Abstract: A refrigeration cycle apparatus includes a refrigerant circuit connecting a compressor, a heat source-side heat exchanger, an expansion device, and a use-side heat exchanger to each other by connecting pipes, an outside air temperature sensor configured to detect an outside air temperature, and a controller configured to operate the refrigeration cycle apparatus and to switch between a normal operation mode for controlling the refrigerant circuit based on an operation load of the use-side heat exchanger and a refrigerant amount determining mode for determining whether or not an amount of refrigerant in the refrigerant circuit is appropriate. The controller is configured to switch the normal operation mode to the refrigerant amount determining mode when the outside air temperature detected by the outside air temperature sensor is within a set temperature range.

Abstract: There is provided an anti-human CRTH2 antibody which has desired activity by recognizing and binding to a specific human CRTH2; the antibody fragment; DNA which encodes the amino acid sequence of the antibody; a vector which comprises the DNA; hybridomas and antibody producing cells which produce the antibody; a method of producing the antibody; a composition which comprises the antibody or the antibody fragment; a treatment method and a diagnostic method of an allergic disease, an autoimmune disease, a disease accompanied by at least one of increase and hyperergasia of eosinophils; a disease accompanied by at least one of increase and hyperergasia of Th2 cells using the antibody or the antibody fragment; and a medicine and a diagnostic agent which comprise the antibody or the antibody fragment.

Abstract: There is provided an anti-human CRTH2 antibody which has desired activity by recognizing and binding to a specific human CRTH2; the antibody fragment; DNA which encodes the amino acid sequence of the antibody; a vector which comprises the DNA; hybridomas and antibody producing cells which produce the antibody; a method of producing the antibody; a composition which comprises the antibody or the antibody fragment; a treatment method and a diagnostic method of an allergic disease, an autoimmune disease, a disease accompanied by at least one of increase and hyperergasia of eosinophils; a disease accompanied by at least one of increase and hyperergasia of Th2 cells using the antibody or the antibody fragment; and a medicine and a diagnostic agent which comprise the antibody or the antibody fragment.

Abstract: There is provided an anti-human CRTH2 antibody which has desired activity by recognizing and binding to a specific human CRTH2; the antibody fragment; DNA which encodes the amino acid sequence of the antibody; a vector which comprises the DNA; hybridomas and antibody producing cells which produce the antibody; a method of producing the antibody; a composition which comprises the antibody or the antibody fragment; a treatment method and a diagnostic method of an allergic disease, an autoimmune disease, a disease accompanied by at least one of increase and hyperergasia of eosinophils; a disease accompanied by at least one of increase and hyperergasia of Th2 cells using the antibody or the antibody fragment; and a medicine and a diagnostic agent which comprise the antibody or the antibody fragment.

Abstract: An air-conditioning apparatus is able to ensure an appropriate flow rate of refrigerant and an appropriate amount of oil returned to a compressor that match operation conditions regardless of an operating state of a refrigerant circuit and a change in an operation condition. The air-conditioning apparatus includes: a first detector configured to detect a refrigerant temperature within an accumulator; a storage unit configured to store information regarding a two-layer separation temperature of refrigerant and refrigerating machine oil; a determiner configured to compare the refrigerant temperature with the two-layer separation temperature and determine a two-layer separation state of the refrigerant and the refrigerating machine oil; a second detector configured to detect a state of the refrigerant sucked by the compressor; and a control unit configured to adjust an opening degree of a flow control valve on the basis of the two-layer separation state and a state of the sucked refrigerant.

Abstract: There is provided an anti-human CRTH2 antibody which has desired activity by recognizing and binding to a specific human CRTH2; the antibody fragment; DNA which encodes the amino acid sequence of the antibody; a vector which comprises the DNA; hybridomas and antibody producing cells which produce the antibody; a method of producing the antibody; a composition which comprises the antibody or the antibody fragment; a treatment method and a diagnostic method of an allergic disease, an autoimmune disease, a disease accompanied by at least one of increase and hyperergasia of eosinophils; a disease accompanied by at least one of increase and hyperergasia of Th2 cells using the antibody or the antibody fragment; and a medicine and a diagnostic agent which comprise the antibody or the antibody fragment.

Abstract: An OCT motion contrast data analysis apparatus includes: a processor; and memory storing computer readable instructions, when executed by the processor, causing the OCT motion contrast data analysis apparatus to execute: acquiring OCT motion contrast data of a subject by an optical coherence tomography; and performing an analysis process with respect to the OCT motion contrast data based on an analysis chart set on image data different from the OCT motion contrast data.

Abstract: In a heat pump apparatus, it is aimed to enhance efficiency of a defrost operation by reducing a loss of heat radiation during the defrost operation and reducing a compressor input during the defrost operation. The heat pump apparatus includes a main refrigerant circuit in which a compressor, a first heat exchanger, an expansion mechanism, and a second heat exchanger are connected sequentially, and also includes a bypass circuit including an on-off valve and providing a connection by bypassing the expansion mechanism. The main refrigerant circuit includes a four-way valve that switches between a heating operation and the defrost operation by switching an order in which the refrigerant circulates through the main refrigerant circuit. The main refrigerant circuit also includes a first temperature detection unit and a second temperature detection unit. Based on values detected by these temperature detection units, a degree of superheat of the first heat exchanger during the defrost operation is computed.

Abstract: When using a plurality of heaters such as heat pump units, capacity is properly distributed according to the required capacity, thereby enabling highly efficient operation of a hot water system. To achieve this, a control apparatus determines the heating capacity of each of the heat pump units in a way that the total heating capacity of the heat pump units reaches the heating capacity required in the hot water system as a whole, and further in a way that the total COP (coefficient of performance) of the heat pump units satisfies predetermined condition. The control apparatus controls each of regulating valves in a way that the heating capacity of each of the heat pump units reaches the above determined heating capacity.

Abstract: A method of manufacturing an air-conditioning apparatus serving as a refrigeration cycle apparatus includes: performing an operation test in a factory under a state in which inert gas (nitrogen) is sealed into respective devices mounted on an outdoor unit (such as a compressor and a four-way valve) and an outdoor pipe connecting the devices in place of refrigerant having flammability; and shipping the air-conditioning apparatus under the state in which the inert gas remains sealed.

Abstract: A refrigeration cycle apparatus includes a refrigerant circuit connecting a compressor, a heat source-side heat exchanger, an expansion device, and a use-side heat exchanger to each other by connecting pipes, an outside air temperature sensor configured to detect an outside air temperature, and a controller configured to operate the refrigeration cycle apparatus and to switch between a normal operation mode for controlling the refrigerant circuit based on an operation load of the use-side heat exchanger and a refrigerant amount determining mode for determining whether or not an amount of refrigerant in the refrigerant circuit is appropriate. The controller is configured to switch the normal operation mode to the refrigerant amount determining mode when the outside air temperature detected by the outside air temperature sensor is within a set temperature range.

Abstract: There is provided a repeated type organ fixing instrument having a plurality of suturing tools. The organ fixing instrument includes a rod-shaped engaging portion, a suture fixed to the engaging portion, a puncture needle for housing a plurality of the engaging portions. A plurality of the engaging portions are extruded one by one from the puncture needle by the operation of a operation unit main body. The suture fixed to at least one of the plurality of engaging portions is inserted within the inside of the puncture needle and wherein the other suture is derived from the inside to the outside of the puncture needle.

Abstract: A heat pump apparatus includes a refrigerant circuit in which a compressor, a condenser, expansion means, and an evaporator are serially connected. Condensation temperature detection means that detects a saturation temperature of the condenser, and evaporation temperature detection means that detects the saturation temperature of the evaporator are provided. Operation efficiency is estimated by a value obtained by dividing heating ability estimated from a detection value of the condensation temperature detection means by a difference between a detection value of condensation temperature detection means and that of evaporation temperature detection means or dissipation power estimated by the difference.

Abstract: To provide a heat pump water heater outdoor unit and heat pump water heater capable of preventing reduction in heating/hot water supply ability even at a low ambient temperature.

Abstract: In a heat pump apparatus, it is aimed to enhance efficiency of a defrost operation by reducing a loss of heat radiation during the defrost operation and reducing a compressor input during the defrost operation. The heat pump apparatus includes a main refrigerant circuit in which a compressor, a first heat exchanger, an expansion mechanism, and a second heat exchanger are connected sequentially, and also includes a bypass circuit including an on-off valve and providing a connection by bypassing the expansion mechanism. The main refrigerant circuit includes a four-way valve that switches between a heating operation and the defrost operation by switching an order in which the refrigerant circulates through the main refrigerant circuit. The main refrigerant circuit also includes a first temperature detection unit and a second temperature detection unit. Based on values detected by these temperature detection units, a degree of superheat of the first heat exchanger during the defrost operation is computed.

Abstract: It is aimed to provide a heat pump type hot-water supply outdoor apparatus that can control a temperature of a compressor shell, according to a water temperature of a water circuit and a temperature of the compressor.

Abstract: It is aimed to simultaneously supply hot water at a required temperature to a high-temperature heating appliance and hot water at a required temperature to a low-temperature heating appliance, the low-temperature heating appliance requiring hot water at a temperature lower than a temperature required by the high-temperature heating appliance, and to enhance efficiency by collecting surplus heat when the temperature of the hot water to be supplied to the low-temperature heating appliance is adjusted. A pipe through which flows the hot water at a high temperature to be supplied to the high-temperature heating appliance is branched into a first supply pipe and a second supply pipe. Heat exchange is effected between the hot water flowing through the first supply pipe and return water which has been supplied to a first appliance.

Abstract: When using a plurality of heaters such as heat pump units, capacity is properly distributed according to the required capacity, thereby enabling highly efficient operation of a hot water system. To achieve this, a control apparatus determines the heating capacity of each of the heat pump units in a way that the total heating capacity of the heat pump units reaches the heating capacity required in the hot water system as a whole, and further in a way that the total COP (coefficient of performance) of the heat pump units satisfies predetermined condition. The control apparatus controls each of regulating valves in a way that the heating capacity of each of the heat pump units reaches the above determined heating capacity.

Abstract: A heat pump type hot water supply outdoor apparatus, in a compressor, a water heat exchanger, a first expansion valve, a medium pressure receiver, a second expansion valve, and an air heat exchanger are connected circularly, has an injection circuit, which is a bypass for a part of the refrigerant between the medium pressure receiver and the second pressure reduction unit, to inject the part of refrigerant into a compression chamber of the compressor, and has a third expansion valve and an internal heat exchanger for carrying out heat exchange between the refrigerant whose pressure is reduced by the third expansion valve and the refrigerant between the medium pressure receiver and the second expansion valve, a pressure detection sensor for detecting a condensing pressure, and a controller for starting an injection control by the third expansion valve at the time when the condensing pressure detected by the pressure sensor or the condensing temperature calculated from the condensing pressure becomes a first pr

Abstract: A heat pump apparatus includes a refrigerant circuit in which a compressor, a condenser, expansion means, and an evaporator are serially connected. Condensation temperature detection means that detects a saturation temperature of the condenser, and evaporation temperature detection means that detects the saturation temperature of the evaporator are provided. Operation efficiency is estimated by a value obtained by dividing heating ability estimated from a detection value of the condensation temperature detection means by a difference between a detection value of condensation temperature detection means and that of evaporation temperature detection means or dissipation power estimated by the difference.