Patents by Inventor Kari Alitalo

Kari Alitalo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VEGFR-3 fusion proteins
    Patent number: 7422741
    Abstract: The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors. Soluble binding constructs able to bind vascular endothelial growth factors, platelet derived growth factors, and other ligands are provided.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: September 9, 2008
    Assignee: Vegenics Limited
    Inventors: Kari Alitalo, Markku M. Jeltsch
  • Antibodies to VEGF-C
    Patent number: 7423125
    Abstract: Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: September 9, 2008
    Assignee: Vegenics Limited
    Inventors: Kari Alitalo, Vladimir Joukov
  • Soluble neuropilin/growth factor receptor fusion proteins
    Patent number: 7420042
    Abstract: Complexes of a protein selected from the group consisting of VEGF-B167, VEGF-C, VEGF-D and processed VEGF-B186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B167, VEGF-C, VEGF-D or processed VEGF-B186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B167, VEGF-C, VEGF-D and/or processed VEGF-B186; and specific binding partners, e.g. antibodies, for such complexes.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: September 2, 2008
    Assignee: Vegenics Limited
    Inventors: Kari Alitalo, Ulf Eriksson, Brigitta Olofsson, Taija Makinen
  • Vascular endothelial growth factor D(VEGF-D) antibodies and methods of use
    Patent number: 7410639
    Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: August 12, 2008
    Assignee: Vegenics Limited
    Inventors: Marc G. Achen, Andrew F. Wilks, Steven A. Stacker, Kari Alitalo
  • Antibodies to PDGF-D
    Patent number: 7408040
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.
    Type: Grant
    Filed: May 31, 2005
    Date of Patent: August 5, 2008
    Assignees: Helsinki University Licensing, Ltd., Luddig Institute for Cancer Research
    Inventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
  • Use of VEGF-C or VEGF-D in Reconstructive Surgery
    Publication number: 20080147045
    Abstract: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
    Type: Application
    Filed: July 24, 2007
    Publication date: June 19, 2008
    Applicants: Licentia Ltd., Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Anne Saaristo, Marika Karkkainen, Tuomas Tammela, Sirpa Asko-Seljavaara, Seppo Yla-Herttuala, Yulong He
  • Vascular endothelial growth factor D (VEGF-D) antibodies and vectors, and methods of use
    Publication number: 20080145366
    Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: March 28, 2007
    Publication date: June 19, 2008
    Applicants: Licentia, Ltd.
    Inventors: Marc G. Achen, Andrew F. Wilks, Steven A. Stacker, Kari Alitalo
  • VASCULAR ENDOTHELIAL GROWTH FACTOR D(VEGF-D) ANTIBODIES AND VECTORS, AND METHODS OF USES
    Publication number: 20080070831
    Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: October 30, 2007
    Publication date: March 20, 2008
    Applicant: VEGENICS LIMITED
    Inventors: MARC ACHEN, Andrew Wilks, Steven Stacker, Kari Alitalo
  • Processed vascular endothelial growth factor-B polypeptides
    Patent number: 7341996
    Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: March 11, 2008
    Assignees: Ludwig Institute for Cancer Research, Licentia Ltd.
    Inventors: Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
  • Vegf-C or Vegf-D Materials and Methods for Stimulation of Neural Stem cells
    Publication number: 20080057028
    Abstract: The present invention relates to VEGF-C or VEGF-D materials and methods for promoting growth and differentiation of neural stem cells, neuronal and neuronal precursor cells, oligodendrocytes and oligodendrocyte precursor cells and materials and methods for administering said cells to inhibit neuropathology.
    Type: Application
    Filed: September 23, 2004
    Publication date: March 6, 2008
    Applicants: INSTITUTE NATIONALE DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Kari Alitalo, Marika Karkkainen, Paula Haiko, Kirsi Sainio, Kirmo Wartiovaara, Jean L. Thomas, Anne Eichmann
  • Growth Factor
    Publication number: 20080058258
    Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: June 29, 2007
    Publication date: March 6, 2008
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA, LTD.
    Inventors: Marc Achen, Andrew Wilks, Steven Stacker, Kari Alitalo
  • Materials and Methods Involving Hybrid Vascular Endothelial Growth Factor DNAs and Proteins
    Publication number: 20080058263
    Abstract: The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses involving the foregoing. Some polypeptides of the invention exhibit unique receptor binding profiles compared to known, naturally occurring vascular endothelial growth factors.
    Type: Application
    Filed: August 28, 2007
    Publication date: March 6, 2008
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA LTD.
    Inventors: Kari Alitalo, Markku Jeltsch
  • Vascular Endothelial Growth Factor D(VEGF-D) Antibodies and Vectors, and Methods of Uses
    Publication number: 20070298493
    Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: August 23, 2007
    Publication date: December 27, 2007
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA LTD.
    Inventors: Marc Achen, Andrew Wilks, Steven Stacker, Kari Alitalo
  • Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins
    Patent number: 7309604
    Abstract: The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses involving the foregoing. Some polypeptides of the invention exhibit unique receptor binding profiles compared to known, naturally occurring vascular endothelial growth factors.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: December 18, 2007
    Assignees: Licentia, Ltd., Ludwig Institute For Cancer Research
    Inventors: Kari Alitalo, Markku M. Jeltsch
  • Tie Receptor and Tie Ligand Materials and Methods for Modulating Female Fertility
    Publication number: 20070280947
    Abstract: The present invention provides materials and methods involving Tie receptors and Angiopoietin ligands for modulating female fertility in mammals, including humans. Materials and methods for inhibiting fertility (e.g., for contraception) or for enhancing fertility (e.g., treating infertility) are contemplated.
    Type: Application
    Filed: June 27, 2005
    Publication date: December 6, 2007
    Applicant: LICENTIA, LTD.
    Inventors: Kari Alitalo, Pirjo Laakkonen, Hajime Kubo, Kirsi Sainio
  • Screening and Therapy for Lymphatic Disorders Involving the FLT4 Receptor Tyrosine Kinase (VEGFR-3)
    Publication number: 20070141609
    Abstract: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
    Type: Application
    Filed: January 3, 2007
    Publication date: June 21, 2007
    Applicants: Ludwig Institute for Cancer Research, Licentia, University of Pittsburgh
    Inventors: Robert Ferrell, Kari Alitalo, David Finegold, Marika Karkkainen
  • Modified VEGF-A with improved angiogenic properties
    Publication number: 20070142282
    Abstract: The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
    Type: Application
    Filed: August 15, 2006
    Publication date: June 21, 2007
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA LTD.
    Inventors: Kari Alitalo, Tuomas Tammela, Salla Keskitalo, Katri Pajusola, Markku Jeltsch, Seppo Yla-Herttuala, Terhi Karpanen, Ulf Eriksson, Marko Uutela
  • Lymphatic and blood endothelial cell genes
    Publication number: 20070110744
    Abstract: The invention provides polynucleotides and genes that are differentially expressed in lymphatic versus blood vascular endothelial cells. These genes are useful targets for treating diseases involving lymphatic vessels, such as lymphedeman, various inflammatory diseases, and cancer metastasis via the lymphatic system.
    Type: Application
    Filed: September 8, 2004
    Publication date: May 17, 2007
    Inventors: Kari Alitalo, Taija Makinen, Tatiana Petrova, Pipsa Saharinen, Juha Saharinen
  • VEGF-C or VEGF-D materials and methods for treatment of neuropathologies
    Publication number: 20070082848
    Abstract: The present invention relates to VEGF-C or VEGF-D materials and methods for promoting growth and differentiation of neural stem cells and materials and methods for administering said cells to inhibit neuropathology.
    Type: Application
    Filed: November 16, 2006
    Publication date: April 12, 2007
    Applicant: LICENTIA LTD.
    Inventors: Kari Alitalo, Marika Karkkainen, Paula Haiko, Kirsi Sainio, Kirmo Wartiovaara
  • Platelet-derived growth factor D, DNA coding therefor, and uses thereof
    Publication number: 20070042413
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: August 22, 2006
    Publication date: February 22, 2007
    Applicants: Ludwig Institute for Cancer Research, Licentia Ltd.
    Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin