Patents by Inventor Katsuyuki Yamanaka
Katsuyuki Yamanaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130259838Abstract: Provided is a cultured cartilage tissue material which enables formation of cartilage tissue being substantially the same as the cartilage tissue actually in the living body, and which is large in volume. The cultured cartilage tissue material is to be used for cartilage regeneration and comprises chondrocytes, and is a mixed body of chondrocytes in a concentration of 1×107 to 1×109 cells/cm3, and a bioabsorbable polymer. A thickness of the thinnest part of the cultured cartilage tissue material is 2.2 to 100 mm. A volume ratio between the chondrocytes and the bioabsorbable polymer is 7:3 to 9.5:0.5. A production amount of glycosaminoglycan is 0.001 to 0.2 ng per unit cell. A content ratio between type I collagen and type II collagen is 10:90 to 1:99. A content of type II collagen is 0.01 to 0.65 mg per 1 mg of dry weight of tissue.Type: ApplicationFiled: March 18, 2013Publication date: October 3, 2013Inventors: Katsuyuki YAMANAKA, Yuuhiro SAKAI, Katsushi YAMAMOTO, Yusuke SHIGEMITSU
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Patent number: 8518432Abstract: A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 ?m diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 ?m diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.Type: GrantFiled: June 22, 2009Date of Patent: August 27, 2013Assignee: GC CorporationInventors: Katsushi Yamamoto, Katsuyuki Yamanaka, Youko Suda, Tadashi Kaneko
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Publication number: 20120183923Abstract: A dental implant is made of a mono metal body from inside to outermost surface of the implant, and the implant surface has macro pores having an inner diameter with the level of several tens of ?m, micro pores having an inner diameter of 1 to 2 ?m, and nano discharge craters having an inner diameter with the level of several tens of nm. A surface treatment method of the implant includes steps of producing macro pores having an inner diameter with the level of several tens of ?m by blast processing, producing micro pores having an inner diameter of 1 to 2 ?m by acid treatment, and producing nano discharge craters having an inner diameter with the level of several tens of nm by anodic oxidation treatment.Type: ApplicationFiled: January 3, 2012Publication date: July 19, 2012Applicant: GC CorporationInventors: Takamitsu TAKAGI, Katsuyuki Yamanaka, Tsuyoshi Noguchi
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Patent number: 8039256Abstract: To efficiently select and proliferate the mesenchymal stem cells without necessity of an exclusive separating device and a complicated separating operation, mesenchymal stem cells are cultured by seeding at least one of a bone marrow solution, an umbilical cord blood, a peripheral blood, a synovial membrane and an amniotic membrane in a liquid culture medium which is filled in a vessel, includes water as its main components and having a specific gravity between 1.06 and 1.10 at 37° C., and making a culture at a temperature 37±2° C. on a ceiling side surface of the vessel, preferably the specific gravity being regulated by use of at least one selected from silica fine powder coated by polyvinyl pyrrolidone, a water soluble copolymer of sucrose and epichlorohydrin, and a water soluble compound including a triiodo aromatic ring.Type: GrantFiled: September 28, 2010Date of Patent: October 18, 2011Assignees: GC Corporation, Two Cells Co., Ltd.Inventors: Yuhiro Sakai, Katsuyuki Yamanaka, Mika Takeda, Tomohisa Okura, Koichiro Tsuji
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Publication number: 20110076770Abstract: To efficiently select and proliferate the mesenchymal stem cells without necessity of an exclusive separating device and a complicated separating operation, mesenchymal stem cells are cultured by seeding at least one of a bone marrow solution, an umbilical cord blood, a peripheral blood, a synovial membrane and an amniotic membrane in a liquid culture medium which is filled in a vessel, includes water as its main components and having a specific gravity between 1.06 and 1.10 g/ml at 37° C., and making a culture at a temperature 37±2° C. on a ceiling side surface of the vessel, preferably the specific gravity being regulated by use of at least one selected from silica fine powder coated by polyvinyl pyrrolidone, a water soluble copolymer of sucrose and epichlorohydrin, and a water soluble compound including a triiodo aromatic ring.Type: ApplicationFiled: September 28, 2010Publication date: March 31, 2011Applicants: GC Corporation, TWO CELLS CO., LTD.Inventors: Yuhiro SAKAI, Katsuyuki Yamanaka, Mika Takeda, Tomohisa Okura, Koichiro Tsuji
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Publication number: 20100158982Abstract: To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.Type: ApplicationFiled: February 22, 2010Publication date: June 24, 2010Applicants: GC CORPORATION, TWO CELLS Co., Ltd.Inventors: Toshitsugu KAWATA, Kaoru Tenjo, Koichiro Tsuji, Katsuyuki Yamanaka
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Publication number: 20090299475Abstract: To provide a bone graft substitute having an appropriate absorption period in a living body and high osteoconductivity, the bone graft substitute contains a carbonate apatite and an osteoinductive factor, the osteoinductive factor is preferably at least one kind selected from a group including BMP (a bone morphogenetic protein), GDF (a growth differentiation factor), TGF-? (a transformation growth factor), FGF (a fibroblast growth factor), IGF (an insulin-like growth factor), PDGF (a platelet-derived growth factor), BDNF (a brain-derived nerve growth factor), and NGF (a nerve growth factor), and the bone graft substitute has open pores, preferably having a diameter of 50 to 1000 ?m and/or a diameter of 0.001 to 5 ?m, with porosity of 20 to 80%.Type: ApplicationFiled: June 1, 2009Publication date: December 3, 2009Applicant: GC CorporationInventors: Katsushi YAMAMOTO, Katsuyuki YAMANAKA, Yuhiro SAKAI, Youko SUDA, Tadashi KANEKO
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Publication number: 20090261492Abstract: A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 ?m diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 ?m diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.Type: ApplicationFiled: June 22, 2009Publication date: October 22, 2009Applicant: GC CorporationInventors: Katsushi Yamamoto, Katsuyuki Yamanaka, Youko Suda, Tadashi Kaneko
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Publication number: 20090246873Abstract: To provide a scaffold for tissue engineering which consists of a bioabsorbable polymer material to be absorbed in a biotissue, and holds strength of the whole scaffold while having a porosity proper for culturing cells inside thereof as well, a method for producing the scaffold for tissue engineering includes steps of dissolving a bioabsorbable polymer material with an organic solvent, drying the solution so as to produce a porous bioabsorbable polymer material having a porosity of 50 to 99%, covering the porous bioabsorbable polymer material with a bioabsorbable polymer material having a thickness of 0.01 to 5 mm, pores of 10 to 3000 ?m diameter, a fracture strength of 0.05 to 0.15 MPa, and a volume of 15 to 90% with respect to the whole scaffold.Type: ApplicationFiled: March 31, 2009Publication date: October 1, 2009Applicant: GC CorporationInventors: Katsushi YAMAMOTO, Katsuyuki Yamanaka, Youko Suda, Yuhiro Sakai, Tadashi Kaneko
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Publication number: 20090228027Abstract: To provide a bone tissue regeneration sheet having a cortical bone tissue layer of 200 ?m or more in thickness, the bone tissue regeneration sheet is produced by seeding chondroblast or stem cells for differentiating to chondrocyte on one side of a porous bioabsorbable polymer sheet, taking the seeded porous body into a culture medium, applying centrifugal force of 100 to 1000 G to the culture medium for a predetermined time so as to aggregate the chondroblast or the stem cells for differentiating to chondrocyte, culturing the aggregated cells in a culture medium not containing serum but containing one or two or more kinds selected from ascorbic acid, an ascorbic acid derivative, and dexamethasone without applying centrifugal force to form a chondrocyte layer having a thickness of 200 ?m or more.Type: ApplicationFiled: March 10, 2009Publication date: September 10, 2009Applicant: GC CorporationInventors: Katsuyuki YAMANAKA, Katsushi YAMAMOTO, Youko SUDA, Yuhiro SAKAI, Tadashi KANEKO
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Publication number: 20090221076Abstract: An objective of the present invention is to provide a production method of a sheet for regenerating a cartilage tissue, which uses a conventional sheet-shaped porous body comprising a biological absorbency synthetic high polymer, such as polylactic acid, polyglycolic acid and a copolymer of lactic acid and glycolic acid. The sheet for regenerating the cartilage tissue can differentiate chondrocytes or stem cells without culturing the cells by pressurizing such as a pressurizing culture like the conventional method, and can accumulate the cells in a supporting carrier with high efficiency.Type: ApplicationFiled: February 28, 2006Publication date: September 3, 2009Applicants: GC Corporation, TWO CELLS Co. Ltd.Inventors: Yukio Kato, Koichiro Tsuji, Katsuyuki Yamanaka
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Publication number: 20090186412Abstract: For easily seeding cells in its scaffold, a porous cell scaffold is produced by steps of filling a guiding solution with kinematic viscosity being 50 to 450% of that of a culture medium, in a whole continuous small hole structure having hole diameters of 5 to 3200 ?m and an average hole diameter of 50 to 1500 ?m, of a sheet-shaped or block-shaped scaffold having a thickness of 2 mm or more, supplying thereafter a culture medium with cells being suspended to an upper side of the scaffold, sucking the guiding solution from a lower side of the scaffold by low suction force, and entering thereby the culture medium with cells being suspended into the whole small hole structure, where a water absorber such as a filter paper is preferably used for sucking the guiding solution by low suction force.Type: ApplicationFiled: January 21, 2009Publication date: July 23, 2009Applicant: GC CorporationInventors: Katsuyuki Yamanaka, Youko Suda, Katsushi Yamamoto, Yuhiro Sakai, Tadashi Kaneko
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Publication number: 20080220521Abstract: To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.Type: ApplicationFiled: May 20, 2008Publication date: September 11, 2008Applicants: GC Corporation, TWO CELLS Co. Ltd.Inventors: Toshitsugu Kawata, Kaoru Tenjo, Koichiro Tsuji, Katsuyuki Yamanaka
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Publication number: 20070233277Abstract: To provide an organism absorbency tube for regenerating nerve tissue and a production method thereof, where the low cost tube can produce easier than a conventional one, various kinds of the different thickness tubes, inner diameters and outer shapes can be easily formed. The tube produces by drying polymer solvent to form sheet-like organism absorbency polymer material; cylindrically rolling thus material to form an overlapped sheet part; heat or solvent meld sealing at least a portion around an end edge on the outer peripheral side thereof. Or a two layers structure tube produces by freeze-drying polymer solvent to form the material; cylindrically rolling thus material; non-freeze-drying polymer solvent to form the high material; cylindrically wrapping thus material around the freeze-dried polymer material to form the sheet part; and heat or solvent meld sealing at least a portion around an edge on the outer peripheral side thereof.Type: ApplicationFiled: March 30, 2007Publication date: October 4, 2007Applicant: GC CorporationInventors: Katsushi YAMAMOTO, Katsuyuki Yamanaka, Youko Suda, Tadashi Kaneko
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Patent number: 7198481Abstract: An injection unit of an injection molding machine capable of preventing a displacement of an axis of a heating barrel and an axis of an injection screw and facilitating a nozzle axis adjustment. A front plate supporting a heating barrel is fixed to a base with a height-adjusting mechanism located in-between. A rear plate is connected to the front plate by connecting members symmetrically arranged. The injection screw inserted in the heating barrel is rotatably supported by a pusher plate to which a ball nut is fixed. A ball screw engaged with the ball nut is rotatably supported by the rear plate. The pusher plate is supported and guided by the support/guide member, and moves forward to inject resin by the rotation of the ball screw. The support/guide member is supported by a supporting member fixed to the front plate.Type: GrantFiled: April 7, 2005Date of Patent: April 3, 2007Assignee: Fanuc LtdInventors: Katsuyuki Yamanaka, Koichi Nishimura, Koji Shima
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Patent number: 7134863Abstract: Jack-up bolts are provided at two places along the rear platen movement direction on both sides of a lower part of a rear platen of an injection molding machine. The jack-up bolt engages threadedly with a bolt hole formed in the rear platen, and a lower end face of the jack-up bolt abuts on the upper surface of a slide plate to support the rear platen. A fixing bolt is inserted in a through hole formed in the jack-up bolt, and is threadedly engaged with a tap hole provided in the slide plate, by which the rear platen and the slide plate are integrated. The rear platen moves while being supported by the slide plate. When the tilt of the rear platen is corrected, the fixing bolt is loosened and the jack-up bolt is turned, by which a distance between the rear platen and the slide plate is adjusted.Type: GrantFiled: April 5, 2005Date of Patent: November 14, 2006Assignee: Fanuc LtdInventors: Katsuyuki Yamanaka, Koichi Nishimura, Shingo Okada, Naruhiro Nishimura
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Publication number: 20060088569Abstract: To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.Type: ApplicationFiled: October 24, 2005Publication date: April 27, 2006Applicants: GC CORPORATION, TWO CELLS Co. Ltd.Inventors: Toshitsugu Kawata, Kaoru Tenjo, Koichiro Tsuji, Katsuyuki Yamanaka
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Publication number: 20060083771Abstract: A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 ?m diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 ?m diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.Type: ApplicationFiled: October 4, 2005Publication date: April 20, 2006Applicant: GC CorporationInventors: Katsushi Yamamoto, Katsuyuki Yamanaka, Youko Suda, Tadashi Kaneko
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Publication number: 20060073228Abstract: A driven pulley is attached via a bearing to a first housing that can move in the axial direction of injection. This driven pulley is connected to a rotation transmitting member by a spline coupling. An injection screw is fastened to this rotation transmitting member. Furthermore, this rotation transmitting member is attached to a second housing via a bearing so as to move in the axial direction. The first housing and second housing are respectively fastened to the outer ring part and inner 0ring part of a load detection device. Since the first and second housings are capable of relative movement in the axial direction of an injection shaft, no pre-load is generated in the load detection device. Movement of the driven pulley caused by the tension of the mounted belt is checked by a bearing. No frictional force is generated in the spline coupling part. Accordingly, the resin pressure that is applied to the injection screw can be accurately measured by the load detection device.Type: ApplicationFiled: October 4, 2005Publication date: April 6, 2006Applicant: FANUC LTDInventors: Katsuyuki Yamanaka, Koichi Nishimura, Koji Shima, Satoshi Yano
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Publication number: 20060030627Abstract: A bioabsorbable granular porous bone filling material having a particle diameter 100 to 3000 ?m used for filling a defect part after removing a lesion, or grafting a self bone, and for reinforcing or filling a jawbone when embedding a dental implant, is produced such that the polymer material containing a particle-shaped material and having the small hole structure with the hole diameter of 5 to 50 ?m is made by mixing the particle-shaped material having a diameter of 100 to 2000 ?m with a solution, where the bioabsorbable polymer is dissolved with an organic solvent, the particle-shaped material being not dissolved with this organic solvent but dissolved with a liquid not dissolving the bioabsorbable polymer, freezing it, drying it to remove the organic solvent, pulverizing the produced material, dissolving the particle-shaped material with the liquid to be removed, and sieving it.Type: ApplicationFiled: July 26, 2005Publication date: February 9, 2006Applicant: GC CorporationInventors: Katsushi Yamamoto, Katsuyuki Yamanaka, Youko Suda, Tadashi Kaneko