, and a fixation base. The second tube assembly is retractable. The fixation base is fixed to the second sleeving end and includes a guiding groove and a key groove. The guiding groove communicates the key groove. While the bump of the puncturing device is entered through the guiding groove, and the puncturing device is rotated to have the bump be in the key groove, the puncturing device is secured to the fixation base, and the puncturing device drives the fixation base to move along an elongated direction of the puncturing device.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor a/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: A semiconductor memory device includes a semiconductor substrate, a first support layer, a first electrode, a capacitor dielectric layer, and a second electrode. The first support layer is disposed on the semiconductor substrate. The first electrode is disposed on the semiconductor substrate and penetrates the first support layer. The capacitor dielectric layer is disposed on the first electrode. The second electrode is disposed on the semiconductor substrate, and at least a part of the capacitor dielectric layer is disposed between the first electrode and the second electrode. The first support layer includes a carbon doped nitride layer, and a carbon concentration of a bottom portion of the first support layer is higher than a carbon concentration of a top portion of the first support layer.

Abstract: A dynamic random access memory (DRAM) includes a first bit line extending along a first direction, a first buried word line extending along a second direction, and an active region overlapping part of the first bit line and part of the first buried word line. Preferably, the active region comprises a V-shape. Moreover, the DRAM also includes at least a storage node contact overlapping one end of the active region, in which the storage node contact includes an ellipse.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: A semiconductor structure having a contact plug includes a substrate. A memory cell region and a peripheral circuit region are defined on the substrate. At least one memory cell is disposed on the substrate within the memory cell region. The memory cell includes a transistor and a capacitor structure. A first planar stacked dielectric layer covers the peripheral circuit region. The first planar stacked dielectric layer includes two first dielectric layers and a second dielectric layer. The first dielectric layer at the bottom of the first planar stacked dielectric layer extends to the memory cell region and covers the capacitor structure. A contact plug is disposed at the peripheral circuit region and penetrates the first planar stacked dielectric layer.

Abstract: An image sensor including a plurality of pixels and a plurality of pixel sensing circuits is provided. The pixels are arranged in a pixel array. The pixels are configured to sense an image to obtain a plurality of reference pictures. The pixels include a plurality of pixel types. The pixel sensing circuits are respectively and electrically connected to the pixels. The pixel sensing circuits are configured to respectively receive a photo current generated by each of the pixels. The pixels have different characteristic curves based on the pixel types, and at least one of an electrode structure parameter and an electrode bias of each of the pixels is determined according to a correspondingly characteristic curve. In addition, an image sensing method is also provided.

Abstract: Contemplated compositions and methods comprise chimeric molecule complexes that advantageously provide activating signaling to immune competent cells when bound to ALL cells. Furthermore, chimeric molecule complexes include an Fc portion to extend serum half live time and facilitate purification.