Patents by Inventor Karl J. Guegler

Karl J. Guegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody specifically binding cyclophilin-type peptidyl-prolyl cis/trans isomerase
    Publication number: 20030068787
    Abstract: The invention provides a human cyclophilin-type peptidyl-prolyl cis/trans isomerase (CPCI), a cDNA that encodes CPCI and an antibody that specifically binds CPCI. The invention also provides methods to diagnose, to stage, to treat, or to monitor the treatment of disorders associated with expression of CPCI.
    Type: Application
    Filed: June 20, 2002
    Publication date: April 10, 2003
    Applicant: Incyte Genomics, Inc.
    Inventors: Jennifer L. Jackson, Neil C. Corley, Karl J. Guegler, Chandra S. Arvizu
  • Calcium binding protein
    Publication number: 20030045466
    Abstract: The invention provides a human calcium binding protein (hCBP) and polynucleotides which identify and encode hCBP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of hCBP.
    Type: Application
    Filed: December 18, 2001
    Publication date: March 6, 2003
    Inventors: Y. Tom Tang, Karl J. Guegler, Neil C. Corley, Gina A. Gorgone, Henry Yue
  • Human RNA binding process
    Patent number: 6524579
    Abstract: The invention provides human RNA binding proteins (RNABP) and polynucleotides which identify and encode RNABP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of RNABP.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: February 25, 2003
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn
  • Human hydrolase-like molecules
    Patent number: 6518029
    Abstract: The invention provides human hydrolase-like molecules (HHLM) and polynucleotides which identify and encode HHLM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HHLM.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: February 11, 2003
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Preeti Lal, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Purvi Shah
  • Human fatty acid beta-oxidation enzymes
    Patent number: 6511833
    Abstract: The invention provides human fatty acid beta-oxidation enzymes (HUFA) and polynucleotides which identify and encode HUFA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUFA.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: January 28, 2003
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Jennifer L. Hillman, Karl J. Guegler, Neil C. Corley, Y. Tom Tang, Purvi Shah
  • Human aflatoxin B1 aldehyde reductase
    Publication number: 20030013853
    Abstract: The invention provides a human aflatoxin B1 aldehyde reductase (AFB1-hAR) and polynucleotides which identify and encode AFB1-hAR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of AFB1-hAR.
    Type: Application
    Filed: May 16, 2000
    Publication date: January 16, 2003
    Inventors: Olga Bandman, Purvi Shah, Karl J. Guegler, Neil C. Corley
  • Molecule associated with apoptosis
    Patent number: 6500642
    Abstract: The invention provides a mammalian cDNA which encodes a mammalian MAPOP-3. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of breast adenocarcinoma. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: December 31, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Henry Yue, Chandra Patterson, Neil C. Corley, Karl J. Guegler
  • Human nucleic acid methylases
    Publication number: 20020192787
    Abstract: The invention provides a human nucleic acid methylases (HNAM) and polynucleotides which identify and encode HNAM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HNAM.
    Type: Application
    Filed: May 22, 2002
    Publication date: December 19, 2002
    Applicant: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Preeti Lal, Neil C. Corley, Karl J. Guegler, Henry Yue
  • Composition for detection of genes encoding membrane-associated proteins
    Patent number: 6492505
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide sequences. The composition can be used as probes or array elements.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: December 10, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Roopa Reddy, Karl J. Guegler, Janice Au-Young
  • Delta-6 desaturase homologs
    Patent number: 6492108
    Abstract: The invention provides a human delta-6 desaturase homolog (D6DH) and polynucleotides which identify and encode D6DH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of D6DH.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: December 10, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Karl J. Guegler, Neil C. Corley, Purvi Shah
  • Human phospholipase A2 protein
    Publication number: 20020177208
    Abstract: The invention provides a human phospholipase A2 protein PHPLA2 and polynucleotides which identify and encode PHPLA2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PHPLA2.
    Type: Application
    Filed: April 16, 2002
    Publication date: November 28, 2002
    Applicant: Incyte Genomics, Inc.
    Inventors: Phillip R. Hawkins, Olga Bandman, Karl J. Guegler, Purvi Shah, Neil C. Corley
  • Human retinoid binding protein
    Publication number: 20020173002
    Abstract: The invention provides a human retinoid binding protein (RBPhu) and polynucleotides which identify and encode RBPhu. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of RBPhu.
    Type: Application
    Filed: December 21, 2001
    Publication date: November 21, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Karl J. Guegler, Purvi Shah
  • Human purinergic P2U receptor
    Patent number: 6479630
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic PU2 receptor (PNR) expressed in human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PNR, expression vectors for the production of purified PNR, antibodies capable of binding specifically to PNR, hybridization probes or oligonucleotides for the detection of PNR-encoding nucleotide sequences, genetically engineered host cells for the expression of PNR, and diagnostic tests based on PNR-encoding nucleic acid molecules or antibodies produced against the polypeptide PNR.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: November 12, 2002
    Assignee: Incyte Genomics
    Inventors: Roger Coleman, Janice Au-Young, Susan G. Stuart, Karl J. Guegler
  • Human GTPase-associated proteins
    Publication number: 20020160488
    Abstract: The invention provides human GTPase-associated proteins (GPAP) and polynucleotides which identify and encode GPAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of GPAP.
    Type: Application
    Filed: April 9, 2002
    Publication date: October 31, 2002
    Applicant: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Preeti Lal, Karl J. Guegler, Neil C. Corley, Chandra Patterson
  • Human transferase
    Patent number: 6471959
    Abstract: The invention provides three human transferases (HUTRAN) and polynucleotides which identify and encode HUTRAN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HUTRAN.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 29, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Preeti Lal, Olga Bandman, Jennifer L. Hillman, Karl J. Guegler, Gina A. Gorgone, Neil C. Corley, Chandra Patterson
  • RAS proteins
    Publication number: 20020146770
    Abstract: The invention provides seven human Ras proteins (RASP) and polynucleotides which identify and encode RASP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of RASP.
    Type: Application
    Filed: January 15, 2002
    Publication date: October 10, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Y. Tom Tang, Preeti Lal, Karl J. Guegler, Neil C. Corley, Chandra Patterson, Sajeev Batra, Mariah R. Baughn
  • Cyclophilin-type peptidyl-prolyl CiS/trans isomerase
    Patent number: 6458575
    Abstract: The invention provides a human cyclophilin-type peptidyl-prolyl cis/trans isomerase (CPCI) and polynucleotides which identify and encode CPCI. The invention also provides expression vectors, host cells, antibodies, agonists, and antagnists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of CPCI.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: October 1, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Chandra Patterson
  • Kinesin-like motor protein
    Publication number: 20020127668
    Abstract: The invention provides a human kinesin-like motor protein (KLIMP) and polynucleotides which identify and encode KLIMP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of KLIMP.
    Type: Application
    Filed: May 2, 2001
    Publication date: September 12, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Y. Tom Tang, Neil C. Corley, Karl J. Guegler, Chandra Patterson
  • Human nucleic acid methylases
    Patent number: 6436683
    Abstract: The invention provides a human nucleic acid methylases (HNAM) and polynucleotides which identify and encode HNAM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HNAM.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: August 20, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Preeti Lal, Neil C. Corley, Karl J. Guegler, Henry Yue
  • Cell surface glycoproteins
    Publication number: 20020107180
    Abstract: The invention provides human cell surface glycoproteins (CSGP) and polynucleotides which identify and encode CSGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CSGP.
    Type: Application
    Filed: November 30, 2001
    Publication date: August 8, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Henry Yue, Neil C. Corley, Karl J. Guegler, Gina A. Gorgone, Mariah R. Baughn