Patents by Inventor Karl Y. Hostetler

Karl Y. Hostetler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20160015726
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: October 2, 2015
    Publication date: January 21, 2016
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Phosphonate compounds
    Patent number: 9206208
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolizm, cancer, viral infections, and the like.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: December 8, 2015
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle
  • Acyclic nucleoside phosphonate diesters
    Patent number: 9156867
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: October 13, 2015
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20150080344
    Abstract: There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral RNA-dependent RNA polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis C virus or a human retrovirus, and treating a subject infected with a virus, including hepatitis C virus or a human retrovirus.
    Type: Application
    Filed: September 29, 2014
    Publication date: March 19, 2015
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Phosphonate Compounds
    Publication number: 20150051174
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: October 29, 2014
    Publication date: February 19, 2015
    Inventors: Karl Y. Hostetler, James R. Beadle
  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20140364397
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: August 20, 2014
    Publication date: December 11, 2014
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Phosphonate compounds
    Patent number: 8889658
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: November 18, 2014
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle
  • Phosphonates with reduced toxicity for treatment of viral infections
    Patent number: 8846643
    Abstract: There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral RNA-dependent RNA polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis C virus or a human retrovirus, and treating a subject infected with a virus, including hepatitis C virus or a human retrovirus.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: September 30, 2014
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20140274959
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: The Regents of the University of California, a California corporation
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20140275532
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: The Regents of the University of California, a California Corporation
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Acyclic nucleoside phosphonate diesters
    Patent number: 8835630
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 16, 2014
    Assignee: The Regents of the University of California, a California corporation
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Phosphonate compounds
    Patent number: 8710030
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: April 29, 2014
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle
  • Phosphonate Compounds
    Publication number: 20140045794
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 13, 2014
    Applicant: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle
  • Lung-targeted drugs
    Patent number: 8318700
    Abstract: Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to glycerol ethers or glycerol phosphate ethers.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: November 27, 2012
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle
  • Phosphonate compounds
    Patent number: 8309565
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: November 13, 2012
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Phosphono-pent-2-en-1-yl nucleosides and analogs
    Patent number: 8222257
    Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are 5-phosphono-pent-2-en-1-yl nucleosides and esters thereof.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: July 17, 2012
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Hyunah Choo
  • Pharmacologically active agents containing esterified phosphonates and methods for use thereof
    Patent number: 8193167
    Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: June 5, 2012
    Assignees: The Regents of the University of California, The United States of America, Department of Veterans Affairs
    Inventors: Karl Y. Hostetler, W. Brad Wan
  • LUNG-TARGETED DRUGS
    Publication number: 20120122818
    Abstract: Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to glycerol ethers or glycerol phosphate ethers.
    Type: Application
    Filed: January 18, 2012
    Publication date: May 17, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Karl Y. Hostetler, James R. Beadle
  • Phosphonate Compounds
    Publication number: 20120058975
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: August 29, 2011
    Publication date: March 8, 2012
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Lung-targeted drugs
    Patent number: 8101745
    Abstract: Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to glycerol ethers or glycerol phosphate ethers.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: January 24, 2012
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle