Abstract: The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.

Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

Abstract: The present disclosure relates to a Bluetooth pairing method and a Bluetooth device. One example method is applied to a first Bluetooth device, and the method includes: detecting a movement parameter of the first Bluetooth device during a movement; if the movement parameter meets a preset condition, enabling Bluetooth, and broadcasting a first query data packet to at least one Bluetooth device within an effective range; receiving a first query response data packet returned by the at least one Bluetooth device within the effective range; determining a to-be-paired Bluetooth device from the at least one Bluetooth device within the effective range based on first information included in the first query response data packet, where the first information includes at least one of first pairing indication information and RSSI information; and sending a pairing request to the to-be-paired Bluetooth device, to pair with the to-be-paired Bluetooth device.

Abstract: Disclosed herein, in certain embodiments, are methods and kits for diagnosing a subject as having hepatocellular carcinoma (HCC) or lung cancer. In some instances, also described herein are methods of determining the prognosis of the subject having HCC or lung cancer. In additional instances, described herein are methods of determining the specific staging of HCC or lung cancer in a subject.

Abstract: A heat dissipating fan includes a base with a central tube, a stator arranged on the base and around the central tube, a rotor connected to and rotated surround the stator and a bearing unit received in the central tube of the base. The bearing unit includes a bearing and an oil seal, where the bearing and an oil seal are molded as one.

Abstract: Disclosed herein are methods and kits for identifying a subject as having breast cancer. Also provided herein are methods and kits for determining the prognosis of a subject having breast cancer and for determining the progression of breast cancer in a subject.

Abstract: Disclosed herein are methods and kits for identifying a subject as having lung cancer. Also provided herein are methods and kits for determining the prognosis of a subject having lung cancer and for determining the progression of lung cancer in a subject.

Abstract: The present invention provides sterols and uses thereof to treat vision disorders. In one embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat and/or prevent vision disorders in a subject. In another embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat cataract or blindness/impaired vision in a subject. In yet another embodiment, composition comprising lanosterol is used to dissolve amyloid-like fibrils of crystallin proteins.

Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Abstract: Disclosed herein are methods and kits for identifying a subject as having colon cancer. Also provided herein are methods and kits for determining the prognosis of a subject having colon cancer and for determining the progression of colon cancer in a subject.

Abstract: Disclosed herein are methods and kits for identifying a subject as having liver cancer. Also provided herein are methods and kits for determining the prognosis of a subject having liver cancer and for determining the progression of liver cancer in a subject.

Abstract: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.

Abstract: Embodiments of the present invention disclose a Bluetooth pairing method and a Bluetooth device. The method is applied to a first Bluetooth device, and the method includes: detecting a movement parameter of the first Bluetooth device during a movement; if the movement parameter meets a preset condition, enabling Bluetooth, and broadcasting a first query data packet to at least one Bluetooth device within an effective range; receiving a first query response data packet returned by the at least one Bluetooth device within the effective range; determining a to-be-paired Bluetooth device from the at least one Bluetooth device within the effective range based on first information included in the first query response data packet, where the first information includes at least one of first pairing indication information and RSSI information; and sending a pairing request to the to-be-paired Bluetooth device, to pair with the to-be-paired Bluetooth device.

Abstract: Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof). Also described herein are methods of modulating the methylation pattern of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof).

Abstract: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.

Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.

Abstract: Disclosed herein are systems, methods, devices, and media for carrying out medical diagnosis of ophthalmic diseases and conditions. Deep learning algorithms enable the automated analysis of ophthalmic images to generate predictions of comparable accuracy to clinical experts.

Abstract: An embolic coil delivery assembly is disclosed. The delivery system may include a tubular member having a distal portion, a proximal portion and a lumen extending therein. The system may further include a tip member secured to the tubular member. The tip member may include a distal portion and a bonding portion. The bonding portion may include a bonding surface. The system may also include an embolic coil releasably disposed within the distal portion of the tip member. The distal portion of the tubular member may extend over the bonding portion of the tip member. The bonding surface may be configured to mechanically interlock with the tubular member.

Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.