Patents by Inventor Keizo Inoue

Keizo Inoue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5374713
    Abstract: Peptide inhibitors of phospholipase A.sub.2 from inflammatory sites having the amino acid sequence given in formula SEQ. I.D.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: December 20, 1994
    Assignee: Teijin Limited
    Inventors: Yorimasa Suwa, Atsushi Imaizumi, Masahiro Okada, Chieko Azuma, Ichiro Kudo, Keizo Inoue
  • Patent number: 5344764
    Abstract: Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites which have an amino acid sequence given in FIGS. 3-1 through 3-3 or an amino acid sequence physiologically equivalent thereto, a process for preparation of said inhibitory protein wherein serum of mammalian animal is enzymatically treated, and a gene coding said inhibitory protein.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: September 6, 1994
    Assignee: Teijin Limited
    Inventors: Yorimasa Suwa, Atsushi Imaizumi, Masahiro Okada, Ichiro Kudo, Keizo Inoue, Yoji Suzuki
  • Patent number: 5116942
    Abstract: Protein having inflammatory phospholipase A.sub.2 inhibitory activity wherein said protein has a nature to be induced from cells by administration of glucocorticoid, for example, having a molecular weight of 40 K and the amino acid sequence from the N-terminal consisting of a N-terminal amino acid-Asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp-.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: May 26, 1992
    Assignee: Teijin Limited
    Inventors: Keizo Inoue, Atsushi Imaizumi, Takashi Kamimura, Yorimasa Suwa, Masahiro Okada, Yoji Suzuki, Ichiro Kudo
  • Patent number: 5103007
    Abstract: Lipid derivatives represented by the formula: ##STR1## wherein R.sup.1 stands for an optionally substituted higher alkyl group, R.sup.2 stands for an optionally substituted lower alkyl group or an optionally substituted nitrogen-containing heterocyclic group, R.sup.3 stands for a tertiary amino group or a quaternary ammonium group, J stands for oxygen atom or S(O)t (where t deontes 0, 1 or 2), m and n respectively denotes 1 or 2, p denotes 0, 1 or 2, q and r respectively denote an integer of 2 to 5.and salts thereof have antitumor activities including differentiation-inducing activity and are useful as antitumor agents.
    Type: Grant
    Filed: October 27, 1989
    Date of Patent: April 7, 1992
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroaki Nomura, Hiroshi Akimoto, Keizo Inoue
  • Patent number: 5081245
    Abstract: A compound represented by the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl group;R.sup.1 represents a higher alkyl group which may be substituted;R.sup.2 represents a hydrogen atom or a lower alkyl group, a lower alkanoyl group or a nitrogen-containing 5- to 7-membered heterocyclic group each of which may be substituted; X represents a divalent group represented by the formula:--(OCH.sub.2 CH.sub.2).sub.p --wherein p represents an integer of 1 to 5, a divalent group represented by the formula:--O(CH.sub.2).sub.q --wherein q represents an integer of 3 to 8, or a divalent group represented by the formula:--(OCH.sub.2 CH.sub.2).sub.p --J--(CH.sub.2).sub.q --wherein J represents an oxygen atom or a group represented by the formula: --S(O).sub.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: January 14, 1992
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroaki Nomura, Hiroshi Akimoto, Eiko Imamiya, Keizo Inoue
  • Patent number: 5011952
    Abstract: A compound of the formula: ##STR1## wherein the wave line means .alpha.-bond or .beta.-bond, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound, pharmaceutical composition containing the compound, and a cell culture of a microorganism Thielavia terricola RF-143 producing the compound are also provided.
    Type: Grant
    Filed: April 30, 1990
    Date of Patent: April 30, 1991
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tadashi Yoshida, Keizo Inoue, Hitoshi Arita, Shigeru Matsutani, Jun'ichi Shoji, Yoshimi Kawamura
  • Patent number: 5008454
    Abstract: Novel compounds having the formula:R.sup.1 --OCH.sub.2 CH.sub.2 CH.sub.2 O--(CH.sub.2).sub.n --R.sup.2wherein R.sup.1 stands for a higher alkyl group; R.sup.2 stands for a primary to tertiary amino group or a quaternary ammonium group; and n denotes an integer of 3 to 10; and salts thereof, have excellent anti-tumor action and therefore are useful as anti-tumor agents.
    Type: Grant
    Filed: March 12, 1990
    Date of Patent: April 16, 1991
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keizo Inoue, Hiroaki Nomura, Akihiro Tasaka
  • Patent number: 4920134
    Abstract: Novel compounds having the formula: ##STR1## wherein ##STR2## represents a nitrogen-containing aromatic 6-membered ring; R.sup.1 represents a higher alkyl group which may be substituted; R.sup.2 represents a tertiary amino group or a quaternary ammonium group; and m represents 2 or 3; and salts thereof have superior antitumor activities including differentiation-inducing activity, and are useful as antitumor agents.
    Type: Grant
    Filed: August 3, 1988
    Date of Patent: April 24, 1990
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keizo Inoue, Hiroaki Nomura, Eiko Imamiya
  • Patent number: 4900083
    Abstract: A vehicle body consists of six independent body sections, i.e., an engine compartment assembly, floor assembly, rear end assembly, a pair of body side assemblies and roof assembly. The assemblies are prepared and painted independently and then respectively provided with equipment such as an engine, suspensions, upholsteries, etc. so as to constitute an engine compartment module, floor module, rear end module, body side modules and roof module, respectively. A complete vehicle or nearly complete vehicle is obtained by joining the modules together with bolts and nuts.
    Type: Grant
    Filed: March 22, 1988
    Date of Patent: February 13, 1990
    Assignee: Nissan Motor Co., Ltd.
    Inventors: Hideyuki Kumasaka, Tarou Haiwara, Katsumi Nakamura, Kenichi Miyazaki, Hiroshi Kuriyama, Kouji Takao, Keizo Inoue
  • Patent number: 4889953
    Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 is a higher alkyl group which may be substituted; R.sup.2 is a hydrogen, a lower alkyl group which may be substituted, a lower alkanoyl group which may be substituted or a lower alkylthiocarbamoyl group; R.sup.3 is a primary to tertiary amino group or a quaternary ammonium group; and n is 2 or 3, and salts thereof, have antitumor activity and platelet activating factor inhibitory activity.
    Type: Grant
    Filed: July 22, 1987
    Date of Patent: December 26, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keizo Inoue, Hiroaki Nomura, Tetsuya Okutani
  • Patent number: 4845219
    Abstract: A compound of the general formula [I]: ##STR1## wherein R.sub.1 represents a higher alkyl group or an N-(higher alkyl)carbamoyl group, R.sub.2 represents a lower alkyl group, an acyl group having at least three carbon atoms, an N-(lower alkyl)carbamoyl group, an N-(lower alkyl)thiocarbamoyl group or a benzyl group, R represents a primary, secondary or tertiary amino group or a quaternary ammonium group, x is 1 or 2, y is a number of 0, 1 or 2, and z is an integer of 2-10, or a pharmaceutically acceptable salt thereof. The novel substances have both anti-tumor activity and platelet activating factor-inhibiting property, and they are effective as an anti-tumor agent without circulatory trouble.
    Type: Grant
    Filed: July 23, 1987
    Date of Patent: July 4, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keizo Inoue, Hiroaki Nomura, Tetsuya Aono
  • Patent number: 4836600
    Abstract: A front floor panel has at a lateral end thereof a first flange for joining with a body side assembly. A floor panel has a second flange for joining with the body side assembly of a modular vehicle body. The first and seond flanges are formed with first and second recesses, respectively. A patch plate is fitted in the first and second recesses to form a smooth continuous joining surface which is joined with the corresponding flange of the body side assembly by interposing therebetween sealant adhesive. The rear floor panel is nearly rectangular and has a continuous upstanding flange extending upwardly from the laterally opposed ends and the rear end thereof for joining with the body side assembly and another body side assembly and a rear end assemby of the modular vehicle body.
    Type: Grant
    Filed: April 21, 1988
    Date of Patent: June 6, 1989
    Assignee: Nissan Motor Co., Ltd.
    Inventors: Kenichi Miyazaki, Katsumi Nakamura, Taro Hagiwara, Keizo Inoue
  • Patent number: 4778912
    Abstract: Phospholipid derivatives of the formula: ##STR1## wherein R.sup.1 is a higher alkyl, acylmethyl or alkylcarbamoyl group which may be substituted by cycloalkyl; R.sup.2 is a lower alkyl which may be substituted by carboxy, formyl or lower acyl, a carbamoyl or thiocarbamoyl group which is substituted by lower alkyl, or an acetoacetyl group; R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen or lower alkyl, or ##STR2## represents a cyclic ammonio group; and n represents an integer of 8 to 14, and salts thereof have antitumor activity.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: October 18, 1988
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keizo Inoue, Hiroaki Normura, Tetsuya Okutani
  • Patent number: 4675430
    Abstract: 2-Alkanoyloxy-3-(N-octadecylcarbamoyloxy)propyl trimethylammonioethyl phosphates and a salt thereof exhibit inhibitory activity against multiplication of tumor cells, and are useful as an antitumor agent.
    Type: Grant
    Filed: June 18, 1986
    Date of Patent: June 23, 1987
    Assignee: Takeda Chemical Industries, Inc.
    Inventors: Keizo Inoue, Hiroaki Nomura, Tetsuya Okutani
  • Patent number: 4159822
    Abstract: A working mechanism for moving a treatment table including an expandable and contractable pneumatic spring coupled to the table, a pneumatic control pressure circuit for controlling the expansion and contraction of the pneumatic spring and a hydraulic checker coupled to the treatment table whereby the treatment table is smoothly moved and maintained at any heighth.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: July 3, 1979
    Assignee: Kabushiki Kaisha Morita Seisakusho
    Inventors: Sadayasu Ota, Keizo Inoue
  • Patent number: 4039837
    Abstract: Method and apparatus for making a tomogram according to this invention include one elongated support member supporting an X-ray tube and a film device in an opposed relation with each other at both ends thereof and one vertical shaft supporting the elongated support member thereon. Movement of the axis of the shaft along a desired curve results in the movement of an X-ray beam in the state of the X-ray beam intersecting the curve. In the meantime, an angle of rotation around the axis of the shaft is adjusted so as to maintain an angle of intersection of the X-ray beam with the curve at a predetermined angle. A film surface is moved relatively with respect to the X-ray beam so as to allow the beam to scan the film surface. The velocity of movement of the film surface is synchronized with the movement of the shaft.
    Type: Grant
    Filed: July 2, 1976
    Date of Patent: August 2, 1977
    Assignee: Kabushiki Kaisha Morita Seisakusho
    Inventors: Sadayasu Ohta, Akio Yada, Keizo Inoue