Patents by Inventor Kari Alitalo

Kari Alitalo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods for colorectal cancer screening, diagnosis and therapy
    Publication number: 20070026405
    Abstract: The invention provides materials and methods for colorectal cancer screening, diagnosis, and therapy.
    Type: Application
    Filed: August 6, 2004
    Publication date: February 1, 2007
    Applicant: LICENTIA, LTD.
    Inventors: Kari Alitalo, Tatiana Petrova, Antii Nykanen
  • Modulation of angiogenesis by Bartonella henselae
    Publication number: 20060286122
    Abstract: The present invention relates to Bartonella henselae as a component of a pharmaceutical composition for the modulation of the angiogenesis; a nucleic acid molecule that is derived from the gene encoding the Bartonella henselae adhesin A protein (BadA), a vector comprising said nucleic acid molecule; a host containing said nucleic acid molecule or said vector; a (poly)peptide encoded by said nucleic acid molecule; a composition comprising Bartonella henselae bacteria; a composition comprising aforesaid (poly)peptide; a method for treating a human or animal being in need of the modulation of the angiogenesis, a method for detecting an infection by Bartonella in a human or animal being, as well as a method for immunizing a cat.
    Type: Application
    Filed: May 4, 2006
    Publication date: December 21, 2006
    Inventors: Volkhard Kempf, Tanja Riess, Ingo Autenrieth, Kari Alitalo, Siv Anderson
  • Door compartment for a refrigerator
    Publication number: 20060279188
    Abstract: A door compartment for a refrigerator including at least one chamber designed to hold products to be cooled, that can be sealed on all sides. The ceiling of the chamber forms the base of an open tray.
    Type: Application
    Filed: August 25, 2004
    Publication date: December 14, 2006
    Applicant: BSH Bosch und Siemens Hausgeräte GmbH
    Inventors: Kari Alitalo, Tatiana Petrova, Antti Nykanen
  • Platelet-derived growth factor D, DNA coding therefor, and uses thereof
    Patent number: 7148037
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: December 12, 2006
    Assignees: Ludwig Institute for Cancer Research, Licentia Ltd.
    Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin
  • Lymphatic endothelial cells materials and methods
    Publication number: 20060269548
    Abstract: The present invention is directed to methods and compositions for isolating lymphatic endothelial cells from a mixed population of cells. More particularly, the inventors have found that certain antibodies that recognize the extracellular domain of VEGFR-3 can be used to specifically isolated lymphatic endothelial cells substantially free of other contaminating non-lymphatic endothelial cells. Methods and compositions for producing such cells and using such cells are described.
    Type: Application
    Filed: July 12, 2002
    Publication date: November 30, 2006
    Inventors: Kari Alitalo, Taija Makinen
  • Progenitor cell materials and methods
    Patent number: 7125714
    Abstract: Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: October 24, 2006
    Assignees: Licentia Ltd., Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Vladimir Joukov
  • Vascular endothelial growth factor D (VEGF-D) antibodies and vectors, and methods of use
    Patent number: 7122654
    Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: October 17, 2006
    Assignees: Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd.
    Inventors: Marc G. Achen, Andrew F. Wilks, Steven Stacker, Kari Alitalo
  • Method for stimulating connective tissue growth or wound healing
    Patent number: 7105481
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: September 12, 2006
    Assignees: Ludwig Institute for Cancer Research, Licentia Ltd.
    Inventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
  • Vascular endothelial growth factor D (VEGF-D) antibodies and vectors, and methods of use
    Publication number: 20060177428
    Abstract: Isolated nucleic acid molecule comprising an antisense nucleic acid sequence which is antisense to a polynucleotide that encodes a VEGF-D polypeptide, vectors and host cells including the same. Also disclosed are methods of inhibiting VEGF-D function or expression in a mammal, for example, in treating cancer, comprising administering to the mammal in need thereof a vector of the present invention.
    Type: Application
    Filed: December 16, 2005
    Publication date: August 10, 2006
    Applicants: Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. OY
    Inventors: Marc Achen, Andrew Wilks, Steven Stacker, Kari Alitalo
  • Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
    Publication number: 20060177901
    Abstract: The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.
    Type: Application
    Filed: January 6, 2006
    Publication date: August 10, 2006
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA, LTD.
    Inventors: Kari Alitalo, Taija Makinen
  • Regulation of vascular endothelium using BMX tyrosine kinase
    Publication number: 20060160761
    Abstract: Vascular endothelia are subject to atherosclerotic and arteriostenotic effects transduced by molecules, such as thrombin, IL-3 and VEGF which can lead to vessel occlusion or stenosis. An endothelial signaling pathway involving the Bmx tyrosine kinase contributes to normal endothelial nonthrombogenic, inflammatory and growth conditions of arterial vessels, and regulation of the pathway can treat or prevent pathological conditions in the vessel walls.
    Type: Application
    Filed: December 14, 2005
    Publication date: July 20, 2006
    Inventors: Niklas Ekman, Elena Arighi, Imre Vastrik, Luca Tamagnone, Kari Alitalo
  • Lymphatic and blood endothelial cell genes
    Publication number: 20060088532
    Abstract: The invention provides polynucleotides and genes that are differentially expressed in lymphatic versus blood vascular endothelial cells. These genes are useful for treating diseases involving lymphatic vessels, such as lymphedema, various inflammatory diseases, and cancer metastasis via the lymphatic system.
    Type: Application
    Filed: March 7, 2003
    Publication date: April 27, 2006
    Inventors: Kari Alitalo, Taija Makinen, Tatiana Petrova, Pipsa Saharinen, Juha Saharinen
  • FLT4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
    Patent number: 7034105
    Abstract: The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: April 25, 2006
    Assignees: Licentia, Ltd., Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Olga Aprelikova, Katri Pajusola, Elina Armstrong, Jaana Korhonen, Arja Kaipainen
  • Antibosies to PDGF-D
    Publication number: 20060030695
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.
    Type: Application
    Filed: May 31, 2005
    Publication date: February 9, 2006
    Inventors: Marko Uutela, Ulf Eriksson, Kari Alitalo
  • Growth factor binding constructs materials and methods
    Publication number: 20060030000
    Abstract: The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors. Soluble binding constructs able to bind vascular endothelial growth factors, platelet derived growth factors, and other ligands are provided.
    Type: Application
    Filed: March 7, 2005
    Publication date: February 9, 2006
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA, LTD.
    Inventors: Kari Alitalo, Markku Jeltsch
  • Compositions and methods for treatment of lymphatic and venous vessel arterialization
    Publication number: 20060025338
    Abstract: The present invention is directed to methods and compositions that may be used in disrupting the association of smooth muscle cells with lymphatic endothelial cells and in correcting the valvular dysfunction in veins and lymphatic vessels. Such compositions are useful for therapeutic and prophylactic treatment of impaired lymphatic and venous function, particularly for the treatment of lymphedema distichiasis or chronic venous insufficiency.
    Type: Application
    Filed: March 8, 2005
    Publication date: February 2, 2006
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA, LTD.
    Inventors: Kari Alitalo, Tatiana Petrova, Terhi Karpanen, Camilla Norrmen
  • Multivalent antibody materials and methods for VEGF/PDGF family of growth factors
    Publication number: 20050282233
    Abstract: The present invention relates to materials and methods for modulating angiogenesis. The compositions of the invention provide antibody substances specific for two or more PDGF/VEGF family members, which are useful for modulating angiogenesis and lymphangiogenesis in a subject.
    Type: Application
    Filed: March 7, 2005
    Publication date: December 22, 2005
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA, LTD.
    Inventors: Ulf Eriksson, Kari Alitalo, Marc Achen, Christoph Renner, Steven Stacker, Hong Li, Pirjo Laakkonen
  • Combination for the treatment of endothelial damage
    Patent number: 6974816
    Abstract: The invention relates to a combination of (a) an inhibitor of platelet-derived growth factor (PDGF) activity and (b) a vector for vascular endothelial growth factor (VEGF-, especially VEGF-C) gene transfer, a pharmaceutical preparation comprising (a) and (b) in combination together with a pharmaceutically acceptable carrier material; a product comprising (a) and (b) as defined above and optionally a pharmaceutically acceptable carrier material, for simultaneous, chronologically staggered or separate use; a method of administering or the use of said combination or product for the treatment of endothelial damage; and/or to the use of (a) and (b) for the manufacture of said pharmaceutical preparation or product for the treatment of endothelial damage.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: December 13, 2005
    Assignees: Licentia Ltd., Ludwig Institiute for Cancer Research
    Inventors: Kari Alitalo, Carl-Henrik Heldin, Olli Leppänen, Arne Östman, Seppo Ylā-Herttuala
  • Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins
    Publication number: 20050267024
    Abstract: The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses involving the foregoing. Some polypeptides of the invention exhibit unique receptor binding profiles compared to known, naturally occurring vascular endothelial growth factors.
    Type: Application
    Filed: February 24, 2005
    Publication date: December 1, 2005
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA, LTD.
    Inventors: Kari Alitalo, Markku Jeltsch
  • Use of VEGF-C or VEGF-D gene or protein to prevent restenosis
    Publication number: 20050256075
    Abstract: The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and/or Vascular Endothelial Growth Factor D (VEGF-D) genes or proteins.
    Type: Application
    Filed: February 24, 2005
    Publication date: November 17, 2005
    Inventors: Kari Alitalo, Seppo Yla-Herttuala, Mikko Hiltunen, Markku Jeltsch, Marc Achen