Abstract: The present invention relates to an antibody which specifically binds to unprocessed and/or partially processed neurotoxin polypeptide or an antibody which specifically binds an epitope consisting of a peptide having an amino acid sequence as shown in any one of SEQ ID NOs: 1 to 16 and to methods for the manufacture of such antibodies. Moreover, the present invention relates to a composition comprising processed neurotoxin polypeptide free of unprocessed or partially processed neurotoxin polypeptide and a method for manufacturing said neurotoxin polypeptide based on the antibodies of the invention. The present invention also relates to the use of the aforementioned antibody for separating processed neurotoxin polypeptides from unprocessed or partially processed neurotoxin polypeptides or for determining unprocessed or partially processed neurotoxin polypeptides. The present invention relates to a method for the manufacture of a medicament.

Abstract: The present invention relates to curable liquid coverlay compositions comprising polyamideimide resins for use in curable compositions for use as protective coverlay coatings for metal clad laminate materials in electronic components, such as flexible circuit boards. In particular, the invention relates to liquid coverlay compositions comprising polyamideimides having a terminal isocyanate group blocked by a thermally-dissociatable isocyanate-blocking group and the use of such compositions in preparation of flexible electronic components.

Abstract: A metering capillary and method for providing at least one defined volume of a target constituent of a sample is provided, the method comprising providing at least one metering capillary having at least two openings; at least partly filling the metering capillary with the sample; carrying out a constituent separation for the at least partial separation of at least two constituents of the sample inside the metering capillary; and dividing the metering capillary into at least two partial pieces, wherein at least one of the partial pieces contains the defined volume of the target constituent.

Abstract: The invention relates to a cooling apparatus for an electric component such as a CPU, a memory or power semiconductor, such as transistors or LEDs, or a processor. The cooling apparatus comprises a heatsink, an impeller that coaxially encloses the heatsink, and a drive motor for the impeller. The heatsink takes the form of a stationary hub having a base for introducing heat from the electronic component that is to be cooled, the hub widening towards the base. Cooling fins are thermally coupled to the hub, the cooling fins being given a spiral-like curve similar to the blades of the impeller. Due to the special design of the hub and the cooling fins as well as the use of a radial flux motor, a highly efficient, particularly compact cooling apparatus can be realized.

Abstract: A method for operating a filter includes forcibly passing a stream of a fluid through a filter wall of the filter from a raw gas side to a clean gas side of the filter so as to separate out particles and particle constituents from the stream, wherein the particles and particle constituents are collected on the raw gas side and performing a regeneration process on the filter during operation of the filter. The regeneration process includes removing particles and particle constituents from the raw gas side of the filter and moving the removed particle constituents to a receiving device disposed on the raw gas side. Alternatively, the filter walls includes a plurality of channels on the raw gas side, each channel closed by a closure wall configured to be partially opened to enable the disposing of the particle constituents.

Abstract: This invention relates to a method of identifying a modulator of an NADPH oxidase, whereby said modulator is suitable as a lead compound and/or as a medicament for the treatment and/or prevention of hearing loss and/or phantom hearing, the method comprising the steps of (a) contacting a test compound with a protein, wherein said protein (i) comprises or consists of the amino acid sequence of any one of SEQ ID NO: 1, 3 or 5, or (ii) is encoded by a nucleic acid comprising or consisting of the sequence of any one of SEQ ID NO: 2, 4, 6, 23 or 24, or (iii) is a fragment of the protein according to (i) or (ii) and exhibits NADPH oxidase activity, or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits NADPH oxidase activity, and optionally with one or more NADPH oxidase subunits, under conditions allowing binding of said test compound to said protein or, if present, said subunit(s); (b) optionally determining whether said test com

Abstract: An open-pore catalyst support comprising a material that comprises a natural sheet silicate and ZrO2. In order to provide a catalyst support, by means of which alkenyl acetate catalysts can be prepared which are characterized by a high level of alkenyl acetate activity over a relatively long period, the catalyst support comprises a material that comprises a natural sheet silicate and ZrO2 in the tetragonal modification.

Abstract: The invention relates to a rope spreading device for rope networks with tensioning ropes that converge at a top point of a support mast at an acute angle. It is an object of the invention to overcome the lack of play space, while making it also possible to vary the tension of the tensioning ropes. Accordingly, a rope spreading device is provided for rope networks with tensioning ropes that converge at a top point of a support mast at an acute angle, wherein the device is characterized in that at least one rope spreader is arranged between a tensioning rope and a support mast. The rope spreader changes the path of the tensioning rope so that a greater usable volume is created between the tensioning ropes and the central support mast, which can be used for climbing and play. Advantageously, the rope spreader may be used to vary the degree of spreading and the tension of the tensioning ropes.

Abstract: The present invention relates to a turbofan propulsion simulator means, in particular for a turbofan of an aircraft or spacecraft, wherein the turbofan propulsion simulator means comprises a modular configuration, wherein the turbofan propulsion simulator means comprises a module, wherein the module is a turbine means to drive the turbofan of the turbofan propulsion simulator means, wherein the turbine means can be coupled with at least two fan means, characterized in that, the at least two fan means to be connected with the turbofan propulsion simulator means comprises almost or essentially the same mass and/or almost or essentially the same barycentre.

Abstract: A gastroscope has an insertion tube with a distal end, at which a sensor is located. The sensor has a first electrode produced of an acid-resistant noble metal, and a second electrode produced of silver. An electrical voltage is applied between the first and second electrodes, and a change in an electrical variable is measured between the first and second electrodes, when ammonia is present. The gastroscope allows screening of gastric acid and the tissue of the stomach lining for Helicobacter pylori in a manner that is gentle for the patient.

Abstract: A gastroscope has an insertion tube with a working channel therein, and a sensor is guided in the working channel via a guidewire. The sensor has a first electrode produced of an acid-resistant noble metal, and a second electrode produced of silver. An electrical voltage is applied between the first and second electrodes, and a change in an electrical variable is measured between the first and second electrodes when ammonia is present. The gastroscope allows screening of gastric acid and tissue in the stomach lining for Helicobacter pylori in a manner that is gentle for the patient.

Abstract: An electro-motor drive, in particular for a fan drive of a motor vehicle, includes a commutator motor, a motor shaft of which is rotatably mounted on axially opposite sides in shaft bearings facing away from the bearing shield in order to substantially dampen the sound of at least bearing play-related contact noise and vibration or humming noise.

Abstract: The present application relates to novel aryl compounds with aminoalkyl substituents, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.

Abstract: An endoscopic capsule has a biocompatible capsule housing that contains at least one sensor device for acquiring medical data. The sensor is arranged on an outer surface of the housing, and has a first electrode produced of an acid-resistant noble metal, and a second electrode produced of silver. An electrical voltage is applied between the first and second electrodes, and a change in an electrical variable is measured between the first and second electrodes when ammonia is present. The endoscopic capsule allows screening of gastric acid and the tissue of the stomach lining for Helicobacter pylori in a manner that is gentle for the patient.

Abstract: The present invention relates to ?-amylase variants that are stabilized to solvent-exerted hydrolysis, in particular at elevated temperatures or high pH, by point mutagenesis of asparagine (N) or glutamine (Q) residues located on the surface of the molecule to give other amino acid residues. The invention further relates to methods of increasing the stability of an ?-amylase to solvent-exerted hydrolysis, in particular at elevated temperatures or high pH, whereby at least one asparagine (N) or glutamine (Q) residue on the surface of the molecule is replaced with a different amino acid residue. The ?-amylase variants obtained thereby exhibit better stability to influences of the solvent, increased processivity, and are suited for numerous industrial areas of use, in particular as active ingredients in detergents and cleansers.

Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.

Abstract: A display device for so-called façade displays is proposed which comprises several supports that can be affixed to the façade of an edifice, in particular a building, on the outside or the inside; a plurality of groups of light-emitting diodes that are provided on the several supports and serve as picture points of the display device; and a control unit for activating the plurality of the groups of light-emitting diodes.

Abstract: Described is a process for preparing an aqueous polymer dispersion from ethylenically unsaturated, free-radically polymerizable monomers. In a first stage, a first polymer is prepared by free-radical emulsion polymerization. In a second stage, an aqueous polymer dispersion is prepared in the presence of the first polymer. The monomers of the first stage comprise monomers with acid groups. The polymerization of the first stage takes place at a low pH of less than 5. The acid groups of the first polymer are neutralized during the polymerization of the second stage to an extent such that the pH of the polymer dispersion at the end of the second stage is greater than 5. The aqueous polymer dispersions can be used as adhesives for producing composite films.

Abstract: Devices and circuits related to Electrostatic discharge (ESD) and Electromagnetic compatibility (EMC) are herein described. An ESD protection device is incorporated into a transistor in order to protect the gate of the transistor from excessive current loads related to ESD or EMC events. In an implementation, a device includes a first diode and a second diode that are electrically connected via their respective cathodes. The breakdown voltage of the first diode is lower than the breakdown voltage of the second diode in order to divert excessive current through the second diode.

Abstract: A process by means of which the colonization by plaque on dental materials can be permanently prevented or delayed without the product properties of the dental material being negatively influenced. The process involves equipping the dental material with anti-plaque substance, namely at least one molecularly dispersely distributed octenidine salt or dequalinium salt. Also disclosed is a dental material so equipped.