Patents by Inventor Kari Alitalo

Kari Alitalo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3)
    Patent number: 6403088
    Abstract: The invention provides antibodies that are reactive with VEGF-C, a polypeptide ligand for Flt4 receptor tyrosine kinase (VEGFR-3).
    Type: Grant
    Filed: February 14, 1996
    Date of Patent: June 11, 2002
    Assignees: Helsinki University Licensing, Ltd., Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Vladimir Joukov
  • Glycosylated VEGF-B and method for increasing the amount of soluble VEGF-B
    Publication number: 20020068694
    Abstract: N-glycosylated VEGF-B proteins, nucleic molecule encoding these proteins, pharmaceutical compositions containing them and a method for increasing the amount of a soluble VEGF-B protein. The VEGF-B proteins are useful in stimulating and maintaining angiogenesis.
    Type: Application
    Filed: July 26, 2001
    Publication date: June 6, 2002
    Inventors: Markku Michael Jeltsch, Kari Alitalo, Birgitta Olofsson, Ulf Eriksson
  • Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
    Patent number: 6361946
    Abstract: Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: March 26, 2002
    Assignees: Licentia Ltd, Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Vladimir Joukov
  • Antibodies specific for vascular endothelial growth factor-B
    Patent number: 6331301
    Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: December 18, 2001
    Assignees: Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. Oy
    Inventors: Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
  • Receptor ligand
    Patent number: 6245530
    Abstract: Provided are ligands for the receptor tyrosine kinase, Flt4. Also provided are cDNAs and vectors encoding the ligands, pharmaceutical compositions and diagnostic reagents.
    Type: Grant
    Filed: January 12, 1996
    Date of Patent: June 12, 2001
    Assignees: Ludwig Institute for Cancer Research, Helsinki University Licensing, Ltd. OY
    Inventors: Kari Alitalo, Vladimir Joukov
  • Vascular endothelial growth factor-D (VEGF-D) polypeptides
    Patent number: 6235713
    Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: May 22, 2001
    Assignees: Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd.
    Inventors: Marc G. Achen, Andrew F. Wilks, Steven A. Stacker, Kari Alitalo
  • FIt4 ligand and methods of use
    Patent number: 6221839
    Abstract: Provided are ligands for the receptor tyrosine kinase, Flt4. Also provided are cDNAs and vectors encoding the ligand, pharmaceutical compositions and diagnostic reagents.
    Type: Grant
    Filed: August 1, 1995
    Date of Patent: April 24, 2001
    Assignees: Helsinki University Licensing Ltd. Oy, Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Vladimir Joukov
  • Vascular endothelial growth factor C (VEGF-C) .DELTA.Cys.sub.156 protein and gene, and uses thereof
    Patent number: 6130071
    Abstract: Provided are purified and isolated VEGF-C cysteine deletion variants that bind to Flt4 receptor tyrosine kinase (VEGFR-3) but demonstrate reduced binding (relative to VEGF-C) to kdr receptor tyrosine kinase (VEGFR-2); polynucleotides encoding the polypeptide; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the foregoing.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: October 10, 2000
    Assignee: Helsinki University Licensing, Ltd.
    Inventors: Kari Alitalo, Vladimir Joukov
  • Antibodies recognizing tie receptor tyrosine kinase and uses thereof
    Patent number: 5955291
    Abstract: The present invention relates to an anti-Tie monoclonal antibody, 3C4C7G6, which is useful as a diagnostic tool for detecting angiogenesis-associated with neoplasia, wound healing, and a variety of other angiogenesis associated diseases and for radiological imaging of blood vessels. In addition, the disclosed antibody is useful as a therapeutic agent.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: September 21, 1999
    Inventors: Kari Alitalo, Juha Partanen, Tomi Makela, Jaana Korhonen, Marja-Terttu Matikainen
  • Vascular endothelial growth factor-b and dna coding therefor
    Patent number: 5928939
    Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
    Type: Grant
    Filed: December 6, 1995
    Date of Patent: July 27, 1999
    Assignee: Ludwig Institute For Cancer Research
    Inventors: Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
  • Promoter for the receptor tyrosine kinase, Tie
    Patent number: 5877020
    Abstract: The present application discloses promoter sequences for Tie, an endothelial cell receptor tyrosine kinase and their use in therapy and diagnosis as well as production of proteins in blood and tissues.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: March 2, 1999
    Assignee: Helsinki University Licensing, Ltd.
    Inventors: Kari Alitalo, Jaana Korhonen
  • Vascular endothelial growth factor-B
    Patent number: 5840693
    Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: November 24, 1998
    Assignees: Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. Oy
    Inventors: Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
  • FLT4, a receptor tyrosine kinase
    Patent number: 5776755
    Abstract: FLT4 gene, expression systems and proteins are provided for use in diagnosis and treatment of conditions related to the tyrosine kinase receptor encoded by the FLT4 gene.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: July 7, 1998
    Assignee: Helsinki University Licensing, Ltd.
    Inventors: Kari Alitalo, Olga Aprelikova, Katri Pajusola, Elina Armstrong, Jaana Korhonen, Arja Kaipainen
  • Vascular endothelial growth factor-B and DNA coding therefor
    Patent number: 5607918
    Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 4, 1997
    Assignees: Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. Oy
    Inventors: Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola