Abstract: Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof). Also described herein are methods of modulating the methylation pattern of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof).

Abstract: Embodiments of the present disclosure relate to runtime type identification (RTTI) of an object. In an embodiment, a computer-implemented method is disclosed. A class inheritance relationship between a plurality of classes in at least one source code section is generated. Respective type identifications are assigned to identify the classes in the class inheritance relationship. In accordance with presence of a first operation related to accessing a target pointer to an object of a target class of the classes, a type identification for the target class is caused to be recorded with at least one bit of a memory address of the target pointer that can be omitted in addressing the target pointer. RTTI is caused to be performed based on the class inheritance relationship and the at least one bit of the memory address of the target pointer. In other embodiments, a system and a computer program product are disclosed.

Abstract: A method and apparatus for displaying a virtual scene, a terminal, and a storage medium. The method includes displaying a virtual scene image on a terminal screen, the virtual scene image including a controlled virtual object in a virtual scene, controlling, in response to the controlled virtual object being located in a first region in the virtual scene, the controlled virtual object to be displayed at a first position on the terminal screen, and controlling, in response to the controlled virtual object entering a second region in the virtual scene, the controlled virtual object to be displayed at a second position on the terminal screen, the second position being offset relative to the first position.

Abstract: This application discloses a method for displaying a virtual environment picture performed by a computer device. The method includes: displaying a first virtual environment picture obtained by observing a virtual environment by using a first observation position; displaying, in response to receiving a first directional instruction generated by a first directional operation, a directional skill indicator pointing to a first direction; and in accordance with a determination that a length of the directional skill indicator is greater than a distance threshold in the first virtual environment picture, displaying a second virtual environment picture obtained by observing the virtual environment by using a second observation position, the second virtual environment picture including the directional skill indicator, and the second observation position being in the first direction of the first observation position or in a surrounding region in the first direction.

Abstract: This application discloses a method for operating virtual characters within a virtual environment performed by a computer device. The method includes: displaying a first virtual environment picture of a virtual environment, the first virtual environment picture including a first region obtained by using a first observation position and a master virtual character located in the virtual environment; displaying, in response to receiving an aiming operation, a regional skill indicator configured to select a target region in the virtual environment where the master virtual character releases a skill; and displaying a second virtual environment picture including a second region obtained by observing the virtual environment by using a second observation position, the second observation position being a position that is offset relative to the first observation position, and the second region including the target region, thereby improving the accuracy of aiming at a target.

Abstract: A virtual object control method is provided. In the method, skill casting is controlled by using a map control, and a corresponding second virtual scene can be displayed when a first trigger operation is performed on the map control, and in response to a casting operation on a target skill, a skill casting target can be determined according to an operation position corresponding to the casting operation. In this case, the selection range of the skill casting target may not be limited to the virtual scene with a virtual object as a center, the casting operation has a higher degree of freedom, and the selection can be accurately performed according to the actual case of a desired casting position when the skill is cast, rather than a rough estimation in the currently displayed virtual scene. Apparatus and non-transitory computer readable storage medium counterpart embodiments are also provided.

Abstract: Disclosed herein are methods and pharmaceutical compositions for the treatment of retinitis pigmentosa, macular degeneration and other retinal conditions by interfering with expression of genes, such as those encoding photoreceptor cell-specific nuclear receptor and neural retina-specific leucine zipper protein, in cells of the eye. These methods and compositions employ nucleic acid based therapies.

Abstract: The present invention relates to solid forms of a substituted benzoxaborole compound, specifically crystalline forms of a compound of formula I, compositions comprising crystalline forms of the compound of formula (I), and methods of their use.

Abstract: A video is received. One or more subtitles are determined for the video. Whether a word found in a background of the video is similar to a word found in the one or more subtitles is determined. Responsive to determining the word found in the background of the video is similar to the word found in the one or more subtitles, one or more updated subtitles are generated. The one or more updated subtitles include the word found in the background of the video and remove the word found in the one or more subtitles that is similar. A metric for the one or more updated subtitles is calculated. Whether the metric is larger than a threshold is determined. Responsive to determining the metric is larger than the threshold, the video is updated to include the one or more updated subtitles.

Abstract: A method, computer system, and a computer program product for predictive maintenance is provided. The present invention may include recording, using an autonomous robot moving along a surface through a plurality of positions in a room, a plurality of data associated with an under-floor appliance provided beneath the surface of the room. The present invention may also include calculating, based on the recorded plurality of data associated with the under-floor appliance provided beneath the surface of the room, a material composition associated with the plurality of positions in the room. The present invention may further include generating, based on the calculated material composition associated with the plurality of positions in the room, a layout diagram for visualizing a layout of the under-floor appliance provided beneath the surface of the room.

Abstract: An oil bearing structure of a fan includes a shaft seat, a rotating shaft, and an oil bearing. The shaft seat includes a boss. A middle portion of the boss defines a slot. One end of the rotating shaft is inserted into the slot. Another end of the rotating shaft is a free end. The oil bearing is sleeved on an outer periphery of the rotating shaft. An axis of the rotating shaft and an axis of the oil bearing are perpendicular to the shaft seat. An effective length of the oil bearing and the rotating shaft is 50%-70% of a length of the fan.

Abstract: Disclosed herein are methods and systems for Artificial Intelligence (AI)-based methods for performing medical diagnosis of diseases and conditions. An automated natural language processing (NLP) system performs deep learning techniques to extract clinically relevant information from electronic health records (EHRs). This framework provides a high diagnostic accuracy that demonstrates a successful AI-based method for systematic disease diagnosis and management.

Abstract: Apparatus and methods use a unique process kit to protect a processing volume of a process chamber. The process kit includes a shield with a frame configured to be insertable into a shield and a foil liner composed of a metallic material that is attachable to the frame at specific points. The specific attachment points are spaced apart to produce an amount of flexibility based on a malleability of the metallic material. The amount of flexibility ranges from approximately 2.5 to approximately 4.5.

Abstract: Embodiments of process kits for use in a process chamber are provided herein. In some embodiments, a process kit for use in a process chamber, includes: a top plate having a central recess disposed in an upper surface thereof; a channel extending from an outer portion of the top plate to the central recess; a plurality of holes disposed through the top plate from a bottom surface of the recess to a lower surface of the top plate; a cover plate configured to be coupled to the top plate and to form a seal along a periphery of the central recess such that the covered recess forms a plenum within the top plate; and a tubular body extending down from the lower surface of the top plate and surrounding the plurality of holes, the tubular body further configured to surround a substrate support.

Abstract: A method for real-time cloud container communications routing is provided. The method monitors network traffic to a first network resource located within a first region. Based on monitoring the network traffic, the method determines a second region associated with at least a portion of the network traffic. The method generates a resource backup of the first network reference. The resource backup represents a current state of the first network resource. The method transfers the resource backup to a second network resource associated with the second region and redirects at least a portion of the network traffic to the second network resource.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end of the elongate shaft to a distal end of the elongate shaft, a medical device disposed proximate the distal end of the elongate shaft, a release wire disposed within the lumen of the elongate shaft, wherein the release wire releasably secures the medical device to the distal end of the elongate shaft, a securement member fixedly attached to the proximal end of the elongate shaft and to a proximal end of the release wire, and a microcatheter configured to deliver the medical device to a treatment site, the elongate shaft and the medical device being slidably disposed within a lumen of the microcatheter. A proximal portion of the securement member may be configured to disengage from a distal portion of the securement member.

Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.

Abstract: Provided herein are energy absorbing composites including a thermoplastic resin, a dilatant, a compatibilizer, a reinforcing filler, and optionally an antioxidant and methods of preparation thereof.

Abstract: The present invention relates to solid forms of a substituted benzoxaborole compound, specifically crystalline forms of a compound of formula I, compositions comprising crystalline forms of the compound of formula (I), and methods of their use.