Abstract: The present application provides bicyclic urea compounds that modulate the activity of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A method for producing one or more of benzene, toluene, or xylene may include contacting a feed stream including C9+ alkylaromatic hydrocarbons with a catalyst mixture to form one or more of benzene, toluene, or xylene. The catalyst mixture may include mesoporous zeolite Beta, ZSM-5 zeolite, one or more active metals, and binder material. The feed stream may include C9+ alkylaromatic hydrocarbons in an amount of at least 10 wt. %. The weight ratio of mesoporous zeolite Beta to ZSM-5 zeolite may be from 2 to 4.

Abstract: A method for producing a hierarchical mesoporous beta includes mixing a beta zeolite with an aqueous metal hydroxide solution and heating the beta zeolite and the aqueous metal hydroxide mixture to produce a desilicated beta zeolite, contacting the desilicated beta zeolite with an ammonium salt solution to produce an intermediate hierarchical mesoporous beta zeolite, and treating the intermediate hierarchical mesoporous beta zeolite with an acidic solution to produce the hierarchical mesoporous beta zeolite. The hierarchical mesoporous beta zeolite includes a molar ratio of silicon to aluminum of greater than 12.5, a total pore volume of greater than or equal to the total pore volume of the intermediate hierarchical mesoporous beta zeolite, and an average mesopore size of greater than or equal to the average mesopore size of the hierarchical mesoporous beta zeolite. The method may also include calcining the intermediate hierarchical mesoporous beta zeolite.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A memory apparatus and method of operation are provided. The apparatus includes memory cells connected to word lines and disposed in memory holes coupled to bit lines. A control means successively applies each of a series of pulses of a program voltage to selected ones of the word lines while simultaneously applying one of a bit line program voltage and a bit line inhibit voltage to ones of the bit lines coupled to the memory holes containing groups of the memory cells connected to the selected ones of the plurality of word lines to program the groups of the memory cells with data. The control means maintains a voltage applied to ones of the plurality of bit lines as the bit line inhibit voltage in response to the ones of the plurality of bit lines remaining unselected when programming a next one of the groups of the memory cells.

Abstract: Method for performing a memory operation with respect to a memory structure having “N”-number of planes, each plane comprising “M”-number of blocks and “X”-number of word lines arranged in a serial order, and electrically connected with each plane are: a voltage bias source, an electronic switching component, and row decoder, the method comprising: with respect to each plane, selecting a block and a word line for application of the operation, wherein the operation has not been applied to the selected block and word line, the selected block of one plane is located in a different block group from the selected block of another plane, and the selected word line of one plane is in a different position within the serial order from a position of the selected word line of another plane; and using the voltage bias source, concurrently applying the operation to the selected blocks and selected word lines.

Abstract: The present disclosure provides a quaternary ammonium hydroxide solution comprising a reaction product of a polyamine and an organic oxirane. The quaternary ammonium hydroxide solution may be used in various applications, such as in removing chemical residue from a metal or dielectric surface.

Abstract: Disclosed in the present invention is an aerosol generating device, comprising a housing and an aerosol medium, wherein one end of the housing is open, and an accommodating cavity and a heating body are arranged in the housing; the aerosol medium comprises an aerosol generating matrix segment and an aerosol extracting segment, a hollow cavity being disposed in the aerosol extracting segment, and the outer side wall of the aerosol extracting segment being provided with aerosol flow guide holes and air flow guide holes both in communication with the hollow cavity; after the aerosol medium extends into the accommodating cavity from the opening, the aerosol generating matrix segment is located in a heating area of the heating body, and the aerosol can permeate from the outer side wall and end face of the aerosol generating matrix segment; the outer side wall of the aerosol medium has a gap with the inner wall of the housing and is in sealed fit with the housing at the open end face; the aerosol flow guide holes a

Abstract: The invention relates to a method, apparatus and electronic device of page display for application. The method comprises: receiving a play instruction for a multimedia content in an application, wherein the multimedia content is configured with a target prop, and the target prop is used for influencing the playing effect of the multimedia content; in response to the play instruction, in a playing page of the application, playing the multimedia content, and dynamically displaying an icon of the target prop in an icon of a publisher, the publisher being used for creating a new multimedia content configured with the target prop and/or turning on a new virtual live studio configured with the target prop.

Abstract: Disclosed is an aerosol generating device, comprising an extraction member and a heating member, the extraction member being internally provided with a hollow cavity for accommodating an aerosol generating substrate segment, and the hollow cavity comprising a first connecting end and a second connecting end which are oppositely arranged; and the heating member comprises a heating body for heating the aerosol generating substrate segment and a sealing plug that is mounted at one end of the heating body; when the heating body extends into the hollow cavity from the second connecting end, same is inserted into the aerosol generating substrate segment that extends from the first connecting end into the hollow cavity, and the sealing plug sealingly cooperates with an end surface opening of the second connecting end.

Abstract: A method for producing one or more of benzene, toluene, or xylene may include contacting a feed stream including C9+ alkylaromatic hydrocarbons with a catalyst mixture to form one or more of benzene, toluene, or xylene. The catalyst mixture may include mesoporous zeolite Beta, ZSM-5 zeolite, one or more active metals, and binder material. The feed stream may include C9+ alkylaromatic hydrocarbons in an amount of at least 10 wt. %. The weight ratio of mesoporous zeolite Beta to ZSM-5 zeolite may be from 2 to 4.

Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.

Abstract: The memory device includes a plurality of memory cells arranged in a plurality of blocks, which are arranged in at least one plane. A controller is in electrical communication with the plurality of memory cells. The controller is configured to define a multi-block group that includes at least two blocks to be erased. The controller is further configured to simultaneously apply at least one erase pulse to the multi-block group. The controller is further configured to individually and sequentially apply a verify pulse to the blocks. In response to all blocks passing verify, the controller is configured to complete the erase operation. In response to at least one of the blocks not passing verify, the controller is configured to individually and sequentially apply an erase pulse and then a verify pulse to the at least one block that did not pass verify.

Abstract: A vehicle window assembly and an assembly method therefor, and a vehicle. The vehicle window assembly includes an exterior decorative member, an encapsulation assembly, and a guide rail. The encapsulation assembly is disposed around a periphery of the exterior decorative member and wraps at least part of the periphery of the exterior decorative member. The encapsulation assembly has a first end and a second end in a direction of an edge S of the exterior decorative member, and the second end is far away from the first end. A limiting groove is defined at the first end of the encapsulation assembly. The guide rail has one end inserted into the limiting groove to limit the guide rail from moving. The guide rail is connected to the second end of the encapsulation assembly to fix the guide rail to the encapsulation assembly.

Abstract: A memory device including an array of memory cells arranged in a plurality of word lines is provided. A control circuitry is configured to program the memory cells of a selected word line to a plurality of leading data states in a plurality of programming loops that include programming and verify pulses. The control circuitry is also configured to count a total number of programming loops during programming of the selected word line. The control circuitry is also configured to program at least one memory cell of the selected word line to a last data state in at least one last data state programming loop. In response to both the total number of programming loops being less than a first predetermined threshold and the number of last data state programming loops being equal to a second predetermined threshold, the control circuitry automatically skips verify in a final programming loop.

Abstract: The disclosure discloses a metal foil, a metal foil with a carrier, a copper-clad laminate and a Printed Circuit Board. Herein, a plurality of protrusions are distributed on one face of the metal foil, and the protrusions have the follow microscopic morphology: the lower half part of the protrusion connected with the one face of the metal foil is provided with a limiting part, and the diameter of a circumscribed circle of the cross section of the limiting part is smaller than the skin depth of the metal foil; and the surface area of the part of the protrusion above the limiting part is larger than the surface area of other parts of the protrusion.

Abstract: A flavor-compensated aerosol generation product comprises a housing, a power supply, a control module, an electronic atomization module and a heat-not-burn module, wherein an accommodation cavity is formed at one end of the housing, and the electronic atomization module and the heat-not-burn module are communicated with each other through a first aerosol channel, a sealing element and a second aerosol channel, the first aerosol channel and the sealing element are arranged between the housing and the accommodation cavity, and the second aerosol channel is arranged inside the middle of the heat-not-burn module. The present invention provides an aerosol generating product for compensating the flavor of the electronic cigarette and the flavor of the heated cigarette.

Abstract: A vehicle window assembly and a vehicle are provided in the present disclosure. The vehicle window assembly includes a glass plate, a guide rail, a mounting member, and a connecting member. The guide rail defines an accommodating space that has an opening facing a glass plate. At least part of the mounting member is disposed in the accommodating space. The mounting member defines a mounting hole in communication with the accommodating space. The connecting member has one end connected to the glass plate, and the other end penetrating through the mounting hole.