Abstract: An immersion mold for a medical device balloon. The mold has a cavity adapted to receive a hollow parison expandable therein to form the balloon. The cavity has a length, a first end, a second end, and a cavity wall with inner and outer surfaces. The mold form cavity wall is provided with one or a plurality of through-holes along the length thereof to facilitate entrance and egress of a heated fluid.

Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.

Abstract: Medical balloons and balloon preforms are made by methods which include the step of selectively removing material from the proximal and/or distal ends of a segment. In the case of a thermoplastic material characterized by one or more glass transition temperatures, the segment may optionally be maintained at a temperature below the glass transition temperature of the segment during the material removal step.

Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

Abstract: An electrical connector (100) for mating with a mating connector (700) along a mating direction includes an insulative housing (1) defining a passageway and a pair of latching members (2) inserted in the passageway. Each latching member has a resisting portion (21) and a latching portion (22) extending forwardly from the resisting portion and deformable from a first position to a second position for latching with the mating connector. The resisting portion includes an upper section (211) and a lower section formed at opposite sides of the latching portion and respectively abutting against the insulative housing along the mating direction when the latching portion is located in the second position.

Abstract: An electrical connector (100) for mating with a mating connector (700) includes an insulative housing (1) defining a resisting face (115), a pair of latching members (2) assembled to the insulative housing, and a shielding shell (6) attached to the insulative housing. Each latching member has a resisting portion (21) and a latching portion (22) extending forwardly from the resisting portion for latching with the mating connector. The shielding shell is formed with a number of blocking plates disposed behind the resisting face of the insulative housing. The latching member is confined between the resisting face and the blocking plate.

Abstract: Disclosed herein are compositions and methods for the identification of a subject at risk for developing type 2 diabetes. Also disclosed is a therapeutic target for the prevention and treatment of type 2 diabetes.

Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Abstract: This invention provides, among other things, novel oxaboroles which are monosubstituted at the 3-, 6-, or 7-position, or disubstituted at the 3-/6- or 3-/7- positions, which are useful for treating bacterial infections, pharmaceutical compositions containing such oxaboroles, as well as combinations of these oxaboroles with at least one additional therapeutically effective agent.

Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.

Abstract: Medical balloons and balloon preforms are made by methods which include the step of selectively removing material from the proximal and/or distal ends of a segment. In the case of a thermoplastic material characterized by one or more glass transition temperatures, the segment may optionally be maintained at a temperature below the glass transition temperature of the segment during the material removal step.

Abstract: A computer-implemented method is provided to facilitate creation of linked inter-related models in a database. The method comprises obtaining a search text and match criteria from a user, and determining whether a prequery exists. If not, a list of all destination items is obtained. If yes, a determination is made whether the prequery is enabled. If not, a list of all destination items is obtained. If enabled, a list of all destination items limited by the prequery is obtained. A determination is then made whether all match criteria is selected. If yes, all items in the destination list are returned to the user. If not, a word list is generated by parsing all words from the search text. All valid synonyms are added for each word in the word list. The items in the destination list are reduced to items that match at least one word in the word list. A determination is made whether one or more additional filters exist. If not, a reduced list filtered by the match criteria is returned to the user.

Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Abstract: Methods of detecting and treating diseases and pathological conditions of the eye are disclosed. In particular a genetic variant of the HtrA1 gene is correlated to age related macular degeneration (AMD). In addition, biologically active agents capable of inhibiting HtrA1 activity are provided, and methods of treating diseases and pathological conditions of the eye are additionally disclosed.

Abstract: Ocular diseases affecting the macula or the vasculature of the eye affect a wide variety of individuals. In particular, Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a significant genetic predisposition. Methods of analyzing one or more mutations in the HtrA1 gene in order to identify individuals with a presusceptability to development of an ocular disease and a pathologic condition of the eye and diagnose those currently suffering from an ocular disease or a pathologic condition of the eye are provided. The methods of the present invention may further include analysis of the CFH gene in order to identify individuals with a presusceptability to development of an ocular disease and a pathologic condition of the eye and diagnose those currently suffering from an ocular disease or a pathologic condition of the eye. Compositions and methods for treating ocular disease and pathologic conditions of the eye are also provided.

Abstract: Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.

Abstract: A cable connector assembly (100) includes an insulative housing (22) having a plurality of contacts received therein, a cable assembly (3) connected with the contacts by a printed circuit board (5), an upper shielding member (11) and a lower shielding member (12) together with the upper shielding member to form a receiving space (10). Each of the upper shielding member and the lower shielding member have a base portion (111, 121) and a plurality of vertical walls (113, 114, 115, 123, 124, 125) extending from the base portion. The lower shielding member (12) defines a stopping portion (126) to prevent the upper shielding member (11) from moving along a transverse direction. The stopping portion (126) is of U-shaped and comprises a first restricting flake (1261) and a second restricting flake (1262), and a corresponding vertical wall (113) of the upper shielding member is located between the first restricting flake (1261) and the second restricting flake (1262).

Abstract: Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.