Abstract: The invention provides an in vitro method for producing isolated mammalian primitive retinal stem cells (pRSCs) comprising: (a) culturing isolated embryonic stem cells (ESCs) from a mammal in a cell culture medium that is free of feeder cells, feeder-conditioned medium or serum so as to produce and grow a culture of the isolated ESCs; and (b) contacting the culture of the isolated ESCs so grown with one or more of an inhibitor for Wnt or TGF-?/BMP signaling so as to differentiate the isolated ESCs of (a) into primitive retinal stem cells thereby producing isolated mammalian pRSCs.

Abstract: In one embodiment, a computing device receives receive a request for particular content associated with an application. The device may determine, based on a first recycling policy associated with a first recycler, that the first recycler associated with the application includes a display object that is capable of being used for containing the particular content. The device may encapsulate the display object with the particular content in a wrapper object and return the wrapper object encapsulating the display object in response to the request. The device may receive an indication that the display object is no longer needed, and extract the display object from the wrapper object. The display object may be stored in the first recycler. The wrapper object without the display object may be disposed in accordance with a second recycling policy associated with a second recycler associated with an operating system of the computing device.

Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Abstract: Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof). Also described herein are methods of modulating the methylation pattern of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof).

Abstract: The invention provides for methods for predicting age of a subject based on the epigenome of the subject.

Abstract: The disclosure herein includes uses and systems for cataract removal and lens regeneration using endogenous stem cells that results in improved outcomes.

Abstract: Disclosed herein are methods, systems, platforms, non-transitory computer-readable medium, services, and kits for determining a cancer type in an individual. Also described herein include methods, systems, platforms, non-transitory computer-readable medium, and compositions for generating a CpG methylation profile database.

Abstract: An axial flow fan includes a fan frame and an impeller received in the fan frame. The fan frame includes a base shell and a flange being formed on the base shell. The base shell further includes an air inlet facing away from the flange. The flange includes a first air outlet. The flange further includes a second air outlet. Air flows through the second air outlet in a direction perpendicular to the air flowing through the first air outlet.

Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.

Abstract: Described herein are compounds that inhibit or prevent protein aggregation, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with protein aggregation.

Abstract: The invention provides for methods for predicting age of a subject based on the epigenome of the subject.

Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

Abstract: Disclosed herein, in certain embodiments, are methods and kits for diagnosing a subject as having hepatocellular carcinoma (HCC) or lung cancer. In some instances, also described herein are methods of determining the prognosis of the subject having HCC or lung cancer. In additional instances, described herein are methods of determining the specific staging of HCC or lung cancer in a subject.

Abstract: A cooling fan with shapes, sizes, and placements of frame and supporting ribs tuned to reduce operational vibration and noise includes a fan frame, a supporting base, and a plurality of ribs. The fan frame includes a bottom plate and a sidewall connected to the bottom plate. The supporting base is formed at the bottom plate. The plurality of ribs extends from an outer circumferential surface of the supporting base to the sidewall. At least one of the plurality of ribs and the fan frame is asymmetrical with respect to the supporting base.

Abstract: A screen printing device and a screen printing method are provided. The screen printing device includes a screen plate and an electrifying device, the screen plate includes a conductive mesh; and the electrifying device is electrically connected with the conductive mesh and configured to apply voltage to the conductive mesh. The screen printing method includes: adopting a printing head to rub against a screen plate to print ink onto a substrate for silk screen printing, wherein the screen plate includes a conductive mesh; and applying voltage with positive or negative polarity to the conductive mesh in the screen printing process.

Abstract: A heat dissipating fan includes a base with a central tube, a stator arranged on the base and around the central tube, a rotor connected to and rotated surround the stator and a bearing unit received in the central tube of the base. The bearing unit includes a bearing and an oil seal, where the bearing and an oil seal are molded as one.