Patents by Inventor Karl J. Guegler

Karl J. Guegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides encoding signal peptide-containing molecules
    Patent number: 8153398
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: April 10, 2012
    Assignee: Incyte Corporation
    Inventors: Preeti G. Lal, Y. Tom Tang, Gina A. Gorgone Simone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Hillman, Olga Bandman
  • Methods for detecting expression of human protease molecules
    Patent number: 8043818
    Abstract: The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUPM.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: October 25, 2011
    Assignee: Incyte Corporation
    Inventors: Olga Bandman, Jennifer Hillman, Henry Yue, Karl J. Guegler, Neil C. Corley, Y. Tom Tang, Purvi Shah
  • Method to Quantify siRNAs, miRNAs and Polymorphic miRNAs
    Publication number: 20110212494
    Abstract: The present teachings provide methods, compositions, and kits for quantifying target, polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3? end of a target polynucleotide, using a ligase that can ligate the 3? end of RNA to the 5? end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleotides that vary by as little as one nucleotide.
    Type: Application
    Filed: January 27, 2011
    Publication date: September 1, 2011
    Applicant: Life Technologies Corporation
    Inventors: Ruoying TAN, Caifu Chen, Karl J. Guegler
  • Methods of screening for compounds that modulate the activity of ADEC, a chemokine expressed in inflamed adenoid
    Patent number: 8008027
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: August 30, 2011
    Assignee: Incyte Corporation
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
  • Vesicle trafficking proteins
    Patent number: 7947804
    Abstract: The invention provides three human vesicle trafficking proteins (VTP) and polynucleotides which identify and encode VTP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of VTP.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: May 24, 2011
    Assignee: Incyte Corporation
    Inventors: Olga Bandman, Preeti Lal, Karl J. Guegler, Purvi Shah, Neil C. Corley
  • Polynucleotides encoding signal peptide-containing molecules
    Publication number: 20110053217
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Application
    Filed: June 9, 2009
    Publication date: March 3, 2011
    Inventors: Preeti Lal, Y. Tom Tang, Gina A. Gorgone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice Au-Young, Henry Yue, Chandra Patterson, Roopa Reddy, Jennifer L. Hillman, Olga Bandman
  • METHODS OF TREATMENT WITH ANTIBODIES TO A CHEMOKINE EXPRESSED IN INFLAMED ADENOID
    Publication number: 20100279333
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Application
    Filed: March 24, 2010
    Publication date: November 4, 2010
    Inventors: KARL J. GUEGLER, PHILLIP R. HAWKINS, CRAIG G. WILDE, JEFFREY J. SEILHAMER
  • Methods of treatment with anitbodies to a chemokine expressed in inflamed adenoid
    Patent number: 7708984
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: May 4, 2010
    Assignee: Incyte Corporation
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
  • HUMAN SIGNAL PEPTIDE-CONTAINING PROTEINS
    Publication number: 20090176707
    Abstract: The invention provides a human signal peptide-containing proteins (SIGP) and polynucleotides which identify and encode SIGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SIGP.
    Type: Application
    Filed: November 13, 2008
    Publication date: July 9, 2009
    Inventors: PREETI LAL, JENNIFER L. HILLMAN, NEIL C. CORLEY, KARL J. GUEGLER, MARIAH R. BAUGHN, SUSAN K. SATHER, PURVI SHAH
  • Polynucleotides encoding signal peptide-containing molecules
    Publication number: 20080187961
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Application
    Filed: October 4, 2007
    Publication date: August 7, 2008
    Inventors: Preeti Lal, Y. Tom Tang, Gina A. Gorgone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice Au-Young, Henry Yue, Chandra Patterson, Roopa Reddy, Jennifer L. Hillman, Olga Bandman
  • Antibodies to a chemokine expressed in inflamed adenoid
    Publication number: 20080138346
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Application
    Filed: June 4, 2007
    Publication date: June 12, 2008
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
  • Antibodies to a chemokine expressed in inflamed adenoid
    Patent number: 7235239
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: June 26, 2007
    Assignee: Incyte Incorporation
    Inventors: Karl J Guegler, Phillip R Hawkins, Craig G Wilde, deceased, Jeffrey J Seilhamer, deceased
  • Human protease molecules
    Patent number: 7045333
    Abstract: The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUPM.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: May 16, 2006
    Assignee: Incyte Corporation
    Inventors: Olga Bandman, Jennifer L. Hillman, Henry Yue, Karl J. Guegler, Neil C. Corley, Y. Tom Tang, Purvi Shah
  • Prostate associated Ets protein
    Patent number: 6919429
    Abstract: The invention provides a human prostate associated Ets protein (PRAEP) and polynucleotides which identify and encode PRAEP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PRAEP.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: July 19, 2005
    Assignee: Incyte Corporation
    Inventors: Olga Bandman, Karl J. Guegler, Preeti Lal, Neil C. Corley
  • Human protease associated proteins
    Patent number: 6881552
    Abstract: The invention provides human protease associated proteins (HPRAP) and polynucleotides which identify and encode HPRAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HPRAP.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: April 19, 2005
    Assignee: Incyte Corporation
    Inventors: Jennifer L. Hillman, Y. Tom Tang, Preeti Lal, Neil C. Corley, Karl J. Guegler, Chandra Patterson
  • Human protease molecules
    Patent number: 6855811
    Abstract: The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUPM.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: February 15, 2005
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Jennifer L. Hillman, Henry Yue, Karl J. Guegler, Neil C. Corley, Y. Tom Tang, Purvi Shah
  • Protein transport-associated molecules
    Patent number: 6838241
    Abstract: The invention provides human protein transport molecules (PTAM) and polynucleotides which identify and encode PTAM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of PTAM.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: January 4, 2005
    Assignee: Incyte Corporation
    Inventors: Y. Tom Tang, Preeti Lal, Olga Bandman, Henry Yue, Neil C. Corley, Karl J. Guegler, Gina A. Gorgone, Mariah R. Baughn, Chandra Patterson
  • DNA encoding oxidoreductase and polypeptide encoded thereby
    Patent number: 6808895
    Abstract: The invention provides human oxidoreductase molecules (OXRE) and polynucleotides which identify and encode OXRE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of OXRE.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: October 26, 2004
    Assignee: Incyte Corporation
    Inventors: Preeti Lal, Karl J. Guegler, Gina A. Gorgone, Neil C. Corley, Mariah R. Baughn, Y. Tom Tang, Jennifer L. Hillman, Olga Bandman, Yalda Azimzai, Janice Au-Young, Henry Yue, Dyung Aina M. Lu, Junming Yang
  • Signal peptide-containing molecules
    Publication number: 20040203106
    Abstract: The invention provides human proliferation and apoptosis related proteins (PROAP) and polynucleotides which identify and encode PROAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of PROAP.
    Type: Application
    Filed: May 5, 2004
    Publication date: October 14, 2004
    Applicant: Incyte Corporation
    Inventors: Y. Tom Tang, Henry Yue, Jennifer L. Hillman, Karl J. Guegler, Neil C. Corley, Preeti Lal, Yalda Azimzai, Mariah R. Baughn, Junming Yang, Leo L. Shih
  • NEK-1-related protein kinase
    Publication number: 20040126805
    Abstract: The invention provides a human Nek1-related protein kinase (NRPK) and polynucleotides which identify and encode NRPK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NRPK.
    Type: Application
    Filed: December 19, 2003
    Publication date: July 1, 2004
    Applicant: Incyte Corporation
    Inventors: Olga Bandman, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn