Patents by Inventor Kazuhisa Uchida

Kazuhisa Uchida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-il-5 antibody composition exhibiting cellular cytotoxicity due to glycosylation
    Patent number: 8101185
    Abstract: The present invention relates to a cell for the production of an anti-IL-5 antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: January 24, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Motoo Yamasaki, Nobuo Hanai, Emi Hosaka, Kazuya Yamano
  • Antibody composition-producing cell with inactivated A-1,6-fusocyltransferase
    Patent number: 8067232
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: November 29, 2011
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Glycoengineered, recombinant antibody to CCR-4 with reduced fucosylation
    Patent number: 8039595
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: October 18, 2011
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • ANTIBODY COMPOSITION-PRODUCING CELL
    Publication number: 20110250643
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: May 6, 2011
    Publication date: October 13, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Yutaka KANDA, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • ANTIBODY COMPOSITION EXHIBITING CELLULAR CYTOTOXICTY DUE TO GLYCOSYLATION
    Publication number: 20110059115
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: June 18, 2010
    Publication date: March 10, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: YUTAKA KANDA, MITSUO SATOH, KAZUYASU NAKAMURA, KAZUHISA UCHIDA, TOYOHIDE SHINKAWA, NAOKO YAMANE, EMI HOSAKA, KAZUYA YAMANO, MOTOO YAMASAKI, NOBUO HANAI
  • ANTIBODY COMPOSITION EXHIBITING CELLULAR CYTOTOXICTY DUE TO GLYCOSYLATION
    Publication number: 20110052610
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: June 18, 2010
    Publication date: March 3, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • ANTIBODY COMPOSITION EXHIBITING CELLULAR CYTOTOXICTY DUE TO GLYCOSYLATION
    Publication number: 20110027271
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: June 16, 2010
    Publication date: February 3, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Yutaka KANDA, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody composition-producing cell in which enzyme expression is inhibited by RNAi
    Patent number: 7846725
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, wherein the expression of GDP-mannose 4,6-dehydrogenase is inhibited by RNA interference.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: December 7, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • METHOD OF MODULATING THE ACTIVITY OF FUNCTIONAL IMMUNE MOLECULES
    Publication number: 20100196371
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: December 23, 2009
    Publication date: August 5, 2010
    Applicant: KYOWA HAKKO KIRIN, LTD.
    Inventors: NOBUO HANAI, KAZUYASU NAKAMURA, EMI HOSAKA, MOTOO YAMASAKI, KAZUHISA UCHIDA, TOYOHIDE SHINKAWA, SUSUMU IMABEPPU, YUTAKA KANDA, NAOKO YAMANE, HIDEHARU ANAZAWA
  • Method of modulating the activity of functional immune molecules to platelet-derived growth factor receptor
    Patent number: 7763246
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: July 27, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Antibody composition exhibiting increased cellular cytotoxicity due to glycosylation
    Patent number: 7741442
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: September 6, 2005
    Date of Patent: June 22, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody composition-producing cell
    Patent number: 7737325
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-modulated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: June 15, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody Composition-Producing Cell
    Publication number: 20100143388
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 10, 2010
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: YUTAKA KANDA, MITSUO SATOH, KAZUYASU NAKAMURA, KAZUHISA UCHIDA, TOYOHIDE SHINKAWA, NAOKO YAMANE, EMI HOSAKA, KAZUYA YAMANO, MOTOO YAMASAKI, NOBUO HANAI
  • Method of modulating the activity of functional immune molecules to interleukin-5 receptor protein
    Patent number: 7718175
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: May 18, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of modulating the activity of functional immune molecules
    Patent number: 7708997
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: May 4, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Methods for producing antibody compositions with increased ADCC
    Patent number: 7708992
    Abstract: The invention relates to methods for modulating the antibody-dependent cellular cytotoxicity of an IgG antibody composition.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: May 4, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of modulating the activity of functional immune molecules to Her-2
    Patent number: 7687061
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: March 30, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of modulating the activity of functional immune molecules to CXCR4 protein
    Patent number: 7682611
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: March 23, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of modulating the activity of functional immune molecules
    Patent number: 7682610
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: March 23, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of modulating the activity of functional immune molecules to GM2
    Patent number: 7655228
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: February 2, 2010
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa