Patents by Inventor Kari Alitalo

Kari Alitalo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vascular endothelial growth factor D (VEGF-D) polypeptides and methods of use
    Patent number: 7662932
    Abstract: The present invention provides VEGF-D polypeptides, which among other things stimulate endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as fragments, dimers, and methods of using the same.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: February 16, 2010
    Assignee: Vegenics Limited
    Inventors: Marc G. Achen, Andrew F. Wilks, Stephen A. Stacker, Kari Alitalo
  • Modulation of angiogenesis by
    Patent number: 7638489
    Abstract: The present invention relates to Bartonella henselae as a component of a pharmaceutical composition for the modulation of the angiogenesis; a nucleic acid molecule that is derived from the gene encoding the Bartonella henselae adhesin A protein (BadA), a vector comprising said nucleic acid molecule; a host containing said nucleic acid molecule or said vector; a (poly)peptide encoded by said nucleic acid molecule; a composition comprising Bartonella henselae bacteria; a composition comprising aforesaid (poly)peptide; a method for treating a human or animal being in need of the modulation of the angiogenesis, a method for detecting an infection by Bartonella in a human or animal being, as well as a method for immunizing a cat.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: December 29, 2009
    Assignee: Eberhard-Karls Universitat Tubingen Universitatsklinikum
    Inventors: Volkhard Kempf, Tanja Riess, Ingo Autenrieth, Kari Alitalo, Siv Anderson
  • Materials and Methods Involving Hybrid Vascular Endothelial Growth Factor DNAs and Proteins
    Publication number: 20090318352
    Abstract: The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses involving the foregoing. Some polypeptides of the invention exhibit unique receptor binding profiles compared to known, naturally occurring vascular endothelial growth factors.
    Type: Application
    Filed: April 10, 2009
    Publication date: December 24, 2009
    Applicant: VEGENICS LIMITED
    Inventors: Kari Alitalo, Markku Michael Jeltsch
  • VEGFR-3 inhibitor materials and methods
    Patent number: 7611711
    Abstract: The present invention relates to the diagnosis, evaluation, and therapeutic intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated by VEGFR-3 ligands VEGF-C and VEGF-D. More particularly, the present invention identifies novel methods and compositions for the inhibition of VEGF-C/D binding to VEGFR-3. The compositions of the present invention will be useful in the inhibition of angiogenesis and lymphangiogenesis.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: November 3, 2009
    Assignee: Vegenics Limited
    Inventors: Kari Alitalo, Erkki Koivunen, Hajime Kubo
  • BMX/ETK TYROSINE KINASE GENE THERAPY MATERIALS AND METHODS
    Publication number: 20090214496
    Abstract: The present invention relates to materials and methods for the treatment of arterial diseases having impaired arteriogenesis and angiogenesis. More particularly, the invention provides materials and methods for treating arterial disease using a gene therapy vector expressing Bmx tyrosine kinase.
    Type: Application
    Filed: January 30, 2007
    Publication date: August 27, 2009
    Applicants: LICENTIA LTD., YALE UNIVERSITY
    Inventors: Kari Alitalo, Wang Min
  • Method for modulating, regulating and/or stabilizing angiogenesis
    Publication number: 20090202491
    Abstract: A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.
    Type: Application
    Filed: December 8, 2008
    Publication date: August 13, 2009
    Inventors: Ulf Eriksson, Kari Alitalo, Marko Uutela
  • SCREENING AND THERAPY FOR LYMPHATIC DISORDERS INVOLVING THE FLT4 RECEPTOR TYROSINE KINASE (VEGFR-3)
    Publication number: 20090191166
    Abstract: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
    Type: Application
    Filed: February 5, 2009
    Publication date: July 30, 2009
    Inventors: Robert E. Ferrell, Kari Alitalo, David N. Finegold, Marika Karkkainen
  • Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins
    Patent number: 7566566
    Abstract: The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses involving the foregoing. Some polypeptides of the invention exhibit unique receptor binding profiles compared to known, naturally occurring vascular endothelial growth factors.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: July 28, 2009
    Assignee: Vengenics Limited
    Inventors: Kari Alitalo, Markku M. Jeltsch
  • Growth Factor Binding Constructs Materials and Methods
    Publication number: 20090155268
    Abstract: The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors. Soluble binding constructs able to bind vascular endothelial growth factors, platelet derived growth factors, and other ligands are provided.
    Type: Application
    Filed: July 28, 2008
    Publication date: June 18, 2009
    Applicant: VEGENICS LIMITED
    Inventors: Kari Alitalo, Markku Michael Jeltsch
  • VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) PROTEIN AND GENE, MUTANTS THEREOF, AND USES THEREOF
    Publication number: 20090104198
    Abstract: Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
    Type: Application
    Filed: October 30, 2007
    Publication date: April 23, 2009
    Inventors: Kari Alitalo, Vladimir Joukov
  • VEGF-D polynucleotides and methods of use
    Publication number: 20090087905
    Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: October 30, 2007
    Publication date: April 2, 2009
    Applicant: VEGENICS LIMITED
    Inventors: Marc G. Achen, Andrew F. Wilks, Steven A. Stacker, Kari Alitalo
  • MODULATION OF VEGF-C/VEGFR-3 INTERACTIONS IN THE TREATMENT OF RHEUMATOID ARTHRITIS
    Publication number: 20090017011
    Abstract: The present invention relates to methods for treating an individual exhibiting symptoms of chronic arthridites, as identified by an elevated level of VEGF-C expression at synovial sites, and provides materials and methods for the modulation of VEGF-C/VEGFR-3 ligand-receptor interactions as a treatment for chronic arthridites.
    Type: Application
    Filed: June 13, 2008
    Publication date: January 15, 2009
    Applicant: VEGENICS LTD.
    Inventors: Kari Alitalo, Karri Paavonen, Yrjo Konttinen
  • Method for modulating, regulating and/or stabilizing angiogenesis
    Patent number: 7476654
    Abstract: A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: January 13, 2009
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Ulf Eriksson, Marko Uutela
  • LYMPHATIC ENDOTHELIAL CELLS MATERIALS AND METHODS
    Publication number: 20080317723
    Abstract: The present invention is directed to methods and compositions for isolating lymphatic endothelial cells from a mixed population of cells. More particularly, the inventors have found that certain antibodies that recognize the extracellular domain of VEGFR-3 can be used to specifically isolated lymphatic endothelial cells substantially free of other contaminating non-lymphatic endothelial cells. Methods and compositions for producing such cells and using such cells are described.
    Type: Application
    Filed: May 22, 2008
    Publication date: December 25, 2008
    Applicant: VEGENICS LIMITED
    Inventors: Kari Alitalo, Taija Makinen
  • GROWTH FACTOR ANTAGONISTS FOR ORGAN TRANSPLANT ALLOIMMUNITY AND ARTERIOSCLEROSIS
    Publication number: 20080267956
    Abstract: The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors, to prevent, inhibit, or ameliorate allograft rejection or arteriosclerosis in organisms that receive an organ transplant.
    Type: Application
    Filed: February 1, 2008
    Publication date: October 30, 2008
    Applicant: VEGENICS LIMITED
    Inventors: Kari Alitalo, Karl B. Lemstrom, Antti I. Nykanen
  • AUTOLOGOUS LYMPH NODE TRANSFER IN COMBINATION WITH VEGF-C OR VEGF-D GROWTH FACTOR THERAPY TO TREAT SECONDARY LYMPHEDEMA AND TO IMPROVE RECONSTRUCTIVE SURGERY
    Publication number: 20080267924
    Abstract: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
    Type: Application
    Filed: February 7, 2008
    Publication date: October 30, 2008
    Applicant: VEGENICS LIMITED
    Inventors: Kari Alitalo, Anne Saaristo, Tuomas Tammela
  • Antibodies to PDGF-D
    Publication number: 20080261888
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.
    Type: Application
    Filed: April 21, 2008
    Publication date: October 23, 2008
    Inventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
  • Vascular Endothelial Growth Factor C (VEGF-C) Protein and Gene, Mutants Thereof, and Uses Thereof
    Publication number: 20080241153
    Abstract: Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
    Type: Application
    Filed: October 30, 2007
    Publication date: October 2, 2008
    Inventors: KARI ALITALO, Vladimir Joukov
  • Vascular Endothelial Growth Factor C (VEGF-C) Protein and Gene, Mutants Thereof, and Uses Thereof
    Publication number: 20080241152
    Abstract: Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
    Type: Application
    Filed: October 30, 2007
    Publication date: October 2, 2008
    Inventors: Kari Alitalo, Vladimir Joukov
  • Neuropilin/VEGF-C/VEGFR-3 Materials and Methods
    Publication number: 20080241142
    Abstract: The present invention relates to identifying modulators of VEGF-C or VEGF-D ligand binding to the nervous system transmembrane protein neuropilin-2 and materials and methods for detecting said modulators.
    Type: Application
    Filed: November 29, 2007
    Publication date: October 2, 2008
    Applicant: LICENTIA LTD.
    Inventors: Kari Alitalo, Marika Karkkainen, Kaisa Karila