Abstract: The present invention provides a method for producing a compound having an alkylated acidic functional group, the method comprising reacting, in a mixture containing two or more compounds having an acidic functional group as substrates, the compounds with an alkylating agent selected from compounds represented by formula A, formula B, or formula C in the presence of a base to alkylate the acidic functional group.

Abstract: A mobile body authentication apparatus capable of preventing an autonomously movable mobile body from illegally moving without permission is provided. A mobile body authentication apparatus includes at least one memory configured to store instructions, and at least one processor configured to execute the instructions to: acquire, from an autonomously movable mobile body, remote identification information, which is information for managing a remote operation of the mobile body, position information indicating the current position of the mobile body, time information that indicates the current time in the mobile body, and authentication information; and execute collation based on the whole of part of the information; and output the result of collation.

Abstract: An object of the present invention is to provide a method for efficiently producing a high-purity peptide compound with a high yield. It has been found that the object can be achieved by supporting a peptide on a solid phase synthesis resin prior to a first elongation reaction in a solid phase process.

Abstract: An update information generation apparatus includes at least one memory configured to store dynamic information on a qualification regarding a mobile body and instructions, and at least one processor configured to execute the instructions to acquire plan information regarding an operation plan for operating the mobile body, acquire achievement information that corresponds to the plan information of the mobile body, calculate an evaluation score for updating static information on the qualification based on the dynamic information, the plan information, and the achievement information, and output update information including the evaluation score and an identifier to a static information management apparatus that manages the static information.

Abstract: An information processing apparatus includes at least one memory storing instructions, and at least one processor. The at least one processor is configured to execute instructions to receive request information including qualification information regarding an operation qualification for operating a mobile body and plan information regarding an operation plan for operating the mobile body, acquire attribute information of the qualification information, determine whether or not to accept a request associated with the request information based on the attribute information, and output a result of the determination regarding the request as a response to the request.

Abstract: Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.

Abstract: Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

Abstract: Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.

Abstract: In order to facilitate fixed-point monitoring over a wide area and for a long time, this water area monitoring device comprises: a detection unit for information, such as water area intrusion, which detects, from sound data that is acquired by means of optical fibers installed in the water or the water bottom and is data pertaining to a sound or a vibration at the respective positions of the optical fibers, at least any one among sounds of water area intrusion or the like that indicate intrusion into a target water area or water area intrusion or the like, which is a prescribed behavior in the target water area, at a time at which sound data is acquired, and changes in sounds or vibrations not caused by the water area intrusion or the like; and an output unit which outputs information indicating the sound such as water area intrusion.

Abstract: Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.

Abstract: It was found that a peptide compound that has an N-substituted-?,?-disubstituted amino acid residue at the N-terminus and containing a dipeptide residue in which the N-substituted-?,?-disubstituted amino acid residue and an N-substituted amino acid residue are linked together, can be efficiently produced by linking an N-unsubstituted-?,?-disubstituted amino acid whose amino group is protected with an electron-withdrawing protecting group to an N-substituted amino acid or a peptide compound having an N-substituted amino acid residue at the N-terminus, and then allowing a substituent-introducing agent to act in the presence of a specific base to selectively introduce a substituent to the amino group at the N-terminus.

Abstract: Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.

Abstract: It was found that a salt formed of an acid and a base having characteristics set forth below can inactivate a deprotecting agent, thereby suppressing redundant peptide elongation: (i) the base is different in type from a base used as a deprotecting agent, and (ii) a conjugate acid of the base has a pKa smaller than that of a conjugate acid of a base used as a deprotecting agent.

Abstract: It was found that a salt formed of an acid and a base having characteristics set forth below can inactivate a deprotecting agent, thereby suppressing redundant peptide elongation: (i) the base is different in type from a base used as a deprotecting agent, and (ii) a conjugate acid of the base has a pKa smaller than that of a conjugate acid of a base used as a deprotecting agent.

Abstract: Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.

Abstract: Provided is an air-permeable sheet (3) to be used in a state of being interposed between a suction stage (1) and an air-impermeable substrate (4) when printing is performed by a sheet-fed method on the surface of the substrate (4) fixed by suction to the suction stage (1), the air-permeable sheet capable of printing a desired printing pattern on the surface of the substrate with high accuracy. The air-permeable sheet (3) includes a non-woven fabric layer (3b) and a support layer (3a) constituted by a woven fabric or knitted fabric.

Abstract: A processor detects a phase difference between a feedback clock and a reference clock of a PLL circuit, generates, based on the phase difference, first frequency information indicating a candidate value of a frequency of an output clock being output from the PLL circuit, generates second frequency information by smoothing the first frequency information, and generates the output clock by determining the frequency based on the second frequency information.

Abstract: A storage device stores first information indicating a first consumption current value during operation of a first partial circuit included in a circuit under design and second information indicating a surplus current value based on an allowable current value of a power source terminal of a second partial circuit and a second consumption current value during operation of the second partial circuit. A design support apparatus compares the surplus current value and the first consumption current value. When determining that the surplus current value is the first consumption current value or greater, the design support apparatus controls a layout apparatus to generate circuit information for a circuit under design where a power-supplying terminal of the second partial circuit and a power source terminal of the first partial circuit are connected.

Abstract: A semiconductor integrated circuit includes: a phase locked loop circuit which outputs a clock signal; an internal circuit which executes processing; a capacitor; and a switch circuit which connects the capacitor to either of the phase locked loop circuit and the internal circuit.

Abstract: [Problem] To provide a target substance detection chip, a target substance detection device, and a target substance detection method, that can be manufactured easily in a small size at low costs with reduction of the number of parts involved in the detection chip constituted by an optical prism and a detection plate used for a SPR sensor and an optical waveguide mode sensor, that can detect a target substance quickly with high sensitivity, and in which an analyte liquid is easily delivered.