Patents by Inventor Karl Y. Hostetler

Karl Y. Hostetler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid-drug conjugates for local therapy of eye diseases
    Patent number: 8017135
    Abstract: Methods are provided for treating pathological conditions of ocular tissue by administering to subjects in need thereof therapeutically active complexes that include amphiphilic analogs of the therapeutically active agents. These complexes exhibit low water solubility and are isolated in either crystalline form, amorphous form, or a combination thereof, within a well-defined particle size range. Administration of such complexes of therapeutically active agents to ocular tissue results in extended release of the therapeutically active agent. Indeed, certain complexes persist for up to about 20-30 weeks or longer after intravitreal injection, thereby providing a sustained release of therapeutically active agent into the structures of the eye.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: September 13, 2011
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, William R. Freeman, Lingyun Cheng
  • Phosphonate compounds
    Patent number: 8008308
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: August 30, 2011
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
    Patent number: 7994143
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: August 9, 2011
    Assignees: Chimerix, Inc., The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
  • Pharmacologically Active Agents Containing Esterified Phosphonates and Methods for Use Thereof
    Publication number: 20100273742
    Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates.
    Type: Application
    Filed: December 10, 2009
    Publication date: October 28, 2010
    Applicant: The Regents of the University of California
    Inventors: Karl Y. Hostetler, W. Brad Wan
  • Metabolically Stable Alkoxyalkyl Esters of Antiviral or Antiproliferative Phosphonates, Nucleoside Phosphonates and Nucleoside Phosphates
    Publication number: 20100249056
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Application
    Filed: June 9, 2010
    Publication date: September 30, 2010
    Applicants: CHIMERIX, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Tim Riley, Paula Francom
  • Phosphonate compounds
    Patent number: 7790703
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: September 7, 2010
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Phosphonate Compounds
    Publication number: 20100173870
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: February 5, 2010
    Publication date: July 8, 2010
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
    Patent number: 7749983
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: July 6, 2010
    Assignees: Chimerix, Inc., The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
  • Phosphonate compounds
    Patent number: 7687480
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: March 30, 2010
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Pharmacologically active agents containing esterified phosphonates and methods for use thereof
    Patent number: 7652001
    Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: January 26, 2010
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, W. Brad Wan
  • Substituted Phosphate Esters of Nucleoside Phosphonates
    Publication number: 20090156545
    Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are obtained by attaching the phosphonate nucleoside of interest to alkyloxyalkyl-phosphate or alkyl-phosphate in a phosphate-phosphono anhydride linkage to provide a modified nucleoside phosphonate drug.
    Type: Application
    Filed: March 30, 2006
    Publication date: June 18, 2009
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline C. Ruiz
  • Prodrugs of pharmaceuticals with improved bioavailability
    Patent number: 7517858
    Abstract: Lipid prodrugs of pharmaceutical agents and their analogs that have increased anticancer, anti-viral, anti-inflammatory, anti-proliferative activity over the parent drug, and methods for making lipid prodrugs. Compositions comprising lipid prodrugs for treating disease and methods for treating disease which involve using the compositions.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 14, 2009
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, Ganesh D. Kini, James R. Beadle
  • Phosphonate compounds
    Patent number: 7452898
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: November 18, 2008
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Lung-Targeted Drugs
    Publication number: 20080221061
    Abstract: Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to glycerol ethers or glycerol phosphate ethers.
    Type: Application
    Filed: December 15, 2005
    Publication date: September 11, 2008
    Applicant: The Regents of The University of California
    Inventors: Karl Y. Hostetler, Beadle R. James
  • Phosphonate compounds
    Patent number: 7098197
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: August 29, 2006
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Phosphonate compounds
    Patent number: 7094772
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: August 22, 2006
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Phosphonate compounds
    Patent number: 7034014
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: April 25, 2006
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Phosphonate compounds
    Publication number: 20040127735
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: January 15, 2004
    Publication date: July 1, 2004
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Phosphonate compounds
    Patent number: 6716825
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorder, e.g., osteoporosis and other disorders of bone metabolisum, cancer, viral infections, and the like.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: April 6, 2004
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Antiviral compounds and methods of administration
    Patent number: 6686462
    Abstract: The invention provides lipophilic phosphonoacid/nucleoside conjugates that exhibit exceptional antiviral activity, including activity against drug-resistant HIV strains. Compounds of the invention include phosphonoacid/nucleoside conjugates where the carboxyl group and phosphonyl groups of the phosphonacid are esterified whereby the compound contains at least one lipophilic group and at least one nucleoside group.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: February 3, 2004
    Assignees: The Regents of the University of California, Dana-Farber Cancer Institute, Inc.
    Inventors: Andre Rosowsky, Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini, Douglas D. Richman