Abstract: A sheet handling apparatus comprises a transport path for transporting sheets, each sheet including individually assigned identification information; a storage that receives and stores the sheets; a feeder that feeds out the sheets stored in the storage to the transport path; and control circuitry configured to: store the identification information of the sheets in a memory; control the feeder to feed out, from the storage, one or more of the sheets in a case that necessity of checking an inventory amount of the sheets in the storage arises; control transport of the one or more sheets to the recognition circuitry and out of the discharge port; and determine an abnormality in the inventory amount of the sheets in the storage based on a comparison of the identification information of each of the one or more sheets with the identification information stored in the memory.

Abstract: A wiring board includes an insulating layer including a first insulating film provided with a first surface and a second surface that is opposite to the first surface, and composed of only resin, and a second insulating film provided with a first surface and a second surface that is opposite to the first surface, including a reinforcing member and resin, in which the reinforcing member is impregnated with the resin, and stacked on the first surface of the first insulating film such that the second surface of the second insulating film contacts the first surface of the first insulating film and the second surface of the first insulating film is exposed outside; and a first wiring layer embedded in the first insulating film, a predetermined surface of the first wiring layer being exposed from the second surface of the first insulating film.

Abstract: An image processing apparatus includes a layout analyzing part that executes layout analysis for image data, an extraction part that extracts a diagrammatic representation from the image data by using a result of the layout analysis, a character recognizing part that executes character recognition for a partial area having a high probability of presence of a character string in a relationship with the extracted diagrammatic representation, and an erecting direction deciding part that decides an erecting direction of the image data by using a result of the character recognition.

Abstract: A treatment tool includes a housing, a sheath rotatable around a predetermined axis of rotation with respect to the housing. An end effector is disposed on a distal-end portion of the sheath and rotatable in unison with the sheath around the axis of rotation. A locking member for restraining rotation of the sheath with respect to the housing by engaging the sheath. A manipulating member is mounted on the housing and moves with respect to the housing for causing the locking member and the sheath to switch between engaging and disengaging positions.

Abstract: Provided is an objective lens which is used so that more information can be accumulated in a large-capacity optical disk and which has a further enhanced numerical aperture NA. The objective lens is a single lens having the numerical aperture NA and a refractive index n, and is configured so as to satisfy: NA?0.91 and 1.61?n<1.72.

Abstract: According to one embodiment, an imprint lithography template comprises a substrate transparent to ultraviolet light. A first mesa region is on the substrate. A surface of the first mesa region includes a pattern region to be pressed into a photocurable resist film. The pattern region having four sides. A second mesa region is also on the substrate. The first mesa region protrudes from a surface of the second mesa region. A blocking film is adjacent to two sides of the four sides pattern region. The two sides to which the blocking film is adjacent are connected to each other at a corner of the pattern region. The blocking film blocks ultraviolet light.

Abstract: A CPU of a console comprises a color image acquisition unit, a distance image acquisition unit, a specification unit, and an estimation unit. The color image acquisition unit acquires a color image, in which a patient and a periphery of the patient are captured, from a visible light camera. The distance image acquisition unit acquires a distance image indicating a distance between a radiation tube and an object, from a TOF camera. The specification unit specifies a kind of the object in the color image. The estimation unit estimates intensity of radiation in an environment captured in the color image based on reference information including the distance image and a specification image as a specification result of the kind of the object.

Abstract: A mechanism that enables developer replenishment by a simpler structure and a mechanism that enables more user-friendly developer replenishment are provided. An attachment port to which a developer supply bottle containing a developer stored therein is detachably attachable is disposed in an interior of an image forming apparatus. The developer supply bottle can be attached when the cover is in an open state. According to this image forming apparatus, when the developer supply bottle is attached to the attachment port, the developer inside the developer supply bottle moves into a developer housing chamber by its own weight.

Abstract: A charging member which is driven so that the surface of the charging member has a speed difference from the surface of an image bearing member. In a cleaning operation for cleaning the charging member by transferring toner adhering to the surface of the charging member from the charging member to the image bearing member and collecting the transferred toner with a developing member, a first charging voltage forming a potential difference between the charging member and the image bearing member is applied to the charging member, and then a second charging voltage having the same polarity as that of the first charging voltage and an absolute value greater than that of the first charging voltage is applied. The potential difference is in a direction in which electrostatic force directed from the charging member to the image bearing member acts on the toner charged to normal polarity.

Abstract: An image forming apparatus includes a rotatable image bearing member to bear an electrostatic latent image, a developing container to accommodate developer including toner and to allow new developer to be replenished by a developer replenishing container, and a developer bearing member to develop the electrostatic latent image into a toner image by using the developer in the developing container. A transfer roller transfers the toner image born on the image bearing member onto the recording material, and a controller notifies replenishment information for prompting replenishing the developing container with the new developer by the developer replenishing container. The controller notifies the replenishment information in a state in which an index correlated with a ratio of an amount of paper dust mixed in the developer in the developing container to an amount of the developer in the developing container has not exceeded a preset threshold value of the index.

Abstract: Provided is a therapeutic agent that effectively acts on a disease associated with abnormal glycosylation of dystroglycan. Also provided is a testing method for diseases associated with abnormal glycosylation of dystroglycan. Specifically, provided is a therapeutic agent for diseases associated with abnormal glycosylation of dystroglycan, containing CDP-ribitol as an active ingredient. Ribitol-phosphate is important in the glycan structure of dystroglycan. In order for ribitol-phosphate to be incorporated into a dystroglycan glycan, a material therefor (sugar donor) is required. In the present invention, it has been found for the first time that CDP-ribitol serves as the sugar donor. It has been confirmed that the glycan of ISPD-deficient cells can be restored by administering CDP-ribitol. Thus, the present invention, which allows CDP-ribitol to be utilized for supplementation therapy, has been completed.

Abstract: In the communication interruption state in which the transmission of a drive control command value DUTY from an engine control unit (ECU) 1 to a fuel pump driver (FPD) 2 is disabled, the FPD 2 is configured so as to drive a fuel pump 4 by using the maximum command value DTYMAX (100%) as a drive control command value DUTY. A stop state of the fuel pump 4 is maintained even if the drive control command value DUTY is the maximum command value DTYMAX when an ignition switch 21 is in the OFF State so as to have stopped the fuel pump 4, while the fuel pump 4 is driven when the ignition switch 21 is in the ON state and the drive control command value DUTY is the maximum command value DTYMAX.

Abstract: In the communication interruption state in which the transmission of a drive control command value DUTY from an engine control unit (ECU) 1 to a fuel pump driver (FPD) 2 is disabled, the FPD 2 is configured so as to drive a fuel pump 4 by using the maximum command value DTYMAX (100%) as a drive control command value DUTY. A stop state of the fuel pump 4 is maintained even if the drive control command value DUTY is the maximum command value DTYMAX when an ignition switch 21 is in the OFF State so as to have stopped the fuel pump 4, while the fuel pump 4 is driven when the ignition switch 21 is in the ON state and the drive control command value DUTY is the maximum command value DTYMAX.

Abstract: A method of manufacturing a wiring substrate includes providing a support that includes a support substrate and first and second metal layers stacked in order over the support substrate. A surface of the second metal layer facing away from the first metal layer is a roughened surface or formed of particles. The second metal layer is selectively etchable with respect to the first metal layer. The method further includes selectively forming a third metal layer on the surface of the second metal layer, forming a first wiring layer that is a laminate of the second and third metal layers by simultaneously roughening the third metal layer and dissolving the second metal layer not covered with the third metal layer using an etchant, forming an insulating layer that covers the first wiring layer on the first metal layer, removing the support substrate, and removing the first metal layer by etching.

Abstract: Provided is a therapeutic agent that effectively acts on a disease associated with abnormal glycosylation of dystroglycan. Also provided is a testing method for diseases associated with abnormal glycosylation of dystroglycan. Specifically, provided is a therapeutic agent for diseases associated with abnormal glycosylation of dystroglycan, containing CDP-ribitol as an active ingredient. Ribitol-phosphate is important in the glycan structure of dystroglycan. In order for ribitol-phosphate to be incorporated into a dystroglycan glycan, a material therefor (sugar donor) is required. In the present invention, it has been found for the first time that CDP-ribitol serves as the sugar donor. It has been confirmed that the glycan of ISPD-deficient cells can be restored by administering CDP-ribitol. Thus, the present invention, which allows CDP-ribitol to be utilized for supplementation therapy, has been completed.

Abstract: An abnormality detection device is configured to detect abnormality in a subject to be driven by a motor via a drive transmission member. The abnormality detection device includes an output signal acquisition unit, a rotational frequency acquisition unit, and a determining unit. The output signal acquisition unit is configured to acquire a rotational frequency output signal output from the motor. The rotational frequency acquisition unit is configured to acquire a motor rotational frequency calculated from the rotational frequency output signal acquired by the output signal acquisition unit. The determining unit is configured to distinctively determine abnormality in the subject to be driven and abnormality in the motor based on the rotational frequency output signal acquired by the output signal acquisition unit and the motor rotational frequency acquired by the rotational frequency acquisition unit.

Abstract: In order to estimate a temperature of a transmission-reception wavefront of a probe head, a first computing unit and a second computing unit are provided. The first computing unit estimates a temperature TA of the transmission-reception wavefront according to a basic function based on an internal temperature T1, an ambient temperature T2, power consumption Ptotal (=Pic+Ptd), and any other parameter. The basic function is a linear function. The second computing unit estimates a temperature TB of the transmission-reception wavefront according to an auxiliary function based on a previously estimated temperature Tpre, an internal temperature difference ?T1, and any other, parameter. A selection unit selects any of the temperatures TA and TB depending on situations.

Abstract: A resonance layer (30) and an acoustic separation layer (34) are arranged adjacent to each other between a piezoelectric element (24) and a circuit board (16) provided with an electronic circuit for driving the piezoelectric element. The acoustic impedance of the resonance layer (30) is higher than that of the piezoelectric element (24), and the acoustic impedance of the acoustic separation layer (34) is lower than that of the circuit board (16). An ultrasonic wave is reflected at the interface between the resonance layer (30) and the acoustic separation layer (34) where the difference in acoustic impedance is large, and the ultrasonic wave propagating to the circuit-board (16) side is reduced.

Abstract: A first forming apparatus includes a forming drum, a forming unit, a conveyance path, and a conveyance unit that conveys the forming drum along the conveyance path. A tire member is formed with tire components wound on the forming drum by the forming unit. The first forming apparatus also includes a measurement unit that performs, on a downstream side of the forming unit in the conveyance path, measurement on the tire components wound on the forming drum while the forming drum is moving through the measurement unit, in a tire radial direction over a width direction of the forming drum, and an inspection unit that performs inspection on winding states of the tire components based on a measurement result due to the measurement unit.

Abstract: A wiring board includes an insulating layer including a first insulating film provided with a first surface and a second surface that is opposite to the first surface, and composed of only resin, and a second insulating film provided with a first surface and a second surface that is opposite to the first surface, including a reinforcing member and resin, in which the reinforcing member is impregnated with the resin, and stacked on the first surface of the first insulating film such that the second surface of the second insulating film contacts the first surface of the first insulating film and the second surface of the first insulating film is exposed outside; and a first wiring layer embedded in the first insulating film, a predetermined surface of the first wiring layer being exposed from the second surface of the first insulating film.