Programmable radio frequency waveform generator for a synchrocyclotron

A synchrocyclotron comprises a resonant circuit that includes electrodes having a gap therebetween across the magnetic field. An oscillating voltage input, having a variable amplitude and frequency determined by a programmable digital waveform generator generates an oscillating electric field across the gap. The synchrocyclotron can include a variable capacitor in circuit with the electrodes to vary the resonant frequency. The synchrocyclotron can further include an injection electrode and an extraction electrode having voltages controlled by the programmable digital waveform generator. The synchrocyclotron can further include a beam monitor. The synchrocyclotron can detect resonant conditions in the resonant circuit by measuring the voltage and or current in the resonant circuit, driven by the input voltage, and adjust the capacitance of the variable capacitor or the frequency of the input voltage to maintain the resonant conditions. The programmable waveform generator can adjust at least one of the oscillating voltage input, the voltage on the injection electrode and the voltage on the extraction electrode according to beam intensity and in response to changes in resonant conditions.

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Description
RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No. 12/011,466, filed Jan. 25, 2008 now U.S. Pat. No. 7,626,347, which is a continuation of U.S. application Ser. No. 11/371,622, filed Mar. 9, 2006, now U.S. Pat. No. 7,402,963, which is a continuation of U.S. application Ser. No. 11/187,633, filed Jul. 21, 2005, now abandoned, which claims the benefit of U.S. Provisional Application No. 60/590,089, filed on Jul. 21, 2004.

The entire teachings of the above applications are incorporated herein by reference.

BACKGROUND OF THE INVENTION

In order to accelerate charged particles to high energies, many types of particle accelerators have been developed since the 1930s. One type of particle accelerator is a cyclotron. A cyclotron accelerates charged particles in an axial magnetic field by applying an alternating voltage to one or more “dees” in a vacuum chamber. The name “dee” is descriptive of the shape of the electrodes in early cyclotrons, although they may not resemble the letter D in some cyclotrons. The spiral path produced by the accelerating particles is normal to the magnetic field. As the particles spiral out, an accelerating electric field is applied at the gap between the dees. The radio frequency (RF) voltage creates an alternating electric field across the gap between the dees. The RF voltage, and thus the field, is synchronized to the orbital period of the charged particles in the magnetic field so that the particles are accelerated by the radio frequency waveform as they repeatedly cross the gap. The energy of the particles increases to an energy level far in excess of the peak voltage of the applied radio frequency (RF) voltage. As the charged particles accelerate, their masses grow due to relativistic effects. Consequently, the acceleration of the particles becomes non-uniform and the particles arrive at the gap asynchronously with the peaks of the applied voltage.

Two types of cyclotrons presently employed, an isochronous cyclotron and a synchrocyclotron, overcome the challenge of increase in relativistic mass of the accelerated particles in different ways. The isochronous cyclotron uses a constant frequency of the voltage with a magnetic field that increases with radius to maintain proper acceleration. The synchrocyclotron uses a decreasing magnetic field with increasing radius and varies the frequency of the accelerating voltage to match the mass increase caused by the relativistic velocity of the charged particles.

In a synchrocyclotron, discrete “bunches” of charged particles are accelerated to the final energy before the cycle is started again. In isochronous cyclotrons, the charged particles can be accelerated continuously, rather than in bunches, allowing higher beam power to be achieved.

In a synchrocyclotron, capable of accelerating a proton, for example, to the energy of 250 MeV, the final velocity of protons is 0.61 c, where c is the speed of light, and the increase in mass is 27% above rest mass. The frequency has to decrease by a corresponding amount, in addition to reducing the frequency to account for the radially decreasing magnetic field strength. The frequency's dependence on time will not be linear, and an optimum profile of the function that describes this dependence will depend on a large number of details.

SUMMARY OF THE INVENTION

Accurate and reproducible control of the frequency over the range required by a desired final energy that compensates for both relativistic mass increase and the dependency of magnetic field on the distance from the center of the dee has historically been a challenge. Additionally, the amplitude of the accelerating voltage may need to be varied over the accelerating cycle to maintain focusing and increase beam stability. Furthermore, the dees and other hardware comprising a cyclotron define a resonant circuit, where the dees may be considered the electrodes of a capacitor. This resonant circuit is described by Q-factor, which contributes to the profile of voltage across the gap.

A synchrocyclotron for accelerating charged particles, such as protons, can comprise a magnetic field generator and a resonant circuit that comprising electrodes, disposed between magnetic poles. A gap between the electrodes can be disposed across the magnetic field. An oscillating voltage input drives an oscillating electric field across the gap. The oscillating voltage input can be controlled to vary over the time of acceleration of the charged particles. Either or both the amplitude and the frequency of the oscillating voltage input can be varied. The oscillating voltage input can be generated by a programmable digital waveform generator.

The resonant circuit can further include a variable reactive element in circuit with the voltage input and electrodes to vary the resonant frequency of the resonant circuit. The variable reactive element may be a variable capacitance element such as a rotating condenser or a vibrating reed. By varying the reactance of such a reactive element and adjusting the resonant frequency of the resonant circuit, the resonant conditions can be maintained over the operating frequency range of the synchrocyclotron.

The synchrocyclotron can further include a voltage sensor for measuring the oscillating electric field across the gap. By measuring the oscillating electric field across the gap and comparing it to the oscillating voltage input, resonant conditions in the resonant circuit can be detected. The programmable waveform generator can be adjusting the voltage and frequency input to maintain the resonant conditions.

The synchrocyclotron can further include an injection electrode, disposed between the magnetic poles, under a voltage controlled by the programmable digital waveform generator. The injection electrode is used for injecting charged particles into the synchrocyclotron. The synchrocyclotron can further including an extraction electrode, disposed between the magnetic poles, under a voltage controlled by the programmable digital waveform generator. The extraction electrode is used to extract a particle beam from the synchrocyclotron.

The synchrocyclotron can further include a beam monitor for measuring particle beam properties. For example, the beam monitor can measure particle beam intensity, particle beam timing or spatial distribution of the particle beam. The programmable waveform generator can adjust at least one of the voltage input, the voltage on the injection electrode and the voltage on the extraction electrode to compensate for variations in the particle beam properties.

This invention is intended to address the generation of the proper variable frequency and amplitude modulated signals for efficient injection into, acceleration by, and extraction of charged particles from an accelerator.

BRIEF DESCRIPTION OF THE DRAWINGS

The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the invention.

FIG. 1A is a plan cross-sectional view of a synchrocyclotron of the present invention.

FIG. 1B is a side cross-sectional view of the synchrocyclotron shown in FIG. 1A.

FIG. 2 is an illustration of an idealized waveform that can be used for accelerating charged particles in a synchrocyclotron shown in FIGS. 1A and 1B.

FIG. 3A depicts a portion of a block diagram of a synchrocyclotron of the present invention that includes a waveform generator system.

FIG. 3B depicts a portion of a block diagram of a synchrocyclotron of the present invention that includes a waveform generator system.

FIG. 4 is a flow chart illustrating the principles of operation of a digital waveform generator and an adaptive feedback system (optimizer) of the present invention.

FIG. 5A shows the effect of the finite propagation delay of the signal across different paths in an accelerating electrode (“dee”) structure.

FIG. 5B shows the input waveform timing adjusted to correct for the variation in propagation delay across the “dee” structure.

FIG. 6A shows an illustrative frequency response of the resonant system with variations due to parasitic circuit effects.

FIG. 6B shows a waveform calculated to correct for the variations in frequency response due to parasitic circuit effects.

FIG. 6C shows the resulting “flat” frequency response of the system when the waveform shown in FIG. 6B is used as input voltage.

FIG. 7A shows a constant amplitude input voltage applied to the accelerating electrodes shown in FIG. 7B.

FIG. 7B shows an example of the accelerating electrode geometry wherein the distance between the electrodes is reduced toward the center.

FIG. 7C shows the desired and resultant electric field strength in the electrode gap as a function of radius that achieves a stable and efficient acceleration of charged particles by applying input voltage as shown in FIG. 7A to the electrode geometry shown in FIG. 7B.

FIG. 7D shows input voltage input as a function of radius that directly corresponds to the electric field strength desired and can be produced using a digital waveform generator.

FIG. 7E shows a parallel geometry of the accelerating electrodes which gives a direct proportionality between applied voltage and electric field strength.

FIG. 7F shows the desired and resultant electric field strength in the electrode gap as a function of radius that achieves a stable and efficient acceleration of charged particles by applying input voltage as shown in FIG. 7D to the electrode geometry shown in FIG. 7E.

FIG. 8A shows an example of a waveform of the accelerating voltage generated by the programmable waveform generator.

FIG. 8B shows an example of a timed ion injector signal.

FIG. 8C shows another example of a timed ion injector signal.

DETAILED DESCRIPTION OF THE INVENTION

This invention relates to the devices and methods for generating the complex, precisely timed accelerating voltages across the “dee” gap in a synchrocyclotron. This invention comprises an apparatus and a method for driving the voltage across the “dee” gap by generating a specific waveform, where the amplitude, frequency and phase is controlled in such a manner as to create the most effective particle acceleration given the physical configuration of the individual accelerator, the magnetic field profile, and other variables that may or may not be known a priori. A synchrocyclotron needs a decreasing magnetic field in order to maintain focusing of the particles beam, thereby modifying the desired shape of the frequency sweep. There are predictable finite propagation delays of the applied electrical signal to the effective point on the dee where the accelerating particle bunch experiences the electric field that leads to continuous acceleration. The amplifier used to amplify the radio frequency (RF) signal that drives the voltage across the dee gap may also have a phase shift that varies with frequency. Some of the effects may not be known a priori, and may be only observed after integration of the entire synchrocyclotron. In addition, the timing of the particle injection and extraction on a nanosecond time scale can increase the extraction efficiency of the accelerator, thus reducing stray radiation due to particles lost in the accelerating and extraction phases of operation.

Referring to FIGS. 1A and 1B, a synchrocyclotron of the present invention comprises electrical coils 2a and 2b around two spaced apart metal magnetic poles 4a and 4b configured to generate a magnetic field. Magnetic poles 4a and 4b are defined by two opposing portions of yoke 6a and 6b (shown in cross-section). The space between poles 4a and 4b defines vacuum chamber 8 or a separate vacuum chamber can be installed between the poles 4a and 4b. The magnetic field strength is generally a function of distance from the center of vacuum chamber 8 and is determined largely by the choice of geometry of coils 2a and 2b and shape and material of magnetic poles 4a and 4b.

The accelerating electrodes comprise “dee” 10 and “dee” 12, having gap 13 therebetween. Dee 10 is connected to an alternating voltage potential whose frequency is changed from high to low during the accelerating cycle in order to account for the increasing relativistic mass of a charged particle and radially decreasing magnetic field (measured from the center of vacuum chamber 8) produced by coils 2a and 2b and pole portions 4a and 4b. The characteristic profile of the alternating voltage in dees 10 and 12 is show in FIG. 2 and will be discussed in details below. Dee 10 is a half-cylinder structure, hollow inside. Dee 12, also referred to as the “dummy dee”, does not need to be a hollow cylindrical structure as it is grounded at the vacuum chamber walls 14. Dee 12 as shown in FIGS. 1A and 1B comprises a strip of metal, e.g. copper, having a slot shaped to match a substantially similar slot in dee 10. Dee 12 can be shaped to form a mirror image of surface 16 of dee 10.

Ion source 18 that includes ion source electrode 20, located at the center of vacuum chamber 8, is provided for injecting charged particles. Extraction electrodes 22 are provided to direct the charge particles into extraction channel 24, thereby forming beam 26 of the charged particles. The ion source may also be mounted externally and inject the ions substantially axially into the acceleration region.

Dees 10 and 12 and other pieces of hardware that comprise a cyclotron, define a tunable resonant circuit under an oscillating voltage input that creates an oscillating electric field across gap 13. This resonant circuit can be tuned to keep the Q-factor high during the frequency sweep by using a tuning means.

As used herein, Q-factor is a measure of the “quality” of a resonant system in its response to frequencies close to the resonant frequency. Q-factor is defined as
Q=1/R×√(L/C),
where R is the active resistance of a resonant circuit, L is the inductance and C is the capacitance of this circuit.

Tuning means can be either a variable inductance coil or a variable capacitance. A variable capacitance device can be a vibrating reed or a rotating condenser. In the example shown in FIGS. 1A and 1B, the tuning means is rotating condenser 28. Rotating condenser 28 comprises rotating blades 30 driven by a motor 31. During each quarter cycle of motor 31, as blades 30 mesh with blades 32, the capacitance of the resonant circuit that includes “dees” 10 and 12 and rotating condenser 28 increases and the resonant frequency decreases. The process reverses as the blades unmesh. Thus, resonant frequency is changed by changing the capacitance of the resonant circuit. This serves the purpose of reducing by a large factor the power required to generate the high voltage applied to the “dees” and necessary to accelerate the beam. The shape of blades 30 and 32 can be machined so as to create the required dependence of resonant frequency on time.

The blade rotation can be synchronized with the RF frequency generation so that by varying the Q-factor of the RF cavity, the resonant frequency of the resonant circuit, defined by the cyclotron, is kept close to the frequency of the alternating voltage potential applied to “dees” 10 and 12.

The rotation of the blades can be controlled by the digital waveform generator, described below with reference to FIG. 3 and FIG. 4, in a manner that maintains the resonant frequency of the resonant circuit close to the current frequency generated by the digital waveform generator. Alternatively, the digital waveform generator can be controlled by means of an angular position sensor (not shown) on the rotating condenser shaft 33 to control the clock frequency of the waveform generator to maintain the optimum resonant condition. This method can be employed if the profile of the meshing blades of the rotating condenser is precisely related to the angular position of the shaft.

A sensor that detects the peak resonant condition (not shown) can also be employed to provide feedback to the clock of the digital waveform generator to maintain the highest match to the resonant frequency. The sensors for detecting resonant conditions can measure the oscillating voltage and current in the resonant circuit. In another example, the sensor can be a capacitance sensor. This method can accommodate small irregularities in the relationship between the profile of the meshing blades of the rotating condenser and the angular position of the shaft.

A vacuum pumping system 40 maintains vacuum chamber 8 at a very low pressure so as not to scatter the accelerating beam.

To achieve uniform acceleration in a synchrocyclotron, the frequency and the amplitude of the electric field across the “dee” gap needs to be varied to account for the relativistic mass increase and radial (measured as distance from the center of the spiral trajectory of the charged particles) variation of magnetic field as well as to maintain focus of the beam of particles.

FIG. 2 is an illustration of an idealized waveform that may be required for accelerating charged particles in a synchrocyclotron. It shows only a few cycles of the waveform and does not necessarily represent the ideal frequency and amplitude modulation profiles. FIG. 2 illustrates the time varying amplitude and frequency properties of the waveform used in a given synchrocyclotron. The frequency changes from high to low as the relativistic mass of the particle increases while the particle speed approaches a significant fraction of the speed of light.

The instant invention uses a set of high speed digital to analog converters (DAC) that can generate, from a high speed memory, the required signals on a nanosecond time scale. Referring to FIG. 1A, both a radio frequency (RF) signal that drives the voltage across dee gap 13 and signals that drive the voltage on injector electrode 20 and extractor electrode 22 can be generated from the memory by the DACs. The accelerator signal is a variable frequency and amplitude waveform. The injector and extractor signals can be either of at least three types: continuous; discrete signals, such as pulses, that may operate over one or more periods of the accelerator waveform in synchronism with the accelerator waveform; or discrete signals, such as pulses, that may operate at precisely timed instances during the accelerator waveform frequency sweep in synchronism with the accelerator waveform. (See below with reference to FIGS. 8A-C.)

FIG. 3 depicts a block diagram of a synchrocyclotron of the present invention 300 that includes particle accelerator 302, waveform generator system 319 and amplifying system 330. FIG. 3 also shows an adaptive feedback system that includes optimizer 350. The optional variable condenser 28 and drive subsystem to motor 31 are not shown.

Referring to FIG. 3, particle accelerator 302 is substantially similar to the one depicted in FIGS. 1A and 1B and includes “dummy dee” (grounded dee) 304, “dee” 306 and yoke 308, injection electrode 310, connected to ion source 312, and extraction electrodes 314. Beam monitor 316 monitors the intensity of beam 318.

Synchrocyclotron 300 includes digital waveform generator 319. Digital waveform generator 319 comprises one or more digital-to-analog converters (DACs) 320 that convert digital representations of waveforms stored in memory 322 into analog signals. Controller 324 controls addressing of memory 322 to output the appropriate data and controls DACs 320 to which the data is applied at any point in time. Controller 324 also writes data to memory 322. Interface 326 provides a data link to an outside computer (not shown). Interface 326 can be a fiber optic interface.

The clock signal that controls the timing of the “analog-to-digital” conversion process can be made available as an input to the digital waveform generator. This signal can be used in conjunction with a shaft position encoder (not shown) on the rotating condenser (see FIGS. 1A and 1B) or a resonant condition detector to fine-tune the frequency generated.

FIG. 3 illustrates three DACs 320a, 320b and 320c. In this example, signals from DACs 320a and 320b are amplified by amplifiers 328a and 328b, respectively. The amplified signal from DAC 320a drives ion source 312 and/or injection electrode 310, while the amplified signal from DAC 320b drives extraction electrodes 314.

The signal generated by DAC 320c is passed on to amplifying system 330, operated under the control of RF amplifier control system 332. In amplifying system 330, the signal from DAC 320c is applied by RF driver 334 to RF splitter 336, which sends the RF signal to be amplified by an RF power amplifier 338. In the example shown in FIG. 3, four power amplifiers, 338a, b, c and d, are used. Any number of amplifiers 338 can be used depending on the desired extent of amplification. The amplified signal, combined by RF combiner 340 and filtered by filter 342, exits amplifying system 330 though directional coupler 344, which ensures that RF waves do not reflect back into amplifying system 330. The power for operating amplifying system 330 is supplied by power supply 346.

Upon exit from amplifying system 330, the signal from DAC 320c is passed on to particle accelerator 302 through matching network 348. Matching network 348 matches impedance of a load (particle accelerator 302) and a source (amplifying system 330). Matching network 348 includes a set of variable reactive elements.

Synchrocyclotron 300 can further include optimizer 350. Using measurement of the intensity of beam 318 by beam monitor 316, optimizer 350, under the control of a programmable processor can adjust the waveforms produced by DACs 320a, b and c and their timing to optimize the operation of the synchrocyclotron 300 and achieve a optimum acceleration of the charged particles.

The principles of operation of digital waveform generator 319 and adaptive feedback system 350 will now be discussed with reference to FIG. 4.

The initial conditions for the waveforms can be calculated from physical principles that govern the motion of charged particles in magnetic field, from relativistic mechanics that describe the behavior of a charged particle mass as well as from the theoretical description of magnetic field as a function of radius in a vacuum chamber. These calculations are performed at step 402. The theoretical waveform of the voltage at the dee gap, RF(ω, t), where ω is the frequency of the electrical field across the dee gap and t is time, is computed based on the physical principles of a cyclotron, relativistic mechanics of a charged particle motion, and theoretical radial dependency of the magnetic field.

Departures of practice from theory can be measured and the waveform can be corrected as the synchrocyclotron operates under these initial conditions. For example, as will be described below with reference to FIGS. 8A-C, the timing of the ion injector with respect to the accelerating waveform can be varied to maximize the capture of the injected particles into the accelerated bunch of particles.

The timing of the accelerator waveform can be adjusted and optimized, as described below, on a cycle-by-cycle basis to correct for propagation delays present in the physical arrangement of the radio frequency wiring; asymmetry in the placement or manufacture of the dees can be corrected by placing the peak positive voltage closer in time to the subsequent peak negative voltage or vice versa, in effect creating an asymmetric sine wave.

In general, waveform distortion due to characteristics of the hardware can be corrected by pre-distorting the theoretical waveform RF(ω, t) using a device-dependent transfer function A, thus resulting in the desired waveform appearing at the specific point on the acceleration electrode where the protons are in the acceleration cycle. Accordingly, and referring again to FIG. 4, at step 404, a transfer function A(ω, t) is computed based on experimentally measured response of the device to the input voltage.

At step 405, a waveform that corresponds to an expression RF(ω, t)/A(ω,t) is computed and stored in memory 322. At step 406, digital waveform generator 319 generates RF /A waveform from memory. The driving signal RF(ω, t)/A(ω, t) is amplified at step 408, and the amplified signal is propagated through the entire device 300 at step 410 to generate a voltage across the dee gap at step 412. A more detailed description of a representative transfer function A(ω,t) will be given below with reference to FIGS. 6A-C.

After the beam has reached the desired energy, a precisely timed voltage can be applied to an extraction electrode or device to create the desired beam trajectory in order to extract the beam from the accelerator, where it is measured by beam monitor at step 414a. RF voltage and frequency is measured by voltage sensors at step 414b. The information about beam intensity and RF frequency is relayed back to digital waveform generator 319, which can now adjust the shape of the signal RF(ω, t)/A(ω, t) at step 406.

The entire process can be controlled at step 416 by optimizer 350. Optimizer 350 can execute a semi- or fully automatic algorithm designed to optimize the waveforms and the relative timing of the waveforms. Simulated annealing is an example of a class of optimization algorithms that may be employed. On-line diagnostic instruments can probe the beam at different stages of acceleration to provide feedback for the optimization algorithm. When the optimum conditions have been found, the memory holding the optimized waveforms can be fixed and backed up for continued stable operation for some period of time. This ability to adjust the exact waveform to the properties of the individual accelerator decreases the unit-to-unit variability in operation and can compensate for manufacturing tolerances and variation in the properties of the materials used in the construction of the cyclotron.

The concept of the rotating condenser (such as condenser 28 shown in FIGS. 1A and 1B) can be integrated into this digital control scheme by measuring the voltage and current of the RF waveform in order to detect the peak of the resonant condition. The deviation from the resonant condition can be fed back to the digital waveform generator 319 (see FIG. 3) to adjust the frequency of the stored waveform to maintain the peak resonant condition throughout the accelerating cycle. The amplitude can still be accurately controlled while this method is employed.

The structure of rotating condenser 28 (see FIGS. 1A and 1B) can optionally be integrated with a turbomolecular vacuum pump, such as vacuum pump 40 shown in FIGS. 1A and 1B, that provides vacuum pumping to the accelerator cavity. This integration would result in a highly integrated structure and cost savings. The motor and drive for the turbo pump can be provided with a feedback element such as a rotary encoder to provide fine control over the speed and angular position of rotating blades 30, and the control of the motor drive would be integrated with the waveform generator 319 control circuitry to insure proper synchronization of the accelerating waveform.

As mentioned above, the timing of the waveform of the oscillating voltage input can be adjusted to correct for propagation delays that arise in the device. FIG. 5A illustrate an example of wave propagation errors due to the difference in distances R1 and R2 from the RF input point 504 to points 506 and 508, respectively, on the accelerating surface 502 of accelerating electrode 500. The difference in distances R1 and R2 results in signal propagation delay that affects the particles as they accelerate along a spiral path (not shown) centered at point 506. If the input waveform, represented by curve 510, does not take into account the extra propagation delay caused by the increasing distance, the particles can go out of synchronization with the accelerating waveform. The input waveform 510 at point 504 on the accelerating electrode 500 experiences a variable delay as the particles accelerate outward from the center at point 506. This delay results in input voltage having waveform 512 at point 506, but a differently timed waveform 514 at point 508. Waveform 514 shows a phase shift with respect to waveform 512 and this can affect the acceleration process. As the physical size of the accelerating structure (about 0.6 meters) is a significant fraction of the wavelength of the accelerating frequency (about 2 meters), a significant phase shift is experienced between different parts of the accelerating structure.

In FIG. 5B, the input voltage having waveform 516 is pre-adjusted relative to the input voltage described by waveform 510 to have the same magnitude, but opposite sign of time delay. As a result, the phase lag caused by the different path lengths across the accelerating electrode 500 is corrected. The resulting waveforms 518 and 520 are now correctly aligned so as to increase the efficiency of the particle accelerating process. This example illustrates a simple case of propagation delay caused by one easily predictable geometric effect. There may be other waveform timing effects that are generated by the more complex geometry used in the actual accelerator, and these effects, if they can be predicted or measured can be compensated for by using the same principles illustrated in this example.

As described above, the digital waveform generator produces an oscillating input voltage of the form RF(ω, t)/A(ω, t), where RF(ω, t) is a desired voltage across the dee gap and A(ω, t) is a transfer function. A representative device-specific transfer function A, is illustrated by curve 600 in FIG. 6A. Curve 600 shows Q-factor as a function of frequency. Curve 600 has two unwanted deviations from an ideal transfer function, namely troughs 602 and 604. These deviation can be caused by effects due to the physical length of components of the resonant circuit, unwanted self-resonant characteristics of the components or other effects. This transfer function can be measured and a compensating input voltage can be calculated and stored in the waveform generator's memory. A representation of this compensating function 610 is shown in FIG. 6B. When the compensated input voltage 610 is applied to device 300, the resulting voltage 620 is uniform with respect to the desired voltage profile calculated to give efficient acceleration.

Another example of the type of effects that can be controlled with the programmable waveform generator is shown in FIG. 7. In some synchrocyclotrons, the electric field strength used for acceleration can be selected to be somewhat reduced as the particles accelerate outward along spiral path 705. This reduction in electric field strength is accomplished by applying accelerating voltage 700, that is kept relatively constant as shown in FIG. 7A, to accelerating electrode 702. Electrode 704 is usually at ground potential. The electric field strength in the gap is the applied voltage divided by the gap length. As shown in FIG. 7B, the distance between accelerating electrodes 702 and 704 is increasing with radius R. The resulting electric field strength as a function or radius R is shown as curve 706 in FIG. 7C.

With the use of the programmable waveform generator, the amplitude of accelerating voltage 708 can be modulated in the desired fashion, as shown in FIG. 7D. This modulation allows to keep the distance between accelerating electrodes 710 and 712 to remain constant, as shown in FIG. 7E. As a result, the same resulting electric field strength as a function of radius 714, shown in FIG. 7F, is produced as shown in FIG. 7C. While this is a simple example of another type of control over synchrocyclotron system effects, the actual shape of the electrodes and profile of the accelerating voltage versus radius may not follow this simple example.

As mentioned above, the programmable waveform generator can be used to control the ion injector (ion source) to achieve optimal acceleration of the charged particles by precisely timing particle injections. FIG. 8A shows the RF accelerating waveform generated by the programmable waveform generator. FIG. 8B shows a precisely timed cycle-by-cycle injector signal that can drive the ion source in a precise fashion to inject a small bunch of ions into the accelerator cavity at precisely controlled intervals in order to synchronize with the acceptance phase angle of the accelerating process. The signals are shown in approximately the correct alignment, as the bunches of particles are usually traveling through the accelerator at about a 30 degree lag angle compared to the RF electric field waveform for beam stability. The actual timing of the signals at some external point such as the output of the digital-to-analog converters, may not have this exact relationship as the propagation delays of the two signals is likely to be different. With the programmable waveform generator, the timing of the injection pulses can be continuously varied with respect to the RF waveform in order to optimize the coupling of the injected pulses into the accelerating process. This signal can be enabled or disabled to turn the beam on and off. The signal can also be modulated via pulse dropping techniques to maintain a required average beam current. This beam current regulation is accomplished by choosing a macroscopic time interval that contains some relatively large number of pulses, on the order of 1000,and changing the fraction of pulses that are enabled during this interval.

FIG. 8C shows a longer injection control pulse that corresponds to a multiple number of RF cycles. This pulse is generated when a bunch of protons are to be accelerated. The periodic acceleration process captures only a limited number of particles that will be accelerated to the final energy and extracted. Controlling the timing of the ion injection can result in lower gas load and consequently better vacuum conditions which reduces vacuum pumping requirements and improves high voltage and beam loss properties during the acceleration cycle. This can be used where the precise timing of the injection shown in FIG. 8B is not required for acceptable coupling of the ion source to the RF waveform phase angle. This approach injects ions for a number of RF cycles which corresponds approximately to the number of “turns” which are accepted by the accelerating process in the synchrocyclotron. This signal is also enabled or disabled to turn the beam on and off or modulate the average beam current.

While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.

Claims

1. A synchrocyclotron comprising:

a magnetic field generator;
a resonant circuit, comprising: electrodes, disposed between magnetic poles, having a gap therebetween across a magnetic field; and a variable reactive element in circuit with the electrodes to vary a resonant frequency of the resonant circuit; and
a voltage input generator to provide a voltage input to the resonant circuit, the voltage input being an oscillating voltage that varies in frequency over a time of acceleration of charged particles.

2. The synchrocyclotron as claimed in claim 1 wherein an amplitude of the voltage input is varied.

3. The synchrocyclotron of claim 1 further including an ion source for injecting charged particles into the synchrocyclotron.

4. The synchrocyclotron of claim 1 further including an extraction electrode disposed between the magnetic poles for extracting a particle beam from the synchrocyclotron.

5. The synchrocyclotron of claim 1 further including a sensor for detecting resonant conditions in the resonant circuit.

6. The synchrocyclotron of claim 5 further including means for adjusting at least one of a frequency of the voltage input, reactance of the variable reactive element, and resonant frequency of the resonant circuit based on the resonant conditions.

7. The synchrocyclotron of claim 1 further including a beam monitor for detecting a particle beam extracted from the synchrocyclotron.

8. The synchrocyclotron of claim 7 wherein the beam monitor is configured to measure at least one of particle beam intensity, particle beam timing, and spatial distribution of the particle beam.

9. The synchrocyclotron as claimed in claim 1 further including a programmable digital waveform generator for generating the oscillating voltage.

10. The synchrocyclotron of claim 9 wherein the programmable waveform generator is configured to compensate for at least one of variations in resonant conditions of the resonant circuit and variations in a particle beam extracted from the synchrocyclotron.

11. A method of accelerating particles in a synchrocyclotron, comprising:

providing particles in the synchrocyclotron;
providing a resonant circuit, the resonant circuit comprising accelerating electrodes having a gap therebetween across a magnetic field; and
with a voltage input generator, applying an oscillating voltage input that varies in frequency during acceleration of the particles to the resonant circuit, the oscillating voltage input creating an oscillating electric field across the gap that accelerates the particles in the synchrocyclotron.

12. The method as in claim 11, further including generating the oscillating voltage input.

13. The method of claim 11, further including varying an amplitude of the oscillating voltage input.

14. The method of claim 11, wherein providing particles includes injecting particles into the synchrocyclotron.

15. The method of claim 11, further including detecting resonant conditions in the resonant circuit.

16. The method of claim 15, further including adjusting at least one of a frequency of the oscillating voltage input, a reactance of a variable reactive element, and a resonant frequency of the resonant circuit based on the resonant conditions.

17. The method of claim 11, further including extracting accelerated particles from the synchrocyclotron to form a particle beam.

18. The method as in claim 17, further including detecting variations in the particle beam.

19. The method as in claim 18, wherein the variations include variations in at least one of particle beam intensity, particle beam timing, and spatial distribution of the particle beam.

20. The method as in claim 18, further including compensating for detected variations in the particle beam.

Referenced Cited
U.S. Patent Documents
2280606 April 1942 Van et al.
2492324 December 1949 Salisbury
2615129 October 1952 McMillan
2616042 October 1952 Weeks
2659000 November 1953 Salisbury
2701304 February 1955 Dickinson
2789222 April 1957 Marvin et al.
3175131 March 1965 Burleigh et al.
3432721 March 1969 Naydan et al.
3582650 June 1971 Avery
3679899 July 1972 Dimeff
3689847 September 1972 Nico
3757118 September 1973 Hodge et al.
3868522 February 1975 Bigham et al.
3886367 May 1975 Castle, Jr.
3925676 December 1975 Bigham et al.
3955089 May 4, 1976 McIntyre et al.
3958327 May 25, 1976 Marancik et al.
3992625 November 16, 1976 Schmidt et al.
4038622 July 26, 1977 Purcell
4047068 September 6, 1977 Ress et al.
4112306 September 5, 1978 Nunan
4129784 December 12, 1978 Tschunt et al.
4139777 February 13, 1979 Rautenbach
4197510 April 8, 1980 Szu
4220866 September 2, 1980 Taumann et al.
4230129 October 28, 1980 LeVeen
4256966 March 17, 1981 Heinz
4336505 June 22, 1982 Meyer
4345210 August 17, 1982 Tran
4353033 October 5, 1982 Karasawa
4425506 January 10, 1984 Brown et al.
4490616 December 25, 1984 Cipollina et al.
4507614 March 26, 1985 Prono et al.
4507616 March 26, 1985 Blosser et al.
4589126 May 13, 1986 Augustsson et al.
4598208 July 1, 1986 Brunelli et al.
4628523 December 9, 1986 Heflin
4633125 December 30, 1986 Blosser et al.
4641057 February 3, 1987 Blosser et al.
4641104 February 3, 1987 Blosser et al.
4651007 March 17, 1987 Perusek et al.
4680565 July 14, 1987 Jahnke
4705955 November 10, 1987 Mileikowsky
4710722 December 1, 1987 Jahnke
4726046 February 16, 1988 Nunan
4734653 March 29, 1988 Jahnke
4737727 April 12, 1988 Yamada et al.
4739173 April 19, 1988 Blosser et al.
4745367 May 17, 1988 Dustmann et al.
4754147 June 28, 1988 Maughan et al.
4769623 September 6, 1988 Marsing et al.
4771208 September 13, 1988 Jongen
4783634 November 8, 1988 Yamamoto et al.
4808941 February 28, 1989 Marsing
4812658 March 14, 1989 Koehler
4843333 June 27, 1989 Marsing et al.
4865284 September 12, 1989 Gosis et al.
4868843 September 19, 1989 Nunan
4868844 September 19, 1989 Nunan
4870287 September 26, 1989 Cole et al.
4880985 November 14, 1989 Jones
4902993 February 20, 1990 Krevet
4904949 February 27, 1990 Wilson
4905267 February 27, 1990 Miller et al.
4917344 April 17, 1990 Prechter et al.
4943781 July 24, 1990 Wilson et al.
4987309 January 22, 1991 Klasen et al.
4996496 February 26, 1991 Kitamura et al.
5017789 May 21, 1991 Young et al.
5017882 May 21, 1991 Finlan
5036290 July 30, 1991 Sonohe et al.
5039057 August 13, 1991 Prechter et al.
5039867 August 13, 1991 Nishihara et al.
5072123 December 10, 1991 Johnsen
5111173 May 5, 1992 Matsuda et al.
5117194 May 26, 1992 Nakanishi et al.
5117212 May 26, 1992 Yamamoto et al.
5117829 June 2, 1992 Miller et al.
5148032 September 15, 1992 Hernandez
5166531 November 24, 1992 Huntzinger
5189687 February 23, 1993 Bova et al.
5240218 August 31, 1993 Dye
5260581 November 9, 1993 Lesyna et al.
5278533 January 11, 1994 Kawaguchi
5317164 May 31, 1994 Kurokawa
5336891 August 9, 1994 Crewe
5341104 August 23, 1994 Anton et al.
5349198 September 20, 1994 Takanaka
5365742 November 22, 1994 Boffito et al.
5374913 December 20, 1994 Pissantezky et al.
5382914 January 17, 1995 Hamm et al.
5401973 March 28, 1995 McKeown et al.
5405235 April 11, 1995 Lebre et al.
5434420 July 18, 1995 McKeown et al.
5440133 August 8, 1995 Moyers et al.
5451794 September 19, 1995 McKeown et al.
5461773 October 31, 1995 Kawaguchi
5463291 October 31, 1995 Carroll et al.
5492922 February 20, 1996 Palkowitz
5511549 April 30, 1996 Legg et al.
5521469 May 28, 1996 Laisne
5561697 October 1, 1996 Takafuji et al.
5585642 December 17, 1996 Britton et al.
5635721 June 3, 1997 Bardi et al.
5668371 September 16, 1997 Deasy et al.
5691679 November 25, 1997 Ackermann et al.
5726448 March 10, 1998 Smith et al.
5751781 May 12, 1998 Brown et al.
5778047 July 7, 1998 Mansfield et al.
5783914 July 21, 1998 Hiramoto et al.
5811944 September 22, 1998 Sampayan et al.
5818058 October 6, 1998 Nakanishi et al.
5821705 October 13, 1998 Caporaso et al.
5825845 October 20, 1998 Blair et al.
5841237 November 24, 1998 Alton
5846043 December 8, 1998 Spath
5851182 December 22, 1998 Sahadevan
5866912 February 2, 1999 Slater et al.
5874811 February 23, 1999 Finlan et al.
5895926 April 20, 1999 Britton et al.
5920601 July 6, 1999 Nigg et al.
5929458 July 27, 1999 Nemezawa et al.
5993373 November 30, 1999 Nonaka et al.
6034377 March 7, 2000 Pu
6057655 May 2, 2000 Jongen
6061426 May 9, 2000 Linders et al.
6094760 August 1, 2000 Nonaka et al.
6241671 June 5, 2001 Ritter et al.
6265837 July 24, 2001 Akiyama et al.
6268610 July 31, 2001 Pu
6278239 August 21, 2001 Caporaso et al.
6279579 August 28, 2001 Riaziat et al.
6316776 November 13, 2001 Hiramoto et al.
6407505 June 18, 2002 Bertsche
6417634 July 9, 2002 Bergstrom
6433336 August 13, 2002 Jongen et al.
6433349 August 13, 2002 Akiyama et al.
6433494 August 13, 2002 Kulish et al.
6441569 August 27, 2002 Janzow
6443349 September 3, 2002 VanDerBurg
6476403 November 5, 2002 Dolinskii et al.
6492922 December 10, 2002 New
6501981 December 31, 2002 Schweikard et al.
6519316 February 11, 2003 Collins
6600164 July 29, 2003 Badura et al.
6621889 September 16, 2003 Mostafavi
6639234 October 28, 2003 Badura et al.
6646383 November 11, 2003 Bertsche et al.
6670618 December 30, 2003 Hartmann et al.
6683318 January 27, 2004 Haberer et al.
6683426 January 27, 2004 Kleeven
6693283 February 17, 2004 Eickhoff et al.
6710362 March 23, 2004 Kraft et al.
6717162 April 6, 2004 Jongen
6736831 May 18, 2004 Hartmann et al.
6745072 June 1, 2004 Badura et al.
6769806 August 3, 2004 Moyers
6774383 August 10, 2004 Norimine et al.
6777689 August 17, 2004 Nelson
6777700 August 17, 2004 Yanagisawa et al.
6799068 September 28, 2004 Hartmann et al.
6800866 October 5, 2004 Amemiya et al.
6803591 October 12, 2004 Muramatsu et al.
6814694 November 9, 2004 Pedroni
6853703 February 8, 2005 Svatos et al.
6864770 March 8, 2005 Nemoto et al.
6865254 March 8, 2005 Nafstadius
6891177 May 10, 2005 Kraft et al.
6897451 May 24, 2005 Kaercher et al.
6914396 July 5, 2005 Symons et al.
6953943 October 11, 2005 Yanagisawa et al.
6969194 November 29, 2005 Nafstadius
6984835 January 10, 2006 Harada
6993112 January 31, 2006 Hesse
7008105 March 7, 2006 Amann et al.
7014361 March 21, 2006 Ein-Gal
7026636 April 11, 2006 Yanagisawa et al.
7038403 May 2, 2006 Mastrangeli et al.
7060997 June 13, 2006 Norimine et al.
7122966 October 17, 2006 Norling et al.
7122978 October 17, 2006 Nakanishi et al.
7173385 February 6, 2007 Caporaso et al.
7208748 April 24, 2007 Sliski et al.
7262565 August 28, 2007 Fujisawa
7318805 January 15, 2008 Schweikard et al.
7348579 March 25, 2008 Pedroni
7355189 April 8, 2008 Yanagisawa et al.
7402963 July 22, 2008 Sliski et al.
7449701 November 11, 2008 Fujimaki et al.
7466085 December 16, 2008 Nutt
7476883 January 13, 2009 Nutt
7541905 June 2, 2009 Antaya
7656258 February 2, 2010 Antaya et al.
7696847 April 13, 2010 Antaya
7728311 June 1, 2010 Gall
7801269 September 21, 2010 Cravens et al.
8003964 August 23, 2011 Stark et al.
20020172317 November 21, 2002 Maksimchuk et al.
20030048080 March 13, 2003 Amemiya et al.
20030125622 July 3, 2003 Schweikard et al.
20030136924 July 24, 2003 Kraft et al.
20030152197 August 14, 2003 Moyers
20030163015 August 28, 2003 Yanagisawa et al.
20030183779 October 2, 2003 Norimine et al.
20030234369 December 25, 2003 Glukhoy
20040000650 January 1, 2004 Yanagisawa et al.
20040017888 January 29, 2004 Seppi et al.
20040056212 March 25, 2004 Yanagisawa et al.
20040061077 April 1, 2004 Muramatsu et al.
20040061078 April 1, 2004 Muramatsu et al.
20040085023 May 6, 2004 Chistakov
20040098445 May 20, 2004 Baumann et al.
20040111134 June 10, 2004 Muramatsu et al.
20040118081 June 24, 2004 Reimoser et al.
20040149934 August 5, 2004 Yanagisawa et al.
20040159795 August 19, 2004 Kaercher et al.
20040173763 September 9, 2004 Moriyama et al.
20040174958 September 9, 2004 Moriyama et al.
20040183033 September 23, 2004 Moriyama et al.
20040183035 September 23, 2004 Yanagisawa et al.
20040200982 October 14, 2004 Moriyama et al.
20040200983 October 14, 2004 Fujimaki et al.
20040213381 October 28, 2004 Harada
20040227104 November 18, 2004 Matsuda et al.
20040232356 November 25, 2004 Norimine et al.
20040240626 December 2, 2004 Moyers
20050058245 March 17, 2005 Ein-Gal
20050089141 April 28, 2005 Brown
20050161618 July 28, 2005 Pedroni
20050184686 August 25, 2005 Caporaso et al.
20050228255 October 13, 2005 Saracen et al.
20050234327 October 20, 2005 Saracen et al.
20050247890 November 10, 2005 Norimine et al.
20060017015 January 26, 2006 Sliski et al.
20060067468 March 30, 2006 Rietzel
20060126792 June 15, 2006 Li
20060145088 July 6, 2006 Ma
20060284562 December 21, 2006 Hruby et al.
20070001128 January 4, 2007 Sliski et al.
20070013273 January 18, 2007 Albert et al.
20070014654 January 18, 2007 Haverfield et al.
20070023699 February 1, 2007 Yamashita et al.
20070029510 February 8, 2007 Hermann et al.
20070051904 March 8, 2007 Kaiser et al.
20070092812 April 26, 2007 Caporaso et al.
20070145916 June 28, 2007 Caporaso et al.
20070171015 July 26, 2007 Antaya
20070181519 August 9, 2007 Khoshnevis
20070284548 December 13, 2007 Kaiser et al.
20080093567 April 24, 2008 Gall
20080218102 September 11, 2008 Sliski
20090096179 April 16, 2009 Stark et al.
20090140671 June 4, 2009 O'Neal, III et al.
20090140672 June 4, 2009 Gall et al.
20090200483 August 13, 2009 Gall et al.
20100045213 February 25, 2010 Sliski et al.
Foreign Patent Documents
2 629 333 May 2007 CA
1537657 October 2004 CN
101061759 October 2007 CN
101932361 December 2010 CN
101933405 December 2010 CN
101933406 December 2010 CN
2753397 September 1978 DE
3148100 June 1983 DE
3530446 March 1986 DE
4101094 May 1992 DE
4411171 October 1995 DE
0 194 728 September 1986 EP
0 221 987 May 1987 EP
0 277 521 August 1988 EP
0 208 163 January 1989 EP
0 222 786 July 1990 EP
0 499 253 August 1992 EP
0 306 966 April 1995 EP
0 388 123 May 1995 EP
0 465 597 May 1997 EP
0 864 337 September 1998 EP
0 776 595 December 1998 EP
1 069 809 January 2001 EP
1 153 398 November 2001 EP
1 348 465 January 2003 EP
1 294 445 March 2003 EP
1 358 908 November 2003 EP
1 402 923 March 2004 EP
0 911 064 June 2004 EP
1 430 932 June 2004 EP
1 454 654 September 2004 EP
1 454 655 September 2004 EP
1 454 656 September 2004 EP
1 454 657 September 2004 EP
1 605 742 December 2005 EP
1 738 798 January 2007 EP
1 371 390 March 2007 EP
1 826 778 August 2007 EP
1 454 653 September 2007 EP
1 477 206 January 2008 EP
1 949 404 July 2008 EP
2 232 961 September 2010 EP
2 232 962 September 2010 EP
2 227 295 May 2011 EP
2227295 May 2011 EP
2 363 170 September 2011 EP
2 363 171 September 2011 EP
2363171 September 2011 EP
2 560 421 August 1985 FR
2 911 843 August 2008 FR
0 957 342 May 1964 GB
2 015 821 September 1979 GB
2 361 523 October 2001 GB
43-23267 October 1968 JP
61-80800 April 1986 JP
62-150804 July 1987 JP
62-186500 August 1987 JP
63-149344 June 1988 JP
63-218200 September 1988 JP
63-226899 September 1988 JP
01-276797 November 1989 JP
4-94198 March 1992 JP
04-128717 April 1992 JP
04-129768 April 1992 JP
04-273409 September 1992 JP
04-337300 November 1992 JP
05-341352 December 1993 JP
06-036893 February 1994 JP
2006 233831 August 1994 JP
2007 260939 October 1995 JP
08-173890 July 1996 JP
08-264298 October 1996 JP
09-162585 June 1997 JP
10-071213 March 1998 JP
11-047287 February 1999 JP
11-102800 April 1999 JP
11-243295 September 1999 JP
2000-294399 October 2000 JP
2001-6900 January 2001 JP
2001-129103 May 2001 JP
2002-164686 June 2002 JP
5046928 March 2008 JP
2009 515671 April 2009 JP
2011 505191 February 2011 JP
2011 505670 February 2011 JP
2011 507151 March 2011 JP
300137 November 1969 SU
569635 August 1977 SU
2009 30160 July 2009 TW
2009 34682 August 2009 TW
2009 39908 September 2009 TW
2009 40120 October 2009 TW
WO 86/07229 December 1986 WO
WO 90/012413 October 1990 WO
WO 92/03028 February 1992 WO
WO 93/02536 February 1993 WO
WO 98/17342 April 1998 WO
WO 99/39385 August 1999 WO
WO 00/40064 July 2000 WO
WO 00/49624 August 2000 WO
WO 2001/126569 April 2001 WO
WO 02/007817 January 2002 WO
WO 03/039212 May 2003 WO
WO 2003/092812 November 2003 WO
WO 2004/026401 April 2004 WO
WO 2004/101070 November 2004 WO
WO 2006/012467 February 2006 WO
WO 2007/061937 May 2007 WO
WO 2007/084701 July 2007 WO
WO 2007/130164 November 2007 WO
WO 2007/145906 December 2007 WO
WO 2008/030911 March 2008 WO
WO 2009/070173 June 2009 WO
WO 2009/070588 June 2009 WO
WO 2009/073480 June 2009 WO
WO 2009/073480 June 2009 WO
WO 2009/048745 November 2009 WO
Other references
  • Schneider, R., et al., “Nevis Synchrocyclotron Conversion Program—RF System,” IEEE Transactions on Nuclear Science USA ns16(3) pp. 430-433 (Jun. 1969).
  • Enchevich, B., et al., “Minimizing Phase Losses in the 680 MeV Synchrocyclotron by Correcting the Accelerating Voltage Amplitude,” Atomnaya Energiya 26:(3), pp. 315-316 (1969).
  • Allardyce, B.W., et al., “Performance & Prospects of the Reconstructed CERN 600 MeV Synchro-Cyclotron,” IEEE Transactions on Nuclear Science USA ns-24:(3), pp. 1631-1633 (Jun. 1977).
  • Blosser, H.G., “Synchrocyclotron Improvement Programs,” IEEE Transactions on Nuclear Science USA ns16:(3), pp. 59-65 (Jun. 1969).
  • Blosser, H.G., “Compact Superconducting Synchrocyclotron Systems for Proton Therapy,” Nuclear Instruments & Methods in Physics Research, B40-42, pp. 1326-1330 (Apr. 1989).
  • Lecroy, W., et al., “Viewing Probe for High Voltage Pulses,” Review of Scientific Instruments USA 31:(12), p. 1354 (Dec. 1960).
  • Schneider, R., et al., “Nevis Synchrocyclotron Conversion Program-R.F.System,” IEEE Transactions on Nuclear Science USA, vol. ns18, No. 3, pp. 303-306 (Jun. 1971).
  • 18th Japan Conference on Radiation and Radioisotopes [Japanese], Nov. 25-27, 1987, 9 pages.
  • 510(k) Summary: Ion Beam Applications SA, FDA, Apr. 13, 2001.
  • 510(k) Summary: Optivus Proton Beam Therapy System, Jul. 21, 2000, 5 pages.
  • Abrosimov, N. K., et al,“1000MeV Proton Beam Therapy Facility at Petersburg Nuclear Physics Institute Synchrocyclotron,” Medical Radiology (Moscow) 32, 10 (1987) revised in Journal of Physics, Conference Series 41, pp. 424-432, Institute of Physics Publishing Limited, 2006.
  • Abrosimov, N. K., et al., “Neutron Time-of-Fight Spectrometer Gneis At the Gatchina 1 GeV Proton Synchrocylotron,” Nuclear Instruments & Methods in Physics Research, A242(1): 121-133 (1985).
  • Adachi, T., et. al. “A 150MeV FFAG Synchrotron with “Return-Yoke Free” Magnet,” Proceedings of the 2001 Particle Accelerator Conference, Chicago (2001).
  • Ageyev, A.I., et. al. “The IHEP Accelerating and Storage Complex (UNK) Status Report,” 11th International Conference on High-Energy Accelerators, pp. 60-70 (Jul. 7-11, 1980).
  • Agosteo, S., et al., “Maze Design of a Gantry Room for Proton Therapy,” Nuclear Instruments & Methods in Physics Research, Section A, 382, pp. 573-582 (1996).
  • Alexeev, V.P., et al., “R4 Design of Superconducting Magnets for Proton Synchrotrons,” Proceedings of the Fifth International Cryogenic Engineering Conference, pp. 531-533 (1974).
  • Allardyce, B.W., et al., “Performance and Prospects of the Reconstructed CERN 600 MeV Synchrocyclotron” IEEE Transactions on Nuclear Science USA NS-24:(3), pp. 1631-1633 (Jun. 1977).
  • Amaldi, U. “Overview of the World Landscape of Hadrontherapy and the Projects of the TERA Foundation,” Physica Medica, An International Journal Devoted to the Applications of Physics to Medicine and Biology, vol. XIV, Supplement 1 (Jul. 1998), 6th Workshop on Heavy Charged Particles in Biology and Medicine, Instituto Scientific Europeo (ISE), Baveno, pp. 76-85 (Sep. 29-Oct. 1, 1997).
  • Amaldi, U., et al. , “The Italian Project for a Hadrontherapy Centre,” Nuclear Instruments and Methods in Physics Research A, 360, pp. 297-301 (1995).
  • Anferov, V., et. al., “Status of the Midwest Proton Radiotherapy Institute,” Proceedings of the 2003 Particle Accelerator Conference, pp. 699-701 (2003).
  • Anferov, V., et. al., “The Indiana University Midwest Proton Radiation Institute,” Proceedings of the 2001 Particle Accelerator Conference, Chicago, pp. 645-647 (2001).
  • Appun, J. “Various Problems of Magnet Fabrication for High-Energy Accelerators, ” Journal for All Engineers Interested in the Nuclear Field, pp. 10-16 (1967) [Lang.: German], English bibliographic information (http://www.osti.gov/energycitations/product.bibliojsp?ostiid=4442292).
  • Arduini, G., et. al., “Physical Specifications of Clinical Proton Beams From a Synchrotron,” Med. Phys. 23 (6), pp. 939-951 (Jun. 1996).
  • Beeckman, W., et. al., “Preliminary Design of a Reduced Cost Proton Therapy Facility Using A Compact, High Field Isochronous Cyclotron,” Nuclear Instruments and Methods in Physics Research B56/57, pp. 1201-1204 (1991).
  • Bellomo, G., et al., “The Superconducting Cyclotron Program at Michigan State University,” Bulletin of the American Physical Society, vol. 25, No. 7, pp. 767 (Sep. 1980).
  • Benedikt, M. And Carli, C. “Matching to Gantries for Medical Synchrotrons,” IEEE Proceedings of the 1997 Particle Accelerator Conference, pp. 1379-1381 (1997).
  • Bieth, C., et. al., “A Very Compact Proton Therapy Facility Based on an Extensive Use of High Temperature Superconductors (HTS),” Cyclotrons and their Applications 1998, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Caen, France, pp. 669672 (Jun. 14-19,1998).
  • Bigham, C.B. “Magnetic Trim Rods for Superconducting Cyclotrons,” Nuclear Instruments and Methods (North-Holland Publishing Co.) 141 (1975), pp. 223-228.
  • Blackmore, E.W., et. al. “Operation of the Triumf Proton Therapy Facility,” IEEE Proceedings of the 1997 Particle Accelerator Conference, vol. 3, pp. 3831-3833 (12-16 May 1997).
  • Bloch, C. “The Midwest Proton Therapy Center, ”Application of Accelerators in Research and Industry, Proceedings of the Fourteenth Intl. Conference, Part Two, pp. 1253-1255 (Nov. 1996).
  • Blosser, H. “Applications of Superconducting Cyclotrons,” Twelfth International Conference on Cyclotrons and Their Applications, pp. 137-144 (May 8-12,1989).
  • Blosser, H. G. “Compact Superconducting Synchrocyclotron Systems for Proton Therapy,” Nuclear Instruments & Methods in Physics Research, Section B40-41, Part II, pp. 1326-1330 (1989).
  • Blosser, H. G. “Synchrocyclotron Improvement Programs,” IEEE Transactions on Nuclear Science USA, http://www.nscl.msu.edu/tech/accelerators/k250photo.html (Feb. 2005).vol. 16,No. 3, Part I, pp. 405-414 (Jun. 1969).
  • Blosser, H., “Application of Superconductivity in Cyclotron Construction,” Ninth International Conference on Cyclotrons and their Applications, pp. 147-157 (Sep. 1981).
  • Blosser, H., “Present and Future Superconducting Cyclotrons,” Bulletin of the American Physical 314 Society, vol. 32, No. 2, p. 171 (Feb. 1987), Particle Accelerator Conference, Washington, D.C. 1987.
  • Blosser, H., et al., “Problems and Accomplishments of Superconducting Cyclotrons,” Proceedings 315 of the 14th International Conference, Cyclotrons and Their Applications, pp. 674-684 (Oct. 1995).
  • Blosser, H., et al., “Superconducting Cyclotron for Medical Application,” IEEE Transactions on Magnetics, vol. 25, No. 2, pp. 1746-1754 (Mar. 1989).
  • Blosser, H., et al., “Advances in Superconducting Cyclotrons at Michigan State University,” Proceedings of the 11th International Conference on Cyclotrons and their Applications, pp. 157-167 (Oct. 1986), Tokyo.
  • Blosser, H., et al., “Characteristics of a 400 (Q2/A) MeV Super-Conducting Heavy-Ion Cyclotron,” Bulletin of the American Physical Society, p. 1026 (Oct. 1974).
  • Blosser, H., et al., “Preliminary Design Study Exploring Building Features Required for a Proton Therapy Facility for the Ontario Cancer Institute,” MSUCL-760a (Mar. 1991).
  • Blosser, H., et. al. “A Compact Superconducting Cyclotron for the Production of High Intensity Protons,” Proceedings of the 1997 Particle Accelerator Conference, vol. 1, pp. 1054-1056 (May 12-16 1997).
  • Blosser, H., et al., “Medical Accelerator Projects at Michigan State Univ.,” IEEE Proceedings of the 1989 Particle Accelerator Conference, vol. 2, pp. 742-746 (Mar. 20-23, 1989).
  • Blosser, H.G., “Future Cyclotrons,” AIP, The Sixth International Cyclotron Conference, pp. 16-32 (1972).
  • Blosser, H.G., “Medical Cyclotrons,” Physics Today, Special Issue Physical Review Centenary, pp. 70-73 (Oct. 1993).
  • Blosser, H.G., “Progress on the Coupled Superconducting Cyclotron Project,” Bulletin of the American Physical Society, vol. 26, No. 4, p. 558 (Apr. 1981).
  • Blosser, H.G., “Superconducting Cyclotrons at Michigan State University,” Nuclear Instruments & Methods in Physics Research, vol. B 24/25, part II, pp. 752-756 (1987).
  • Blosser, H.G., “The Michigan State University Superconducting Cyclotron Program,” Nuclear Science, vol. NS-26, No. 2, pp. 2040-2047 (Apr. 1979).
  • Blosser, H.G., et al, “Superconducting Cyclotrons,” Seventh International Conference on Cyclotrons and their Applications, pp. 584-594 (Aug. 19-22, 1975).
  • Botha, A.H., et al., “A New Multidisciplinary Separated-Sector Cyclotron Facility,” IEEE Transactions on Nuclear Science, vol. NS-24, No. 3, pp. 1118-1120 (1977).
  • Chichili, D.R., et al., “Fabrication of Nb3Sn Shell-Type Coils with Pre-Preg Ceramic Insulation,” American Institute of Physics Conference Proceedings, AIP USA, No. 711, (XP-002436709, ISSN: 0094-243X), 2004, pp. 450-457.
  • Chong, C.Y., et al., Radiology Clinic North American 7,3319 (1969).
  • Chu, et al., “Instrumentation for Treatment of Cancer Using Proton and Light-ion Beams,” Review of Scientific Instruments, 64 (8), pp. 2055-2122 (Aug., 1993).
  • Cole, et al., “Design and Application of a Proton Therapy Accelerator,” Fermi National Accelerator Laboratory, IEEE, (1985).
  • Conradie, et al., “Proposed New Facilities for Proton Therapy at iThemba Labs,” Proceedings of EP AC, pp. 560-562 (2002).
  • CE/Source of Ions for Use in Sychro-Cyclotrons Search, Jan. 31, 2005, 9 pages.
  • Coupland, J.H. “High-field (5T) Pulsed Superconducting Dipole Magnet,” Proceedings of the Institution of Electrical Engineers, vol. 121, No. 7, pp. 771-778 (Jul. 1974).
  • Coutrakon, G. et al., “A Prototype Beam Delivery System for the Proton Medical Accelerator At Lorna Linda,” Medical Physics, vol. 18(6), pp. 1093-1099 (Nov/Dec 1991).
  • Coutrakon, G. et al., “Proton Synchrotrons for Cancer Therapy, ” Application of Accelerators in Research and Industry—Sixteenth International Conf., American Institute of Physics, vol. 576, pp. 861-864 (Nov. 1-5,2000).
  • CPAC Highlights Its Proton Therapy Program at ESTRO Annual Meeting, TomoTherapy Incorporated, Sep. 18, 2008, Madison, Wisconsin, pp. 1-2.
  • Cuttone, G., “Applications of a Particle Accelerators in Medical Physics,” Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud, V.S. Sofia, 44 Cantania, Italy (17 pages). No. date.
  • Dahl, P., “Superconducting Magnet System,” American Institute of Physics, AIP Conference Proceedings, vol. 2, pp. 1329-1376 (1987-1988).
  • Dugan, G. et al. “Tevatron Status,” IEEE, Particle Accelerator Conference, Accelerator Science & Technology (1989), pp. 426-430.
  • Eickhoff, et al. “The Proposed Accelerator Facility for Light Ion Cancer Therapy in Heidelberg,” Proceedings of the 1999 Particle Accelerator Conference, New York, pp. 2513-2515 (1999).
  • Enchevich, B. et al., “Minimizing Phase Losses in the 680 MeV Synchrocyclotron by Correcting the Accelerating Voltage Amplitude,” Atomnaya Energiya 26:(3), pp. 315-316 (1969).
  • Endo, K., et. al., “Compact Proton and Carbon Ion Synchrotrons for Radiation Therapy,” Proceedings of EPAC 2002, Paris France, pp. 2733-2735 (2002).
  • Flanz, J.B. et al., “Large Medical Gantries,” 1995 Particle Accelerator Conference, Massachusetts General Hospital, pp. 1-5 (1995).
  • Flanz, J.B. et al., “The Northeast Proton Therapy Center at Massachusetts General Hospital,” Fifth Workshop on Heavy Charge Particles in Biology and Medicine, GSI, Darmstadt (Aug. 1995).
  • Flanz, J.B. et. al. “Treating Patients with the NPTC Accelerator Based Proton Treatment Facility,” Proceedings of the 2003 Particle Accelerator Conference (2003), pp. 690-693.
  • Flood, W. S. And Frazier, P. E. “The Wide-Band Driven RF System for the Berkeley 88-Inch Cyclotron,” American Institute of Physics, Conference Proceedings., No. 9, 459-466 (1972).
  • Foster, G. W. and Kashikhin, V. S. “Superconducting Superferric Dipole Magent with Cold Iron Core for the VLHC,” IEEE Transactions on Applied Superconductivity, vol. 12, No. 1, pp. 111-115 (Mar. 2002).
  • Friesel, D. L. et al. “Design and Construction Progress on the IUCF Midwest Proton Radiation Institute,” Proceedings of EPAC 2002, pp. 2736-2738 (2002).
  • Fukumoto, S. “Cyclotron Versus Synchrotron for Proton Beam Therapy,” KEK Preprint, No. 95-122, pp. 533-536 (1995).
  • Fukumoto, S. et. al., “A Proton Therapy Facility Plan,” Cyclotrons and their Applications, Proceedings of the 13th International Conference, Vancouver, Canada, pp. 258-261 (Jul. 6-10, 1992).
  • Gordon, M.M. et. al., “Design Study for a Compact 200 MeV Cyclotron,” AIP Conference Proceedings Sixth International Cyclotron Conference, No. 9, pp. 78-86 (1972).
  • Gordon, M.M., “Extraction Studies for a 250 MeV Superconducting Synchrocyclotron,” Proceedings of the 1987 IEEE Particle Accelerator Conference: Accelerator Engineering and Technology, pp. 1255-1257 (1987).
  • Goto, A. et al., “Progress on the Sector Magnets for the Riken SRC,” American Institute of Physics, CP600, Cyclotrons and Their Applications 2001, Sixteenth International Conference (2001), pp. 319-323.
  • Graffman, S. et. al., “Design Studies for a 200 MeV Proton Clinic for Radiotherapy,” AIP Conference Proceedings: Cyclotrons 1972, No. 9, pp. 603-615 (1972).
  • Graffman, S. et. al. “Proton radiotherapy with the Uppsala cyclotron. Experience and Plans,” Strahlentherapie, 161, No. 12, pp. 764-770 (1985).
  • Graffman, S., et al., “Clinical Trials in Radiotherapy and the Merits of High Energy Protons,” Acta Radiol. Therapy Phys. Biol. 9:1-23 (1970).
  • Hede, Karyn, Research Groups Promoting Proton Therapy “Lite,” Journal of the National Cancer Institute, 98(23):1682-1684 (2006).
  • Heinz, W. “Superconducting Pulsed Magnetic Systems for High-Energy Synchrotrons,” Proceedings of the Fourth International Cryogenic Engineering Conference, pp. 55-63. (May 24-26, 1972).
  • Hentschel, R., et. al., “Plans for the German National Neutron Therapy Centre with a Hospital-Based 70 MeV Proton Cyclotron at University Hospital Essen/Germany,” Cyclotrons and their Applications, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Caen, Franco, pp. 21-23 (Jun. 14-19, 1998).
  • Hepburn, J.D., et. al., “Superconducting Cyclotron Neutron Source for Therapy,” International Journal of Radiation Oncology Biology Physics, vol. 3 complete, pp. 387-391 (1977).
  • Hirabayashi, H. “Development of Superconducting Magnets for Beam Lines and Accelerator at KEK,” IEEE Transaction on Magnetics, vol. Mag-17, No. 1, pp. 728-731 (Jan. 1981).
  • Indiana's mega-million proton therapy cancer center welcomes its first patients: [online] Press release, Health & Medicine Week, 2004, retrieved from NewsRx.com, Mar. 1, 2004, pp. 119-120.
  • Ishibashi, K. And McInturff, A. “Winding Design Study of Superconducting /OT Dipoles for a Synchrotron,” IEEE Transactions on Magnetics, vol. MAG-19, No. 3, pp. 1364-1367 (1983).
  • Ishibashi, K. and McInturff, A., “Stress Analysis of Superconducting /OT Magnets for Synchrotron,” Proceedings of the Ninth International Cryogenic Engineering Conference, pp. 513-516 (May 11-14, 1982).
  • Jahnke, A., et. al. “First Superconducting Prototype Magnets for a Compact Synchrotron Radiation Source in Operation,” IEEE Transactions on Magnetics, vol. 24, No. 2 (Mar. 1988), pp. 1230-1232.
  • Jones, and Dershem. “Synchrotron Radiation from Proton in a 20 TEV, 10 TESLA 367 Superconducting Super Collider,” Proceedings of the 12th International Conference on High-Energy Accelerators, pp. 138-140 (Aug. 11-16, 1983).
  • Jones, D.T.L. “Present Status and Future Trends of Heavy Particle Radiotherapy,” Cyclotrons and their Applications 1998, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, pp. 13-20 (Jun. 14-19, 1998).
  • Jones, D.T.L. And Mills, S.J. “The South African National Accelerator Centre: Particle Therapy and Isotope Production Programmes,” Radiation Physics and Chemistry, vol. 51, Nos. 4-6, pp. 571-578 (Apr.-Jun. 1998).
  • Jones, D.T.L., et. al. “Status Report of the NAC Particle Therapy Programme,” Stralentherapie und Onkologie, vol. 175, Suppl. II, pp. 30-32 (Jun. 1999).
  • Jones, D.T.L. “Progress with the 200 MeV Cyclotron Facility at the National Accelerator Centre,” Commission of the European Communities Radiation Protection Proceedings, Fifth Symposium on Neutron Dosimetry, vol. II, pp. 989-998 (Sep. 17-21, 1984).
  • Jongen, Y. et al., “The Proton Therapy System for the NPTC: Equipment Description and Progress Report,” Nuclear Instruments and methods in Physics Research, Section B, vol. 113, No. 1, pp. 522-525 (1996).
  • Jongen, Y., et al., “The Proton Therapy System for MGH's NPTC: Equipment Description and Progress Report,” Bulletin du Cancer Radiotherapie, Proceedings of the meeting of the European Heavy Particle Therapy Group, vol. 83, Suppl. 1, pp. 219-222 (1996).
  • Jongen, Y., et al., “Development of a Low-Cost Compact Cyclotron System for Proton Therapy,” National Institute of Radiol. Sci No. 81, pp. 189-200 (1991).
  • Jongen, Y., et. al. “Progress report on the IBA-SHI Small Cyclotron for Cancer Therapy,” Nuclear Instruments and Methods in Physics Research, Section B, vol. 79, issue 1-4, pp. 885-889 (1993).
  • Kanai, et al., “Three-dimensional Beam Scanning for Proton Therapy,” Nuclear Instruments and Methods in Physic Research, Sep. 1, 1983, The Netherlands, vol. 214, No. 23, pp. 491-496.
  • Karlin, D.L., et al., “Medical Protonic Tract of Synchropshylotron of the Leningrad Institute of Nuclear Physics,” Medical Radiology (Moscow) 28,13 (1983). (English Abstract).
  • Karlin, D.L., et al., “The State and Prospects in the Development of the Medical Proton Tract on the Synchrocyclotron in Gatchina,” Med. Radiology, Moscow, vol. 28(3), pp. 28-32 (Mar. 1983)(German with English Abstract on end of p. 32).
  • Kats, M. M. And Onosovskii, K. K. “A Planar Magnetooptical System for the Irradiation of a Lying Patient with a Proton Beam from Various Directions,” Instruments and Experimental Techniques, vol. 39, No. 1, pp. 127-131 (1996).
  • Kats, M. M. And Onosovskii, K. K. “A Simple, Compact, Flat System for the Irradiation of a Lying Patient with a Proton Beam from Different Directions,” Instruments and Experimental Techniques, vol. 39, No. 1, p. 132-134 (1996).
  • Kats, M.M. And Druzhinin, B.L. “Comparison of Methods for Irradiating Prone Patients” Atomic Energy, vol. 94, No. 2, pp. 120-123 (2003).
  • Khoroshkov, V. S., et al., “Moscow Hospital-Based Proton Therapy Facility Design” Am. Journal Clinical Oncology: CCT, vol. 17, No. 2, pp. 109-114 (1994).
  • Kim, J. and Blosser, H., “Optimized Magnet for a 250 MeV Proton Radiotherapy Cyclotron,” Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 345-347 (May 2001).
  • Kim, J. And Yun, C. “A Light-Ion Superconducting Cyclotron System for Multi-Disciplinary Users,” Journal of the Korean Physical Society, vol. 43, No. 3, pp. 325-331 (Sep. 2003).
  • Kim, J., et al., “Design Study of a Superconducting Cyclotron for Heavy Ion Therapy,” Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 324-326 (May 13-17, 2001).
  • Kim, J., et al., “Construction of 8 T Magnet Test Stand for Cyclotron Studies,” IEEE Transactions on Applied Superconductivity, vol. 3, No. 1, pp. 266-268 (Mar. 1993).
  • Kim, J.W. “An Eight Tesla Superconducting Magnet for Cyclotron Studies,” Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy (1994).
  • Kim, J.W., et al., “Trim Coil System for the Riken Superconducting Ring Cyclotron,” Proceedings at the 1997 Particle Accelerator Conference, IEEE, vol. 3, pp. 214-235 (Dec. 1981). OR 3422-3424, 1998).
  • Kishida, N. And Yano, Y. “Beam Transport System for the RIKEN SSC (H), ”Scientific Papers of the Institute of Physical and Chemical Research, vol. 75, No. 4, pp. 214-235 (Dec. 1981).
  • Koehler, A.M., et al., “Range Modulators for Protons and Heavy Ions,” Nuclear Instruments and Methods, vol. 131, pp. 437-440 (1975).
  • Koto, M. And Tsujii, H. “Future of Particle Therapy,” Japanese Journal of Cancer Clinics, vol. 47, No. 1, pp. 95-98 (2001) [Lang.: Japanese], English abstract (http://sciencelinks.jp/jeast/article/200206/00002002060 IA0511453 .mill).
  • Kraft, G. et al., “Hadrontherapy in Oncology,” Elsevier Science, 1994.
  • Larsson, B. “Biomedical Program for the Converted 200-MeV Synchrocyclotron at the Gustaf Werner Institute,” Radiation Research, 104, pp. S310-S318 (1985).
  • Larsson, B., et al., “The High-Energy Proton Beam As a Neurosurgical Tool,” Nature vol. 182, pp. 1222-1223 (1958).
  • Lawrence, J.H., “Proton Irradiation of the Pituitary,” Cancer, vol. 10, pp. 795-798 (1957).
  • Lawrence, J.H., et al., “Heavy Particles in Acromegaly and Cushing's Disease,” Endocrine and Norendocrine Hormone Producing Tumors, pp. 29-61 (1973).
  • Lawrence, J.H., et al., “Successful Treatment of Acromegaly: Metabolic and Clinical Studies in 145 Patients,” The Journal of Clinical Endrocrinology and Metabolism, 31 (2): (1970).
  • Lecroy, W., et al., “Viewing Probe for High Voltage Pulses,” Review of Scientific Instruments USA 31(12), p. 1354 (Dec. 1960).
  • Linfoot, J.A., et al., “Acromegaly,” Hormonal Proteins and Peptides, pp. 191-246 (1975).
  • Livingston, M.S., et al. “A Capillary Ion Source for the Cyclotron,” Review Science Instruments, vol. 10, p. 9. 63-67, (1939).
  • LLNL, UC Davis Team Up to Fight Cancer, Lawrence Livermore National Laboratory, Apr. 28, 2006, SF-Jun. 4, 2002, Livermore, California, pp. 1-4.
  • Mandrillon, P. “High Energy Medical Accelerators,” EPAC 90, 2nd European Particle Accelerator Conference, vol. 2, (Jun. 12-16, 1990), pp. 54-58.
  • Marti, F., et al., “High Intensity Operation of a Superconducting Cyclotron,” Proceedings of the 14th International Conference, Cyclotrons and Their Applications, pp. 45-48 (Oct. 1995).
  • Martin, P. “Operational Experience with Superconducting Synchrotron Magnets,” Proceedings of the 1987 IEEE Particle Accelerator Conference, vol. 3 of 3, pp. 1379-1382 (Mar. 16-19, 1987).
  • Meot, F., et al. , “ETOILE Hadrontherapy Project, Review of Design Studies,” Proceedings of EPAC 2002, pp. 2745-2747 (2002).
  • Miyamoto, S., et al., “Development of the Proton Therapy System,” The Hitachi Hyoron, vol. 79, 10, pp. 775-779 (1997) [Lang: Japanese], English abstract (http://www.hitachi.com/rev/1998/revfeb98/rev4706.htm).
  • Montelius, A, et al., “The Narrow Proton Beam Therapy Unit at the Svedberg Laboratory in Uppsala,” ACTA Oncologica, vol. 30, pp. 739-745 (1991).
  • Moser, H.O., et al., “Nonlinear Beam Optics with Real Fields in Compact Storage Rings, ”Nuclear Instruments & Methods in Physics Research/Section B30, Feb. 1988, No. 1, pp. 105-109.
  • National Cancer Institute Funding (Senate-Sep. 21, 1992) (www.thomas.loc.gov/cgi-bin/query/z?r102:S21SE2-712 (2 pages).
  • Nicholson, J. “Applications of Proton Beam Therapy,” Journal of the American Society of Radiologic Technologists, vol. 67, No. 5, pp. 439-441 (May/Jun. 1996).
  • Nolen, J.A., et al., “The Integrated Cryogenic—Superconducting Beam Transport System Planned for MSU,” Proceedings of the 12th International Conference on High-Energy Accelerators, pp. 549-551 (Aug. 1983).
  • Norimine, T., et al., “A Design of a Rotating Gantry with Easy Steering for Proton Therapy,” Proceedings of EPAC 2002, pp. 2751-2753 (2002).
  • Okumura, T., et al., “Overview and Future Prospect of Proton Radiotherapy,” Japanese Journal of Cancer Clinics, vol. 43, No. 2, pp. 209-214 (1997) [Lang.: Japanese].
  • Okumura, T., et al., “Proton Radiotherapy,” Japanese Journal of Cancer and Chemotherapy, (20), No. 14, pp. 2149-2155 (1993) [Lang.: Japanese] Outstanding from Search Reports, “Accelerator of Polarized Portons at Fermilab,” 20 pages, 2005.
  • Palmer, R. and Tollestrup, A V. “Superconducting Magnet Technology for Accelerators,” Annual Review of Nuclear and Particle Science, vol. 34, pp. 247-284 (1984).
  • Patent Assignee and Keyword Searches for Synchrocyclotron, Jan. 25, 2005 (77 pages).
  • Patterson, “An Accelerated Collaboration Meets with Beaming Success,” Lawrence Livermore National Laboratory, Apr. 12, 2006, S&TR Livermore, CA. pp. 1-3, http://www.llnl.gov/str/April06/Caporaso.html.
  • Pavlovic, M. “Beam-Optics Study of the Gantry Beam Delivery System for Light-Ion Cancer Therapy,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 399, No. 2, pp. 439-454 (1997).
  • Pedroni, E. “Accelerators for Charged Particle Therapy: Performance Criteria from the User Point of View,” Cyclotrons and their Applications, Proceedings of the 13th International Conference, pp. 226-233 (1992).
  • Pedroni, E. “Latest Developments in Proton Therapy,” Proceedings of EPAC 2000, pp. 240-244 (2000).
  • Pedroni, E. and Enge, H. “Beam Optics Design of Compact Gantry for Proton Therapy,” Medical & Biological Engineering & Computing, vol. 33, No. 3, pp. 271-277 (May 1995).
  • Pedroni, E. and Jermann, M. “SGSMP: Bulletin Mar. 2002 Proscan Project, Progress Report on the PROSCAN Project of PSI,” [online] retrieved from www.sgsmp.ch/protA23.htm, (5 pages) Mar. 2002.
  • Pedroni, E., et al., “A Novel Gantry for Proton Therapy at the Paul Scherrer Institute,” Cycloctrons 430 and Their Applications 2001: Sixteenth International Conference. AIP Conference Proceedings, vol. 600, pp. 13-17 (2001).
  • Pedroni, E., et al., “The 200-MeV proton therapy project at the Paul Scherrer Institute: Conceptual Design and Practical Realization,” Medical Physics, vol. 22, No. 1, pp. 37-53 (Jan. 1995).
  • Potts, R., et al., “MPWP6-Therapy III: Treatment Aids and Techniques,” Medical Physics, vol. 15, No. 5, p. 798 (Sep/Oct 1988).
  • Pourrahimi, S. et al., “Powder Metallurgy Processed Nb3Sn(Ta) Wire for High Field NMR Magnets,” IEEE Transactions on Applied Superconductivity, vol. 5, No. 2, (Jun. 1995), pp. 1603-1606.
  • Prieels, D., et al., “The IBA State-of-the-Art Proton Therapy System, Performances and Recent Results,” Application of Accelerators in Research and Industry—Sixteenth International. Conference, American Institute of Physics, vol. 576, pp. 857-860 (2000).
  • Rabin, M. S. Z., et al., “Compact Designs for Comprehensive Proton Beam Clinical Facilities,” Nuclear Instruments and Methods in Physics Research 40(41):1335-1339(1989).
  • Research & Development Magazine, “Proton Therapy Center Nearing Completion,” vol. 41, No. 9, Aug. 1999 (2 pages)(www.rdmga.com).
  • Resmini, F., “Design Characteristics of the K=800 Superconducting Cyclotron at M.S.U.,” Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, IEEE Transaction on Nuclear Science, vol. NS-26, No. 2, Apr. 1979 (8 pages).
  • RetroSearch “Berkeley 88-Inch Cyclotron ‘RF’ or 'Frequency Control,” Jan. 21, 2005 (36 pages).
  • RetroSearch “Berkeley 88-Inch Cyclotron,” Jan. 24, 2005 (170 pages).
  • RetroSearch “Bernard Gottschalk, Cyclotron, Beams, Compensated Upstream Modulator, Compensated Scatter,” Jan. 21, 2005 (20 pages).
  • RetroSearch “Cyclotron with ‘RF’ or 'Frequency Control,” Jan. 21, 2005 (49 pages).
  • RetroSearch “Gottschalk, Bernard, Harvard Cyclotron Wheel”, Jan. 21, 2005 (20 pages).
  • RetroSearch “Lorna Linda University Beam Compensation,” Jan. 21, 2005 (60 pages).
  • RetroSearch “Lorna Linda University, Beam Compensation Foil Wedge,” Jan. 21, 2005 (15 pages).
  • Rifuggiato, D., et al., “Status Report of the LNS Superconducting Cyclotron,” Nukleonika, vol. 48, pp. S131-S134 (Supplement 2, 2003).
  • Rode, C.H. “Tevatron Cryogenic System,” Proceedings of the 12th International Conference on High-Energy Accelerators , Fermi/ab, pp., 529-535 (Aug. 11-16, 1983).
  • Salzburger, H., et al., “Superconducting Synchrotron Magnets Supraleitende Synchrotronmagnete,” Siemens AG., Erlangen (West Germany). Abteilung Technische Physik, Report No. BMFT-FB-T- 75-25, Oct. 1975, p. 147, Journal Announcement: GRAI7619; STAR1415, Subm-Sponsored by Bundesmin. Fuer Forsch. U. Technol. In German; English Summary.
  • Schillo, M., et al., “Compact Superconducting 250 MeV Proton Cyclotron for the PSI Proscan Proton Therapy Project,” Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 37-39 (2001).
  • Schneider et al., “Superconducting Cyclotrons,” IEEE Transactions on Magnetics, vol. MAG-11, No. 2, Mar. 1975, pp. 443-446.
  • Schneider, R., et al., “Nevis Synchrocyclotron Conversion Program—RF System,” IEEE Transactions on Nuclear Science USA NS 16(3) pp. 430-433 (Jun. 1969).
  • Schreuder, AN., et al., “The Non-orthogonal Fixed Beam Arrangement for the Second Proton Therapy Facility at the National Accelerator Centre,” Application of Accelerators in Research and Industry, American Institute of Physics, Proceedings of the Fifteenth International Conference, Part Two, pp. 963-966 (Nov 1998).
  • Schreuder, H.W. “Recent Developments in Superconducting Cyclotrons,” Proceedings of the 1995 Particle Accelerator Conference, vol. 1, pp. 317-321 (May 1-5, 1995).
  • Schubert, J.R. And Blosser, H. “Conceptual Design of a High Field Ultra-Compact Cyclotron for Nuclear Physics Research,” Proceedings of the 1997 Particle Accelerator Conference, vol. 1, pp. 1060-1062 (May 12-16, 1997).
  • Schubert, J. R. “Extending the Feasibility Boundary of the Isochronous Cyclotron” Dissertation submitted to Michigan State University, 1997, Abstract http://adsabs.harvard.edulabs/1998PhDT....... 147S.
  • Shelaev, I. A., et al., “Design Features of a Model Superconducting Synchrotron of JINR” Proceedings of the 12th International Conference on High-energy Accelerators, pp. 416-418 (Aug. 11-16, 1983).
  • Shintomi, T., et al., “Technology and Materials for the Superconducting Super Collider (SSC) Project,” [Lang.: Japanese], The Iron and Steel Institute of Japan 00211575, vol. 78, No. 8 (19920801), pp. 1305-1313, http://ci.nii.ac.jp/naid/110001493249/eni , 1992.
  • Sisterson, J.M. “World Wide Proton Therapy Experience in 1997,” The American Institute of Physics, Applications of Accelerators in Research and Industry, Proceedings of the Fifteenth International Conference, Part Two, pp. 959-962 (Nov 1998).
  • Sisterson, J.M. “Clinical Use of Proton and Ion Beams From a World-Wide Perspective,” Nuclear Instruments and Methods in Physics Research, Section B, Vols. 40-41, pp. 1350-1353 (1989).
  • Slater, J.M., et al., “Developing a Clinical Proton Accelerator Facility: Consortium-Assisted Technology Transfer,” Conference Record of the 1991 IEEE Particle Accelerator Conference: Accelerator Science and Technology, vol. 1 , pp. 532-536 (May 6-9 1991).
  • Slater, J.M., et al., “Development of a Hospital-Based Proton Beam Treatment Center,” International Journal of Radiation Oncology Biology Physics, vol. 14, No. 4, pp. 761-775 (Apr. 1988).
  • Smith, A, et al., “The Northeast Proton Therapy Center at Massachusetts General Hospital,” Journal of Brachytherapy International, pp. 137-139 (Jan 1997).
  • Snyder, S.L. And Marti, F. “Central Region Design Studies for a Proposed 250 MeV Proton Cyclotron,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 355, pp. 618-623 (1995).
  • Soga, F. “Progress of Particle Therapy in Japan,” Application of Accelerators in Research and Industry, American Institute of Physics, Sixteenth International Conference, pp. 869-872 (Nov 2000).
  • Spiller, P., et al., “The GSI Synchrotron Facility Proposal for Acceleration of High Intensity Ion and Proton Beams,” Proceedings of the 2003 Particle Accelerator Conference, vol. 1, pp. 589 -591 (May 12-16 2003).
  • Stanford, A.L., et al., “Method of Temperature Control in Microwave Ferroelectric Measurements,” Sperry Microwave Electronics Company, Clearwater, Florida, Sep. 19, 1960 (1 page).
  • Superconducting Cyclotron Contract awarded by Paul Scherrer Institute (PSI), Villigen, Switzerland, http://www.accel.de/News/superconductingcyclotroncontract.html (Feb. 3, 2005).
  • Tadashi, T., et al., “Large Superconducting Super Collider (SSC) In The Planning and Materials Technology,” vol. 78, No. 8 (Aug. 1, 1992), pp. 1305-1313, The Iron and Steel Institute of Japan 00211575.
  • Takada, Y. “Conceptual Design of a Proton Rotating Gantry for Cancer Therapy,” Japanese Journal of Medical Physics, vol. 15, No. 4, pp. 270-284 (1995).
  • Takada, Y. “A Review of Rotating Gantries for Heavy Charged Particle Therapy,” Symposium of Research Center for Charged Particle Therapy on Fundamental Development of the Charged Particle Therapy, Chiba (Japan), Nov. 13-14, 2001.
  • Takayama, T., et al. , “Compact Cyclotron for Proton Therapy,” Proceedings of the 8th Symposium on Accelerator Science and Technology, Japan (Nov. 25-27, 1991) pp. 380-382.
  • Teng, L. C. “The Fermilab Tevatron,” Coral Gables 1981, Proceedings, Gauge Theories, Massive Neutrinos, and Proton Decay, pp. 43-62 (1981).
  • UC Davis “Crocker Nuclear Laboratory Houses a Medium-Energy Particle Accelerator,” Crocker Nuclear Laboratory, University of California (2009).
  • “The Cutting Edge of Cancer Therapy Using Proton Beams,” The Journal of Practical Pharmacy, vol. 46, No. 1, pp. 97-103 (1995). [Japanese] (English Abstract).
  • “The K250 Proton therapy Cyclotron,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.eduttech/accelerators/k250.html (Feb. 2005).
  • “The K250 Proton-therapy Cyclotron Photo Illustration,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k250photo.html (Feb. 2005).
  • “The K100 Neutron-therapy Cyclotron,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k100.html (Feb. 2005).
  • Tobias, C.A., et al., “Pituitary Irradiation with High-Energy Proton Beams A Preliminary Report,” Cancer Research, vol. 18, No. 2, pp. 121-134 (1958).
  • Tom, J.L. “The Use of Compact Cyclotrons for Producing Fast Neutrons for Therapy in a Rotatable Isocentric Gantry,” IEEE Transaction on Nuclear Science, vol. 26, No. 2, pp. 2294-2298 (Apr. 1979).
  • Trinks, U., et al., “The Tritron: A Superconducting Separated-Orbit Cyclotron,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 244, pp. 273-282 (1986).
  • Tsuji, H. “The Future and Progress of Proton Beam Radiotherapy,” Journal of Japanese Society for Therapeutic Radiology and Oncology, vol. 6, No. 2, pp. 63-76 (1994).
  • Tsuji, H., “Cancer Therapy Using Proton Beams: the Newest State of Affairs and Future Prospects,” Isotope News, No. 9, pp. 2-7 (1992). (English Abstract).
  • UC Davis School of Medicine, “Unlikely Partners Turn Military Defense into Cancer Offense,” Current Issue Summer 2008, Sacramento, California, pp. 1-2.
  • Umegaki, K., et al., “Development of Advanced Proton Beam Therapy System for Cancer Treatment,” Hitachi Hyoron, vol. 85, No. 9, pp. 605-608 (2003) [Lang.: Japanese],( English abstract), http://www.hitachi.corn/ICSFiles/afieldfile/2004/06/0/r200304104.pdf or http://wwvv.hitachi.com/rev/archive/2003/200564912606.html (full text) [Hitachi, vol. 52, No. 4 Dec. 2003].
  • Umezawa, M., et al., “Beam Commissioning of the New Proton Therapy System for University of Tsukuba,” Proceedings of the 2001 Particle Accelerator Conference, vol. 1, pp. 648-650 (Jun. 18-22, 2001).
  • van Steenbergen, A. “Superconducting Synchroton Development at BNL,” Proceedings of the 8th International Conference on High-Energy Accelerators CERN 1971, pp. 196-198 (1971).
  • van Steenbergen, A. “The CMS, a Cold Magnet Synchrotron to Upgrade the Proton Energy Range of the BNL Facility,” IEEE Transactions on Nuclear Science, vol. 18, Issue 3, pp. 694-698 (Jun. 1971).
  • Vandeplassche, D., et al., “235 MeV Cyclotron for MHG's Northeast Proton Therapy Center (NPTC): Present Status,” EPAC 96, Fifth European Partical Accelerator Conference, vol. 3, pp. 2650-2652 (Jun. 10-14, 1996).
  • Vorobiev, L.G., et al., “Concepts of a compact achromatic proton gantry with a wide scanning field,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 406, No. 2, pp. 307-310(1998).
  • Vrenken, H., et al., “A Design of a Compact Gantry for Proton Therapy With 2D-Scanning,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 426, No. 2, pp. 618-624 (1999).
  • Wikipedia, “Cyclotron,” http://en.wikipedia.org/wiki/Cyclotron (originally visited Oct. 6,2005, revisited Jan. 28,2009)(7 pages).
  • Wikipedia, “Synchrotron,” http://en.wikiipedia.org/wiki/Synchrotron (originally visited Oct. 6, 2005, revisited Jan. 28, 2009)(7pages).
  • Wu, X., “Conceptual Design and Orbit Dynamics in a 250 MeV Superconducting Synchrocyclotron,” Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy (1990).
  • York, R.C., et al., “Present Status and Future Possibilities at NSCL-MSU,” EPAC 94, Fourth European Particle Accelerator Conference, pp. 554-556 (Jun. 1994).
  • York, R.C., et al., “The NSCL Coupled Cyclotron Project—Overview and Status,” Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, pp. 687-691 (Jun. 1998).
  • Yudelev, M., et. al. “Hospital Based Superconducting Cyclotron for Neutron Therapy: Medical Physics Perspective,” Cyclotrons and their applications 2001, 16th International Conference. American Institute of Physics Conference Proceedings, vol. 600, pp. 40-43 (May 13-17, 2001). http://www.osti.gov/energycitations/productbiblio.jsp?ostiid=20468164 http://adsabs. harvard.edu/abs/2001AIPC..600 ...40Y http://scitation.aip.org/getabs/servlet/GetabsServlet?prog= normal&id= APCPCS000600000001000040000001&idtype=cvips&gifs=yes.
  • Zherbin, E. A., et al., “Proton Beam Therapy at the Leningrad Synchrocyclotron (Clinicomethodological Aspects and Therapeutic Results),” pp. 17-22, Aug. 1987, vol. 32(8)(German with English abstract on ˜es 21-22).
  • Canadian Office action from Canadian application No. 2,629,333 issued May 11, 2011 (2 pages).
  • Canadian Office action from Canadian application No. 2,629,333 issued Aug. 30, 2010 (5 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Aug. 22, 2011 (4 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Mar. 21, 2011 (6 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Dec. 25, 2009 (8 pages).
  • Chinese Office Action from Chinese Application No. 200780102281.X issued Dec. 7, 2011 with English translation (23 pages).
  • Chinese Office action from Chinese application No. 200880125832.9, mailed Sep. 22, 2011 (11 pages).
  • Chinese Office action from Chinese application No. 200880125918.1, mailed Sep. 15, 2011 (111 pages).
  • European Patent Office communication for application No. 06838033.6, patent No. 1949404, mailed Aug. 5, 2009 (1 page).
  • European Patent Office communication from European application No. 07868958.5, mailed Jul. 16, 2010 (2 pages).
  • European Search Report from application No. EP 06838033.6 (PCT/US2006/044853) mailed May 11, 2009 (69 pages).
  • International Preliminary Report on Patentability for PCT application No. PCT/US2007/001506 mailed Jul. 5, 2007 (15 pages).
  • International Preliminary Report on Patentability for PCT/US2007/00 1628, mailed Apr. 22,2008 (15 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2008/084695, mailed Jun. 10, 2010 (10 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2008/084699, mailed Jun. 10, 2010 (8 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2007/086109, mailed Jun. 10, 2010 (7 pages).
  • International Search Report and Written Opinion for PCT application No. PCT/US2008/084695 mailed Jan. 26, 2009 (15 pages).
  • International Search Report and Written Opinion for PCT application No. PCT/US2007/001506 mailed Jul. 5, 2007, Publication No. WO 2007/084701, Published Jul. 26, 2007 (14 pages).
  • International Search Report and Written Opinion mailed Oct. 1, 2009 in PCT application No. PCT/US2008/077513 (73 pages).
  • International Search Report dated Aug. 26, 2008 in PCT application No. PCT/US2007/086109 (6 pages).
  • International Search Report for PCT/US2007/001628 mailed Feb. 18, 2008 (4 pages).
  • Invitation to Pay Additional Fees and, where applicable, Protest Fees with partial search report for application No. PCT/US2008/077513 mailed Jul. 3, 2009 (62 pages).
  • PCT application No. PCT/US2005/25942 filed on Jul. 21, 2005, with Publication No. WO 2006/012452, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2006/44853, filed on Nov. 17, 2006, with Publication No. WO 2007/1061937, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2007/01506 filed on Jan. 19, 2007, with Publication No. WO 2007/084701, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2007/01628 filed on Jan. 19, 2007, with Publication No. WO 2007/1130164, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2007/086109 filed on Nov. 30, 2007, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2007177693 filed on Sep. 6, 2007 with Publication No. WO 2007/177693, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2008/077513, filed on Sep. 24, 2008, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2008/084695 filed on Nov. 25, 2008, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT International Preliminary Report on Patentability of corresponding PCT application No. PCT/US2006/044853, mailed May 29, 2008 (34 pages).
  • PCT International Search report and Written Opinion of PCT application No. PCT/US2006/044853, mailed Oct. 5, 2007 (10 pages).
  • Written Opinion dated Aug. 26, 2008 in PCT application No. PCT/US2007/086109 (6 pages).
  • Written Opinion for PCT/US2007/001628, mailed Feb. 18, 2008 (11 pages).
  • Dialog Search, Jan. 31,2005 (18 pages).
  • European Communication from corresponding European application No. 11/65422.4 mailed Sep. 2, 2011 (5 pages).
  • European Communication from corresponding European application No. 11/65423.2 mailed Sep. 2, 2011 (5 pages).
  • European Communication from European application No. 06838033.6 mailed Apr. 20, 2010 (7 pages).
  • European Communication from European application No. 07868958.5, mailed Nov. 26, 2010 (50 pages).
  • European Patent Office communication from European application No. 08855024.9, mailed Jul. 30, 2010 (2 pages).
  • European Patent Office communication from European application No. 08856764.9, mailed Jul. 30, 2010 (2 pages).
  • European Search Report from corresponding European application No. 11165422.4 mailed Aug. 8, 2011 (118 pages).
  • European Search Report from corresponding European application No. 11165423.2 mailed Aug. 8, 2011 (118 pages).
  • Literature Author and Keyword Search, Feb. 14, 2005 (44 pages).
  • Literature Author and Keyword Searches (Synchrotron), Jan. 25, 2005 (78 pages).
  • Literature Keyword Search, Jan. 24, 2005 (96 pages).
  • Literature Search and Keyword Search for Synchrocyclotron, Jan. 25, 2005 (68 pages).
  • Literature Search by Company Name/Component Source, Jan. 24, 2005 (111 pages).
  • Literature Search, Jan. 26, 2005 (36 pages).
  • “Patent Assignee Search 'Paul Scherrer Institute,” Library Services at Fish & Richardson P.C., Mar. 20, 2007 (40 pages).
  • “Patent Prior Art Search for ‘Proton Therapy System’ ,” Library Services at Fish & Richardson P.C., Mar. 20, 2007 (46 pages).
  • Response to Chinese Office action of Jan. 25, 2010 in Chinese application No. 200680051421.0, filed Jun. 24, 2010 (34 pages).
  • Response to European Communication of Apr. 20, 2010, from European application No. 06838033.6, filed Nov. 2, 2010 (13 pages).
  • Response to European Communication of Jul. 16, 2010 in European application No. 07868958.5 filed Aug. 26, 2010 (9 pages).
  • Response to European Communication of Nov. 26, 2010 in European application no. 07868958.5, filed Mar. 28, 2011 (9 pages).
  • Revised Patent Keyword Search, Jan. 25, 2005 (88 pages).
  • Voluntary amendment filed Apr. 18, 2011 in corresponding Chinese application No. CN200780102281.X, including English translation of claim amendments (10 pages).
  • Worldwide Patent Assignee Search, Jan. 24, 2005 (224 pages).
  • Worldwide Patent Keyword Search, Jan. 24, 2005 (94 pages).
  • Office Action and response history of U.S. Appl. No. 11/601,056 to Aug. 24, 2009.
  • Office Action and response history of U.S. Appl. No. 11/601,056 to Mar. 24, 2009.
  • Office Action and response history of U.S. Appl. No. 11/601,056 up to Jan. 14, 2010.
  • U.S. Appl. No. 10/949,734, filed on Sep. 24, 2004, Patent No. 7,208,748, issued on Apr. 24, 2007, including copy of application as filed, transaction history from PAIR (PTO website), and allowed claims.
  • U.S. Appl. No. 11/187,633, filed on Jul. 21, 2005, including copy of application as filed, transaction history from PAIR (PTO website), and pending claims.
  • U.S. Appl. No. 11/371,622, filed on Mar. 9, 2006, including copy of application as filed, transaction history from PAIR (PTO website), and pending claims.
  • U.S. Appl. No. 11/463,403, filed on Aug. 9, 2006, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/724,055, filed on Mar. 14, 2007, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/948,662, filed on Nov. 30, 2007, including copy of application as filed, transaction history from PAIR (PTO website), and pending claims.
  • U.S. Provisional Appl. No. 60/590,088, filed on Jul. 21, 2004, including copy of application as filed, transaction history from PAIR (PTO website).
  • U.S. Provisional Appl. No. 60/850,565, filed on Oct. 10, 2006, including copy of application as filed, transaction history from PAIR (PTO website).
  • U.S. Provisional Appl. No. 60/991,454, filed on Nov. 30, 2007, including copy of application as filed, transaction history from PAIR (PTO website).
  • U.S. Provisional Appl. No. 60/738,404, filed on Nov. 18, 2005, including copy of application as filed, transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/517,490, filed on Sep. 7, 2006, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/601,056, filed on Nov. 17, 2006, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/624,769, filed on Jan. 19, 2007, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/870,961, filed on Oct. 11, 2007, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 12/275,103, filed on Nov. 20, 2008, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • Non Final Office Action from U.S. Appl. No. 12/275,103 mailed Feb. 1, 2011 (6 pages).
  • Non Final Office Action from U.S. Appl. No. 12/618,297 mailed May 13, 2011 (44 pages).
  • Office action from U.S. Appl. No. 11/948,662, mailed Oct. 14, 2011 (5 pages).
  • Response to Non Final Office Action issued Feb. 1, 2011 in U.S. Appl. No. 12/275,103 filed May 2, 2011 (13 pages).
  • Response to Office action mailed Oct. 14, 2011 from U.S. Appl. No. 11/648,662, filed Dec. 14, 2011 (12 pages).
  • Chinese Office action from Chinese application No. 200880125832.9, mailed Jun. 5, 2012. English Translation will follow upon receipt (5 pages).
  • International Search Report and Written Opinion of the International Searching Authority from International application No. PCT/US2008/084699, mailed Feb. 4, 2009 (11 pages).
  • U.S. Examiner EPHREM ALEMU, USPTO Non Final Office Action in U.S. Appl. No. 11/948,359, dated Aug. 20, 2010 (12 pages).
  • Fish & Richardson P.C., Response to Non Final Office action mailed Aug. 20, 2010 in U.S. Appl. No. 11/948,359, filed on Feb. 22, 2011 (17 pages).
  • Office action from corresponding Canadian Application No. 2,574,122 mailed Nov. 14, 2012 (6 pages).
  • Response in English of Office Action from Chinese application No. 200880125832.9 mailed Jun. 5, 2012, filed Oct. 12, 2012 (6 pages).
  • English translation of Chinese Office action from Chinese application No. 200880125832.9, mailed Jun. 5, 2012 (5 pages).
  • Response with English translation to Chinese Office Action from Chinese application No. 200880125832.9 issued Sep. 22, 2011, filed on Apr. 9, 2012 (23 pages).
  • Chinese Office action with English translation from Chinese Application No. 200880125832.9, issued Mar. 4, 2013 (8 pages).
  • Blosser, H. et al, “Progress Toward an Experiment to Study the Effect of RF Grounding in an Internal Ion Source on Axial Oscillations of the Beam in a Cyclotron”, Cyclotrons and Their Applications 2001, 16th International Conference, 2001 American Institute of Physics, Belgium and Michigan, USA, pp. 274-276 (2001).
  • Flanz, et al., “Operation of a Cyclotron Based Proton Therapy Facility”, Massachusetts General Hospital, Boston, MA 02114, pp. 1-4, retrieved from Internet in 2009.
  • Krevet, et al, “Design of a Strongly Curved Superconducting Bending Magnet for a Compact Synchrotron Light Source”, Advances in Cryogenic Engineering, vol. 33, pp. 25-32 (Dec. 3, 1988).
  • Lawrence, J.H., et al., “Treatment of Pituitary Tumors With Heavy Particles”, Diagnosis and Treatment of Pituitary Tumors, pp. 253-262 (1970).
  • Toyoda, E., “Proton Therapy System”, Sumitomo Heavy Industries, Ltd. (2004).
  • Source Search Cites of U.S. and Foreign Patents/Published applications in the name of Mitsubishi Denki Kabushiki Kaisha and Containing the Keywords (Proton and Synchrocyclotron), 8 pages (2009).
  • Flood, W. S. And Frazier, P. E. “The Wide-Band Driven RF System for the Berkeley 88-Inch Cyclotron” American Institute of Physics, Conference Proceedings., No. 9, 459-466 (1972).
Patent History
Patent number: 8466635
Type: Grant
Filed: Oct 22, 2009
Date of Patent: Jun 18, 2013
Patent Publication Number: 20100045213
Assignee: Mevion Medical Systems, Inc. (Littleton, MA)
Inventors: Alan Sliski (Lincoln, MA), Kenneth Gall (Harvard, MA)
Primary Examiner: Tung X Le
Application Number: 12/603,934
Classifications
Current U.S. Class: Synchrotron (315/503); Cyclotron (315/502); With Injection Or Extraction Means (315/507)
International Classification: H05H 15/00 (20060101);