Abstract: Knee implants having a convex outer surface formed of a stack of sheets of bacterial cellulose that is between 2-10 mm thick and has been impregnated and crosslinked to form a hydrogel having a concentration of cross-linked bacterial cellulose nanofibers of between 2-20 weight % of the hydrogel, so that the hydrogel has a tensile strength of greater than 5 MPa, a tensile modulus of greater than 8 MPa, and a compression strength of greater than 14 MPa. The implant may have a metallic body and may be generally mushroom-shaped.

Abstract: Artificial cartilage materials for repair and replacement of cartilage (e.g., load-bearing, articular cartilage). The artificial cartilage materials described herein include triple-network hydrogels including a cross-linked fiber network (e.g., a bacterial cellulose nanofiber network) and a double-network hydrogel (e.g., a double-network hydrogel including polfacrylamide-methyl propyl sulfonic acid). The artificial cartilage may be coated onto or formed into an implant (e.g., plug). The artificial cartilage may include a surface macroporosity, e.g., 0.1-300 micrometers diameter. Also described herein are methods of forming and methods of using the triple-network hydrogel artificial cartilage materials.

Abstract: A method includes forming a mixture including a therapeutic agent and a solid delivery medium, injecting the mixture into a reservoir within an orthopedic implant body, and storing the injected mixture in the reservoir.

Abstract: An orthopedic implant device includes an implant body with a reservoir configured store a therapeutic agent. A wall of the implant body has opposite side surfaces, including a side surface facing into the reservoir. Elution channels reach from the reservoir through the body wall. The elution channels include an elongated channel traversing a thickness of the body wall between the opposite side surfaces. The elongated channel may have a length greater than twice the thickness.

Abstract: A method includes forming a mixture including a therapeutic agent and a solid delivery medium, injecting the mixture into a reservoir within an orthopedic implant body, and storing the injected mixture in the reservoir.

Abstract: A fixation device is disclosed. The fixation device includes a first component and a second component. The first component has a top surface, a base, at least one locking projection, and at least one tapered projection extending from the top surface. The at least one locking projection includes a first locking element. The fixation device further includes a second component having a top surface, a base, at least one locking aperture, and at least one second aperture corresponding to the projections on the first component. The at least one locking apertures includes a second locking element. In some embodiments, the at least one locking projection on the first component is configured to lock together with the at least one locking aperture on the second component to secure together two ends of a surgical mesh suture or tape suture.

Abstract: A polymer is composed of a linear chain acrylate and a multi-functional acrylate cross-linker. The polymerized composition exhibits a transition at a temperature between about 34° C. and about 50° C. The polymerized composition exhibits shape memory effects. In one embodiment, the linear chain is tert-butyl acrylate and the crosslinker is polyethylene glycol dimethacrylate. The resultant shape memory polymers may be used in medical devices to provide devices with different shapes for pre and post implantation.

Abstract: A synchrocyclotron comprises a resonant circuit that includes electrodes having a gap therebetween across the magnetic field. An oscillating voltage input, having a variable amplitude and frequency determined by a programmable digital waveform generator generates an oscillating electric field across the gap. The synchrocyclotron can include a variable capacitor in circuit with the electrodes to vary the resonant frequency. The synchrocyclotron can further include an injection electrode and an extraction electrode having voltages controlled by the programmable digital waveform generator. The synchrocyclotron can further include a beam monitor. The synchrocyclotron can detect resonant conditions in the resonant circuit by measuring the voltage and or current in the resonant circuit, driven by the input voltage, and adjust the capacitance of the variable capacitor or the frequency of the input voltage to maintain the resonant conditions.

Abstract: A system includes a patient support and an outer gantry on which an accelerator is mounted to enable the accelerator to move through a range of positions around a patient on the patient support. The accelerator is configured to produce a proton or ion beam having an energy level sufficient to reach a target in the patient. An inner gantry includes an aperture for directing the proton or ion beam towards the target.

Abstract: A system includes a patient support and an outer gantry on which an accelerator is mounted to enable the accelerator to move through a range of positions around a patient on the patient support. The accelerator is configured to produce a proton or ion beam having an energy level sufficient to reach a target in the patient. An inner gantry includes a robotic arm capable of directing an aperture for directing the proton or ion beam towards the target.

Abstract: Methods of manufacturing a three-dimensional, biodegradable, thermoset polymeric network composition having desirable degradation and mechanical properties, comprising a macromer component cross-linked with a monofunctional acrylate-containing component. The macromer component can comprise a diacrylate-containing component polymerized with an amine-containing component, wherein the molar ratio of the diacrylate-containing component to the amine-containing component is greater than or equal to 1.

Abstract: Provided herein are shape memory polymer spinal cages including polymers with intended deployment at temperatures far below the onset of the glassy transition of the shape memory polymer. The described shape memory polymer spinal cages are adapted to be deployed by mechanical activation rather than thermal activation or activation by other stimuli. Thus, the shape memory polymers used herein are configured to have transition temperatures far above their temperatures of intended use, thereby requiring mechanical activation to recover stored strains.

Abstract: A polymer is composed of a linear chain acrylate and a multi-functional acrylate cross-linker. The polymerized composition exhibits a transition at a temperature between about 34° C. and about 50° C. The polymerized composition exhibits shape memory effects. In one embodiment, the linear chain is tert-butyl acrylate and the crosslinker is polyethylene glycol dimethacrylate. The resultant shape memory polymers may be used in medical devices to provide devices with different shapes for pre and post implantation.

Abstract: Intramedullary medical devices (e.g., intramedullary nails) and methods for their use and manufacture are described herein. The intramedullary medical devices described herein may provide sustained compressive forces across a bone fusion site despite bone resorption processes. Through various embodiments, the intramedullary medical devices described herein may provide non-linear force curves relative to displacement. Intramedullary medical devices are described with multiple elements made of different materials. Examples of intramedullary medical devices are described with shape memory alloys.

Abstract: A synchrocyclotron includes magnetic structures to provide a magnetic field to a cavity, a particle source to provide a plasma column to the cavity, where the particle source has a housing to hold the plasma column, and where the housing is interrupted at an acceleration region to expose the plasma column, and a voltage source to provide a radio frequency (RF) voltage to the cavity to accelerate particles from the plasma column at the acceleration region.

Abstract: Methods and apparatus described herein may utilize activation of an SMP material to install medical devices with respect to a surgical site. Activation of the SMP material may be performed with the use of a triggering force and/or a constraint applied to the SMP material. Activation using a triggering force and/or a constraint may be used to create varied activation rates in an SMP material and varying speeds and times of activation to occur in shape memory polymers in devices. The disclosure also describes devices using wedge elements for activation of shape memory response in the SMP material.

Abstract: Intramedullary medical devices (e.g., intramedullary nails) and methods for their use and manufacture are described herein. The intramedullary medical devices described herein may provide sustained compressive forces across a bone fusion site despite bone resorption processes. Through various embodiments, the intramedullary medical devices described herein may provide non-linear force curves relative to displacement. Intramedullary medical devices are described with multiple elements made of different materials. Examples of intramedullary medical devices are described with shape memory alloys.

Abstract: A synchrocyclotron comprises a resonant circuit that includes electrodes having a gap therebetween across the magnetic field. An oscillating voltage input, having a variable amplitude and frequency determined by a programmable digital waveform generator generates an oscillating electric field across the gap. The synchrocyclotron can include a variable capacitor in circuit with the electrodes to vary the resonant frequency. The synchrocyclotron can further include an injection electrode and an extraction electrode having voltages controlled by the programmable digital waveform generator. The synchrocyclotron can further include a beam monitor. The synchrocyclotron can detect resonant conditions in the resonant circuit by measuring the voltage and or current in the resonant circuit, driven by the input voltage, and adjust the capacitance of the variable capacitor or the frequency of the input voltage to maintain the resonant conditions.

Abstract: A synchrocyclotron comprises includes a resonant circuit that includes electrodes having a gap therebetween across the magnetic field. An oscillating voltage input, having a variable amplitude and frequency determined by a programmable digital waveform generator generates an oscillating electric field across the gap. The synchrocyclotron can include a variable capacitor in circuit with the electrodes to vary the resonant frequency. The synchrocyclotron can further include an injection electrode and an extraction electrode having voltages controlled by the programmable digital waveform generator. The synchrocyclotron can further include a beam monitor. The synchrocyclotron can detect resonant conditions in the resonant circuit by measuring the voltage and or and/or current in the resonant circuit, driven by the input voltage, and adjust the capacitance of the variable capacitor or the frequency of the input voltage to maintain the resonant conditions.