Patents by Inventor Kang Zhang

Kang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180016285
    Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 18, 2018
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • Publication number: 20180010192
    Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
    Type: Application
    Filed: February 16, 2017
    Publication date: January 11, 2018
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Publication number: 20170342496
    Abstract: Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof). Also described herein are methods of modulating the methylation pattern of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof).
    Type: Application
    Filed: May 31, 2017
    Publication date: November 30, 2017
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Publication number: 20170327519
    Abstract: The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.
    Type: Application
    Filed: May 9, 2017
    Publication date: November 16, 2017
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu AKAMA, David Scott CARTER, Jason S. HALLADAY, Robert T. JACOBS, Yang LIU, Jacob J. PLATTNER, Yong-Kang ZHANG, Michael John WITTY
  • Publication number: 20170316539
    Abstract: In one embodiment, a computing device receives receive a request for particular content associated with an application. The device may determine, based on a first recycling policy associated with a first recycler, that the first recycler associated with the application includes a display object that is capable of being used for containing the particular content. The device may encapsulate the display object with the particular content in a wrapper object and return the wrapper object encapsulating the display object in response to the request. The device may receive an indication that the display object is no longer needed, and extract the display object from the wrapper object. The display object may be stored in the first recycler. The wrapper object without the display object may be disposed in accordance with a second recycling policy associated with a second recycler associated with an operating system of the computing device.
    Type: Application
    Filed: July 20, 2017
    Publication date: November 2, 2017
    Inventors: Qixing Du, Ashwin Bhat, Jonathan M. Kaldor, I Chien Peng, Joshua Li, Kang Zhang
  • Patent number: 9796735
    Abstract: The compounds are of the class of 3,7 substituted benzoxaboroles, useful for killing and/or inhibiting the growth of microorganisms.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: October 24, 2017
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • Publication number: 20170281828
    Abstract: An artificial cornea is fabricated by separately culturing live stromal cells, live corneal endothelial cells (CECs) and live corneal epithelial cells (CEpCs), and 3D bioprinting separate stromal, CEC and CEpC layers to encapsulate the cells into separate hydrogel nanomeshes. The CEC layer is attached to a first side of the stromal layer and the CEpC layer to a second side of the stromal layer to define the artificial cornea.
    Type: Application
    Filed: September 24, 2015
    Publication date: October 5, 2017
    Inventors: Kang ZHANG, Shaochen CHEN, Xin QU, Hong OUYANG
  • Publication number: 20170258819
    Abstract: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
    Type: Application
    Filed: May 18, 2017
    Publication date: September 14, 2017
    Inventors: Stephen J. BAKER, Virginia Sanders, Tsutomu Akama, Carolyn Bellinger-Kawahara, Yvonne Freund, Kirk R. Maples, Jacob J. Plattner, Yong-Kang Zhang, Huchen Zhou, Vincent S. Hernandez
  • Patent number: 9760964
    Abstract: A computing device receives a request for content for a content layout in a displayable region of a screen associated with the device. The device determines, based on application-tailored recycling policies, whether a recycler includes a display object that is suitable for recycling or re-use. If it does not, the device creates the display object and fills it with the content. If it does, and if the display object contains the content, the device updates elements of the display object as needed; otherwise, if the display object does not contain the content, the device fills the display object with the content and returns it. The recycling or re-using may also be performed with sub-elements of a display object, some of which may comprise nested display objects.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: September 12, 2017
    Assignee: Facebook, Inc.
    Inventors: Qixing Du, Ashwin Bhat, Jonathan M. Kaldor, I Chien Peng, Joshua Li, Kang Zhang
  • Publication number: 20170239273
    Abstract: The disclosure generally relates to compositions and uses thereof to treat vision disorders that affect the normal function of the lens in the eye in a subject having or at risk of developing such vision disorders.
    Type: Application
    Filed: August 22, 2015
    Publication date: August 24, 2017
    Inventors: Kang ZHANG, Stanley KIM, Jie ZHU, Rui HOU, J Jefferson PERRY
  • Publication number: 20170233698
    Abstract: The invention provides an isolated limbal stem or progenitor cell (LSC) population or LSC-like population comprising a chemically synthesized, recombinant or isolated nucleic acid encoding PAX6 integrated into a chromosome, or alternatively, not integrated remaining as an extrachromosomal genetic material, wherein the isolated LSC population is substantially free of non-LSC cells or wherein the LSC-like population is substantially free of non-LSC-like cells, or wherein the isolated LSC or LSC-like population is substantially free of non-LSC and non-LSC-like cells and uses thereof.
    Type: Application
    Filed: June 29, 2015
    Publication date: August 17, 2017
    Inventors: Kang Zhang, Hong Quyang, Rui Hou, Huimin Cai
  • Publication number: 20170218009
    Abstract: Described herein are compounds that inhibit or prevent protein aggregation, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with protein aggregation.
    Type: Application
    Filed: February 2, 2017
    Publication date: August 3, 2017
    Inventors: Rui HOU, Kang ZHANG
  • Patent number: 9682092
    Abstract: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: June 20, 2017
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Virginia Sanders, Tsutomu Akama, Carolyn Bellinger-Kawahara, Yvonne Freund, Kirk R. Maples, Jacob J. Plattner, Yong-Kang Zhang, Huchen Zhou, Vincent S. Hernandez
  • Publication number: 20170112500
    Abstract: An embolic coil delivery assembly is disclosed. The delivery system may include a tubular member having a distal portion, a proximal portion and a lumen extending therein. The system may further include a tip member secured to the tubular member. The tip member may include a distal portion and a bonding portion. The bonding portion may include a bonding surface. The system may also include an embolic coil releasably disposed within the distal portion of the tip member. The distal portion of the tubular member may extend over the bonding portion of the tip member. The bonding surface may be configured to mechanically interlock with the tubular member.
    Type: Application
    Filed: October 19, 2016
    Publication date: April 27, 2017
    Inventors: Nicholas L. Tassoni, Mary-Claire Anderson, Gary J. Pederson, JR., Ken Xiao Kang Zhang
  • Patent number: 9617285
    Abstract: Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 11, 2017
    Assignees: ELI LILLY AND COMPANY, ANACOR PHARMACEUTICALS, INC.
    Inventors: Tsutomu Akama, Kurt Jarnagin, Jacob J. Plattner, Shon Roland Pulley, William Hunter White, Yong-Kang Zhang, Yasheen Zhou
  • Patent number: 9599806
    Abstract: Methods and systems for autofocusing of an imaging system are presented. Provided is an imaging system and an optical interferometry system for generating one or more images corresponding to a target region in a subject. The method provides calibration information that identifies a focal position of the optical interferometry system corresponding to a determined focal position of the imaging system. A subsequent focal position of the imaging system is determined for generating a desired image corresponding to at least one of another target region in the subject and another position of the target region relative to the imaging system based on the calibration information.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: March 21, 2017
    Assignee: General Electric Company
    Inventors: Zhangyi Zhong, Chun Zhan, Kang Zhang, Daniel Curtis Gray
  • Publication number: 20170072025
    Abstract: Disclosed herein are methods and pharmaceutical compositions for the treatment of glaucoma by interfering with expression of genes, such as p16, in cells of the eye. These methods and compositions employ nucleic acid based therapies.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 16, 2017
    Inventors: Lianghong ZHENG, Jie ZHU, Ling ZHAO, Michael AI, Oulan LI, Kang ZHANG
  • Publication number: 20170066787
    Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 9, 2017
    Inventors: Stephen J. BAKER, Tsutomu Akama, Vincent S. Hernandez, Karin M. Hold, Kirk R. Maples, Jacob J. Plattner, Virginia Sanders, Yong-Kang Zhang, Gregory T. Fieldson
  • Publication number: 20170065617
    Abstract: The present invention provides sterols and uses thereof to treat vision disorders. In one embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat and/or prevent vision disorders in a subject. In another embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat cataract or blindness/impaired vision in a subject. In yet another embodiment, composition comprising lanosterol is used to dissolve amyloid-like fibrils of crystallin proteins.
    Type: Application
    Filed: April 26, 2016
    Publication date: March 9, 2017
    Inventors: Kang Zhang, Rui Hou
  • Publication number: 20170066788
    Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 9, 2017
    Inventors: Stephen J. BAKER, Tsutomu Akama, Carolyn Bellinger-Kawahara, Vincent S. Hernandez, Karin M. Hold, James J. Leyden, Kirk R. Maples, Jacob J. Plattner, Virginia Sanders, Yong-Kang Zhang