Programmable radio frequency waveform generator for a synchrocyclotron

A synchrocyclotron comprises includes a resonant circuit that includes electrodes having a gap therebetween across the magnetic field. An oscillating voltage input, having a variable amplitude and frequency determined by a programmable digital waveform generator generates an oscillating electric field across the gap. The synchrocyclotron can include a variable capacitor in circuit with the electrodes to vary the resonant frequency. The synchrocyclotron can further include an injection electrode and an extraction electrode having voltages controlled by the programmable digital waveform generator. The synchrocyclotron can further include a beam monitor. The synchrocyclotron can detect resonant conditions in the resonant circuit by measuring the voltage and or and/or current in the resonant circuit, driven by the input voltage, and adjust the capacitance of the variable capacitor or the frequency of the input voltage to maintain the resonant conditions. The programmable waveform generator can adjust at least one of the oscillating voltage input, the voltage on the injection electrode and the voltage on the extraction electrode according to beam intensity and in response to changes in resonant conditions.

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Description
RELATED APPLICATIONS

This application is a reissue application of U.S. application Ser. No. 12/603,934 filed on Oct. 22, 2009 now U.S. Pat. No. 8,952,634, which is a continuation of U.S. application Ser. No. 12/011,466, filed Jan. 25, 2008 now U.S. Pat. No. 7,626,347, which is a continuation of U.S. application Ser. No. 11/371,622, filed Mar. 9, 2006, now U.S. Pat. No. 7,402,963, which is a continuation of U.S. application Ser. No. 11/187,633, filed Jul. 21, 2005, now abandoned, which claims the benefit of U.S. Provisional Application No. 60/590,089, filed on Jul. 21, 2004.

The entire teachings of the above applications are incorporated herein by reference.

BACKGROUND OF THE INVENTION

In order to accelerate charged particles to high energies, many types of particle accelerators have been developed since the 1930s. One type of particle accelerator is a cyclotron. A cyclotron accelerates charged particles in an axial magnetic field by applying an alternating voltage to one or more “dees” in a vacuum chamber. The name “dee” is descriptive of the shape of the electrodes in early cyclotrons, although they may not resemble the letter D in some cyclotrons. The spiral path produced by the accelerating particles is normal to the magnetic field. As the particles spiral out, an accelerating electric field is applied at the gap between the dees. The radio frequency (RF) voltage creates an alternating electric field across the gap between the dees. The RF voltage, and thus the field, is synchronized to the orbital period of the charged particles in the magnetic field so that the particles are accelerated by the radio frequency waveform as they repeatedly cross the gap. The energy of the particles increases to an energy level far in excess of the peak voltage of the applied radio frequency (RF) voltage. As the charged particles accelerate, their masses grow due to relativistic effects. Consequently, the acceleration of the particles becomes non-uniform and the particles arrive at the gap asynchronously with the peaks of the applied voltage.

Two types of cyclotrons presently employed, an isochronous cyclotron and a synchrocyclotron, overcome the challenge of increase in relativistic mass of the accelerated particles in different ways. The isochronous cyclotron uses a constant frequency of the voltage with a magnetic field that increases with radius to maintain proper acceleration. The synchrocyclotron uses a decreasing magnetic field with increasing radius and varies the frequency of the accelerating voltage to match the mass increase caused by the relativistic velocity of the charged particles.

In a synchrocyclotron, discrete “bunches” of charged particles are accelerated to the final energy before the cycle is started again. In isochronous cyclotrons, the charged particles can be accelerated continuously, rather than in bunches, allowing higher beam power to be achieved.

In a synchrocyclotron, capable of accelerating a proton, for example, to the energy of 250 MeV, the final velocity of protons is 0.61 c, where c is the speed of light, and the increase in mass is 27% above rest mass. The frequency has to decrease by a corresponding amount, in addition to reducing the frequency to account for the radially decreasing magnetic field strength. The frequency's dependence on time will not be linear, and an optimum profile of the function that describes this dependence will depend on a large number of details.

SUMMARY OF THE INVENTION

Accurate and reproducible control of the frequency over the range required by a desired final energy that compensates for both relativistic mass increase and the dependency of magnetic field on the distance from the center of the dee has historically been a challenge. Additionally, the amplitude of the accelerating voltage may need to be varied over the accelerating cycle to maintain focusing and increase beam stability. Furthermore, the dees and other hardware comprising a cyclotron define a resonant circuit, where the dees may be considered the electrodes of a capacitor. This resonant circuit is described by Q-factor, which contributes to the profile of voltage across the gap.

A synchrocyclotron for accelerating charged particles, such as protons, can comprise a magnetic field generator and a resonant circuit that comprising electrodes, disposed between magnetic poles. A gap between the electrodes can be disposed across the magnetic field. An oscillating voltage input drives an oscillating electric field across the gap. The oscillating voltage input can be controlled to vary over the time of acceleration of the charged particles. Either or both the amplitude and the frequency of the oscillating voltage input can be varied. The oscillating voltage input can be generated by a programmable digital waveform generator.

The resonant circuit can further include a variable reactive element in circuit with the voltage input and electrodes to vary the resonant frequency of the resonant circuit. The variable reactive element may be a variable capacitance element such as a rotating condenser or a vibrating reed. By varying the reactance of such a reactive element and adjusting the resonant frequency of the resonant circuit, the resonant conditions can be maintained over the operating frequency range of the synchrocyclotron.

The synchrocyclotron can further include a voltage sensor for measuring the oscillating electric field across the gap. By measuring the oscillating electric field across the gap and comparing it to the oscillating voltage input, resonant conditions in the resonant circuit can be detected. The programmable waveform generator can be adjusting the voltage and frequency input to maintain the resonant conditions.

The synchrocyclotron can further include an injection electrode, disposed between the magnetic poles, under a voltage controlled by the programmable digital waveform generator. The injection electrode is used for injecting charged particles into the synchrocyclotron. The synchrocyclotron can further including an extraction electrode, disposed between the magnetic poles, under a voltage controlled by the programmable digital waveform generator. The extraction electrode is used to extract a particle beam from the synchrocyclotron.

The synchrocyclotron can further include a beam monitor for measuring particle beam properties. For example, the beam monitor can measure particle beam intensity, particle beam timing or spatial distribution of the particle beam. The programmable waveform generator can adjust at least one of the voltage input, the voltage on the injection electrode and the voltage on the extraction electrode to compensate for variations in the particle beam properties.

This invention is intended to address the generation of the proper variable frequency and amplitude modulated signals for efficient injection into, acceleration by, and extraction of charged particles from an accelerator.

BRIEF DESCRIPTION OF THE DRAWINGS

The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the invention.

FIG. 1A is a plan cross-sectional view of a synchrocyclotron of the present invention.

FIG. 1B is a side cross-sectional view of the synchrocyclotron shown in FIG. 1A.

FIG. 2 is an illustration of an idealized waveform that can be used for accelerating charged particles in a synchrocyclotron shown in FIGS. 1A and 1B.

FIG. 3A depicts a portion of a block diagram of a synchrocyclotron of the present invention that includes a waveform generator system.

FIG. 3B depicts a portion of a block diagram of a synchrocyclotron of the present invention that includes a waveform generator system.

FIG. 4 is a flow chart illustrating the principles of operation of a digital waveform generator and an adaptive feedback system (optimizer) of the present invention.

FIG. 5A shows the effect of the finite propagation delay of the signal across different paths in an accelerating electrode (“dee”) structure.

FIG. 5B shows the input waveform timing adjusted to correct for the variation in propagation delay across the “dee” structure.

FIG. 6A shows an illustrative frequency response of the resonant system with variations due to parasitic circuit effects.

FIG. 6B shows a waveform calculated to correct for the variations in frequency response due to parasitic circuit effects.

FIG. 6C shows the resulting “flat” frequency response of the system when the waveform shown in FIG. 6B is used as input voltage.

FIG. 7A shows a constant amplitude input voltage applied to the accelerating electrodes shown in FIG. 7B.

FIG. 7B shows an example of the accelerating electrode geometry wherein the distance between the electrodes is reduced toward the center.

FIG. 7C shows the desired and resultant electric field strength in the electrode gap as a function of radius that achieves a stable and efficient acceleration of charged particles by applying input voltage as shown in FIG. 7A to the electrode geometry shown in FIG. 7B.

FIG. 7D shows input voltage input as a function of radius that directly corresponds to the electric field strength desired and can be produced using a digital waveform generator.

FIG. 7E shows a parallel geometry of the accelerating electrodes which gives a direct proportionality between applied voltage and electric field strength.

FIG. 7F shows the desired and resultant electric field strength in the electrode gap as a function of radius that achieves a stable and efficient acceleration of charged particles by applying input voltage as shown in FIG. 7D to the electrode geometry shown in FIG. 7E.

FIG. 8A shows an example of a waveform of the accelerating voltage generated by the programmable waveform generator.

FIG. 8B shows an example of a timed ion injector signal.

FIG. 8C shows another example of a timed ion injector signal.

DETAILED DESCRIPTION OF THE INVENTION

This invention relates to the devices and methods for generating the complex, precisely timed accelerating voltages across the “dee” gap in a synchrocyclotron. This invention comprises an apparatus and a method for driving the voltage across the “dee” gap by generating a specific waveform, where the amplitude, frequency and phase is controlled in such a manner as to create the most effective particle acceleration given the physical configuration of the individual accelerator, the magnetic field profile, and other variables that may or may not be known a priori. A synchrocyclotron needs a decreasing magnetic field in order to maintain focusing of the particles beam, thereby modifying the desired shape of the frequency sweep. There are predictable finite propagation delays of the applied electrical signal to the effective point on the dee where the accelerating particle bunch experiences the electric field that leads to continuous acceleration. The amplifier used to amplify the radio frequency (RF) signal that drives the voltage across the dee gap may also have a phase shift that varies with frequency. Some of the effects may not be known a priori, and may be only observed after integration of the entire synchrocyclotron. In addition, the timing of the particle injection and extraction on a nanosecond time scale can increase the extraction efficiency of the accelerator, thus reducing stray radiation due to particles lost in the accelerating and extraction phases of operation.

Referring to FIGS. 1A and 1B, a synchrocyclotron of the present invention comprises electrical coils 2a and 2b around two spaced apart metal magnetic poles 4a and 4b configured to generate a magnetic field. Magnetic poles 4a and 4b are defined by two opposing portions of yoke 6a and 6b (shown in cross-section). The space between poles 4a and 4b defines vacuum chamber 8 or a separate vacuum chamber can be installed between the poles 4a and 4b. The magnetic field strength is generally a function of distance from the center of vacuum chamber 8 and is determined largely by the choice of geometry of coils 2a and 2b and shape and material of magnetic poles 4a and 4b.

The accelerating electrodes comprise “dee” 10 and “dee” 12, having gap 13 therebetween. Dee 10 is connected to an alternating voltage potential whose frequency is changed from high to low during the accelerating cycle in order to account for the increasing relativistic mass of a charged particle and radially decreasing magnetic field (measured from the center of vacuum chamber 8) produced by coils 2a and 2b and pole portions 4a and 4b. The characteristic profile of the alternating voltage in dees 10 and 12 is show in FIG. 2 and will be discussed in details below. Dee 10 is a half-cylinder structure, hollow inside. Dee 12, also referred to as the “dummy dee”, does not need to be a hollow cylindrical structure as it is grounded at the vacuum chamber walls 14. Dee 12 as shown in FIGS. 1A and 1B comprises a strip of metal, e.g. copper, having a slot shaped to match a substantially similar slot in dee 10. Dee 12 can be shaped to form a mirror image of surface 16 of dee 10.

Ion source 18 that includes ion source electrode 20, located at the center of vacuum chamber 8, is provided for injecting charged particles. Extraction electrodes 22 are provided to direct the charge particles into extraction channel 24, thereby forming beam 26 of the charged particles. The ion source may also be mounted externally and inject the ions substantially axially into the acceleration region.

Dees 10 and 12 and other pieces of hardware that comprise a cyclotron, define a tunable resonant circuit under an oscillating voltage input that creates an oscillating electric field across gap 13. This resonant circuit can be tuned to keep the Q-factor high during the frequency sweep by using a tuning means.

As used herein, Q-factor is a measure of the “quality” of a resonant system in its response to frequencies close to the resonant frequency. Q-factor is defined as
Q=1/R×√(L/C),
where R is the active resistance of a resonant circuit, L is the inductance and C is the capacitance of this circuit.

Tuning means can be either a variable inductance coil or a variable capacitance. A variable capacitance device can be a vibrating reed or a rotating condenser. In the example shown in FIGS. 1A and 1B, the tuning means is rotating condenser 28. Rotating condenser 28 comprises rotating blades 30 driven by a motor 31. During each quarter cycle of motor 31, as blades 30 mesh with blades 32, the capacitance of the resonant circuit that includes “dees” 10 and 12 and rotating condenser 28 increases and the resonant frequency decreases. The process reverses as the blades unmesh. Thus, resonant frequency is changed by changing the capacitance of the resonant circuit. This serves the purpose of reducing by a large factor the power required to generate the high voltage applied to the “dees” and necessary to accelerate the beam. The shape of blades 30 and 32 can be machined so as to create the required dependence of resonant frequency on time.

The blade rotation can be synchronized with the RF frequency generation so that by varying the Q-factor of the RF cavity, the resonant frequency of the resonant circuit, defined by the cyclotron, is kept close to the frequency of the alternating voltage potential applied to “dees” 10 and 12.

The rotation of the blades can be controlled by the digital waveform generator, described below with reference to FIG. 3 and FIG. 4, in a manner that maintains the resonant frequency of the resonant circuit close to the current frequency generated by the digital waveform generator. Alternatively, the digital waveform generator can be controlled by means of an angular position sensor (not shown) on the rotating condenser shaft 33 to control the clock frequency of the waveform generator to maintain the optimum resonant condition. This method can be employed if the profile of the meshing blades of the rotating condenser is precisely related to the angular position of the shaft.

A sensor that detects the peak resonant condition (not shown) can also be employed to provide feedback to the clock of the digital waveform generator to maintain the highest match to the resonant frequency. The sensors for detecting resonant conditions can measure the oscillating voltage and current in the resonant circuit. In another example, the sensor can be a capacitance sensor. This method can accommodate small irregularities in the relationship between the profile of the meshing blades of the rotating condenser and the angular position of the shaft.

A vacuum pumping system 40 maintains vacuum chamber 8 at a very low pressure so as not to scatter the accelerating beam.

To achieve uniform acceleration in a synchrocyclotron, the frequency and the amplitude of the electric field across the “dee” gap needs to be varied to account for the relativistic mass increase and radial (measured as distance from the center of the spiral trajectory of the charged particles) variation of magnetic field as well as to maintain focus of the beam of particles.

FIG. 2 is an illustration of an idealized waveform that may be required for accelerating charged particles in a synchrocyclotron. It shows only a few cycles of the waveform and does not necessarily represent the ideal frequency and amplitude modulation profiles. FIG. 2 illustrates the time varying amplitude and frequency properties of the waveform used in a given synchrocyclotron. The frequency changes from high to low as the relativistic mass of the particle increases while the particle speed approaches a significant fraction of the speed of light.

The instant invention uses a set of high speed digital to analog converters (DAC) that can generate, from a high speed memory, the required signals on a nanosecond time scale. Referring to FIG. 1A, both a radio frequency (RF) signal that drives the voltage across dee gap 13 and signals that drive the voltage on injector electrode 20 and extractor electrode 22 can be generated from the memory by the DACs. The accelerator signal is a variable frequency and amplitude waveform. The injector and extractor signals can be either of at least three types: continuous; discrete signals, such as pulses, that may operate over one or more periods of the accelerator waveform in synchronism with the accelerator waveform; or discrete signals, such as pulses, that may operate at precisely timed instances during the accelerator waveform frequency sweep in synchronism with the accelerator waveform. (See below with reference to FIGS. 8A-C.)

FIG. 3 depicts a block diagram of a synchrocyclotron of the present invention 300 that includes particle accelerator 302, waveform generator system 319 and amplifying system 330. FIG. 3 also shows an adaptive feedback system that includes optimizer 350. The optional variable condenser 28 and drive subsystem to motor 31 are not shown.

Referring to FIG. 3, particle accelerator 302 is substantially similar to the one depicted in FIGS. 1A and 1B and includes “dummy dee” (grounded dee) 304, “dee” 306 and yoke 308, injection electrode 310, connected to ion source 312, and extraction electrodes 314. Beam monitor 316 monitors the intensity of beam 318.

Synchrocyclotron 300 includes digital waveform generator 319. Digital waveform generator 319 comprises one or more digital-to-analog converters (DACs) 320 that convert digital representations of waveforms stored in memory 322 into analog signals. Controller 324 controls addressing of memory 322 to output the appropriate data and controls DACs 320 to which the data is applied at any point in time. Controller 324 also writes data to memory 322. Interface 326 provides a data link to an outside computer (not shown). Interface 326 can be a fiber optic interface.

The clock signal that controls the timing of the “analog-to-digital” conversion process can be made available as an input to the digital waveform generator. This signal can be used in conjunction with a shaft position encoder (not shown) on the rotating condenser (see FIGS. 1A and 1B) or a resonant condition detector to fine-tune the frequency generated.

FIG. 3 illustrates three DACs 320a, 320b and 320c. In this example, signals from DACs 320a and 320b are amplified by amplifiers 328a and 328b, respectively. The amplified signal from DAC 320a drives ion source 312 and/or injection electrode 310, while the amplified signal from DAC 320b drives extraction electrodes 314.

The signal generated by DAC 320c is passed on to amplifying system 330, operated under the control of RF amplifier control system 332. In amplifying system 330, the signal from DAC 320c is applied by RF driver 334 to RF splitter 336, which sends the RF signal to be amplified by an RF power amplifier 338. In the example shown in FIG. 3, four power amplifiers, 338a, b, c and d, are used. Any number of amplifiers 338 can be used depending on the desired extent of amplification. The amplified signal, combined by RF combiner 340 and filtered by filter 342, exits amplifying system 330 though directional coupler 344, which ensures that RF waves do not reflect back into amplifying system 330. The power for operating amplifying system 330 is supplied by power supply 346.

Upon exit from amplifying system 330, the signal from DAC 320c is passed on to particle accelerator 302 through matching network 348. Matching network 348 matches impedance of a load (particle accelerator 302) and a source (amplifying system 330). Matching network 348 includes a set of variable reactive elements.

Synchrocyclotron 300 can further include optimizer 350. Using measurement of the intensity of beam 318 by beam monitor 316, optimizer 350, under the control of a programmable processor can adjust the waveforms produced by DACs 320a, b and c and their timing to optimize the operation of the synchrocyclotron 300 and achieve a optimum acceleration of the charged particles.

The principles of operation of digital waveform generator 319 and adaptive feedback system 350 will now be discussed with reference to FIG. 4.

The initial conditions for the waveforms can be calculated from physical principles that govern the motion of charged particles in magnetic field, from relativistic mechanics that describe the behavior of a charged particle mass as well as from the theoretical description of magnetic field as a function of radius in a vacuum chamber. These calculations are performed at step 402. The theoretical waveform of the voltage at the dee gap, RF(ω, t), where ω is the frequency of the electrical field across the dee gap and t is time, is computed based on the physical principles of a cyclotron, relativistic mechanics of a charged particle motion, and theoretical radial dependency of the magnetic field.

Departures of practice from theory can be measured and the waveform can be corrected as the synchrocyclotron operates under these initial conditions. For example, as will be described below with reference to FIGS. 8A-C, the timing of the ion injector with respect to the accelerating waveform can be varied to maximize the capture of the injected particles into the accelerated bunch of particles.

The timing of the accelerator waveform can be adjusted and optimized, as described below, on a cycle-by-cycle basis to correct for propagation delays present in the physical arrangement of the radio frequency wiring; asymmetry in the placement or manufacture of the dees can be corrected by placing the peak positive voltage closer in time to the subsequent peak negative voltage or vice versa, in effect creating an asymmetric sine wave.

In general, waveform distortion due to characteristics of the hardware can be corrected by pre-distorting the theoretical waveform RF(ω, t) using a device-dependent transfer function A, thus resulting in the desired waveform appearing at the specific point on the acceleration electrode where the protons are in the acceleration cycle. Accordingly, and referring again to FIG. 4, at step 404, a transfer function A(ω, t) is computed based on experimentally measured response of the device to the input voltage.

At step 405, a waveform that corresponds to an expression RF(ω, t)/A(ω,t) is computed and stored in memory 322. At step 406, digital waveform generator 319 generates RF /A waveform from memory. The driving signal RF(ω, t)/A(ω, t) is amplified at step 408, and the amplified signal is propagated through the entire device 300 at step 410 to generate a voltage across the dee gap at step 412. A more detailed description of a representative transfer function A(ω,t) will be given below with reference to FIGS. 6A-C.

After the beam has reached the desired energy, a precisely timed voltage can be applied to an extraction electrode or device to create the desired beam trajectory in order to extract the beam from the accelerator, where it is measured by beam monitor at step 414a. RF voltage and frequency is measured by voltage sensors at step 414b. The information about beam intensity and RF frequency is relayed back to digital waveform generator 319, which can now adjust the shape of the signal RF(ω, t)/A(ω, t) at step 406.

The entire process can be controlled at step 416 by optimizer 350. Optimizer 350 can execute a semi- or fully automatic algorithm designed to optimize the waveforms and the relative timing of the waveforms. Simulated annealing is an example of a class of optimization algorithms that may be employed. On-line diagnostic instruments can probe the beam at different stages of acceleration to provide feedback for the optimization algorithm. When the optimum conditions have been found, the memory holding the optimized waveforms can be fixed and backed up for continued stable operation for some period of time. This ability to adjust the exact waveform to the properties of the individual accelerator decreases the unit-to-unit variability in operation and can compensate for manufacturing tolerances and variation in the properties of the materials used in the construction of the cyclotron.

The concept of the rotating condenser (such as condenser 28 shown in FIGS. 1A and 1B) can be integrated into this digital control scheme by measuring the voltage and current of the RF waveform in order to detect the peak of the resonant condition. The deviation from the resonant condition can be fed back to the digital waveform generator 319 (see FIG. 3) to adjust the frequency of the stored waveform to maintain the peak resonant condition throughout the accelerating cycle. The amplitude can still be accurately controlled while this method is employed.

The structure of rotating condenser 28 (see FIGS. 1A and 1B) can optionally be integrated with a turbomolecular vacuum pump, such as vacuum pump 40 shown in FIGS. 1A and 1B, that provides vacuum pumping to the accelerator cavity. This integration would result in a highly integrated structure and cost savings. The motor and drive for the turbo pump can be provided with a feedback element such as a rotary encoder to provide fine control over the speed and angular position of rotating blades 30, and the control of the motor drive would be integrated with the waveform generator 319 control circuitry to insure proper synchronization of the accelerating waveform.

As mentioned above, the timing of the waveform of the oscillating voltage input can be adjusted to correct for propagation delays that arise in the device. FIG. 5A illustrate an example of wave propagation errors due to the difference in distances R1 and R2 from the RF input point 504 to points 506 and 508, respectively, on the accelerating surface 502 of accelerating electrode 500. The difference in distances R1 and R2 results in signal propagation delay that affects the particles as they accelerate along a spiral path (not shown) centered at point 506. If the input waveform, represented by curve 510, does not take into account the extra propagation delay caused by the increasing distance, the particles can go out of synchronization with the accelerating waveform. The input waveform 510 at point 504 on the accelerating electrode 500 experiences a variable delay as the particles accelerate outward from the center at point 506. This delay results in input voltage having waveform 512 at point 506, but a differently timed waveform 514 at point 508. Waveform 514 shows a phase shift with respect to waveform 512 and this can affect the acceleration process. As the physical size of the accelerating structure (about 0.6 meters) is a significant fraction of the wavelength of the accelerating frequency (about 2 meters), a significant phase shift is experienced between different parts of the accelerating structure.

In FIG. 5B, the input voltage having waveform 516 is pre-adjusted relative to the input voltage described by waveform 510 to have the same magnitude, but opposite sign of time delay. As a result, the phase lag caused by the different path lengths across the accelerating electrode 500 is corrected. The resulting waveforms 518 and 520 are now correctly aligned so as to increase the efficiency of the particle accelerating process. This example illustrates a simple case of propagation delay caused by one easily predictable geometric effect. There may be other waveform timing effects that are generated by the more complex geometry used in the actual accelerator, and these effects, if they can be predicted or measured can be compensated for by using the same principles illustrated in this example.

As described above, the digital waveform generator produces an oscillating input voltage of the form RF(ω, t)/A(ω, t), where RF(ω, t) is a desired voltage across the dee gap and A(ω, t) is a transfer function. A representative device-specific transfer function A, is illustrated by curve 600 in FIG. 6A. Curve 600 shows Q-factor as a function of frequency. Curve 600 has two unwanted deviations from an ideal transfer function, namely troughs 602 and 604. These deviation can be caused by effects due to the physical length of components of the resonant circuit, unwanted self-resonant characteristics of the components or other effects. This transfer function can be measured and a compensating input voltage can be calculated and stored in the waveform generator's memory. A representation of this compensating function 610 is shown in FIG. 6B. When the compensated input voltage 610 is applied to device 300, the resulting voltage 620 is uniform with respect to the desired voltage profile calculated to give efficient acceleration.

Another example of the type of effects that can be controlled with the programmable waveform generator is shown in FIG. 7. In some synchrocyclotrons, the electric field strength used for acceleration can be selected to be somewhat reduced as the particles accelerate outward along spiral path 705. This reduction in electric field strength is accomplished by applying accelerating voltage 700, that is kept relatively constant as shown in FIG. 7A, to accelerating electrode 702. Electrode 704 is usually at ground potential. The electric field strength in the gap is the applied voltage divided by the gap length. As shown in FIG. 7B, the distance between accelerating electrodes 702 and 704 is increasing with radius R. The resulting electric field strength as a function or radius R is shown as curve 706 in FIG. 7C.

With the use of the programmable waveform generator, the amplitude of accelerating voltage 708 can be modulated in the desired fashion, as shown in FIG. 7D. This modulation allows to keep the distance between accelerating electrodes 710 and 712 to remain constant, as shown in FIG. 7E. As a result, the same resulting electric field strength as a function of radius 714, shown in FIG. 7F, is produced as shown in FIG. 7C. While this is a simple example of another type of control over synchrocyclotron system effects, the actual shape of the electrodes and profile of the accelerating voltage versus radius may not follow this simple example.

As mentioned above, the programmable waveform generator can be used to control the ion injector (ion source) to achieve optimal acceleration of the charged particles by precisely timing particle injections. FIG. 8A shows the RF accelerating waveform generated by the programmable waveform generator. FIG. 8B shows a precisely timed cycle-by-cycle injector signal that can drive the ion source in a precise fashion to inject a small bunch of ions into the accelerator cavity at precisely controlled intervals in order to synchronize with the acceptance phase angle of the accelerating process. The signals are shown in approximately the correct alignment, as the bunches of particles are usually traveling through the accelerator at about a 30 degree lag angle compared to the RF electric field waveform for beam stability. The actual timing of the signals at some external point such as the output of the digital-to-analog converters, may not have this exact relationship as the propagation delays of the two signals is likely to be different. With the programmable waveform generator, the timing of the injection pulses can be continuously varied with respect to the RF waveform in order to optimize the coupling of the injected pulses into the accelerating process. This signal can be enabled or disabled to turn the beam on and off. The signal can also be modulated via pulse dropping techniques to maintain a required average beam current. This beam current regulation is accomplished by choosing a macroscopic time interval that contains some relatively large number of pulses, on the order of 1000,and changing the fraction of pulses that are enabled during this interval.

FIG. 8C shows a longer injection control pulse that corresponds to a multiple number of RF cycles. This pulse is generated when a bunch of protons are to be accelerated. The periodic acceleration process captures only a limited number of particles that will be accelerated to the final energy and extracted. Controlling the timing of the ion injection can result in lower gas load and consequently better vacuum conditions which reduces vacuum pumping requirements and improves high voltage and beam loss properties during the acceleration cycle. This can be used where the precise timing of the injection shown in FIG. 8B is not required for acceptable coupling of the ion source to the RF waveform phase angle. This approach injects ions for a number of RF cycles which corresponds approximately to the number of “turns” which are accepted by the accelerating process in the synchrocyclotron. This signal is also enabled or disabled to turn the beam on and off or modulate the average beam current.

While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.

Claims

1. A synchrocyclotron comprising:

a magnetic field generator to produce a magnetic field;
a resonant circuit, comprising: electrodes, disposed within a cavity between magnetic poles, having a gap therebetween across a the magnetic field; and a variable reactive element in circuit with the electrodes to vary a resonant frequency of the resonant circuit; and
an extraction channel to receive charged particles from the cavity and to output a particle beam from the synchrocyclotron;
a sensor to measure a voltage in the resonant circuit; and
a voltage input generator to provide adjust a frequency of a voltage input to the resonant circuit based on an intensity of the particle beam output by the synchrocyclotron and a frequency of the voltage measured in the resonant circuit, the voltage input being an oscillating voltage that varies in frequency over a time of acceleration of the charged particles.

2. The synchrocyclotron as claimed in claim 1 wherein an amplitude of the voltage input is varied.

3. The synchrocyclotron of claim 1 further including an ion source for injecting charged particles into the synchrocyclotron.

4. The synchrocyclotron of claim 1 further including an extraction electrode disposed between the magnetic poles for extracting a the particle beam from the synchrocyclotron.

5. The synchrocyclotron of claim 1 further including a wherein the sensor is for detecting resonant conditions in the resonant circuit.

6. The synchrocyclotron of claim 5 further including means for adjusting at least one of a the frequency of the voltage input, reactance of the variable reactive element, and resonant frequency of the resonant circuit based on the resonant conditions.

7. The synchrocyclotron of claim 1 further including a beam monitor for detecting a particle beam extracted from the synchrocyclotron.

8. The synchrocyclotron of claim 7 wherein the beam monitor is configured to measure at least one of particle beam intensity, particle beam timing, and spatial distribution of the particle beam.

9. The synchrocyclotron as claimed in claim 1 further including wherein the voltage input generator comprises a programmable digital waveform generator for generating the oscillating voltage.

10. The synchrocyclotron of claim 9 wherein the programmable waveform generator is configured to compensate for at least one of variations in resonant conditions of the resonant circuit and variations in a the particle beam extracted from the synchrocyclotron.

11. A method of accelerating particles in a synchrocyclotron, comprising:

providing particles in a cavity of the synchrocyclotron;
providing a resonant circuit in the cavity, the resonant circuit comprising accelerating electrodes having a gap therebetween across a magnetic field; and
using a sensor to measure a voltage in the resonant circuit;
with using a voltage input generator, applying an oscillating adjusting, based on an intensity of a particle beam output by the synchrocyclotron and a frequency of a voltage measured in the resonant circuit, a frequency of a voltage input that varies in frequency during acceleration of the particles to the resonant circuit, the oscillating voltage input creating an oscillating electric field across the gap that accelerates the particles in the synchrocyclotron cavity; and
receiving the particles from the cavity in an extraction channel and outputting a particle beam from the extraction channel.

12. The method as in claim 11, further including generating the oscillating voltage input.

13. The method of claim 11, further including varying an amplitude of the oscillating voltage input.

14. The method of claim 11, wherein providing particles includes injecting particles into the synchrocyclotron.

15. The method of claim 11, further including detecting resonant conditions in the resonant circuit.

16. The method of claim 15, further including adjusting at least one of a frequency of the oscillating voltage input, a reactance of a variable reactive element, and a resonant frequency of the resonant circuit based on the resonant conditions.

17. The method of claim 11, further including extracting accelerated particles from the synchrocyclotron to form a the particle beam.

18. The method as in claim 17, further including detecting variations in the particle beam.

19. The method as in claim 18, wherein the variations include variations in at least one of particle beam intensity, particle beam timing, and spatial distribution of the particle beam.

20. The method as in claim 18, further including compensating for detected variations in the particle beam.

21. A particle accelerator configured to generate a particle beam, the particle accelerator comprising:

an ion source to provide pulses of charged particles that are accelerated in a cavity to form the particle beam;
a beam monitor to obtain information about the particle beam, the information comprising information about an intensity of the particle beam; and
a waveform generator comprising a controller to receive the information about the intensity and to write data to memory, the waveform generator comprising a driver to provide voltage to the cavity to accelerate the charged particles; and
circuitry to control operation of the ion source based on the information about the intensity so that the pulses are provided at timed instances in synchronism with a sweep of a frequency of the voltage that accelerates the charged particles.

22. The particle accelerator of claim 21, further comprising:

magnetic pole pieces that border the cavity, the cavity housing at least part of the ion source;
wherein the voltage comprises an oscillating voltage having a frequency that varies over a time to accelerate the charged particles.

23. The particle accelerator of claim 21, wherein the voltage comprises an oscillating voltage having a frequency that varies over a time to accelerate the charged particles.

24. The particle accelerator of claim 21, further comprising:

magnetic pole pieces that border the cavity, the cavity housing at least part of the ion source;
wherein the voltage comprises an oscillating voltage having a frequency that varies over a time to accelerate the charged particles; and
wherein the ion source is controlled to provide pulses of charged particles at a same point in each cycle of the oscillating voltage.

25. The particle accelerator of claim 21, wherein the operation of the ion source is controlled by turning the ion source on and off during a time interval in order to obtain a desired beam current.

26. The particle accelerator of claim 21, wherein the operation of the ion source is controlled by selecting a time interval and by dropping a number of pulses that occur during the time interval to obtain a desired beam current.

27. The particle accelerator of claim 21, wherein the particle accelerator comprises a synchrocyclotron.

28. The particle accelerator of claim 21, wherein the waveform generator comprises digital circuitry, the digital circuitry comprising a digital-to-analog converter (DAC) to generate an analog signal based on the data, the analog signal for controlling the ion source.

29. A particle accelerator configured to generate a particle beam, the particle accelerator comprising:

an ion source to inject charged particles into a resonant cavity;
magnetic pole pieces that border the resonant cavity, the resonant cavity having a radio frequency (RF) voltage to accelerate the charged particles to produce the particle beam;
a feedback system to provide at least one property of the particle beam; and
circuitry to receive an injection control pulse that extends over multiple cycles of the RF voltage and to control, based on the at least one property, the injection control pulse based on cycles of the RF voltage so that charged particles are injected continuously over at least some of the multiple cycles.

30. The particle accelerator of claim 29, wherein the at least one property comprises an intensity of the particle beam.

31. The particle accelerator of claim 29, wherein the at least one property comprises a spatial distribution of the particle beam.

32. The particle accelerator of claim 29, wherein the at least one property comprises a timing associated with the particle beam.

33. The particle accelerator of claim 29, wherein the injection control pulse controls operation of the ion source by turning the ion source on and off during a time interval in order to maintain a beam current.

34. The particle accelerator of claim 29, wherein the injection control pulse controls operation of the ion source by selecting a time interval and wherein the circuitry is configured to drop a number of pulses that occur during the time interval to maintain a beam current.

35. The particle accelerator of claim 29, wherein the particle accelerator comprises a synchrocyclotron.

36. The particle accelerator of claim 29, wherein the feedback system comprises a beam monitor to monitor the particle beam to obtain the at least one property.

37. The particle accelerator of claim 29, wherein the circuitry comprises a digital waveform generator.

38. A synchrocyclotron comprising:

magnetic pole pieces that border a cavity;
an ion source to provide, to the cavity, ions that are accelerated to form a particle beam;
a voltage generator to provide voltage to the cavity, the voltage comprising an oscillating voltage having a frequency that varies over a time of acceleration of the ions;
a sensor to measure the oscillating voltage in the cavity; and
a control circuit to control, based on the oscillating voltage measured by the sensor, a timing at which ions are provided by the ion source, the timing being controlled so that ions are provided into the cavity for a limited time and at a same point in each of multiple frequency sweeps of the oscillating voltage, at least part of the control circuit comprising digital circuitry, the digital circuitry comprising an interface that provides a data link to a computer.

39. The synchrocyclotron of claim 38, further comprising:

a beam monitor to provide information about the particle beam, the information comprising information based on an intensity of the particle beam;
wherein the control circuit is configured to control the timing based also on the information based on the intensity.

40. The synchrocyclotron of claim 38, further comprising:

a beam monitor to provide information about the particle beam, the information comprising information based on a spatial distribution of the particle beam;
wherein the control circuit is configured to control the timing based also on the information based on the spatial distribution.

41. The synchrocyclotron of claim 38, further comprising:

a beam monitor to provide information about the particle beam, the information comprising information based on a timing of the particle beam;
wherein the control circuit is configured to control the timing based also on the information based on a timing of the particle beam.

42. The synchrocyclotron of claim 38, wherein the at least part of the control circuit comprises a programmable processor.

43. The synchrocyclotron of claim 38, wherein the control circuit is configured to control the timing so as to cause the ion source to provide particles into the cavity over a number of cycles of the oscillating voltage.

44. The synchrocyclotron of claim 38, wherein the control circuit is configured to control the timing by turning the ion source on and off during a time interval in order to maintain a beam current.

45. The synchrocyclotron of claim 38, wherein the digital circuitry comprises a programmable processor.

46. The synchrocyclotron of claim 38, wherein voltage generator comprises a digital waveform generator that includes the control circuit.

47. A synchrocyclotron comprising:

a particle source to provide charged particles into a cavity having a magnetic field;
a voltage circuit to cause acceleration of the charged particles in the cavity via an oscillating electric field, the oscillating electric field to vary over a time of acceleration of the charged particles, the voltage circuit comprising a resonant circuit that comprises accelerating electrodes having a gap therebetween across the magnetic field and a driver to drive an oscillating voltage input to produce the oscillating electric field across the gap, the oscillating voltage input to vary over the time of acceleration of the charged particles; and
a control circuit to control the particle source to provide the charged particles for a limited time during each of multiple frequency sweeps of the oscillating electric field across the gap, the limited time synchronizing with an acceptance phase angle of the synchrocyclotron, at least part of the control circuit comprising digital circuitry, the digital circuitry comprising an interface that provides a data link to a computer.

48. The synchrocyclotron of claim 47, further comprising:

a beam monitor to provide information about a particle beam, the information comprising information based on an intensity of the particle beam;
wherein the control circuit is configured to control the particle source based also on the information based on the intensity.

49. The synchrocyclotron of claim 47, further comprising:

a beam monitor to provide information about a particle beam, the information comprising information based on a spatial distribution of the particle beam;
wherein the control circuit is configured to control the particle source based also on the information based on the spatial distribution.

50. The synchrocyclotron of claim 47, further comprising:

a beam monitor to provide information about a particle beam, the information comprising information based on a timing of the particle beam;
wherein the control circuit is configured to control the particle source based also on the information based on a timing of the particle beam.

51. The synchrocyclotron of claim 47, wherein the control circuit is configured to control the particle source based on variations of the oscillating electric field over time.

52. The synchrocyclotron of claim 47, wherein the control circuit is configured to control the particle source so as to cause the particle source to inject particles at a same point in each cycle of the oscillating electric field.

53. The synchrocyclotron of claim 47, wherein the control circuit is configured to control the particle source by turning the particle source on and off during a time interval in order to obtain a desired beam current.

54. The synchrocyclotron of claim 47, wherein the digital circuitry comprises a programmable processor.

55. The synchrocyclotron of claim 47, wherein voltage circuit and the control circuit are components of a digital waveform generator.

56. A particle accelerator comprising:

a cavity having a magnetic field;
an ion source to provide charged particles to the cavity;
a digital waveform generator to apply an oscillating voltage input to a resonant circuit that comprises accelerating electrodes having a gap therebetween across the magnetic field to drive an oscillating electric field across the gap and accelerate the charged particles within the cavity;
a beam monitor to measure a property of a particle beam comprised of the charged particles that have been accelerated;
wherein the digital waveform generator is configured to control the oscillating voltage input and the ion source to compensate for variations in the property of the particle beam; and
a programmable processor to control at least part of the digital waveform generator.

57. The particle accelerator of claim 56, wherein digital waveform generator is configured to vary an amplitude of the oscillating voltage input.

58. The particle accelerator of claim 56, wherein digital waveform generator is configured to vary a frequency of the oscillating voltage input.

59. The particle accelerator of claim 56, wherein digital waveform generator is configured to vary an amplitude and a frequency of oscillating voltage input.

60. The particle accelerator of claim 59, wherein digital waveform generator is configured to vary a frequency of the oscillating voltage input in order to maintain resonant conditions in the cavity.

61. The particle accelerator of claim 60, further comprising:

a variable reactive element in circuit with the oscillating voltage input and the accelerating electrodes.

62. The particle accelerator of claim 56, wherein the property comprises particle beam timing.

63. The particle accelerator of claim 56, wherein the property comprises spatial distribution of the particle beam.

64. A particle accelerator comprising

magnetic pole pieces that border a cavity;
a voltage generator to provide voltage to the cavity, the voltage comprising an oscillating voltage having a frequency that varies over a time of acceleration of charged particles;
an ion source that is controllable to output, over a period of time, pulses of charged particles that are accelerated in the cavity based on the oscillating voltage to form a particle beam;
control circuitry to regulate a current of the particle beam by controlling the ion source so as not to output at least some of the pulses during the period of time; and
a beam monitor to obtain at least one property of the particle beam;
wherein the control circuitry is configured to control a timing at which some of the pulses are output based on the oscillating voltage and an acceptance phase angle of the synchrocyclotron and to control, based on the at least one property, the ion source so as to change a number of the pulses that are not output during the period of time across different cycles of the voltage.

65. The particle accelerator of claim 64, wherein the at least one property comprises an intensity of the particle beam.

66. The particle accelerator of claim 64, wherein the at least one property comprises a timing associated with the particle beam.

67. The particle accelerator of claim 64, wherein the at least one property comprises a spatial distribution of the particle beam.

68. The particle accelerator of claim 64, further comprising:

a resonant circuit, comprising: electrodes, disposed between magnetic pole pieces, having a gap therebetween across the magnetic field; and a variable reactive element in circuit with the electrodes to vary a resonant frequency of the resonant circuit; and
wherein the voltage generator is configured to provide the voltage to the resonant circuit.

69. The particle accelerator of claim 68, wherein the voltage generator is digitally controllable to change an amplitude of the voltage.

70. The particle accelerator of claim 69, wherein the control circuit is configured to regulate the current based on the at least one property.

71. A particle accelerator configured to generate a particle beam, the particle accelerator comprising:

an ion source to provide charged particles into a resonant cavity;
electrodes in the resonant cavity, the electrodes being separated by a gap;
a voltage circuit to output a radio frequency (RF) voltage to at least one of the electrodes to produce an oscillating electric field across the gap, the RF voltage having a frequency that varies to accelerate the charged particles to form the particle beam; and
a feedback system to detect information about the frequency of the oscillating electric field, and to adjust a timing of operation of the voltage circuit and the ion source based on the information so that the charged particles are provided to the resonant cavity in synchronism with a variation in the frequency of the RF voltage.

72. The particle accelerator of claim 71, wherein the feedback system comprises a voltage sensor configured to measure the oscillating electric field across the gap.

73. The particle accelerator of claim 71, wherein the feedback system comprises a digital control circuit configured to write data based on the information to memory, and to output data from memory to generate one or more waveforms upon which future outputs of the RF voltage are based.

74. The particle accelerator of claim 71, wherein the feedback system comprises:

a beam monitor to detect an intensity of the particle beam; and
a control circuit to control operation of the ion source based on the intensity detected.

75. The particle accelerator of claim 72, wherein the particle accelerator is a synchrocyclotron.

76. The particle accelerator of claim 71, wherein the timing of operation of the voltage circuit is varied to compensate for physical features of the particle accelerator.

77. The particle accelerator of claim 71, wherein the information comprises a peak resonant condition of the resonant cavity; and

wherein the feedback system is configured to control the timing of operation of the voltage circuit based on the peak resonant condition.

78. The particle accelerator of claim 77, wherein the timing of operation of the voltage circuit is controlled so that the RF voltage output matches a voltage of the resonant circuit corresponding to the peak resonant condition.

79. The particle accelerator of claim 71, wherein the feedback system comprises a programmable processor to control the timing of operation of at least one of the voltage circuit or the ion source based on the information.

80. A synchrocyclotron configured to output a particle beam, the synchrocyclotron comprising:

an ion source to provide charged particles to a resonant cavity for orbital acceleration to form the particle beam, the particle beam comprising multiple pulses;
a voltage source to provide a radio frequency (RF) voltage to the resonant cavity, the voltage source comprising an amplifier to change an amplitude of the RF voltage before providing the RF voltage to the resonant cavity;
a control system to control operation of the ion source in order to control intensities of individual pulses among the multiple pulses comprising the particle beam, the control system comprising a programmable processor to control the operation of the ion source based on a frequency of the RF voltage in the resonant cavity; and
a beam monitor to detect an intensity of the particle beam;
wherein the programmable processor is configured to control operation of the ion source based also on information about the detected intensity.

81. The synchrocyclotron of claim 80, wherein the operation of the ion source is controlled by turning the ion source on and off during a time interval.

82. The synchrocyclotron of claim 80, wherein the operation of the ion source is controlled by selectively providing charged particles from the ion source over a number of cycles of the frequency of the RF voltage.

83. The synchrocyclotron of claim 80, wherein the operation of the ion source is controlled to control a timing at which the charged particles are provided.

84. The synchrocyclotron of claim 80, wherein the operation of the ion source is controlled to inject the charged particles at a same time relative to each cycle among multiple cycles of the frequency of the RF voltage.

85. The synchrocyclotron of claim 80, wherein the operation of the ion source is controlled to inject the charged particles continuously over multiple cycles of the frequency of the RF voltage.

86. The synchrocyclotron of claim 80, further comprising:

magnetic pole pieces that border the resonant cavity in which the charged particles accelerate; and
a resonant circuit to control a resonant frequency within the resonant cavity;
wherein the voltage source is configured to provide the RF voltage to the resonant circuit, the RF voltage comprising an oscillating voltage that varies over a time of acceleration of the charged particles; and
wherein the voltage source comprises a digital waveform generator that includes the control system.

87. The synchrocyclotron of claim 80, wherein the operation of the ion source is controlled to inject the charged particles so as to compensate for detected variations of the particle beam.

88. The synchrocyclotron of claim 80, wherein the operation of the ion source is controlled to inject the charged particles periodically.

89. The synchrocyclotron of claim 80, wherein controlling intensities of individual pulses comprises controlling pulse widths of the individual pulses.

90. A synchrocyclotron comprising:

magnetic pole pieces that border a cavity in which charged particles accelerate;
a resonant circuit to control a resonant frequency within the cavity;
a voltage circuit to provide voltage to the resonant circuit, the voltage comprising an oscillating voltage that varies over a time of acceleration of the charged particles; and
a feedback system to detect parameters based on operation of the resonant circuit, and to control the voltage circuit based on a least one of the parameters so as to maintain a resonant condition in the resonant circuit;
wherein the parameters comprises an amplitude of the voltage and a frequency of the voltage, and wherein the voltage circuit comprises an amplifier to change the amplitude of the voltage to maintain beam focusing.

91. The synchrocyclotron of claim 90, wherein the feedback system comprises a control circuit to control a property of the voltage based on the at least one parameter.

92. The synchrocyclotron of claim 91, wherein the control circuit is configured to control the property of the voltage by writing data about the property to memory.

93. The synchrocyclotron of claim 90, further comprising:

an ion source to provide the charged particles to the cavity, the charged particles to accelerate in the cavity to form a particle beam;
an extraction channel to output the particle beam from the synchrocyclotron; and
a beam monitor to obtain information about a property of the particle beam;
wherein the feedback system is configured to receive the information about the property of the particle beam, and to use the information to control operation of the ion source.

94. The synchrocyclotron of claim 93, wherein the property of the particle beam is an intensity of the particle beam.

95. The synchrocyclotron of claim 93, wherein the property of the particle beam is particle beam timing or spatial distribution of the particle beam.

96. The synchrocyclotron of claim 90, wherein the resonant circuit comprises:

electrodes in the cavity, the electrodes having a gap therebetween across a magnetic field in the cavity produced by the magnetic pole pieces; and
a variable reactive element in circuit with the electrodes to vary the resonant frequency.

97. The synchrocyclotron of claim 96, further comprising:

an angular position sensor associated with the variable reactive element to output information about a position of the variable reactive element;
wherein at least one parameter comprises the information about the position.

98. The synchrocyclotron of claim 90, wherein at least part of the voltage circuit comprises digital circuitry.

99. The synchrocyclotron of claim 90, wherein at least one parameter comprises a timing parameter.

100. The synchrocyclotron of claim 93, wherein the feedback system is configured to use the information to generate, based on digital data, timing waveforms to control the voltage circuit.

101. The synchrocyclotron of claim 90, wherein the feedback system is adaptive.

102. A synchrocyclotron comprising:

a magnetic field generator;
a resonant circuit comprising a variable reactive element to vary a resonant frequency of the resonant circuit;
a source to provide a voltage input to the resonant circuit, the voltage input being an oscillating voltage that varies over a time of acceleration of charged particles;
a feedback system to vary at least one property of the voltage input to the resonant circuit; and
one or more sensors to detect that there has been a deviation from a peak resonant condition in the resonant circuit;
wherein the voltage input is controlled by the feedback system based on the deviation in order to maintain the peak resonant condition.

103. The synchrocyclotron of claim 102, wherein the at least one property comprises amplitude of the voltage input.

104. The synchrocyclotron of claim 102, wherein the at least one property comprises frequency of the voltage input.

105. The synchrocyclotron of claim 102, wherein the at least one property comprises amplitude of the voltage input and frequency of the voltage input.

106. The synchrocyclotron of claim 102, wherein the feedback system is configured to maintain the peak resonant condition.

107. The synchrocyclotron of claim 102, further comprising:

an ion source to provide the charged particles that form a particle beam following acceleration; and
a beam monitor to monitor the at least one property of the particle beam;
wherein the feedback system comprises control circuitry to receive the at least one property of the particle beam, and to control at least one of the voltage input or the ion source based on the at least one property to compensate for variations in the particle beam.

108. The synchrocyclotron of claim 107, wherein the at least one property comprises beam intensity, beam timing, or beam spatial distribution.

109. The synchrocyclotron of claim 107, wherein the voltage input is generated by a programmable digital waveform generator.

Referenced Cited
U.S. Patent Documents
2280606 April 1942 Van et al.
2492324 December 1949 Salisbury
2615129 October 1952 McMillan
2616042 October 1952 Weeks
2659000 November 1953 Salisbury
2701304 December 1955 Dickinson
2789222 April 1957 Marvin et al.
3175131 March 1965 Burleigh et al.
3432721 March 1969 Naydan et al.
3582650 June 1971 Avery
3679899 July 1972 Dimeff
3689847 September 1972 Verster
3757118 September 1973 Hodge et al.
3868522 February 1975 Bigham et al.
3886367 May 1975 Castle
3925676 December 1975 Bigham et al.
2958327 May 1976 Marancik et al.
3955089 May 4, 1976 McIntyre et al.
3958327 May 25, 1976 Marancik et al.
3992625 November 16, 1976 Schmidt et al.
4038622 July 26, 1977 Purcell
4047068 September 6, 1977 Ress et al.
4112306 September 5, 1978 Nunan
4129784 December 12, 1978 Tschunt et al.
4139777 February 13, 1979 Rautenbach
4197510 April 8, 1980 Szu
4220866 September 2, 1980 Symmons et al.
4230129 October 28, 1980 LeVeen
4256966 March 17, 1981 Heinz
4293772 October 6, 1981 Stieber
4336505 June 22, 1982 Meyer
4342060 July 27, 1982 Gibson
4345210 August 17, 1982 Tran
4353033 October 5, 1982 Karasawa
4425506 January 10, 1984 Brown et al.
4490616 December 25, 1984 Cipollina et al.
4507614 March 26, 1985 Prono et al.
4507616 March 26, 1985 Blosser et al.
4589126 May 13, 1986 Augustsson et al.
4598208 July 1, 1986 Brunelli et al.
4628523 December 9, 1986 Heflin
4633125 December 30, 1986 Blosser et al.
4641057 February 3, 1987 Blosser et al.
4641104 February 3, 1987 Blosser et al.
4651007 March 17, 1987 Perusek et al.
4680565 July 14, 1987 Jahnke
4705955 November 10, 1987 Mileikowsky
4710722 December 1, 1987 Jahnke
4726046 February 16, 1988 Nunan
4734653 March 29, 1988 Jahnke
4736173 April 5, 1988 Basil, Jr. et al.
4737727 April 12, 1988 Yamada et al.
4739173 April 19, 1988 Blosser et al.
4745367 May 17, 1988 Dustmann et al.
4754147 June 28, 1988 Maughan et al.
4763483 August 16, 1988 Olsen
4767930 August 30, 1988 Stieber et al.
4769623 September 6, 1988 Marsing et al.
4771208 September 13, 1988 Jongen et al.
4783634 November 8, 1988 Yamamoto et al.
4808941 February 28, 1989 Marsing
4812658 March 14, 1989 Koehler
4843333 June 27, 1989 Marsing et al.
4845371 July 4, 1989 Stieber
4865284 September 12, 1989 Gosis et al.
4868843 September 19, 1989 Nunan
4868844 September 19, 1989 Nunan
4870287 September 26, 1989 Cole et al.
4880985 November 14, 1989 Jones
4894541 January 16, 1990 Ono
4896206 January 23, 1990 Denham
4902993 February 20, 1990 Krevet
4904949 February 27, 1990 Wilson
4905267 February 27, 1990 Miller et al.
4917344 April 17, 1990 Prechter et al.
4943781 July 24, 1990 Wilson et al.
4945478 July 31, 1990 Merickel et al.
4968915 November 6, 1990 Wilson et al.
4987309 January 22, 1991 Klasen et al.
4992744 February 12, 1991 Fujita et al.
4996496 February 26, 1991 Kitamura et al.
5006759 April 9, 1991 Krispel
5010562 April 23, 1991 Hernandez et al.
5012111 April 30, 1991 Ueda
5017789 May 21, 1991 Young et al.
5017882 May 21, 1991 Finlan
5036290 July 30, 1991 Sonobe et al.
5039057 August 13, 1991 Prechter et al.
5039867 August 13, 1991 Nishihara et al.
5046078 September 3, 1991 Hernandez et al.
5072123 December 10, 1991 Johnsen
5111042 May 5, 1992 Sullivan et al.
5111173 May 5, 1992 Matsuda et al.
5117194 May 26, 1992 Nakanishi et al.
5117212 May 26, 1992 Yamamoto et al.
5117829 June 2, 1992 Miller et al.
5148032 September 15, 1992 Hernandez
5166531 November 24, 1992 Huntzinger
5189687 February 23, 1993 Bova et al.
5191706 March 9, 1993 Cosden
5240218 August 31, 1993 Dye
5260579 November 9, 1993 Yasuda et al.
5260581 November 9, 1993 Lesyna et al.
5278533 January 11, 1994 Kawaguchi
5285166 February 8, 1994 Hiramoto et al.
5297037 March 22, 1994 Ifuku
5317164 May 31, 1994 Kurokawa
5336891 August 9, 1994 Crewe
5341104 August 23, 1994 Anton et al.
5349198 September 20, 1994 Takanaka
5365742 November 22, 1994 Boffito et al.
5374913 December 20, 1994 Pissantezky et al.
5382914 January 17, 1995 Hamm et al.
5401973 March 28, 1995 McKeown et al.
5405235 April 11, 1995 Lebre et al.
5434420 July 18, 1995 McKeown et al.
5440133 August 8, 1995 Moyers et al.
5451794 September 19, 1995 McKeown et al.
5461773 October 31, 1995 Kawaguchi
5463291 October 31, 1995 Carroll et al.
5464411 November 7, 1995 Schulte et al.
5492922 February 20, 1996 Palkowitz
5511549 April 30, 1996 Legg et al.
5521469 May 28, 1996 Laisne
5538942 July 23, 1996 Koyama et al.
5549616 August 27, 1996 Schulte et al.
5561697 October 1, 1996 Takafuji et al.
5585642 December 17, 1996 Britton et al.
5633747 May 27, 1997 Nikoonahad
5635721 June 3, 1997 Bardi et al.
5668371 September 16, 1997 Deasy et al.
5672878 September 30, 1997 Yao
5691679 November 25, 1997 Ackermann et al.
5726448 March 10, 1998 Smith et al.
5727554 March 17, 1998 Kalend et al.
5730745 March 24, 1998 Schulte et al.
5744919 April 28, 1998 Mishin
5751781 May 12, 1998 Brown et al.
5778047 July 7, 1998 Mansfield et al.
5783914 July 21, 1998 Hiramoto et al.
5784431 July 21, 1998 Kalend et al.
5797924 August 25, 1998 Schulte et al.
5811944 September 22, 1998 Sampayan et al.
5818058 October 6, 1998 Nakanishi et al.
5821705 October 13, 1998 Caporaso et al.
5825845 October 20, 1998 Blair et al.
5841237 November 24, 1998 Alton
5846043 December 8, 1998 Spath
5851182 December 22, 1998 Sahadevan
5866912 February 2, 1999 Slater et al.
5874811 February 23, 1999 Finlan et al.
5895926 April 20, 1999 Britton et al.
5917293 June 29, 1999 Saito et al.
5920601 July 6, 1999 Nigg et al.
5929458 July 27, 1999 Nemezawa et al.
5963615 October 5, 1999 Egley et al.
5993373 November 30, 1999 Nonaka et al.
6008499 December 28, 1999 Hiramoto et al.
6034377 March 7, 2000 Pu
6057655 May 2, 2000 Jongen
6061426 May 9, 2000 Linders et al.
6064807 May 16, 2000 Arai et al.
6066851 May 23, 2000 Madono et al.
6080992 June 27, 2000 Nonaka et al.
6087670 July 11, 2000 Hiramoto et al.
6094760 August 1, 2000 Nonaka et al.
6118848 September 12, 2000 Reiffel
6140021 October 31, 2000 Nakasuji et al.
6144875 November 7, 2000 Schweikard et al.
6158708 December 12, 2000 Egley et al.
6207952 March 27, 2001 Kan et al.
6219403 April 17, 2001 Nishihara
6222905 April 24, 2001 Yoda et al.
6241671 June 5, 2001 Ritter et al.
6246066 June 12, 2001 Yuehu
6256591 July 3, 2001 Yoda et al.
6265837 July 24, 2001 Akiyama et al.
6268610 July 31, 2001 Pu
6278239 August 21, 2001 Caporaso et al.
6279579 August 28, 2001 Riaziat et al.
6307914 October 23, 2001 Kunieda et al.
6316776 November 13, 2001 Hiramoto et al.
6366021 April 2, 2002 Meddaugh et al.
6369585 April 9, 2002 Yao
6380545 April 30, 2002 Yan
6407505 June 18, 2002 Bertsche
6414614 July 2, 2002 Melanson
6417634 July 9, 2002 Bergstrom
6433336 August 13, 2002 Jongen et al.
6433349 August 13, 2002 Akiyama et al.
6433494 August 13, 2002 Kulish et al.
6441569 August 27, 2002 Janzow
6443349 September 3, 2002 Van Der Burg
6465957 October 15, 2002 Whitham et al.
6472834 October 29, 2002 Hiramoto et al.
6476403 November 5, 2002 Dolinskii et al.
6492922 December 10, 2002 New
6493424 December 10, 2002 Whitham
6498444 December 24, 2002 Hanna et al.
6501981 December 31, 2002 Schweikard et al.
6519316 February 11, 2003 Collins
6576916 June 10, 2003 Smith et al.
6593696 July 15, 2003 Ding et al.
6594336 July 15, 2003 Nishizawa et al.
6600164 July 29, 2003 Badura et al.
6617598 September 9, 2003 Matsuda
6621889 September 16, 2003 Mostafavi
6627875 September 30, 2003 Afeyan
6639234 October 28, 2003 Badura et al.
6646383 November 11, 2003 Bertsche et al.
6670618 December 30, 2003 Hartmann et al.
6683318 January 27, 2004 Haberer et al.
6683426 January 27, 2004 Kleeven
6693283 February 17, 2004 Eickhoff et al.
6703613 March 9, 2004 Kaji
6710362 March 23, 2004 Kraft et al.
6713773 March 30, 2004 Lyons et al.
6713976 March 30, 2004 Zumoto et al.
6717162 April 6, 2004 Jongen
6736831 May 18, 2004 Hartmann et al.
6745072 June 1, 2004 Badura et al.
6769806 August 3, 2004 Moyers
6774383 August 10, 2004 Norimine et al.
6777689 August 17, 2004 Nelson
6777700 August 17, 2004 Yanagisawa et al.
6780149 August 24, 2004 Schulte
6799068 September 28, 2004 Hartmann et al.
6800866 October 5, 2004 Amemiya et al.
6803591 October 12, 2004 Muramatsu et al.
6814694 November 9, 2004 Pedroni
6819117 November 16, 2004 Wilsher
6822244 November 23, 2004 Beloussov et al.
6853142 February 8, 2005 Chistyakov
6853703 February 8, 2005 Svatos et al.
6864770 March 8, 2005 Nemoto et al.
6865254 March 8, 2005 Nafstadius
6873123 March 29, 2005 Marchand et al.
6891177 May 10, 2005 Kraft et al.
6891924 May 10, 2005 Yoda et al.
6894300 May 17, 2005 Reimoser et al.
6897451 May 24, 2005 Kaercher et al.
6902646 June 7, 2005 Mahoney
6914396 July 5, 2005 Symons et al.
6936832 August 30, 2005 Norimine et al.
6953943 October 11, 2005 Yanagisawa et al.
6965116 November 15, 2005 Wagner et al.
6969194 November 29, 2005 Nafstadius
6979832 December 27, 2005 Yanagisawa et al.
6984835 January 10, 2006 Harada
6992312 January 31, 2006 Yanagisawa et al.
6993112 January 31, 2006 Hesse
7008105 March 7, 2006 Amann et al.
7011447 March 14, 2006 Moyers
7012267 March 14, 2006 Moriyama et al.
7014361 March 21, 2006 Ein-Gal
7026636 April 11, 2006 Yanagisawa et al.
7038403 May 2, 2006 Mastrangeli et al.
7041479 May 9, 2006 Swartz et al.
7045781 May 16, 2006 Adamec et al.
7049613 May 23, 2006 Yanagisawa et al.
7053389 May 30, 2006 Yanagisawa et al.
7054801 May 30, 2006 Sakamoto et al.
7060997 June 13, 2006 Norimine et al.
7071479 July 4, 2006 Yanagisawa et al.
7073508 July 11, 2006 Moyers
7081619 July 25, 2006 Bashkirov et al.
7084410 August 1, 2006 Beloussov et al.
7091478 August 15, 2006 Haberer
7102144 September 5, 2006 Matsuda et al.
7122811 October 17, 2006 Matsuda et al.
7122966 October 17, 2006 Norling et al.
7122978 October 17, 2006 Nakanishi et al.
7135678 November 14, 2006 Wang et al.
7138771 November 21, 2006 Bechthold et al.
7154107 December 26, 2006 Yanagisawa et al.
7154108 December 26, 2006 Tadokoro et al.
7154991 December 26, 2006 Earnst et al.
7162005 January 9, 2007 Bjorkholm
7173264 February 6, 2007 Moriyama et al.
7173265 February 6, 2007 Miller et al.
7173385 February 6, 2007 Caporaso et al.
7186991 March 6, 2007 Kato et al.
7193227 March 20, 2007 Hiramoto et al.
7199382 April 3, 2007 Rigney et al.
7208748 April 24, 2007 Sliski et al.
7212608 May 1, 2007 Nagamine et al.
7212609 May 1, 2007 Nagamine et al.
7221733 May 22, 2007 Takai et al.
7227161 June 5, 2007 Matsuda et al.
7247869 July 24, 2007 Tadokoro et al.
7257191 August 14, 2007 Sommer
7259529 August 21, 2007 Tanaka
7262424 August 28, 2007 Moriyama et al.
7262565 August 28, 2007 Fujisawa
7274018 September 25, 2007 Adamec et al.
7280633 October 9, 2007 Cheng et al.
7295649 November 13, 2007 Johnsen
7297967 November 20, 2007 Yanagisawa et al.
7301162 November 27, 2007 Matsuda et al.
7307264 December 11, 2007 Brusasco et al.
7317192 January 8, 2008 Ma
7318805 January 15, 2008 Schweikard et al.
7319231 January 15, 2008 Moriyama et al.
7319336 January 15, 2008 Baur et al.
7323682 January 29, 2008 McCauley
7331713 February 19, 2008 Moyers
7332880 February 19, 2008 Ina et al.
7345291 March 18, 2008 Kats
7345292 March 18, 2008 Moriyama et al.
7348557 March 25, 2008 Armit
7348579 March 25, 2008 Pedroni
7351988 April 1, 2008 Naumann et al.
7355189 April 8, 2008 Yanagisawa et al.
7368740 May 6, 2008 Beloussov et al.
7372053 May 13, 2008 Yamashita et al.
7378672 May 27, 2008 Harada
7381979 June 3, 2008 Yamashita et al.
7397054 July 8, 2008 Natori et al.
7397901 July 8, 2008 Johnsen
7398309 July 8, 2008 Baumann et al.
7402822 July 22, 2008 Guertin et al.
7402823 July 22, 2008 Guertin et al.
7402824 July 22, 2008 Guertin et al.
7402963 July 22, 2008 Sliski
7405407 July 29, 2008 Hiramoto et al.
7425717 September 16, 2008 Matsuda et al.
7432516 October 7, 2008 Peggs et al.
7439528 October 21, 2008 Nishiuchi et al.
7446328 November 4, 2008 Rigney et al.
7446490 November 4, 2008 Jongen et al.
7449701 November 11, 2008 Fujimaki et al.
7453076 November 18, 2008 Welch et al.
7456415 November 25, 2008 Yanagisawa et al.
7465944 December 16, 2008 Ueno et al.
7466085 December 16, 2008 Nutt
7468506 December 23, 2008 Rogers et al.
7473913 January 6, 2009 Hermann et al.
7476867 January 13, 2009 Fritsch et al.
7476883 January 13, 2009 Nutt
7482606 January 27, 2009 Groezinger et al.
7491161 February 17, 2009 Taguchi
7492556 February 17, 2009 Atkins et al.
7507975 March 24, 2009 Mohr
7518108 April 14, 2009 Frey et al.
7525104 April 28, 2009 Harada
7541905 June 2, 2009 Antaya
7547901 June 16, 2009 Guertin et al.
7554096 June 30, 2009 Ward et al.
7554097 June 30, 2009 Ward et al.
7555103 June 30, 2009 Johnsen
7557358 July 7, 2009 Ward et al.
7557359 July 7, 2009 Ward et al.
7557360 July 7, 2009 Ward et al.
7557361 July 7, 2009 Ward et al.
7560715 July 14, 2009 Pedroni
7560717 July 14, 2009 Matsuda et al.
7567694 July 28, 2009 Lu et al.
7574251 August 11, 2009 Lu et al.
7576499 August 18, 2009 Caporaso et al.
7579603 August 25, 2009 Birgy et al.
7579610 August 25, 2009 Grozinger et al.
7582866 September 1, 2009 Furuhashi et al.
7582885 September 1, 2009 Katagiri et al.
7582886 September 1, 2009 Trbojevic
7586112 September 8, 2009 Chiba et al.
7598497 October 6, 2009 Yamamoto et al.
7609009 October 27, 2009 Tanaka et al.
7609809 October 27, 2009 Kapatoes et al.
7609811 October 27, 2009 Siljamaki et al.
7615942 November 10, 2009 Sanders et al.
7626347 December 1, 2009 Sliski et al.
7627267 December 1, 2009 Saiki
7629598 December 8, 2009 Harada
7639853 December 29, 2009 Olivera et al.
7639854 December 29, 2009 Schnarr et al.
7643661 January 5, 2010 Ruchala et al.
7656258 February 2, 2010 Antaya et al.
7659521 February 9, 2010 Pedroni
7659528 February 9, 2010 Uematsu
7668291 February 23, 2010 Nord et al.
7672429 March 2, 2010 Urano et al.
7679073 March 16, 2010 Urano et al.
7682078 March 23, 2010 Rietzel
7692166 April 6, 2010 Muraki et al.
7692168 April 6, 2010 Moriyama et al.
7696499 April 13, 2010 Miller et al.
7696847 April 13, 2010 Antaya
7701677 April 20, 2010 Schultz et al.
7709818 May 4, 2010 Matsuda et al.
7710051 May 4, 2010 Caporaso et al.
7718982 May 18, 2010 Sliski et al.
7728311 June 1, 2010 Gall
7746978 June 29, 2010 Cheng et al.
7755305 July 13, 2010 Umezawa et al.
7759642 July 20, 2010 Nir
7763867 July 27, 2010 Birgy et al.
7767988 August 3, 2010 Kaiser et al.
7770231 August 3, 2010 Prater et al.
7772577 August 10, 2010 Saito et al.
7773723 August 10, 2010 Nord et al.
7773788 August 10, 2010 Lu et al.
7778488 August 17, 2010 Nord et al.
7783010 August 24, 2010 Clayton
7784127 August 31, 2010 Kuro et al.
7786451 August 31, 2010 Ward et al.
7786452 August 31, 2010 Ward et al.
7789560 September 7, 2010 Moyers
7791051 September 7, 2010 Beloussov et al.
7796731 September 14, 2010 Nord et al.
7801269 September 21, 2010 Cravens et al.
7801270 September 21, 2010 Nord et al.
7801988 September 21, 2010 Baumann et al.
7807982 October 5, 2010 Nishiuchi et al.
7809107 October 5, 2010 Nord et al.
7812319 October 12, 2010 Diehl et al.
7812326 October 12, 2010 Grozinger et al.
7816657 October 19, 2010 Hansmann et al.
7817778 October 19, 2010 Nord et al.
7817836 October 19, 2010 Chao et al.
7834334 November 16, 2010 Grozinger et al.
7834336 November 16, 2010 Boeh et al.
7835494 November 16, 2010 Nord et al.
7835502 November 16, 2010 Spence et al.
7839972 November 23, 2010 Ruchala et al.
7839973 November 23, 2010 Nord et al.
7848488 December 7, 2010 Mansfield
7857756 December 28, 2010 Warren et al.
7860216 December 28, 2010 Jongen et al.
7860550 December 28, 2010 Saracen et al.
7868301 January 11, 2011 Diehl
7875861 January 25, 2011 Huttenberger et al.
7875868 January 25, 2011 Moriyama et al.
7881431 February 1, 2011 Aoi et al.
7894574 February 22, 2011 Nord et al.
7906769 March 15, 2011 Blasche et al.
7914734 March 29, 2011 Livingston
7919765 April 5, 2011 Timmer
7920040 April 5, 2011 Antaya et al.
7920675 April 5, 2011 Lomax et al.
7928415 April 19, 2011 Bert et al.
7934869 May 3, 2011 Ivanov et al.
7940881 May 10, 2011 Jongen et al.
7943913 May 17, 2011 Balakin
7947969 May 24, 2011 Pu
7949096 May 24, 2011 Cheng et al.
7950587 May 31, 2011 Henson et al.
7960710 June 14, 2011 Kruip et al.
7961844 June 14, 2011 Takeda et al.
7977648 July 12, 2011 Westerly et al.
7977656 July 12, 2011 Fujimaki et al.
7977657 July 12, 2011 Flynn et al.
7982198 July 19, 2011 Nishiuchi et al.
7982416 July 19, 2011 Tanaka et al.
7984715 July 26, 2011 Moyers
7986768 July 26, 2011 Nord et al.
7987053 July 26, 2011 Schaffner
7989785 August 2, 2011 Emhofer et al.
7990524 August 2, 2011 Jureller et al.
7997553 August 16, 2011 Sloan et al.
8002466 August 23, 2011 Von Neubeck et al.
8003964 August 23, 2011 Stark et al.
8009803 August 30, 2011 Nord et al.
8009804 August 30, 2011 Siljamaki et al.
8039822 October 18, 2011 Rietzel
8041006 October 18, 2011 Boyden et al.
8044364 October 25, 2011 Yamamoto
8049187 November 1, 2011 Tachikawa
8053508 November 8, 2011 Korkut et al.
8053739 November 8, 2011 Rietzel
8053745 November 8, 2011 Moore
8053746 November 8, 2011 Timmer et al.
8063381 November 22, 2011 Tsoupas et al.
8067748 November 29, 2011 Balakin
8069675 December 6, 2011 Radovinsky et al.
8071966 December 6, 2011 Kaiser et al.
8080801 December 20, 2011 Safai
8085899 December 27, 2011 Nord et al.
8089054 January 3, 2012 Balakin
8093564 January 10, 2012 Balakin
8093568 January 10, 2012 Mackie et al.
8111125 February 7, 2012 Antaya et al.
8129699 March 6, 2012 Balakin
8144832 March 27, 2012 Balakin
8153989 April 10, 2012 Tachikawa et al.
8173981 May 8, 2012 Trbojevic
8188688 May 29, 2012 Balakin
8198607 June 12, 2012 Balakin
8222613 July 17, 2012 Tajiri et al.
8227768 July 24, 2012 Smick et al.
8232536 July 31, 2012 Harada
8288742 October 16, 2012 Balakin
8291717 October 23, 2012 Radovinsky et al.
8294127 October 23, 2012 Tachibana
8304725 November 6, 2012 Komuro et al.
8304750 November 6, 2012 Preikszas et al.
8309941 November 13, 2012 Balakin
8330132 December 11, 2012 Guertin et al.
8334520 December 18, 2012 Otaka et al.
8335397 December 18, 2012 Takane et al.
8344340 January 1, 2013 Gall et al.
8350214 January 8, 2013 Otaki et al.
8368038 February 5, 2013 Balakin
8368043 February 5, 2013 Havelange et al.
8373143 February 12, 2013 Balakin
8373145 February 12, 2013 Balakin
8373146 February 12, 2013 Balakin
8378299 February 19, 2013 Frosien
8378321 February 19, 2013 Balakin
8382943 February 26, 2013 Clark
8389949 March 5, 2013 Harada et al.
8399866 March 19, 2013 Balakin
8405042 March 26, 2013 Honda et al.
8405056 March 26, 2013 Amaldi et al.
8415643 April 9, 2013 Balakin
8416918 April 9, 2013 Nord et al.
8421041 April 16, 2013 Balakin
8426833 April 23, 2013 Trbojevic
8436323 May 7, 2013 Iseki et al.
8440987 May 14, 2013 Stephani et al.
8445872 May 21, 2013 Behrens et al.
8466441 June 18, 2013 Iwata et al.
8472583 June 25, 2013 Star-Lack et al.
8483357 July 9, 2013 Siljamaki et al.
8487278 July 16, 2013 Balakin
8552406 October 8, 2013 Phaneuf et al.
8552408 October 8, 2013 Hanawa et al.
8569717 October 29, 2013 Balakin
8575563 November 5, 2013 Cameron et al.
8581215 November 12, 2013 Balakin
8581523 November 12, 2013 Gall et al.
8581525 November 12, 2013 Antaya et al.
8637833 January 28, 2014 Balakin
8653314 February 18, 2014 Pelati et al.
8653473 February 18, 2014 Yajima
8766218 July 1, 2014 Jongen
8791435 July 29, 2014 Balakin
8901509 December 2, 2014 Balakin
8905908 December 9, 2014 Matsuguma et al.
8907311 December 9, 2014 Gall et al.
8952634 February 10, 2015 Sliski et al.
8963112 February 24, 2015 Balakin
8970137 March 3, 2015 Gall et al.
8975816 March 10, 2015 Scheitrum et al.
9012866 April 21, 2015 Benna et al.
9028384 May 12, 2015 Iikura
9044600 June 2, 2015 Balakin
9056199 June 16, 2015 Balakin
9176468 November 3, 2015 Ueno et al.
9451688 September 20, 2016 Jongen
9452301 September 27, 2016 Gall et al.
9723705 August 1, 2017 Gall et al.
20020172317 November 21, 2002 Maksimchuk et al.
20030048080 March 13, 2003 Amemiya et al.
20030125622 July 3, 2003 Schweikard et al.
20030136924 July 24, 2003 Kraft et al.
20030146759 August 7, 2003 Bashkirov et al.
20030152197 August 14, 2003 Moyers
20030163015 August 28, 2003 Yanagisawa et al.
20030183779 October 2, 2003 Norimine et al.
20030234369 December 25, 2003 Glukhoy
20040000650 January 1, 2004 Yanagisawa et al.
20040017888 January 29, 2004 Seppi et al.
20040056212 March 25, 2004 Yanagisawa et al.
20040061077 April 1, 2004 Muramatsu et al.
20040061078 April 1, 2004 Muramatsu et al.
20040085023 May 6, 2004 Chistyakov
20040098445 May 20, 2004 Baumann et al.
20040111134 June 10, 2004 Muramatsu et al.
20040118081 June 24, 2004 Reimoser et al.
20040149934 August 5, 2004 Yanagisawa et al.
20040159795 August 19, 2004 Kaercher et al.
20040173763 September 9, 2004 Moriyama et al.
20040174958 September 9, 2004 Moriyama et al.
20040183033 September 23, 2004 Moriyama et al.
20040183035 September 23, 2004 Yanagisawa et al.
20040200982 October 14, 2004 Moriyama et al.
20040200983 October 14, 2004 Fujimaki et al.
20040213381 October 28, 2004 Harada
20040227104 November 18, 2004 Matsuda et al.
20040232356 November 25, 2004 Norimine et al.
20040240626 December 2, 2004 Moyers
20050058245 March 17, 2005 Ein-Gal
20050089141 April 28, 2005 Brown
20050161618 July 28, 2005 Pedroni
20050184686 August 25, 2005 Caporaso et al.
20050228255 October 13, 2005 Saracen et al.
20050234327 October 20, 2005 Saracen et al.
20050238134 October 27, 2005 Brusasco et al.
20050247890 November 10, 2005 Norimine et al.
20060017015 January 26, 2006 Sliski et al.
20060067468 March 30, 2006 Rietzel
20060126792 June 15, 2006 Li
20060145088 July 6, 2006 Ma
20060170381 August 3, 2006 Amaldi et al.
20060173294 August 3, 2006 Ein-Gal
20060175991 August 10, 2006 Fujisawa
20060273264 December 7, 2006 Nakayama et al.
20060284562 December 21, 2006 Hruby et al.
20070001128 January 4, 2007 Sliski et al.
20070013273 January 18, 2007 Albert et al.
20070014654 January 18, 2007 Haverfield et al.
20070023699 February 1, 2007 Yamashita et al.
20070029510 February 8, 2007 Hermann et al.
20070051904 March 8, 2007 Kaiser et al.
20070061937 March 22, 2007 Gall
20070092812 April 26, 2007 Caporaso et al.
20070114945 May 24, 2007 Mattaboni et al.
20070133752 June 14, 2007 Ein-Gal
20070145916 June 28, 2007 Caporaso et al.
20070170994 July 26, 2007 Peggs et al.
20070171015 July 26, 2007 Antaya
20070181519 August 9, 2007 Khoshnevis
20070252093 November 1, 2007 Fujimaki et al.
20070284548 December 13, 2007 Kaiser et al.
20080067452 March 20, 2008 Moriyama et al.
20080078937 April 3, 2008 Tsuchiya et al.
20080093567 April 24, 2008 Gall
20080218102 September 11, 2008 Sliski
20080234531 September 25, 2008 Welch et al.
20080270517 October 30, 2008 Baumann et al.
20090096179 April 16, 2009 Stark et al.
20090101832 April 23, 2009 Diehl
20090140671 June 4, 2009 O'Neal et al.
20090140672 June 4, 2009 Gall et al.
20090200483 August 13, 2009 Gall et al.
20090230299 September 17, 2009 Shichi et al.
20090236545 September 24, 2009 Timmer
20090296885 December 3, 2009 Boeh et al.
20090309046 December 17, 2009 Balakin
20090314960 December 24, 2009 Balakin
20090321665 December 31, 2009 Timmer et al.
20100006770 January 14, 2010 Balakin
20100027745 February 4, 2010 Balakin
20100038552 February 18, 2010 Trbojevic
20100045213 February 25, 2010 Sliski et al.
20100046697 February 25, 2010 Balakin
20100051833 March 4, 2010 Guertin et al.
20100192303 August 5, 2010 Miller et al.
20100209335 August 19, 2010 Mills
20100230617 September 16, 2010 Gall
20100308235 December 9, 2010 Sliski et al.
20110006212 January 13, 2011 Shchory et al.
20110220809 September 15, 2011 Yajima et al.
20110233423 September 29, 2011 Balakin
20110240874 October 6, 2011 Iwata
20110284760 November 24, 2011 Balakin
20110299919 December 8, 2011 Stark et al.
20120014501 January 19, 2012 Pelc et al.
20120081041 April 5, 2012 Cheung et al.
20120126140 May 24, 2012 Gall et al.
20120217903 August 30, 2012 Tanaka et al.
20120313003 December 13, 2012 Trbojevic
20130053616 February 28, 2013 Gall et al.
20130127375 May 23, 2013 Sliski et al.
20130131424 May 23, 2013 Sliski et al.
20130193352 August 1, 2013 Bert et al.
20130237425 September 12, 2013 Leigh et al.
20130249443 September 26, 2013 Antaya et al.
20140028220 January 30, 2014 Bromberg et al.
20140042934 February 13, 2014 Tsutsui
20140062344 March 6, 2014 Gall et al.
20140094643 April 3, 2014 Gall et al.
20140097920 April 10, 2014 Goldie et al.
20150009917 January 8, 2015 Cho et al.
20150009918 January 8, 2015 Yeoum et al.
20150161793 June 11, 2015 Takahashi
20170028224 February 2, 2017 Gall et al.
Foreign Patent Documents
2005267078 February 2006 AU
2005267078 July 2009 AU
2629333 May 2007 CA
2629333 May 2007 CA
1377521 October 2002 CN
1537657 October 2004 CN
1631061 June 2005 CN
1816243 August 2006 CN
101061759 October 2007 CN
101061759 October 2007 CN
101361156 February 2009 CN
101932361 December 2010 CN
101932361 December 2010 CN
101933405 December 2010 CN
101933405 December 2010 CN
101933406 December 2010 CN
101933406 December 2010 CN
102036461 April 2011 CN
102036461 April 2011 CN
101061759 May 2011 CN
2005800245224 May 2011 CN
102172106 August 2011 CN
2010105813842 November 2012 CN
104244562 December 2014 CN
104812443 July 2015 CN
104812444 July 2015 CN
104822417 August 2015 CN
2753397 June 1978 DE
2753397 June 1978 DE
2753397 September 1978 DE
3148100 June 1983 DE
3148100 June 1983 DE
35 30 446 August 1984 DE
3530446 March 1986 DE
3530446 March 1986 DE
31 48 100 June 1986 DE
4101094 May 1992 DE
4411171 October 1995 DE
4411171 October 1995 DE
0044153 January 1982 EP
0044153 January 1982 EP
0 194 728 September 1986 EP
0194728 September 1986 EP
0208163 January 1987 EP
0 221 987 May 1987 EP
0221987 May 1987 EP
0222786 May 1987 EP
0276123 July 1988 EP
0 277 521 August 1988 EP
0277521 August 1988 EP
0 208 163 January 1989 EP
0306966 March 1989 EP
0 222 786 July 1990 EP
0388123 September 1990 EP
0 221 987 January 1991 EP
0465597 January 1992 EP
0 499 253 August 1992 EP
0499253 August 1992 EP
0 306 966 April 1995 EP
0 388 123 May 1995 EP
0 465 597 May 1997 EP
0776595 June 1997 EP
0 911 064 June 1998 EP
0 864 337 September 1998 EP
0864337 September 1998 EP
0 776 595 December 1998 EP
0911064 April 1999 EP
1 069 809 January 2001 EP
1069809 January 2001 EP
1 153 398 April 2001 EP
1 153 398 November 2001 EP
1153398 November 2001 EP
1265462 December 2002 EP
1 348 465 January 2003 EP
1 294 445 March 2003 EP
1294445 March 2003 EP
1 348 465 October 2003 EP
1348465 October 2003 EP
1 358 908 November 2003 EP
1358908 November 2003 EP
1 371 390 December 2003 EP
1371390 December 2003 EP
1 402 923 March 2004 EP
1402923 March 2004 EP
0 911 064 June 2004 EP
1 430 932 June 2004 EP
1430932 June 2004 EP
1 454 653 September 2004 EP
1 454 654 September 2004 EP
1 454 655 September 2004 EP
1 454 656 September 2004 EP
1 454 657 September 2004 EP
1454653 September 2004 EP
1454654 September 2004 EP
1454655 September 2004 EP
1454656 September 2004 EP
1454657 September 2004 EP
1 477 206 November 2004 EP
1477206 November 2004 EP
1 605 742 December 2005 EP
1605742 December 2005 EP
1 738 798 January 2007 EP
1738798 January 2007 EP
1 371 390 March 2007 EP
1790203 May 2007 EP
1790203 May 2007 EP
1 826 778 August 2007 EP
1826778 August 2007 EP
1 454 653 September 2007 EP
1 477 206 January 2008 EP
1 949 404 July 2008 EP
1949404 July 2008 EP
2026640 February 2009 EP
2183753 February 2010 EP
2394498 February 2010 EP
2 227 295 May 2010 EP
2183753 May 2010 EP
2227295 May 2010 EP
2 232 961 September 2010 EP
2 232 962 September 2010 EP
2227295 September 2010 EP
2227295 September 2010 EP
2232961 September 2010 EP
2232961 September 2010 EP
2232962 September 2010 EP
2232962 September 2010 EP
2259664 December 2010 EP
2259664 December 2010 EP
1 605 742 June 2011 EP
2 363 170 September 2011 EP
2 363 171 September 2011 EP
2363170 September 2011 EP
2363170 September 2011 EP
2363171 September 2011 EP
2363171 September 2011 EP
2394498 December 2011 EP
2814304 December 2014 EP
2900324 August 2015 EP
2900325 August 2015 EP
2900326 August 2015 EP
2 560 421 August 1985 FR
2560421 August 1985 FR
2911843 August 2008 FR
2911843 August 2008 FR
0 957 342 May 1964 GB
0957342 May 1964 GB
1360085 July 1974 GB
1485329 September 1977 GB
2 015 821 September 1979 GB
2015821 September 1979 GB
1583400 January 1981 GB
2 361 523 October 2001 GB
2361523 October 2001 GB
43-23267 October 1968 JP
S48-108098 December 1973 JP
U48-108098 December 1973 JP
57-162527 October 1982 JP
58-141000 August 1983 JP
58-141000 September 1983 JP
61-80800 April 1986 JP
S61-80800 April 1986 JP
61-225798 October 1986 JP
S63-218200 October 1986 JP
62-150804 July 1987 JP
S62-150804 July 1987 JP
62-186500 August 1987 JP
S62-186500 August 1987 JP
62-186500 November 1987 JP
10-071213 March 1988 JP
63-149344 June 1988 JP
S63-149344 June 1988 JP
63-218200 September 1988 JP
63-226899 September 1988 JP
S63-226899 September 1988 JP
64-89621 April 1989 JP
10247600 September 1989 JP
01-276797 November 1989 JP
01-302700 December 1989 JP
H01-276797 December 1989 JP
H01-302700 December 1989 JP
4-94198 March 1992 JP
04-128717 April 1992 JP
04-129768 April 1992 JP
04-273409 September 1992 JP
04-337300 November 1992 JP
05-341352 December 1993 JP
06-036893 February 1994 JP
H06-036893 February 1994 JP
06-233831 August 1994 JP
H06-233831 August 1994 JP
06-036893 October 1994 JP
06-036893 December 1994 JP
07-260939 October 1995 JP
07-263196 October 1995 JP
2007 260939 October 1995 JP
H07-260939 October 1995 JP
H07-263196 October 1995 JP
08-173890 July 1996 JP
H08-173890 July 1996 JP
08-264298 October 1996 JP
H08-264298 October 1996 JP
09-162585 June 1997 JP
H09-162585 June 1997 JP
10-071213 March 1998 JP
H10-071213 March 1998 JP
10270200 October 1998 JP
11-047287 February 1999 JP
11-47287 February 1999 JP
11-102800 March 1999 JP
11-102800 April 1999 JP
H11-102800 April 1999 JP
11-243295 September 1999 JP
2000-243309 September 2000 JP
2000-294399 October 2000 JP
2000-294399 October 2000 JP
2001-6900 January 2001 JP
2001-009050 January 2001 JP
2011 505191 February 2001 JP
2001-129103 May 2001 JP
2001-129103 May 2001 JP
2001-346893 December 2001 JP
2002-164686 June 2002 JP
2002-164686 June 2002 JP
2003-504628 February 2003 JP
2003-517755 May 2003 JP
2003-517755 May 2003 JP
2004-139944 May 2004 JP
2005-526578 September 2005 JP
2006-032282 February 2006 JP
2006233831 September 2006 JP
2007260939 October 2007 JP
2007-319439 December 2007 JP
2008-012121 January 2008 JP
05-046928 March 2008 JP
2008-507826 March 2008 JP
2008-507826 March 2008 JP
5046928 March 2008 JP
2008-089341 April 2008 JP
04-128717 July 2008 JP
04-129768 August 2008 JP
2008-270039 November 2008 JP
2009 515671 April 2009 JP
2009-515671 April 2009 JP
2009-516905 April 2009 JP
2009-516905 April 2009 JP
04-273409 June 2009 JP
04-337300 September 2009 JP
43-23267 September 2009 JP
2010-204020 September 2010 JP
2010-536130 November 2010 JP
2011-505191 February 2011 JP
2011-505191 February 2011 JP
2011-505670 February 2011 JP
2011-505670 February 2011 JP
2011 507151 March 2011 JP
2011-507151 March 2011 JP
2011-521425 July 2011 JP
2011-210494 October 2011 JP
2011-224342 November 2011 JP
05-046928 October 2012 JP
05-341352 November 2013 JP
300137 November 1969 RU
569635 August 1977 RU
300137 November 1969 SU
569635 August 1977 SU
200934682 August 2008 TW
200930160 July 2009 TW
200930160 July 2009 TW
2009 34682 August 2009 TW
200934682 August 2009 TW
200939908 September 2009 TW
200939908 September 2009 TW
200940120 October 2009 TW
200940120 October 2009 TW
201422278 June 2014 TW
201422279 June 2014 TW
201424466 June 2014 TW
S64-89621 June 2014 TW
201429514 August 2014 TW
201433331 September 2014 TW
201434508 September 2014 TW
201438787 October 2014 TW
WO 86/07229 December 1986 WO
WO-8607229 December 1986 WO
WO-9012413 October 1990 WO
WO 92/03028 February 1992 WO
WO-9203028 February 1992 WO
WO 93/02536 February 1993 WO
WO-9302536 February 1993 WO
WO 98/17342 April 1998 WO
WO-9817342 April 1998 WO
WO 99/39385 August 1999 WO
WO-9939385 August 1999 WO
WO 00/40064 July 2000 WO
WO-0040064 July 2000 WO
WO 00/49624 August 2000 WO
WO-0049624 August 2000 WO
WO 01/026230 April 2001 WO
WO 01/126569 April 2001 WO
WO-0126230 April 2001 WO
WO-01126569 April 2001 WO
WO-2001126569 April 2001 WO
WO-0207817 January 2002 WO
WO 03/039212 May 2003 WO
WO-03039212 May 2003 WO
WO 03/092812 November 2003 WO
WO-2003/092340 November 2003 WO
WO-03092812 November 2003 WO
WO 2004/026401 April 2004 WO
WO-2004026401 April 2004 WO
WO 2004/101070 November 2004 WO
WO-2004101070 November 2004 WO
WO-2005/102453 November 2005 WO
WO-2006/012452 February 2006 WO
WO 2006/012467 February 2006 WO
WO-2006/012467 February 2006 WO
WO-2006012467 February 2006 WO
WO 2006-012467 December 2006 WO
WO 2007/061937 May 2007 WO
WO-2007061937 May 2007 WO
WO 2007/084701 July 2007 WO
WO-2007084701 July 2007 WO
WO 2007/130164 November 2007 WO
WO-2007130164 November 2007 WO
WO 2007/145906 December 2007 WO
WO-2007145906 December 2007 WO
WO 2008/030911 March 2008 WO
WO-2008030911 March 2008 WO
WO-2008081480 July 2008 WO
WO 2008/081480 October 2008 WO
WO 2009/048745 April 2009 WO
WO-2009048745 April 2009 WO
WO-2009/056165 May 2009 WO
WO 2009/070173 June 2009 WO
WO 2009/070588 June 2009 WO
WO 2009/073480 June 2009 WO
WO 2009/073480 June 2009 WO
WO-2009070173 June 2009 WO
WO-2009070588 June 2009 WO
WO-2009073480 June 2009 WO
WO-2009080080 July 2009 WO
WO 2009/048745 November 2009 WO
WO-2010089574 August 2010 WO
WO-2010/149740 December 2010 WO
WO-2012/044957 April 2012 WO
WO-2012/071142 May 2012 WO
WO-2013/079311 June 2013 WO
WO-2013098089 July 2013 WO
WO-2013/142409 September 2013 WO
WO-2014/018876 January 2014 WO
WO-2014/052708 April 2014 WO
WO-2014/052709 April 2014 WO
WO-2014/052716 April 2014 WO
WO-2014/052718 April 2014 WO
WO-2014/052719 April 2014 WO
WO-2014/052721 April 2014 WO
WO-2014/052722 April 2014 WO
Other references
  • US 8,581,524 B2, 11/2013, O'Neil et al. (withdrawn)
  • Angert, N (GSI, Darmstadt), CAS—CERN Accelerator School : 5th General Accelerator Physics Course, Jyväskylä, Finland, Sep. 7-18, 1992, pp. 619-642 (CERN-1994-001).
  • Communication pursuant to Rule 71(3) EPC Annex to EPO Form 2004 for EP10175727.6, 42 pages (Jul. 28, 2017).
  • File history of U.S. Appl. No. 14/039,307 (downloaded Mar. 13, 2017).
  • Extended Search Report for EP10175727, 7 pages (Dec. 19, 2015).
  • First Office Action for 201380062111.9, 46 pages (Jun. 1, 2016).
  • International Preliminary Report on Patentability issued in PCT application No. PCT/US2013/062103 on Apr. 9, 2015, (11 pages).
  • Office Action for JP2015-534721, 14 pages (Feb. 3, 2016).
  • Pedroni, E. et al., Cancer Therapy with 200 MEV Protons at PSI. Development of a Fast Beam Scanning Method and Future Plans for a Hospital Based Facility, pp. 277-279 (1990).
  • U.S. Appl. No. 11/371,622, filed on Mar. 9, 2006.
  • File History of U.S. Appl. No. 11/187,633.
  • File History of U.S. Appl. No. 13/618,939.
  • File History of U.S. Pat. No. 7402963.
  • File History of U.S. Pat. No. 7626347.
  • File History of U.S. Pat. No. 8952634.
  • Communication under Rule 71(3) EPC for EP1719182.9, 36 pages (Oct. 16, 2018).
  • An Accelerated Collaboration Meets with Beaming Success, Lawrence Livermore National Laboratory, Apr. 12, 2006, S&TR, Livermore, California, pp. 1-3, http://www.llnl.gov/str/April06/Caporaso.html.
  • Cohen, R. et al., Nevis Synchrocyclotron Conversion Project, IEEE Transactions on Nuclear Science, IEEE SelVice Center, New York, NY, US, vol. 16, No. 3, Jun. 1, 1969, pp. 421-425, XP011351570, ISSN: 0018-9499, DOI: 10.1109/TNS.1969.4325264 abstract; figures I-4a Chap. 1, p. 421-2; chap. 11 from p. 423, col. 2 to p. 425, col. 1. (5 pages).
  • Dey, M.K., et al., Coil Centering for the Kolkata Superconducting Cyclotron Magnet, Cyclotrons and their applications, Proceedings, 18th International Conference, Cyclotrons 2007, Giardini Naxo, Italy, Oct. 1-5, 2007 (3 pages).
  • Elo, Don, et al., Mechanical Design of Regenerative Deflector for the Berkeley 88-Inch Cyclotron, Proceedings of the International Conference on Isochronous Cyclotrons, Gatlinburg, Tennessee, Aug. 1966 (7 pages).
  • European Communication issued in European application No. 13774886.9 on Jun. 12, 2015, with amended claims filed on Jun. 12, 2015 (20 pages).
  • European Communication issued in European application No. 13783422.2 on Jun. 12, 2015 (2 pages).
  • File History for U.S. Appl. 14/039,307 as of Sep. 12, 2017, 836 pages (retrieved Nov. 27, 2018).
  • File history of U.S. Appl. No. 10/949,734 (now U.S. Pat. No. 7,208,748) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 11/371,622 (now U.S. Pat. No. 7,402,963) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 11/463,403 (now U.S. Pat. No. 7,656,258) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 11/517,490 (now U.S. Pat. No. 7,701,677) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 11/601,056 (now U.S. Pat. No. 7,728,311) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 11/624,769 (now U.S. Pat. No. 7,541,905) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 11/724,055 (now U.S. Pat. No. 7,718,982) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 11/870,961 (now U.S. Pat. No. 8,003,964) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 11/948,662 (now U.S. Pat. No. 8581523) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 12/275,103 (now U.S. Pat. No. 8,344,340) (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 60/590,088 (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 60/850,565 (downloaded Mar. 14, 2017).
  • File history of U.S. Appl. No. 60/991,454 (downloaded Mar. 14, 2017).
  • First Chinese Office Action for CN201380062115.7, 7 pages (Dec. 12, 2016), and English translation 9 pages (Dec. 12, 2016).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2013/062119 dated Mar. 31, 2015 (7 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2013/062137 dated Mar. 31, 2015 (9 pages).
  • International Search Report and Written Opinion from PCT application No. PCT/US2013/062119 dated Nov. 26, 2013 (9 pages).
  • Japanese Office Action for Application JP2015-534728, 6 pages (dated Mar. 28, 2016). Note: English translation has not been received from Associate.
  • Japanese Office Action for Application JP2015-534721, 14 pages (dated Feb. 3, 2016) (with English Translation).
  • Ormrod, J.H., et al., The Chalk-River Superconducting Cyclotron, Proceedings of the International Conference on Cyclotrons and their applications '79, 1979 (6 pages).
  • Rainwater, James, Status of the Nevis Synchrocyclotron Modification, AIP Conference Proceedings No. 9, 1972 (14 pages).
  • Response to European Communication issued in European application No. 13774886.9 on Jun. 12, 2015, filed on Dec. 9, 2015 (26 pages).
  • Response to European Communication issued in European application No. 13783422.2 on Jun. 12, 2015, filed on Dec. 8, 2015 (19 pages).
  • Second Chinese Office Action for CN201380062111.9, 10 pages (Apr. 5, 2017), and English Translation 16 pages (Apr. 5, 2017).
  • U.S. Appl. No. 13/830,792 filed on Mar. 14, 2013, including the USPTO electronic file for 13/830,792.
  • U.S. Appl. No. 13/949,459 filed on Jul. 24, 2013, including the USPTO electronic file for 13/949,459.
  • U.S. Appl. No. 61/676,377 filed Jul. 27, 2012, including the USPTO electronic file for 61/676,377.
  • Verster, N. F., Regenerative Beam Extraction from the 150-MeV Synchrocyclotron at the Laboratoire Curie, Proceedings of Sector-Focused Cyclotrons 1959, 1959, pp. 224-229 (6 pages).
  • Enchevich, I B et al. “Minimizing Phase Losses in the 680 Mev Synchrocyclotron by Correcting the Accelerating Voltage Amplitude”, in Atomnaja Energya. (Soviet Atomic Energy) Soviet Atomic Energy, Atomnaja Energya. (Moscow, SU, Mar. 1, 1969), vol. 26, No. 3, pp. 315-316, XP008069829.
  • Extended European Search Report (EP 19165255.1) 7 pages, Sep. 24, 2019.
  • Amaldi, Cyclinacs, Novel Fast-Cycling Accelerators for Hadrontherapy, 2007, Cyclotrons and Their Applications, 18th International Conference, pp. 166-168.
  • Appun, J. “Various Problems of Magnet Fabrication for High-Energy Accelerators, ” Journal for All Engineers Interested in the Nuclear Field, pp. 10-16 (1967) [Lang.: German], English bibliographic information(http://www.osti.gov/energycitations/product.biblio.jsp?osti.sub.--id=444- 2292).
  • Blom, Mikael, Development of a Scanning System for Proton Therapy in Uppsala, Department of Radiation Sciences, Uppsala University, 2450-2451.
  • Blosser, H., et. al. “A Compact Superconducting Cyclotron for the Production of High Intensity Protons,” Proceedings of the 1997 Particle Accelerator Conference, vol. 1, pp. 1054-1056 (May 12-16, 1997).
  • Canadian Office action from Canadian application No. 2,629,333 dated Aug. 30, 2010 (5 pages).
  • Chichili, D.R., et al., “Fabrication of Nb.sup.3Sn Shell-Type Coils with Pre-Preg Ceramic Insulation,” American Institute of Physics Conference Proceedings, AIP USA, No. 711, (XP-002436709, ISSN: 0094-243X), 2004, pp. 450-457.
  • Chinese Office action from Chinese application No. 200880125832.9, dated Sep. 22, 2011 (11 pages).
  • Chinese Office action from Chinese application No. 200880125918.1, dated Sep. 15, 2011 (111 pages).
  • English translation of Chinese Office action from Chinese application No. 200880125832.9, dated Jun. 5, 2012 (5 pages).
  • European Communication from corresponding European application No. 11/65422.4 dated Sep. 2, 2011 (5 pages).
  • European Communication from corresponding European application No. 11/65423.2 dated Sep. 2, 2011 (5 pages).
  • European Communication from European application No. 07868958.5, dated Nov. 26, 2010 (50 pages).
  • European Patent Office communication from European application No. 07868958.5, dated Jul. 16, 2010 (2 pages).
  • European Patent Office communication from European application No. 08856764.9, dated Jul. 30, 2010 (2 pages).
  • European Search Report from European Application No. 10175751.6 dated Nov. 18, 2010 (8 pages).
  • Favale, A. et al., Pre-conceptual Design of a Rapid Cycling Medical Synchrotron, The AES/BNL collaboration, 45 pages (Oct. 27, 1999).
  • File History for U.S. Appl. No. 14/039,307 as of Jan. 13, 2017, 343 pages.
  • Fish & Richardson P.C., Response to Non Final Office action dated Aug. 20, 2010 in U.S. Appl. No. 11/948,359, filed on Feb. 22, 2011 (17 pages).
  • Grözinger, Sven Oliver, Volume Conformal Irradiation of Moving Target Volumes with Scanned Ion Beams, Vom Fachbereich Physik der Technischen Universität Darmstadt, 110 pages (2004).
  • International Preliminary Report on Patentability for PCT application No. PCT/US2007/001506 dated Jul. 5, 2007 (15 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2007/086109, dated Jun. 10, 2010 (7 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2008/084695, dated Jun. 10, 2010 (10 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2008/084699, dated Jun. 10, 2010 (8 pages).
  • International Preliminary Report on Patentability issued in PCT application PCT/US2013/062103 dated Apr. 9, 2015 (11 pages).
  • International Search Report and Written Opinion for PCT application No. PCT/US2007/001506 dated Jul. 5, 2007, Publication No. WO 2007/084701, Published Jul. 26, 2007 (14 pages).
  • International Search Report and Written Opinion for PCT application No. PCT/US2008/084695 dated Jan. 26, 2009 (15 pages).
  • International Search Report and Written Opinion from corresponding PCT application No. PCT/US2013/062103 dated Apr. 14, 2014 (13 pages).
  • International Search Report for PCT/US2007/001628 dated Feb. 18, 2008 (4 pages).
  • Invitation to Pay Additional Fees and, where applicable, Protest Fees with partial search report for application No. PCT/US2008/077513 dated Jul. 3, 2009 (62 pages).
  • Jones et al., “Status Report of the NAC Particle Therapy Programme,” Stralentherapie and Onkologie, vol. 175, Suppl. II, Jun. 1999, pp. 30-32.
  • Kanazawa, M. et al., Beam Control in the Spot Scanning Irradiation, Proceedings of the Second Asian Particle Accelerator Conference, China; 846-848 (2001).
  • Kawachi, K. et al., Three Dimensional Spot Beam Scanning Method for Proton Conformation Radiation Therapy, Acta Radiologica, Supplementum 364, 10 pages (1982).
  • Lorin, S. et al., Development of a compact proton scanning system in Uppsala with a moveable second magnet, Phys. Med. Biol, 45:1151-1163 (2000).
  • Murphy, M. and Lin, P., Intra-fraction dose delivery timing during stereotactic radiotherapy can influence the radiobiological effect, Med. Phys., 34(2):481-484 (2007).
  • Non Final Office Action from U.S. Appl. No. 12/275,103 dated Feb. 1, 2011 (6 pages).
  • Non Final Office Action from U.S. Appl. No. 12/618,297 dated May 13, 2011 (44 pages).
  • Office Action and response history of U.S. Appl. No. 11/601,056 dated Aug. 24, 2009.
  • Office Action and response history of U.S. Appl. No. 11/601,056 dated Mar. 24, 2009.
  • Office Action and response history of U.S. Appl. No. 11/601,056 up dated Jan. 14, 2010.
  • Office Action for JP2015-534721, 14 pages, dated (Feb. 3, 2016).
  • Office action from U.S. Appl. No. 11/948,662, dated Oct. 14, 2011 (5 pages).
  • Pardo, J. et al., Simulation of the performance of the CNAO facility's Beam Delivery System, PTCOG 46, Zibo, China, 17 pages (2007).
  • PCT application No. PCT/US2005/25942 filed on Jul. 21, 2005, with Publication No. WO 2006/012452.
  • Pourrahimi, S. et al., “Powder Metallurgy Processed Nb.sup.3Sn(Ta) Wire for High Field NMR Magnets,” IEEE Transactions on Applied Superconductivity, vol. 5, No. 2, (Jun. 1995), pp. 1603-1606.
  • Response to Non Final Office Action dated Feb. 1, 2011 in U.S. Appl. No. 12/275,103 filed May 2, 2011 (13 pages).
  • Second Office Action (English) for JP2015-534721, 5 pages (Dec. 26, 2016).
  • Second Office Action (Japanese) for JP2015-534721, 5 pages (Dec. 26, 2016).
  • Shinji Sato et al., “Dynamic Intensity Control System with RF-knockout Slow-Extraction in the HIMAC Synchrotron—” Nuclear Instruments and Methods in Physics Research A 574, 2007, pp. 226-231.
  • Superconducting Cyclotron Contract awarded by Paul Scherrer Institute (PSI), Villigen, Switzerland, http://www.accel.de/News/superconducting.sub.--cyclotron.sub.--contract.h- tml (Feb. 3, 2005).
  • Takayama, T., et al. , “Compact Cyclotron for Proton Therapy,” Proceedings of the 8.sup.th Symposium on Accelerator Science and Technology, Japan (Nov. 25-27, 1991) pp. 380-382.
  • U.S. Appl. No. 10/949,734, filed Sep. 24, 2004, Patent No. 7,208,748, issued on Apr. 24, 2007.
  • U.S. Appl. No. 11/187,633, filed on Jul. 21, 2005.
  • U.S. Appl. No. 11/371,622, filed Mar. 9, 2006.
  • U.S. Appl. No. 11/463,403, filed Aug. 9, 2006.
  • U.S. Appl. No. 11/517,490, filed Sep. 7, 2006.
  • U.S. Appl. No. 11/601,056, filed Nov. 17, 2006.
  • U.S. Appl. No. 11/624,769, filed Jan. 19, 2007.
  • U.S. Appl. No. 11/724,055, filed Mar. 14, 2007.
  • U.S. Appl. No. 11/870,961, filed Oct. 11, 2007.
  • U.S. Appl. No. 11/948,662, filed Nov. 30, 2007.
  • U.S. Appl. No. 12/275,103, filed Nov. 20, 2008.
  • USPTO Non Final Office Action in U.S. Appl. No. 11/948,359, dated Aug. 20, 2010 (12 pages).
  • U.S. Appl. No. 60/590,088, filed Jul. 21, 2004.
  • U.S. Appl. No. 60/738,404, filed Nov. 18, 2005.
  • U.S. Appl. No. 60/850,565, filed Oct. 10, 2006.
  • U.S. Appl. No. 60/991,454, filed on Nov. 30, 2007.
  • Uli Weber et al., “Depth Scanning for a Conformal Ion Beam Treatment of Deep Seated Tumours—” Physics in Medicine and Biology IOP Publishing UK, vol. 45, No. 12, Dec. 2000, pp. 3627-3641.
  • Umegaki et al., “Development of an Advance Proton Beam Therapy System for Cancer Treatment” Hitachi Hyoron, 2003, 85(9):605-608 [Lang.: Japanese], English Abstract, http://www.hitachi.com/ICSFiles/afieldfile/2004/06/01/r2003.sub.--04.sub.- --104.pdfor http://www.hitachi.com/rev/archive/2003/2005649.sub.--12626.html (full text) [Hitachi, 52(4), Dec. 2003].
  • van Steenbergen, A. “Superconducting Synchroton Development at BNL,” Proceedings of the 8.sup.th International Conference on High-Energy Accelerators CERN 1971, pp. 196-198 (1971).
  • Written Opinion for PCT/US2007/001628, dated Feb. 18, 2008 (11 pages).
  • Yudelev, M., et. al. “Hospital Based Superconducting Cyclotron for Neutron Therapy: Medical Physics Perspective,” Cyclotrons and their applications 2001, 16th International Conference. American Institute of Physics Conference Proceedings, vol. 600,pp. 40-43 (May 13-17, 2001). http://www.osti.gov/energycitations/productbiblio.jsp?osti.sub.--id=20468- 164 http://adsabs. harvard.edu/abs/2001A1PC..600 . . . 40Y http://scitation.aip.org/getabs/servlet/GetabsServlet?prog= normal&id=APCPCS000600000001000040000001&idtype=cvips&gifs=yes.
  • Zherbin, E. A., et al., “Proton Beam Therapy at the Leningrad Synchrocyclotron (Clinicomethodological Aspects and Therapeutic Results),” pp. 17-22, Aug. 1987, vol. 32(8)(German with English abstract on .about.es 21-22).
  • Extended European Search report for EP17191182.9, 10 pages (Jan. 29, 2018).
  • Schneider, R., et al., “Nevis Synchrocyclotron Conversion Program—RF System,” IEEE Transactions on Nuclear Science USA ns16 (3) pp. 430-433 (Jun. 1269).
  • Enchevich, B., et al., “Minimizing Phase Losses in the 680 MeV Synchrocyclotron by Correcting the Accelerating Voltage Amplitude,” Atomnaya Energiya 26:(3), pp. 315-316 (1969).
  • Allardyce, B.W., et al., “Performance & Prospects of the Reconstructed CERN 600 MeV Synchro-Cyclotron,” IEEE Transactions on Nuclear Science USA ns-24: (3), pp. 1631-1633 (Jun. 1977).
  • Blosser, H.G., “Synchrocyclotron Improvement Programs,” IEEE Transactions on Nuclear Science USA ns16: (3), pp. 59-65 (Jun. 1969).
  • Blosser, H.G., “Compact Superconducting Synchrocyclotron Systems for Proton Therapy,” Nuclear Instruments & Methods in Physics Research, B40-42, pp. 1326-1330 (Apr. 1989).
  • Lecroy, W., et al., “Viewing Probe for High Voltage Pulses,” Review of Scientific Instruments USA 31:;(12), p. 1354 (Dec. 1960).
  • Schneider, R., et al., “Nevis Synchrocyclotron Conversion Program-R.F.System,” IEEE Transactions on Nuclear Science USA, vol. ns18, No. 3, pp. 303-306 (Jun. 1971).
  • 18th Japan Conference on Radiation and Radioisotopes [Japanese], Nov. 25-27, 1987, 9 pages.
  • 510(k) Summary: Ion Beam Applications SA, FDA, Apr. 13, 2001.
  • 510(k) Summary: Optivus Proton Beam Therapy System, Jul. 21, 2000, 5 pages.
  • Abrosimov, N. K., et al,“1000MeV Proton Beam Therapy Facility at Petersburg Nuclear Physics Institute Synchrocyclotron,” Medical Radiology (Moscow) 32, 10 (1987) revised in Journal of Physics, Conference Series 41, pp. 424-432, Institute of Physics Publishing Limited, 2006.
  • Abrosimov, N. K., et al., “Neutron Time-of-Fight Spectrometer Gneis At the Gatchina 1 GeV Proton Synchrocylotron,” Nuclear Instruments & Methods in Physics Research, A242(1): 121-133 (1985).
  • Adachi, T., et. al. “A 150MeV FFAG Synchrotron with “Return-Yoke Free” Magnet,” Proceedings of the 2001 Particle Accelerator Conference, Chicago (2001).
  • Ageyev, A.I., et. al. “The IHEP Accelerating and Storage Complex (UNK) Status Report,” 11th International Conference on High-Energy Accelerators, pp. 60-70 (Jul. 7-11, 1980).
  • Agosteo, S., et al., “Maze Design of a Gantry Room for Proton Therapy,” Nuclear Instruments & Methods in Physics Research, Section A, 382, pp. 573-582 (1996).
  • Alexeev, V.P., et al., “R4 Design of Superconducting Magnets for Proton Synchrotrons,” Proceedings of the Fifth International Cryogenic Engineering Conference, pp. 531-533 (1974).
  • Allardyce, B.W., et al., “Performance and Prospects of the Reconstructed CERN 600 MeV Synchrocyclotron” IEEE Transactions on Nuclear Science USA NS-24:(3), pp. 1631-1633 (Jun. 1977).
  • Amaldi, U. “Overview of the World Landscape of Hadrontherapy and the Projects of the TERA Foundation,” Physica Medica, An International Journal Devoted to the Applications of Physics to Medicine and Biology, vol. XIV, Supplement 1 (Jul. 1998), 6th Workshop on Heavy Charged Particles in Biology and Medicine, Instituto Scientific Europeo (ISE), Baveno, pp. 76-85 (Sep. 29-Oct. 1, 1997).
  • Amaldi, U., et al. , “The Italian Project for a Hadrontherapy Centre,” Nuclear Instruments and Methods in Physics Research A, 360, pp. 297-301 (1995).
  • Anferov, V., et. al., “Status of the Midwest Proton Radiotherapy Institute,” Proceedings of the 2003 Particle Accelerator Conference, pp. 699-701 (2003).
  • Anferov, V., et. al., “The Indiana University Midwest Proton Radiation Institute,” Proceedings of the 2001 Particle Accelerator Conference, Chicago, pp. 645-647 (2001).
  • Appun, J. “Various Problems of Magnet Fabrication for High-Energy Accelerators,” Journal for All Engineers Interested in the Nuclear Field, pp. 10-16 (1967) [Lang.: German], English bibliographic information (http://www.osti.gov/energycitations/product.biblio.jsp?osti__id=4442292).
  • Arduini, G., et. al., “Physical Specifications of Clinical Proton Beams From a Synchrotron,” Med. Phys. 23 (6), pp. 939-951 (Jun. 1996).
  • Beeckman, W., et. al., “Preliminary Design of a Reduced Cost Proton Therapy Facility Using A Compact, High Field Isochronous Cyclotron,” Nuclear Instruments and Methods in Physics Research B56/57, pp. 1201-1204 (1991).
  • Bellomo, G., et al., “The Superconducting Cyclotron Program at Michigan State University,” Bulletin of the American Physical Society, vol. 25, No. 7, p. 767 (Sep. 1980).
  • Benedikt, M. And Carli, C. “Matching to Gantries for Medical Synchrotrons,” IEEE Proceedings of the 1997 Particle Accelerator Conference, pp. 1379-1381 (1997).
  • Bieth, C., et. al., “A Very Compact Proton Therapy Facility Based on an Extensive Use of High Temperature Superconductors (HTS),” Cyclotrons and their Applications 1998, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Caen, France, pp. 669-672 (Jun. 14-19, 1998).
  • Bigham, C.B. “Magnetic Trim Rods for Superconducting Cyclotrons,” Nuclear Instruments and Methods (North-Holland Publishing Co.) 141 (1975), pp. 223-228.
  • Blackmore, E.W., et. al. “Operation of the Triumf Proton Therapy Facility,” IEEE Proceedings of the 1997 Particle Accelerator Conference, vol. 3, pp. 3831-3833 (May 12-16, 1997).
  • Bloch, C. “The Midwest Proton Therapy Center, ” Application of Accelerators in Research and Industry, Proceedings of the Fourteenth Int'l. Conference, Part Two, pp. 1253-1255 (Nov. 1996).
  • Blosser, H. “Applications of Superconducting Cyclotrons,” Twelfth International Conference on Cyclotrons and Their Applications, pp. 137-144 (May 8-12, 1989).
  • Blosser, H. G. “Compact Superconducting Synchrocyclotron Systems for Proton Therapy,” Nuclear Instruments & Methods in Physics Research, Section B40-41, Part II, pp. 1326-1330 (1989).
  • Blosser, H. G. “Synchrocyclotron Improvement Programs,” IEEE Transactions on Nuclear Science USA, http://www.nscl.msu.edu/tech/accelerators/k250photo.html (Feb. 2005).vol. 16,No. 3, Part I, pp. 405-414 (Jun. 1969).
  • Blosser, H., “Application of Superconductivity in Cyclotron Construction,” Ninth International Conference on Cyclotrons and their Applications, pp. 147-157 (Sep. 1981).
  • Blosser, H., “Present and Future Superconducting Cyclotrons,” Bulletin of the American Physical 314 Society, vol. 32, No. 2, p. 171 (Feb. 1987), Particle Accelerator Conference, Washington, D.C. 1987.
  • Blosser, H., et al., “Problems and Accomplishments of Superconducting Cyclotrons,” Proceedings 315 of the 14th International Conference, Cyclotrons and Their Applications, pp. 674-684 (Oct. 1995).
  • Blosser, H., et al., “Superconducting Cyclotron for Medical Application,” IEEE Transactions on Magnetics, vol. 25, No. 2, pp. 1746-1754 (Mar. 1989).
  • Blosser, H., et al., “Advances in Superconducting Cyclotrons at Michigan State University,” Proceedings of the11th International Conference on Cyclotrons and their Applications, pp. 157-167 (Oct. 1986), Tokyo.
  • Blosser, H., et al., “Characteristics of a 400 (Q2/A) MeV Super-Conducting Heavy-Ion Cyclotron,” Bulletin of the American Physical Society, p. 1026 (Oct. 1974).
  • Blosser, H., et al., “Preliminary Design Study Exploring Building Features Required for a Proton Therapy Facility for the Ontario Cancer Institute,” MSUCL-760a (Mar. 1991).
  • Blosser, H., et al., “Medical Accelerator Projects at Michigan State Univ.,” IEEE Proceedings of the 1989 Particle Accelerator Conference, vol. 2, pp. 742-746 (Mar. 20-23, 1989).
  • Blosser, H.G., “Future Cyclotrons,” AIP, The Sixth International Cyclotron Conference, pp. 16-32 (1972).
  • Blosser, H.G., “Medical Cyclotrons,” Physics Today, Special Issue Physical Review Centenary, pp. 70-73 (Oct. 1993).
  • Blosser, H.G., “Progress on the Coupled Superconducting Cyclotron Project,” Bulletin of the American Physical Society, vol. 26, No. 4, p. 558 (Apr. 1981).
  • Blosser, H.G., “Superconducting Cyclotrons at Michigan State University,” Nuclear Instruments & Methods in Physics Research, vol. B 24/25, part II, pp. 752-756 (1987).
  • Blosser, H.G., “The Michigan State University Superconducting Cyclotron Program,” Nuclear Science, vol. NS-26, No. 2, pp. 2040-2047 (Apr. 1979).
  • Blosser, H.G., et al, “Superconducting Cyclotrons,” Seventh International Conference on Cyclotrons and their Applications, pp. 584-594 (Aug. 19-22, 1975).
  • Botha, A.H., et al., “A New Multidisciplinary Separated-Sector Cyclotron Facility,” IEEE Transactions on Nuclear Science, vol. NS-24, No. 3, pp. 1118-1120 (1977).
  • Chichili, D.R., et al., “Fabrication of Nb3Sn Shell-Type Coils with Pre-Preg Ceramic Insulation,” American Institute of Physics Conference Proceedings, AIP USA, No. 711, (XP-002436709, ISSN: 0094-243X), 2004, pp. 450-457.
  • Chong, C.Y., et al., Radiology Clinic North American 7,3319 (1969).
  • Chu, et al., “Instrumentation for Treatment of Cancer Using Proton and Light-ion Beams,” Review of Scientific Instruments, 64 (8), pp. 2055-2122 (Aug. 1993).
  • Cole, et al., “Design and Application of a Proton Therapy Accelerator,” Fermi National Accelerator Laboratory, IEEE, (1985).
  • Conradie, et al., “Proposed New Facilities for Proton Therapy at iThemba Labs,” Proceedings of EP AC, pp. 560-562 (2002).
  • CE/Source of Ions for Use in Sychro-Cyclotrons Search, Jan. 31, 2005, 9 pages.
  • Coupland, J.H. “High-field (5T) Pulsed Superconducting Dipole Magnet,” Proceedings of the Institution of Electrical Engineers, vol. 121, No. 7, pp. 771-778 (Jul. 1974).
  • Coutrakon, G. et al., “A Prototype Beam Delivery System for the Proton Medical Accelerator At Lorna Linda,” Medical Physics, vol. 18(6), pp. 1093-1099 (Nov./Dec. 1991).
  • Coutrakon, G. et al., “Proton Synchrotrons for Cancer Therapy, ” Application of Accelerators in Research and Industry—Sixteenth International Conf., American Institute of Physics, vol. 576, pp. 861-864 (Nov. 1-5, 2000).
  • CPAC Highlights Its Proton Therapy Program at ESTRO Annual Meeting, TomoTherapy Incorporated, Sep. 18, 2008, Madison, Wisconsin, pp. 1-2.
  • Cuttone, G., “Applications of a Particle Accelerators in Medical Physics,” Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud, V.S. Sofia, 44 Cantania, Italy (17 pages). No date.
  • Dahl, P., “Superconducting Magnet System,” American Institute of Physics, AIP Conference Proceedings, vol. 2, pp. 1329-1376 (1987-1988).
  • Dugan, G. et al. “Tevatron Status,” IEEE, Particle Accelerator Conference, Accelerator Science & Technology (1989), pp. 426-430.
  • Eickhoff, et al. “The Proposed Accelerator Facility for Light Ion Cancer Therapy in Heidelberg,” Proceedings of the 1999 Particle Accelerator Conference, New York, pp. 2513-2515 (1999).
  • Endo, K., et. al., “Compact Proton and Carbon Ion Synchrotrons for Radiation Therapy,” Proceedings of EPAC 2002, Paris France, pp. 2733-2735 (2002).
  • Flanz, J.B. et al., “Large Medical Gantries,” 1995 Particle Accelerator Conference, Massachusetts General Hospital, pp. 1-5 (1995).
  • Flanz, J.B. et al., “The Northeast Proton Therapy Center at Massachusetts General Hospital,” Fifth Workshop on Heavy Charge Particles in Biology and Medicine, GSI, Darmstadt (Aug. 1995).
  • Flanz, J.B. et. al. “Treating Patients with the NPTC Accelerator Based Proton Treatment Facility,” Proceedings of the 2003 Particle Accelerator Conference (2003), pp. 690-693.
  • Flood, W. S. And Frazier, P. E. “The Wide-Band Driven RF System for the Berkeley 88-Inch Cyclotron,” American Institute of Physics, Conference Proceedings., No. 9, 459-466 (1972).
  • Foster, G. W. and Kashikhin, V. S. “Superconducting Superferric Dipole Magent with Cold Iron Core for the VLHC,” IEEE Transactions on Applied Superconductivity, vol. 12, No. 1, pp. 111-115 (Mar. 2002).
  • Friesel, D. L. et al. “Design and Construction Progress on the IUCF Midwest Proton Radiation Institute,” Proceedings of EPAC 2002, pp. 2736-2738 (2002).
  • Fukumoto, S. “Cyclotron Versus Synchrotron for Proton Beam Therapy,” KEK Preprint, No. 95-122, pp. 533-536 (1995).
  • Fukumoto, S. et. al., “A Proton Therapy Facility Plan,” Cyclotrons and their Applications, Proceedings of the 13th International Conference, Vancouver, Canada, pp. 258-261 (Jul. 6-10, 1992).
  • Gordon, M.M. et. al., “Design Study for a Compact 200 MeV Cyclotron,” AIP Conference Proceedings Sixth International Cyclotron Conference, No. 9, pp. 78-86 (1972).
  • Gordon, M.M., “Extraction Studies for a 250 MeV Superconducting Synchrocyclotron,” Proceedings of the 1987 IEEE Particle Accelerator Conference: Accelerator Engineering and Technology, pp. 1255-1257 (1987).
  • Goto, A. et al., “Progress on the Sector Magnets for the Riken SRC,” American Institute of Physics, CP600, Cyclotrons and Their Applications 2001, Sixteenth International Conference (2001), pp. 319-323.
  • Graffman, S. et. al., “Design Studies for a 200 MeV Proton Clinic for Radiotherapy,” AIP Conference Proceedings: Cyclotrons 1972, No. 9, pp. 603-615 (1972).
  • Graffman, S. et. al. “Proton radiotherapy with the Uppsala cyclotron. Experience and Plans,” Strahlentherapie, 161, No. 12, pp. 764-770 (1985).
  • Graffman, S., et al., “Clinical Trials in Radiotherapy and the Merits of High Energy Protons,” Acta Radiol. Therapy Phys. Biol. 9:1-23 (1970).
  • Hede, Karyn, Research Groups Promoting Proton Therapy “Lite,” Journal of the National Cancer Institute, 98(23):1682-1684 (2006).
  • Heinz, W. “Superconducting Pulsed Magnetic Systems for High-Energy Synchrotrons,” Proceedings of the Fourth International Cryogenic Engineering Conference, pp. 55-63. (May 24-26, 1972).
  • Hentschel, R., et. al., “Plans for the German National Neutron Therapy Centre with a Hospital-Based 70 MeV Proton Cyclotron at University Hospital Essen/Germany,” Cyclotrons and their Applications, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Caen, Franco, pp. 21-23 (Jun. 14-19, 1998).
  • Hepburn, J.D., et. al., “Superconducting Cyclotron Neutron Source for Therapy,” International Journal of Radiation Oncology Biology Physics, vol. 3 complete, pp. 387-391 (1977).
  • Hirabayashi, H. “Development of Superconducting Magnets for Beam Lines and Accelerator at KEK,” IEEE Transaction on Magnetics, vol. Mag-17, No. 1, pp. 728-731 (Jan. 1981).
  • Indiana's mega-million proton therapy cancer center welcomes its first patients: [online] Press release, Health & Medicine Week, 2004, retrieved from NewsRx.com, Mar. 1, 2004, pp. 119-120.
  • Ishibashi, K. And McInturff, A. “Winding Design Study of Superconducting /OT Dipoles for a Synchrotron,” IEEE Transactions on Magnetics, vol. MAG-19, No. 3, pp. 1364-1367 (1983).
  • Ishibashi, K. and McInturff, A., “Stress Analysis of Superconducting /OT Magnets for Synchrotron,” Proceedings of the Ninth International Cryogenic Engineering Conference, pp. 513-516 (May 11-14, 1982).
  • Jahnke, A., et. al. “First Superconducting Prototype Magnets for a Compact Synchrotron Radiation Source in Operation,” IEEE Transactions on Magnetics, vol. 24, No. 2 (Mar. 1988), pp. 1230-1232.
  • Jones, and Dershem. “Synchrotron Radiation from Proton in a 20 TEV, 10 TESLA 367 Superconducting Super Collider,” Proceedings of the 12th International Conference on High-Energy Accelerators, pp. 138-140 (Aug. 11-16, 1983).
  • Jones, D.T.L. “Present Status and Future Trends of Heavy Particle Radiotherapy,” Cyclotrons and their Applications 1998, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, pp. 13-20 (Jun. 14-19, 1998).
  • Jones, D.T.L. And Mills, S.J. “The South African National Accelerator Centre: Particle Therapy and Isotope Production Programmes,” Radiation Physics and Chemistry, vol. 51, Nos. 4-6, pp. 571-578 (Apr.-Jun. 1998).
  • Jones, D.T.L., et. al. “Status Report of the NAC Particle Therapy Programme,” Stralentherapie und Onkologie, vol. 175, Suppl. II, pp. 30-32 (Jun. 1999).
  • Jones, D.T.L. “Progress with the 200 MeV Cyclotron Facility at the National Accelerator Centre,” Commission of the European Communities Radiation Protection Proceedings, Fifth Symposium on Neutron Dosimetry, vol. II, pp. 989-998 (Sep. 17-21, 1984).
  • Jongen, Y. et al., “The Proton Therapy System for the NPTC: Equipment Description and Progress Report,” Nuclear Instruments and methods in Physics Research, Section B, vol. 113, No. 1, pp. 522-525 (1996).
  • Jongen, Y., et al., “The Proton Therapy System for MGH's NPTC: Equipment Description and Progress Report,” Bulletin du Cancer Radiotherapie, Proceedings of the meeting of the European Heavy Particle Therapy Group, vol. 83, Suppl. 1, pp. 219-222 (1996).
  • Jongen, Y., et al., “Development of a Low-Cost Compact Cyclotron System for Proton Therapy,” National Institute of Radiol. Sci No. 81, pp. 189-200 (1991).
  • Jongen, Y., et. al. “Progress report on the IBA-SHI Small Cyclotron for Cancer Therapy,” Nuclear Instruments and Methods in Physics Research, Section B, vol. 79, issue 1-4, pp. 885-889 (1993).
  • Kanai, et al., “Three-dimensional Beam Scanning for Proton Therapy,” Nuclear Instruments and Methods in Physic Research, Sep. 1, 1983, The Netherlands, vol. 214, No. 23, pp. 491-496.
  • Karlin, D.L., et al., “Medical Protonic Tract of Synchropshylotron of the Leningrad Institute of Nuclear Physics,” Medical Radiology (Moscow) 28,13 (1983). (English Abstract).
  • Karlin, D.L., et al., “The State and Prospects in the Development of the Medical Proton Tract on the Synchrocyclotron in Gatchina,” Med. Radiology, Moscow, vol. 28(3), pp. 28-32 (Mar. 1983)(German with English Abstract on end of p. 32).
  • Kats, M. M. And Onosovskii, K. K. “A Planar Magnetooptical System for the Irradiation of a Lying Patient with a Proton Beam from Various Directions,” Instruments and Experimental Techniques, vol. 39, No. 1, pp. 127-131 (1996).
  • Kats, M. M. And Onosovskii, K. K. “A Simple, Compact, Flat System for the Irradiation of a Lying Patient with a Proton Beam from Different Directions,” Instruments and Experimental Techniques, vol. 39, No. 1, p. 132-134 (1996).
  • Kats, M.M. And Druzhinin, B.L. “Comparison of Methods for Irradiating Prone Patients” Atomic Energy, vol. 94, No. 2, pp. 120-123 (2003).
  • Khoroshkov, V. S., et al., “Moscow Hospital-Based Proton Therapy Facility Design” Am. Journal Clinical Oncology: CCT, vol. 17, No. 2, pp. 109-114 (1994).
  • Kim, J. and Blosser, H., “Optimized Magnet for a 250 MeV Proton Radiotherapy Cyclotron,” Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 345-347 (May 2001).
  • Kim, J. And Yun, C. “A Light-Ion Superconducting Cyclotron System for Multi-Disciplinary Users,” Journal of the Korean Physical Society, vol. 43, No. 3, pp. 325-331 (Sep. 2003).
  • Kim, J., et al., “Design Study of a Superconducting Cyclotron for Heavy Ion Therapy,” Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 324-326 (May 13-17, 2001).
  • Kim, J., et al., “Construction of 8 T Magnet Test Stand for Cyclotron Studies,” IEEE Transactions on Applied Superconductivity, vol. 3, No. 1, pp. 266-268 (Mar. 1993).
  • Kim, J.W. “An Eight Tesla Superconducting Magnet for Cyclotron Studies,” Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy (1994).
  • Kim, J.W., et al., “Trim Coil System for the Riken Superconducting Ring Cyclotron,” Proceedings at the 1997 Particle Accelerator Conference, IEEE, vol. 3, pp. 214-235 (Dec. 1981). or 3422-3424, 1998).
  • Kishida, N. And Yano, Y. “Beam Transport System for the RIKEN SSC (H), ” Scientific Papers of the Institute of Physical and Chemical Research, vol. 75, No. 4, pp. 214-235 (Dec. 1981).
  • Koehler, A.M., et al., “Range Modulators for Protons and Heavy Ions,” Nuclear Instruments and Methods, vol. 131, pp. 437-440 (1975).
  • Koto, M. And Tsujii, H. “Future of Particle Therapy,” Japanese Journal of Cancer Clinics, vol. 47, No. 1, pp. 95-98 (2001) [Lang.: Japanese], English abstract (http://sciencelinks.jp/jeast/article/200206/00002002060 IA0511453 .mill).
  • Kraft, G. et al., “Hadrontherapy in Oncology,” Elsevier Science, 1994.
  • Larsson, B. “Biomedical Program for the Converted 200-MeV Synchrocyclotron at the Gustaf Werner Institute,” Radiation Research, 104, pp. S310-S318 (1985).
  • Larsson, B., et al., “The High-Energy Proton Beam As a Neurosurgical Tool,” Nature vol. 182, pp. 1222-1223 (1958).
  • Lawrence, J.H., “Proton Irradiation of the Pituitary,” Cancer, vol. 10, pp. 795-798 (1957).
  • Lawrence, J.H., et al., “Heavy Particles in Acromegaly and Cushing's Disease,” Endocrine and Norendocrine Hormone Producing Tumors, pp. 29-61 (1973).
  • Lawrence, J.H., et al., “Successful Treatment of Acromegaly: Metabolic and Clinical Studies in 145 Patients,” The Journal of Clinical Endrocrinology and Metabolism, 31 (2): (1970).
  • Linfoot, J.A., et al., “Acromegaly,” Hormonal Proteins and Peptides, pp. 191-246 (1975).
  • Livingston, M.S., et al. “A Capillary Ion Source for the Cyclotron,” Review Science Instruments, vol. 10, p. 9. 63-67, (1939).
  • LLNL, UC Davis Team Up to Fight Cancer, Lawrence Livermore National Laboratory, Apr. 28, 2006, SF-Jun. 4, 2002, Livermore, California, pp. 1-4.
  • Mandrillon, P. “High Energy Medical Accelerators,” EPAC 90, 2nd European Particle Accelerator Conference, vol. 2, (Jun. 12-16, 1990), pp. 54-58.
  • Marti, F., et al., “High Intensity Operation of a Superconducting Cyclotron,” Proceedings of the 14th International Conference, Cyclotrons and Their Applications, pp. 45-48 (Oct. 1995).
  • Martin, P. “Operational Experience with Superconducting Synchrotron Magnets,” Proceedings of the 1987 IEEE Particle Accelerator Conference, vol. 3 of 3, pp. 1379-1382 (Mar. 16-19, 1987).
  • Meot, F., et al. , “ETOILE Hadrontherapy Project, Review of Design Studies,” Proceedings of EPAC 2002, pp. 2745-2747 (2002).
  • Miyamoto, S., et al., “Development of the Proton Therapy System,” The Hitachi Hyoron, vol. 79, 10, pp. 775-779 (1997) [Lang: Japanese], English abstract (http://www.hitachi.com/rev/1998/revfeb98/rev4706.htm).
  • Montelius, A, et al., “The Narrow Proton Beam Therapy Unit at the Svedberg Laboratory in Uppsala,” ACTA Oncologica, vol. 30, pp. 739-745 (1991).
  • Moser, H.O., et al., “Nonlinear Beam Optics with Real Fields in Compact Storage Rings, ” Nuclear Instruments & Methods in Physics Research/Section B30, Feb. 1988, No. 1, pp. 105-109.
  • National Cancer Institute Funding (Senate-Sep. 21, 1992) (www.thomas.loc.gov/cgi-bin/query/z?r102:S21SE2-712 (2 pages).
  • Nicholson, J. “Applications of Proton Beam Therapy,” Journal of the American Society of Radiologic Technologists, vol. 67, No. 5, pp. 439-441 (May/Jun. 1996).
  • Nolen, J.A., et al., “The Integrated Cryogenic—Superconducting Beam Transport System Planned for MSU,” Proceedings of the 12th International Conference on High-Energy Accelerators, pp. 549-551 (Aug. 1983).
  • Norimine, T., et al., “A Design of a Rotating Gantry with Easy Steering for Proton Therapy,” Proceedings of EPAC 2002, pp. 2751-2753 (2002).
  • Okumura, T., et al., “Overview and Future Prospect of Proton Radiotherapy,” Japanese Journal of Cancer Clinics, vol. 43, No. 2, pp. 209-214 (1997) [Lang.: Japanese].
  • Okumura, T., et al., “Proton Radiotherapy,” Japanese Journal of Cancer and Chemotherapy, (20), No. 14, pp. 2149-2155 (1993) [Lang.: Japanese] Outstanding from Search Reports, “Accelerator of Polarized Portons at Fermilab,” 20 pages, 2005.
  • Palmer, R. and Tollestrup, A V. “Superconducting Magnet Technology for Accelerators,” Annual Review of Nuclear and Particle Science, vol. 34, pp. 247-284 (1984).
  • Patent Assignee and Keyword Searches for Synchrocyclotron, Jan. 25, 2005 (77 pages).
  • Patterson, “An Accelerated Collaboration Meets with Beaming Success,” Lawrence Livermore National Laboratory, Apr. 12, 2006, S&TR Livermore, CA. pp. 1-3, http://www.llnl.gov/str/April06/Caporaso.html.
  • Pavlovic, M. “Beam-Optics Study of the Gantry Beam Delivery System for Light-Ion Cancer Therapy,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 399, No. 2, pp. 439-454 (1997).
  • Pedroni, E. “Accelerators for Charged Particle Therapy: Performance Criteria from the User Point of View,” Cyclotrons and their Applications, Proceedings of the 13th International Conference, pp. 226-233 (1992).
  • Pedroni, E. “Latest Developments in Proton Therapy,” Proceedings of EPAC 2000, pp. 240-244 (2000).
  • Pedroni, E. and Enge, H. “Beam Optics Design of Compact Gantry for Proton Therapy,” Medical & Biological Engineering & Computing, vol. 33, No. 3, pp. 271-277 (May 1995).
  • Pedroni, E. and Jermann, M. “SGSMP: Bulletin Mar. 2002 Proscan Project, Progress Report on the PROSCAN Project of PSI,” [online] retrieved from www.sgsmp.ch/protA23.htm, (5 pages) Mar. 2002.
  • Pedroni, E., et al., “A Novel Gantry for Proton Therapy at the Paul Scherrer Institute,” Cycloctrons 430 and Their Applications 2001: Sixteenth International Conference. AIP Conference Proceedings, vol. 600, pp. 13-17 (2001).
  • Pedroni, E., et al., “The 200-MeV proton therapy project at the Paul Scherrer Institute: Conceptual Design and Practical Realization,” Medical Physics, vol. 22, No. 1, pp. 37-53 (Jan. 1995).
  • Potts, R., et al., “MPWP6-Therapy III: Treatment Aids and Techniques,” Medical Physics, vol. 15, No. 5, p. 798 (Sep./Oct. 1988).
  • Pourrahimi, S. et al., “Powder Metallurgy Processed Nb.3Sn(Ta) Wire for High Field NMR Magnets,” IEEE Transactions on Applied Superconductivity, vol. 5, No. 2, (Jun. 1995), pp. 1603-1606.
  • Prieels, D., et al., “The IBA State-of-the-Art Proton Therapy System, Performances and Recent Results,” Application of Accelerators in Research and Industry—Sixteenth International. Conference, American Institute of Physics, vol. 576, pp. 857-860 (2000).
  • Rabin, M. S. Z., et al., “Compact Designs for Comprehensive Proton Beam Clinical Facilities,” Nuclear Instruments and Methods in Physics Research 40(41):1335-1339(1989).
  • Research & Development Magazine, “Proton Therapy Center Nearing Completion,” vol. 41, No. 9, Aug. 1999 (2 pages)(www.rdmga.com).
  • Resmini, F., “Design Characteristics of the K=800 Superconducting Cyclotron at M.S.U.,” Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, IEEE Transaction on Nuclear Science, vol. NS-26, No. 2, Apr. 1979 (8 pages).
  • RetroSearch “Berkeley 88-Inch Cyclotron ‘RF’ or 'Frequency Control,” Jan. 21, 2005 (36 pages).
  • RetroSearch “Berkeley 88-Inch Cyclotron,” Jan. 24, 2005 (170 pages).
  • RetroSearch “Bernard Gottschalk, Cyclotron, Beams, Compensated Upstream Modulator, Compensated Scatter,” Jan. 21, 2005 (20 pages).
  • RetroSearch “Cyclotron with ‘RF’ or 'Frequency Control,” Jan. 21, 2005 (49 pages).
  • RetroSearch “Gottschalk, Bernard, Harvard Cyclotron Wheel”, Jan. 21, 2005 (20 pages).
  • RetroSearch “Lorna Linda University Beam Compensation,” Jan. 21, 2005 (60 pages).
  • RetroSearch “Lorna Linda University, Beam Compensation Foil Wedge,” Jan. 21, 2005 (15 pages).
  • Rifuggiato, D., et al., “Status Report of the LNS Superconducting Cyclotron,” Nukleonika, vol. 48, pp. S131-S134 (Supplement 2, 2003).
  • Rode, C.H. “Tevatron Cryogenic System,” Proceedings of the 12th International Conference on High-Energy Accelerators , Fermi/ab, pp. 529-535 (Aug. 11-16, 1983).
  • Salzburger, H., et al., “Superconducting Synchrotron Magnets Supraleitende Synchrotronmagnete,” Siemens AG., Erlangen (West Germany). Abteilung Technische Physik, Report No. BMFT-FB-T- 75-25, Oct. 1975, p. 147, Journal Announcement: GRAI7619; STAR1415, Subm-Sponsored by Bundesmin. Fuer Forsch. U. Technol. In German; English Summary.
  • Schillo, M., et al., “Compact Superconducting 250 MeV Proton Cyclotron for the PSI Proscan Proton Therapy Project,” Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 37-39 (2001).
  • Schneider et al., “Superconducting Cyclotrons,” IEEE Transactions on Magnetics, vol. MAG-11, No. 2, Mar. 1975, pp. 443-446.
  • Schneider, R., et al., “Nevis Synchrocyclotron Conversion Program—RF System,” IEEE Transactions on Nuclear Science USA NS 16(3) pp. 430-433 (Jun. 1969).
  • Schreuder, AN., et al., “The Non-orthogonal Fixed Beam Arrangement for the Second Proton Therapy Facility at the National Accelerator Centre,” Application of Accelerators in Research and Industry, American Institute of Physics, Proceedings of the Fifteenth International Conference, Part Two, pp. 963-966 (Nov. 1998).
  • Schreuder, H.W. “Recent Developments in Superconducting Cyclotrons,” Proceedings of the 1995 Particle Accelerator Conference, vol. 1, pp. 317-321 (May 1-5, 1995).
  • Schubert, J.R. And Blosser, H. “Conceptual Design of a High Field Ultra-Compact Cyclotron for Nuclear Physics Research,” Proceedings of the 1997 Particle Accelerator Conference, vol. 1, pp. 1060-1062 (May 12-16, 1997).
  • Schubert, J. R. “Extending the Feasibility Boundary of the Isochronous Cyclotron” Dissertation submitted to Michigan State University, 1997, Abstract http://adsabs.harvard.edulabs/1998PhDT....... 147S.
  • Shelaev, I. A., et al., “Design Features of a Model Superconducting Synchrotron of JINR” Proceedings of the 12th International Conference on High-energy Accelerators, pp. 416-418 (Aug. 11-16, 1983).
  • Shintomi, T., et al., “Technology and Materials for the Superconducting Super Collider (SSC) Project,” [Lang.: Japanese], The Iron and Steel Institute of Japan 00211575, vol. 78, No. 8 (19920801), pp. 1305-1313, http://ci.nii.ac.jp/naid/110001493249/eni , 1992.
  • Sisterson, J.M. “World Wide Proton Therapy Experience in 1997,” The American Institute of Physics, Applications of Accelerators in Research and Industry, Proceedings of the Fifteenth International Conference, Part Two, pp. 959-962 (Nov. 1998).
  • Sisterson, J.M. “Clinical Use of Proton and Ion Beams From a World-Wide Perspective,” Nuclear Instruments and Methods in Physics Research, Section B, Vols. 40-41, pp. 1350-1353 (1989).
  • Slater, J.M., et al., “Developing a Clinical Proton Accelerator Facility: Consortium-Assisted Technology Transfer,” Conference Record of the 1991 IEEE Particle Accelerator Conference: Accelerator Science and Technology, vol. 1 , pp. 532-536 (May 6-9 1991).
  • Slater, J.M., et al., “Development of a Hospital-Based Proton Beam Treatment Center,” International Journal of Radiation Oncology Biology Physics, vol. 14, No. 4, pp. 761-775 (Apr. 1988).
  • Smith, A, et al., “The Northeast Proton Therapy Center at Massachusetts General Hospital,” Journal of Brachytherapy International, pp. 137-139 (Jan. 1997).
  • Snyder, S.L. And Marti, F. “Central Region Design Studies for a Proposed 250 MeV Proton Cyclotron,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 355, pp. 618-623 (1995).
  • Soga, F. “Progress of Particle Therapy in Japan,” Application of Accelerators in Research and Industry, American Institute of Physics, Sixteenth International Conference, pp. 869-872 (Nov. 2000).
  • Spiller, P., et al., “The GSI Synchrotron Facility Proposal for Acceleration of High Intensity Ion and Proton Beams,” Proceedings of the 2003 Particle Accelerator Conference, vol. 1, pp. 589 -591 (May 12-16, 2003).
  • Stanford, A.L., et al., “Method of Temperature Control in Microwave Ferroelectric Measurements,” Sperry Microwave Electronics Company, Clearwater, Florida, Sep. 19, 1960 (1 page).
  • Superconducting Cyclotron Contract awarded by Paul Scherrer Institute (PSI), Villigen, Switzerland, http://www.accel.de/News/superconducting_cyclotron_contract.html (Feb. 3, 2005).
  • Tadashi, T., et al., “Large Superconducting Super Collider (SSC) In The Planning and Materials Technology,” vol. 78, No. 8 (Aug. 1, 1992), pp. 1305-1313, The Iron and Steel Institute of Japan 00211575.
  • Takada, Y. “Conceptual Design of a Proton Rotating Gantry for Cancer Therapy,” Japanese Journal of Medical Physics, vol. 15, No. 4, pp. 270-284 (1995).
  • Takada, Y. “A Review of Rotating Gantries for Heavy Charged Particle Therapy,” Symposium of Research Center for Charged Particle Therapy on Fundamental Development of the Charged Particle Therapy, Chiba (Japan), Nov. 13-14, 2001.
  • Teng, L. C. “The Fermilab Tevatron,” Coral Gables 1981, Proceedings, Gauge Theories, Massive Neutrinos, and Proton Decay, pp. 43-62 (1981).
  • UC Davis “Crocker Nuclear Laboratory Houses a Medium-Energy Particle Accelerator,” Crocker Nuclear Laboratory, University of California (2009).
  • “The Cutting Edge of Cancer Therapy Using Proton Beams,” The Journal of Practical Pharmacy, vol. 46, No. 1, pp. 97-103 (1995). [Japanese] (English Abstract).
  • “The K250 Proton therapy Cyclotron,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k250.html (Feb. 2005).
  • “The K250 Proton-therapy Cyclotron Photo Illustration,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k250photo.html (Feb. 2005).
  • “The K100 Neutron-therapy Cyclotron,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k100.html (Feb. 2005).
  • Tobias, C.A., et al., “Pituitary Irradiation with High-Energy Proton Beams A Preliminary Report,” Cancer Research, vol. 18, No. 2, pp. 121-134 (1958).
  • Tom, J.L. “The Use of Compact Cyclotrons for Producing Fast Neutrons for Therapy in a Rotatable Isocentric Gantry,” IEEE Transaction on Nuclear Science, vol. 26, No. 2, pp. 2294-2298 (Apr. 1979).
  • Trinks, U., et al., “The Tritron: A Superconducting Separated-Orbit Cyclotron,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 244, pp. 273-282 (1986).
  • Tsuji, H. “The Future and Progress of Proton Beam Radiotherapy,” Journal of Japanese Society for Therapeutic Radiology and Oncology, vol. 6, No. 2, pp. 63-76 (1994).
  • Tsuji, H., “Cancer Therapy Using Proton Beams: the Newest State of Affairs and Future Prospects,” Isotope News, No. 9, pp. 2-7 (1992). (English Abstract).
  • UC Davis School of Medicine, “Unlikely Partners Turn Military Defense into Cancer Offense,” Current Issue Summer 2008, Sacramento, California, pp. 1-2.
  • Umezawa, M., et al., “Beam Commissioning of the New Proton Therapy System for University of Tsukuba,” Proceedings of the 2001 Particle Accelerator Conference, vol. 1, pp. 648-650 (Jun. 18-22, 2001).
  • van Steenbergen, A. “The CMS, a Cold Magnet Synchrotron to Upgrade the Proton Energy Range of the BNL Facility,” IEEE Transactions on Nuclear Science, vol. 18, Issue 3, pp. 694-698 (Jun. 1971).
  • Vandeplassche, D., et al., “235 MeV Cyclotron for MHG's Northeast Proton Therapy Center (NPTC): Present Status,” EPAC 96, Fifth European Partical Accelerator Conference, vol. 3, pp. 2650-2652 (Jun. 10-14, 1996).
  • Vorobiev, L.G., et al., “Concepts of a compact achromatic proton gantry with a wide scanning field,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 406, No. 2, pp. 307-310 (1998).
  • Vrenken, H., et al., “A Design of a Compact Gantry for Proton Therapy With 2D-Scanning,” Nuclear Instruments and Methods in Physics Research, Section A, vol. 426, No. 2, pp. 618-624 (1999).
  • Wikipedia, “Cyclotron,” http://en.wikipedia.org/wiki/Cyclotron (originally visited Oct. 6, 2005, revisited Jan. 28, 2009)(7 pages).
  • Wikipedia, “Synchrotron,” http://en.wikiipedia.org/wiki/Synchrotron (originally visited Oct. 6, 2005, revisited Jan. 28, 2009)(7pages).
  • Wu, X., “Conceptual Design and Orbit Dynamics in a 250 MeV Superconducting Synchrocyclotron,” Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy (1990).
  • York, R.C., et al., “Present Status and Future Possibilities at NSCL-MSU,” EPAC 94, Fourth European Particle Accelerator Conference, pp. 554-556 (Jun. 1994).
  • York, R.C., et al., “The NSCL Coupled Cyclotron Project—Overview and Status,” Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, pp. 687-691 (Jun. 1998).
  • Canadian Office action from Canadian application No. 2,629,333 issued May 11, 2011 (2 pages).
  • Canadian Office action from Canadian application No. 2,629,333 issued Aug. 30, 2010 (5 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Aug. 22, 2011 (4 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Mar. 21, 2011 (6 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Dec. 25, 2009 (8 pages).
  • Chinese Office Action from Chinese Application No. 200780102281.X issued Dec. 7, 2011 with English translation (23 pages).
  • Chinese Office action from Chinese application No. 200880125832.9, mailed Sep. 22, 2011 (11 pages).
  • Chinese Office action from Chinese application No. 200880125918.1, mailed Sep. 15, 2011 (111 pages).
  • European Patent Office communication for application No. 06838033.6, patent No. 1949404, mailed Aug. 5, 2009 (1 page).
  • European Patent Office communication from European application No. 07868958.5, mailed Jul. 16, 2010 (2 pages).
  • European Search Report from application No. EP 06838033.6 (PCT/US2006/044853) mailed May 11, 2009 (69 pages).
  • International Preliminary Report on Patentability for PCT application No. PCT/US2007/001506 mailed Jul. 5, 2007 (15 pages).
  • International Preliminary Report on Patentability for PCT/US2007/00 1628, mailed Apr. 22,2008 (15 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2008/084695, mailed Jun. 10, 2010 (10 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2008/084699, mailed Jun. 10, 2010 (8 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2007/086109, mailed Jun. 10, 2010 (7 pages).
  • International Search Report and Written Opinion for PCT application No. PCT/US2008/084695 mailed Jan. 26, 2009 (15 pages).
  • International Search Report and Written Opinion for PCT application No. PCT/US2007/001506 mailed Jul. 5, 2007, Publication No. WO 2007/084701, Published Jul. 26, 2007 (14 pages).
  • International Search Report and Written Opinion mailed Oct. 1, 2009 in PCT application No. PCT/US2008/077513 (73 pages).
  • International Search Report dated Aug. 26, 2008 in PCT application No. PCT/US2007/086109 (6 pages).
  • International Search Report for PCT/US2007/001628 mailed Feb. 18, 2008 (4 pages).
  • Invitation to Pay Additional Fees and, where applicable, Protest Fees with partial search report for application No. PCT/US2008/077513 mailed Jul. 3, 2009 (62 pages).
  • PCT application No. PCT/US2005/25942 filed on Jul. 21, 2005, with Publication No. WO 2006/012452, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2006/44853, filed on Nov. 17, 2006, with Publication No. WO 2007/1061937, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2007/01506 filed on Jan. 19, 2007, with Publication No. WO 2007/084701, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2007/01628 filed on Jan. 19, 2007, with Publication No. WO 2007/1130164, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2007/086109 filed on Nov. 30, 2007, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2007177693 filed on Sep. 6, 2007 with Publication No. WO 2007/177693, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2008/077513, filed on Sep. 24, 2008, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT application No. PCT/US2008/084695 filed on Nov. 25, 2008, including copy of application as filed, transaction history from PAIR (PTO website).
  • PCT International Preliminary Report on Patentability of corresponding PCT application No. PCT/US2006/044853, mailed May 29, 2008 (34 pages).
  • PCT International Search report and Written Opinion of PCT application No. PCT/US2006/044853, mailed Oct. 5, 2007 (10 pages).
  • Written Opinion dated Aug. 26, 2008 in PCT application No. PCT/US2007/086109 (6 pages).
  • Written Opinion for PCT/US2007/001628, mailed Feb. 18, 2008 (11 pages).
  • Dialog Search, Jan. 31, 2005 (18 pages).
  • European Communication from corresponding European application No. 11/65422.4 mailed Sep. 2, 2011 (5 pages).
  • European Communication from corresponding European application No. 11/65423.2 mailed Sep. 2, 2011 (5 pages).
  • European Communication from European application No. 06838033.6 mailed Apr. 20, 2010 (7 pages).
  • European Communication from European application No. 07868958.5, mailed Nov. 26, 2010 (50 pages).
  • European Patent Office communication from European application No. 08855024.9, mailed Jul. 30, 2010 (2 pages).
  • European Patent Office communication from European application No. 08856764.9, mailed Jul. 30, 2010 (2 pages).
  • European Search Report from corresponding European application No. 11165422.4 mailed Aug. 8, 2011 (118 pages).
  • European Search Report from corresponding European application No. 11165423.2 mailed Aug. 8, 2011 (118 pages).
  • Literature Author and Keyword Search, Feb. 14, 2005 (44 pages).
  • Literature Author and Keyword Searches (Synchrotron), Jan. 25, 2005 (78 pages).
  • Literature Keyword Search, Jan. 24, 2005 (96 pages).
  • Literature Search and Keyword Search for Synchrocyclotron, Jan. 25, 2005 (68 pages).
  • Literature Search by Company Name/Component Source, Jan. 24, 2005 (111 pages).
  • Literature Search, Jan. 26, 2005 (36 pages).
  • “Patent Assignee Search 'Paul Scherrer Institute,” Library Services at Fish & Richardson P.C., Mar. 20, 2007 (40 pages).
  • “Patent Prior Art Search for ‘Proton Therapy System’,” Library Services at Fish & Richardson P.C., Mar. 20, 2007 (46 pages).
  • Response to Chinese Office action of Jan. 25, 2010 in Chinese application No. 200680051421.0, filed Jun. 24, 2010 (34 pages).
  • Response to European Communication of Apr. 20, 2010, from European application No. 06838033.6, filed Nov. 2, 2010 (13 pages).
  • Response to European Communication of Jul. 16, 2010 in European application No. 07868958.5 filed Aug. 26, 2010 (9 pages).
  • Response to European Communication of Nov. 26, 2010 in European application No. 07868958.5, filed Mar. 28, 2011 (9 pages).
  • Revised Patent Keyword Search, Jan. 25, 2005 (88 pages).
  • Voluntary amendment filed Apr. 18, 2011 in corresponding Chinese application No. CN200780102281.X, including English translation of claim amendments (10 pages).
  • Worldwide Patent Assignee Search, Jan. 24, 2005 (224 pages).
  • Worldwide Patent Keyword Search, Jan. 24, 2005 (94 pages).
  • Office Action and response history of U.S. Appl. No. 11/601,056 to Aug. 24, 2009.
  • Office Action and response history of U.S. Appl. No. 11/601,056 to Mar. 24, 2009.
  • Office Action and response history of U.S. Appl. No. 11/601,056 up to Jan. 14, 2010.
  • U.S. Appl. No. 10/949,734, filed on Sep. 24, 2004, Patent No. 7,208,748, issued on Apr. 24, 2007, including copy of application as filed, transaction history from PAIR (PTO website), and allowed claims.
  • U.S. Appl. No. 11/187,633, filed on Jul. 21, 2005, including copy of application as filed, transaction history from PAIR (PTO website), and pending claims.
  • U.S. Appl. No. 11/371,622, filed on Mar. 9, 2006, including copy of application as filed, transaction history from PAIR (PTO website), and pending claims.
  • U.S. Appl. No. 11/463,403, filed on Aug. 9, 2006, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/724,055, filed on Mar. 14, 2007, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/948,662, filed on Nov. 30, 2007, including copy of application as filed, transaction history from PAIR (PTO website), and pending claims.
  • U.S. Provisional Appl. No. 60/590,088, filed on Jul. 21, 2004, including copy of application as filed, transaction history from PAIR (PTO website).
  • U.S. Provisional Appl. No. 60/850,565, filed on Oct. 10, 2006, including copy of application as filed, transaction history from PAIR (PTO website).
  • U.S. Provisional Appl. No. 60/991,454, filed on Nov. 30, 2007, including copy of application as filed, transaction history from PAIR (PTO website).
  • U.S. Provisional Appl. No. 60/738,404, filed on Nov. 18, 2005, including copy of application as filed, transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/517,490, filed on Sep. 7, 2006, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/601,056, filed on Nov. 17, 2006, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/624,769, filed on Jan. 19, 2007, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 11/870,961, filed on Oct. 11, 2007, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • U.S. Appl. No. 12/275,103, filed on Nov. 20, 2008, including copy of application as filed (including pending claims), transaction history from PAIR (PTO website).
  • Non Final Office Action from U.S. Appl. No. 12/275,103 mailed Feb. 1, 2011 (6 pages).
  • Non Final Office Action from U.S. Appl. No. 12/618,297 mailed May 13, 2011 (44 pages).
  • Office action from U.S. Appl. No. 11/948,662, mailed Oct. 14, 2011 (5 pages).
  • Response to Non Final Office Action issued Feb. 1, 2011 in U.S. Appl. No. 12/275,103 filed May 2, 2011 (13 pages).
  • Response to Office action mailed Oct. 14, 2011 from U.S. Appl. No. 11/648,662, filed Dec. 14, 2011 (12 pages).
  • Chinese Office action from Chinese application No. 200880125832.9, mailed Jun. 5, 2012. English Translation will follow upon receipt (5 pages).
  • International Search Report and Written Opinion of the International Searching Authority from International application No. PCT/US2008/084699, mailed Feb. 4, 2009 (11 pages).
  • U.S. Examiner EPHREM ALEMU, USPTO Non Final Office Action in U.S. Appl. No. 11/948,359, dated Aug. 20, 2010 (12 pages).
  • Fish & Richardson P.C., Response to Non Final Office action mailed Aug. 20, 2010 in U.S. Appl. No. 11/948,359, filed on Feb. 22, 2011 (17 pages).
  • Office action from corresponding Canadian Application No. 2,574,122 mailed Nov. 14, 2012 (6 pages).
  • Response in English of Office Action from Chinese application No. 200880125832.9 mailed Jun. 5, 2012, filed Oct. 12, 2012 (6 pages).
  • English translation of Chinese Office action from Chinese application No. 200880125832.9, mailed Jun. 5, 2012 (5 pages).
  • Response with English translation to Chinese Office Action from Chinese application No. 200880125832.9 issued Sep. 22, 2011, filed on Apr. 9, 2012 (23 pages).
  • Chinese Office action with English translation from Chinese Application No. 200880125832.9, issued Mar. 4, 2013 (8 pages).
  • Blosser, H. et al, “Progress Toward an Experiment to Study the Effect of RF Grounding in an Internal Ion Source on Axial Oscillations of the Beam in a Cyclotron”, Cyclotrons and Their Applications 2001, 16th International Conference, 2001 American Institute of Physics, Belgium and Michigan, USA, pp. 274-276 (2001).
  • Flanz, et al., “Operation of a Cyclotron Based Proton Therapy Facility”, Massachusetts General Hospital, Boston, MA 02114, pp. 1-4, retrieved from Internet in 2009.
  • Krevet, et al, “Design of a Strongly Curved Superconducting Bending Magnet for a Compact Synchrotron Light Source”, Advances in Cryogenic Engineering, vol. 33, pp. 25-32 (Dec. 3, 1988).
  • Lawrence, J.H., et al., “Treatment of Pituitary Tumors With Heavy Particles”, Diagnosis and Treatment of Pituitary Tumors, pp. 253-262 (1970).
  • Toyoda, E., “Proton Therapy System”, Sumitomo Heavy Industries, Ltd. (2004).
  • Source Search Cites of U.S. and Foreign Patents/Published applications in the name of Mitsubishi Denki Kabushiki Kaisha and Containing the Keywords (Proton and Synchrocyclotron), 8 pages (2009).
  • Flanz, et al., “Scanning Beam Technologies”, PTCOG 2008, 28 pages.
  • Gordon et al., “Design Study for a Compact 200 MeV Cyclotron” AIP Conference Proceedings Sixth International Cyclotron Conference, 1972, No. 9:78-86.
  • Gordon, “Extraction Studies fo a 250 MeV Superconducting Synchrocyclotron,” Proceedings of the 1987 IEEE Particle Accelerator Conference: Accelerator Engineering an Technology, 1987, pp. 1255-1257.
  • Renner et al., “Preliminary Results of a Raster Scanning Beam Delivery System”, IEEE, 1989, 3 pages.
  • Single Room Proton Therapy Facility, ACCEL, Oct. 2006, 1 page.
  • Timmer, “The ACCEL Single Room Proton Therapy Facility” ACCEL Instruments GmbH, PTCOG 45, Oct. 2006, Houston, Texas, 18 pages.
  • Non-Final Office Action with English translation from Japanese Patent Office 2010-536131, Jun. 4, 2013, 10 pages JP action first cited and filed with USPTO on Jun. 13, 2012.
  • Office action issued in Taiwan IPO Pat. Application No. 097138794, recieved Feb. 8, 2012, 7 pages.
  • Response to Chinese Office Action from Corresponding Chinese application No. 200880125832.9, issued Sep. 22, 2011, filed on Apr. 9, 2012, 23 pages (with English translation).
  • Response to Chinese Patent application No. 200880125832.9 office action filed May 20, 2013, 6 pages.
  • Response to Office action from Canadian Application No. 2,574,122 mailed Nov. 14, 2012, filed May 13, 2013, 32 pages.
  • “Beam Delivery and Properties,” Journal of the ICRU , 2007, 7(2):20 pages.
  • “510(k) Summary: Ion Beam Applications S.A.”, FDA, Jul. 12, 2001, 5 pages.
  • “510(k) Summary: Optivus Proton Beam Therapy System”, Jul. 21, 2000, 5 page.
  • “An Accelerated Collaboration Meets with Beaming Success,” Lawrence Livermore National Laboratory, Apr. 12, 2006, S&TR, Livermore, California, pp. 1-3, http://www.llnl.gov/April06/Caporaso.html.
  • “Indiana's mega-million proton therapy cancer center welcomes first patients”[online] Press release, Health & Medicine Week, 2004, retrieved from NewsRx.com, Mar. 1, 2004, pp. 119-120.
  • “LLNL, UC Davis Team UP to Fight Cancer,” Lawrence Livermore National Laboratory, Apr. 28, 2006, SF-06-04-02, Livermore, California, pp. 1-4.
  • “Patent Assignee Search 'Pau; Scherrer Institute,” Library Services at Fish & Richardson P.C., Mar. 20, 2007, 40 pages.
  • “Superconducting Cyclotron Contract” awarded by Paul Scherrer Institute (PSI), Villigen, Switzerland, http://www.accel.de/News/superconducting_cyclotron_contract.htm, Jan. 2009, 1 page.
  • “The Davis 76-Inch Isochronous Cyclotron”, Beam On: Crocker Nuclear Laboratory, University of California, 2009, 1 page.
  • “The K100 Neutron-therapy Cyclotron,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k100, Feb. 2005, 1 page.
  • “The K250 Proton therapy Cyclotron,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k250.html, Feb. 2005, 2 pages.
  • “The K250 Proton-therapy Cyclotron Photo Illustration,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/media/image/experimental-equipment-technology/250.html, Feb. 2005, 2 pages.
  • Abrosimov et al., “1000MeV Proton Beam Therapy Facility at Petersburg Nuclear Physics Institute Synchrocyclotron,” Medical Radiology (Moscow) 32, 10 (1987) revised in Journal of Physics, Conference Series 41, 2006, pp. 424-432, Institute of Physics Publishing Limited.
  • Adachi et al., “A 150MeV FFAG Synchrotron with Return-Yoke Free Magent,” Proceedings of the 2001 Particle Accelerator Conference, Chicago, 2001, 3 pages.
  • Ageyev et al., “The IHEP Accelerating and Storage Complex (UNK) Status Report,” 11th International Conference on High-nergy Accelerators, 1980, pp. 60-70.
  • Agosteo et al., “Maze Design of a gantry room for proton therapy,” Nuclear Instruments & Methods In Physics Research, 1996, Section A, 382, pp. 573-582.
  • Alexeev et al., “R4 Design of Superconducting Magents for Proton Synchrotrons,” Proceedings of the Fifth International Cryogenic Engineering Conference, 1974, pp. 531-533.
  • Allardyce et al., “Performance and Prospects o the Reconstructed CERN 600 MeV Synchrocyclotron,” IEEE Transactions on Nuclear Science USA, Jun. 1977, ns-24:(3)1631-1633.
  • Alonso, “Magnetically Scanned Ion Beams for Radiation Therapy,” Accelerator & Fusion Research Division, Lawrence Berkeley Laboratory, Berkeley, CA, Oct. 1988, 13 pages.
  • Amaldi et al., “The Italian project for a hadrontherapy centre” Nuclear Instruments and Methods in Physics Research A, 1995, 360, pp. 297-301.
  • Amaldi, “Overview of the world landscape of Hadrontherapy and the projects of the TERA foundation,” Physica Medica, An International journal Devoted to the Applications of Physics to Medicine and Biology, Jul. 1998, vol. XIV, Supplement 1, 6th Workshop on Heavy Charged Particles in Biology and Medicine, Instituto Scientific Europeo (ISE), Sep. 29-Oct. 1, 1977, Baveno, pp. 76-85.
  • Anferov et al., “Status of the Midwest Proton Radiotherapy Institute,” Proceedings of the 2003 particle Accelerator Conference, 2003, pp. 699-701.
  • Anferov et al., “The Indiana University Midwest Proton Radiation Institute,” Proceedings of the 2001 Particle Accelerator Conference, 2001, Chicago, pp. 645-647.
  • Appun, “Various problems of magnet fabrication for high-energy accelerators,” Journal for All Engineers Interested in the Nuclear Field, 1967, pp. 10-16 (1967) [Lang.: German], English bibliographic information (http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=4442292).
  • Arduini et al. “Physical specification of clinical proton beams from a synchrotron,” Med. Phys, Jun. 1996, 23 (6): 939-951.
  • Badano et al., “Proton-Ion Medical Machine Study (PIMMS) Part I,” PIMMS, Jan. 1999, 238 pages.
  • Beeckman et al., “Preliminary design of a reduced cost proton therapy facility using a compact, high field isochronous cyclotron,” Nuclear Instruments and Methods in Physics Reasearch B56/57, 1991, pp. 1201-1204.
  • Bellomo et al., “The Superconducting Cyclotron Program at Michigan State University,” Bulletin of the American Physical Society,Sep. 1980, 25(7):767.
  • Benedikt an Carli, “Matching to Gantries for Medical Synchrotrons” IEEE Proceedings of the 1997 Particle Accelerator Conference, 1997, pp. 1379-1381.
  • Bieth et al., “A Very Compact Protontherapy Facility Based on an Extensive Use of High Temperature Superconductors (HTS)” Cyclotrons and their Applications 1998, Proceedings o the Fifteenth International Conference on Cyclotrons an their Applications, Caen, Jun. 14-19, 1998, pp. 669-672.
  • Bigham, “Magnetic Trim Rods for Superconducting Cyclotrons,” Nuclear Instruments and Methods (North-Holland Publishing Co.), 1975, 141:223-228.
  • Bimbot, “First Studies of the External Beam from the Orsay S.C. 200 MeV,” Institut de Physique Nucleaire, BP 1, Orsay France, IEEE, 1979, pp. 1923-1926.
  • Blackmore et al., “Operation of the Triumf Proton Therapy Facility,” IEEE Proceedings of the 1997 Particle Accelerator Conferenc, May 12-16, 19973:3831-3833.
  • Bloch,“The Midwest Proton Therapy Center,” Application of Accelerators in Research and Industry, Proceedings of the Fourteenth Int'l. Conf., Part Two, Nov. 1996, pp. 1253-1255.
  • Blosser et al., “Problems and Accomplishments of Superconducting Cyclotrons,” Proceeding of the 14th International Conference, Cyclotrons and Their Applications, Oct. 1995, pp. 674-684.
  • Blosser et al., “Superconducting Cyclotrons”, Seventh International Conference on Cylotrons and their Applications, Aug. 19-22, 1975, pp. 584-594.
  • Blosser et al., “Progress toward an experiment to study the effect of RF grounding in an internal ion source on axial oscillations o the beam in a cyclotron,” National Superconducting Cyclotron Laboratory, Michigan State University, Report MSUCL-760, CP600, Cyclotrons and their Applications 2011, Sixteenth International Conference, 2001, pp. 274-276.
  • Blosser et al., “A Compact Superconducting Cyclotron for the Production of High Intensity Protons,” Proceedings of the 1997 Particle Accelerator Conference, May 12-16, 1997, 1:1054-1056.
  • Blosser et al., “Advances in Superconducting Cyclotrons at Michigan State University,” Proceedings of the 11th International Conference on Cyclotrons and their Applications, Oct. 1986, pp. 157-167, Tokyo.
  • Blosser et al., “Characteristics of a 400 (Q2/A) MeV Super-Conducting Heavy-Ion Cyclotron,” Bulletin of the American Physical Society, Oct. 1974, p. 1026.
  • Blosser et al., “Medical Accelerator Projects at Michigan State Univ.” IEEE Proceedings of the 1989 Particle Accelerator Conference, Mar. 20-23, 1989, 2:742-746.
  • Blosser et al., “Superconducting Cyclotron for Medical Application”, IEEE Transactions on Magnetics, Mar. 1989, 25(2): 1746-1754.
  • Blosser, “Application of Superconductivity in Cyclotron Construction,” Ninth International Conference on Cyclotrons and their Applications, Sep. 1981, pp.147-157.
  • Blosser, “Applications of Superconducting Cyclotrons,” Twelfth International Conference on Cyclotrons and Their Applications, May 8-12, 1989, pp. 137-144.
  • Blosser, “Future Cyclotron,” AIP, The Sixth International Cyclotron Conference, 1972, pp. 16-32.
  • Blosser, “Medical Cyclotrons,” Physics Today, Special Issue Physical Review Centenary, Oct. 1993, pp. 70-73.
  • Blosser, “Preliminary Design Study Exploring Building Features Required for a Proton therapy Facility for the Ontario Cancer Institute”, Mar. 1991, MSUCL-760a, 53 pages.
  • Blosser, “Progress on the Coupled Superconducting Cyclotron Project,” Bulletin of the American Physical Society, Apr. 1981, 26(4):558.
  • Blosser, “Synchrocyclotron Improvement Programs,” IEEE Transactions on Nuclear Science USA, Jun. 1969, 16(3):Part I, pp. 405-414.
  • Blosser, “The Michigan State University Superconducting Cyclotron Program,” Nuclear Science, Apr. 1979, NS-26(2):2040-2047.
  • Blosser, H., Present and Future Superconducting Cyclotrons, Bulletin of the American Physical Society, Feb. 1987, 32(2):171 Partical Accelerator Conference, Washington, D.C.
  • Blosser, H.G., “Superconducting Cyclotrons at Michigan State Univesity”, Nuclear Instruments & Methods in Physics Research, 1987, vol. B 24/25, part II, pp. 752-756.
  • Botha et al., “A New Multidisciplinary Separated-Sector Cyclotron Facility,” IEEE Transactions on Nuclear Science, 1977, NS-24(3):1118-1120.
  • Canadian Office action issued in Canadian application No. 2,629,333 issued Aug. 30, 2010, 5 pages.
  • Chichili et al., “Fabrication of Nb3Sn Shell-Type Coils with Pre-Preg Ceramic Insulation,” American Institute of Physics Conference Proceedings, AIP USA, No. 711, (XP-002436709, ISSN:0094-243X), 2004, pp. 450-457.
  • Chinese Office action from Corresponding Chinese application No. 200880125832.9, mailed Jun. 5, 2012, 6 pages.
  • Chinese Office Action issued in Chinese Application No. 200780102281.X, dated Dec. 7, 2011, 23 pages (with English translation).
  • Chinese Office action issued in Chinese application No. 200880125832.9, dated Sep. 22, 2011, 111 pages.
  • Chinese Office action issued in Chinese application No. 200880125918.1, dated Sep. 15, 2011, 111 pages.
  • Chong et al., Radiology Clinic North American 7, 3319, 1969, 27 pages.
  • Chu et al., “Performance Specifications for Proton Medical Facility,” Lawrence Berkeley Laboratory, University of California, Mar. 1993, 128 pages.
  • Chu et al., “Instrumentation for Treatment of Cancer Using Proton and Light-ion Beams,” Review of Scientific Instruments, Aug. 1993, 64 (8):2055-2122.
  • Chu, “Instrumentation in Medical Systems,” Accelerator an Fusion Research Division, Lawrence Berkeley Laboratory, University of California, Berkeley, CA, May 1995, 9 pages.
  • Cole et al., “Design and Application of a Proton Therapy Accelerator,” Fermi National Accelerator Laboratory, IEEE, 1985, 5 pages.
  • Collins, et al., “The Indiana University Proton Therapy Systems,” Proceedings of EPAC 2006, Edinburgh, Scotland, 2006, 3 pages.
  • Conradi et al., “Proposed New Facilities fo Proton Therapy at iThemba Labs,” Proceedings of EPAC, 2002, pp. 560-562.
  • Source Search “Cites of U.S. and Foreign Patents/Published applications in the name of Mitsubishi Denki Kabushiki Kaisha and Containing the Keywords (Proton and Synchrocyclotron),” Jan. 2005, 8 pages.
  • Cosgrove et al., “Microdosimetric Studies on the Orsay Proton Synchrocyclotron at73 and 200 MeV,” Radiation Protection Dosimetry, 1997, 70(1-4):493-496.
  • Coupland, “High-field (5 T) pulsed superconducting dipole magnet,” Proceedings of the Institution of Electrical Engineers, Jul. 1974, 121(7):771-778.
  • Coutrakon et al., “Proton Synchrotrons for Cancer Therapy,” Application of Accelerators in Research and Industry—Sixteenth International Conf., American Institute of Physics, Nov. 1-5, 2000, vol. 576, pages 861-864.
  • Coutrakon et al., “A Prototype beam delivery system for the proton medical accelerator at Loma Linda,” Medical Physics, Nov./Dec. 1991, 18(6):1093-1099.
  • Cuttone, “Applications of a Particle Accelerators in Medical Physics,” Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud, V.S. Sofia, 44 Cantania, Italy, Jan. 2010, 17 pages.
  • Dahl P, “Superconducting Magnet System,” Amerian Institute of Physics, AIP Conference Proceedings, 1987-1988, 2: 1329-1376.
  • Dialog Search, Jan. 31, 2005, 17 pages.
  • Dugan et al., “Tevatron Status” IEEE, Particle Accelerator Conference, Accelerator Science & Technology, 1989, pp. 426-430.
  • Eickhoff et al., “The Proposed Accelerator Facility for Light Ion Cancer Therapy in Heidelberg,” Proceedings of the 1999 Particle Accelerator Conference, New York, 1999, pp. 2513-2515.
  • Enchevich et al., “Minimizing Phase Losses in the 680 MeV Synchrocyclotron by Correcting the Accelerating Voltage Amplitude,” Atomnaya Energiya, 1969, 26:(3):315-316.
  • Endo et al., “Compact Proton an Carbon Ion Synchrotrons for Radiation Therapy,” Proceedings of EPAC 2002, Paris France, 2002, pp. 2733-2735.
  • European Communication issued in corresponding European application No. 11165422.4, dated Sep. 2, 2011, 5 pages.
  • European Communication issued in European application No. 07868958.5, dated Nov. 26, 2010, 50 pages.
  • European Patent Office communication issued in European application No. 08856764.9, dated Jul. 30, 2010, 2 pages.
  • European Patent Office communication issued in European application No. 07868958.5, dated Jul. 16, 2010, 2 pages.
  • European Search Report issued in European Application No. 11165423.2, dated Aug. 8, 2011, 118 pages.
  • Flanz et al., “Treating Patients with the NPTC Accelerator Based Proton Treatment Facility,” Proceedings of the 2003 Particle Accelerator Conference, 2003, pp. 690-693.
  • Flanz et al., “Large Medical Gantries,” Particle Accelerator Conference, Massachusetts General Hospital, 1995, pp. 1-5.
  • Flanz et al., “The Northeast Proton Therapy Center at Massachusetts General Hospital,” fifth Workshop on Heavy Charge Particle in Biology and Medicine, GSI, Darmstadt, Aug. 1995, 11 pages.
  • Flood and Frazier,. “The Wide-Band Driven RF System for the Berkeley 88-Inch Cyclotron,” American Institute of Physics, Conference Proceedings., No. 9, 1972, 459-466.
  • Foster and Kashikhin, “Superconducting Superferric Dipole Magent with Cold Iron Core for the VLHC,” IEEE Transactions on Applied Superconductivity, Mar. 2002, 12(1):111-115.
  • Friesel et al., “Design and Construction Progress on the IUCF Midwest Proton Radiation Institute,” Proceedings of EPAC 2002, 2002, pp. 2736-2738.
  • Fukumoto et al., “A Proton Therapy Facility Plan” Cyclotron and their Applications, Proceedings of the 13th Intenational Conference, Vancouver, Canada, Jul. 6-10, 1992, pp. 258-261.
  • Goto et al., “Progress on the Sector Magnets for the Riken SRC,” American Institute of Physics, CP600, Cyclotrons and Their Applications 2001, Sixteenth International Conference, 2001, pp. 319-323.
  • Graffman et al., “Design Studies for a 200 MeV Proton Clinic Radiotherapy,” AIP Conference Proceedings: Cyclotrons—1972, 1972, No. 9, pp. 603-615.
  • Graffman et al., Acta Radiol. Therapy Phys. Biol. 1970, 9, 1 (1970).
  • Graffman, et al. “Proton radiotherapy with the Uppsala cyclotron. Experience and plans” Strahlentherapie, 1985, 161(12):764-770.
  • Hede, “Research Groups Promoting Proton Therapy Lite,” Journal of the National Cancer Institute, Dec. 6, 2006, 98(23):1682-1684.
  • Heinz, “superconducting Pulsed Magnetic Systems for High-Energy Synchrotrons,” Proceedings o th Fourth International Cryogenic Engineering Conference, May 24-26, 1972, pp. 55-63.
  • Hentschel et al., “Plans for the German National Neutron Therapy Centre with a Hospital-Based 70 MeV Proton Cyclotron at University Hospital Essen/Germany,” Cyclotrons and their Applications, Caen, Franco, Jun. 14-19, 1998, pp. 21-23.
  • Hepburn et al., “Superconducting Cyclotron Neutron Source for Therapy,” International Journal o Radiation Oncology Biology Physics, vol. 3 complete, 1977, pp. 387-391.
  • Hirabayashi, “Development of Superconducting Magnets for Beam Lines and Accelerator at KEK,” IEEE Transactionon Magnetics, Jan. 1981, Mag-17(1):728-731.
  • International Preliminary Report on Patentability issued in PCT Application No. PCT/US2008/084695, dated Jun. 10, 2010, 10 pages.
  • International Preliminary Report on Patentability issued in PCT Application No. PCT/US2008/084699, dated Jun. 10, 2010, 8 pages.
  • International Preliminary Report on Patentability issued in PCT Application No. PCT/US2007/086109, dated Jun. 10, 2010, 7 pages.
  • International Preliminary Report on Patentability in Internation Application No. PCT/US2006/44853, dated May 29, 2008, 8 pages.
  • International Preliminary Report on Patentability in Internation Application No. PCT/US2007/001506, dated Jul. 5, 2007, 15 pages.
  • International Preliminary Report on Patentability in Internation Application No. PCT/US2007/001628, dated Apr. 22, 2008, 15 pages.
  • International Search Report and Written Opinion in International Application No. PCT/US2006/44853, dated Oct. 5, 2007, 3 pages.
  • International Search Report and Written Opinion in International Application No. PCT/US2007/001506, dated Jul. 5, 2007, Publication No. WO2007/084701, Published Jul. 26, 2007, 14 pages.
  • International Preliminary Report on Patentability on International Application No. PCT/US2008/077513, dated Apr. 22, 2010.
  • International Search Report and Written Opinion in International Application No. PCT/US2008/077513, dated Oct. 1, 2009, 73 pages.
  • International Search Report and Written Opinion in International Application No. PCT/US2008/084695, dated Jan. 26, 2009, 15 pages.
  • International Search Report in International Application No. PCT/US2007/001628, dated Feb. 18, 2008, 4 pages.
  • International Search Report and Written Opinion in International Application No. PCT/US2007/086109, dated Aug. 26, 2008, 6 pages.
  • International Search Report and Written Opinion in International Application No. PCT/US2008/084699, dated Feb. 4, 2009, 11 pages.
  • Ishibashi an McInturff, “Winding Design Study of Superconducting 10 T Dipoles for a Synchrotron,” IEEE Transactions on Magnetics, MAG-19(3):1364-1367.
  • Ishibashi and McInturff, “Stress Analysis of Superconducting 10T Magnets fo Synchrotron,” Proceedings of the Ninth International Cryogenic Engineering Conference, May 11-14, 1982, pp. 513-516.
  • Jahnke et al., “First Superconducting Prototype Magnets for a Compact Synchrotron Radiation Source in Operation,” IEEE Transactions on Magnetics, Mar. 1988, 24(2):1230-1232.
  • Jones and Dershem, “Synchrotron Radiation from Proton in a 20 TEV, 10 TESLA Superconducting Super Collide,” Procedings of the 12th International Conference on High-Energy Accelerator, Aug. 11-16, 1983, pp. 138-140.
  • Jones and Mills, “The South African National Accelerator Centre: Particle Therapy an Isotope Production Programmes,” Radiation Physics and Chemistry, Apr.-Jun. 1998, 51(4-6):571-578.
  • Jones et al., “Status Report of the NAC Particle Therapy Programme,” Stralentherapie und Onkologie, vol. 175, Suppl. II, Jun. 1999, pp. 30-32.
  • Jones, “Progress with the 200 MeV Cyclotron Facility at the National Accelerator Centre,” Commission of the European Communities Radiation Protection Procedings, fifth Symposium on Neuton Dosimetry, Sep. 17-21, 1984, vol. II, pp. 989-998.
  • Jones “Present Status and Future Trends of Heavy Particle Radiotherapy,” Cyclotrons and their Applications 1998, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Jun. 14-19, 1998, pp. 13-20.
  • Jongen et al., “Development of a Low-cost Compact Cyclotron System for Proton Therapy,” National Institute of Radiol. Sci, 1991, No. 81, pp. 189-200.
  • Jongen et al., “Progress report on the IBA-SHI small cyclotron for cancer therapy” Nuclear Instruments and Methods in Physics Research, Section B, vol. 79, issue 1-4, 1993, pp. 885-889.
  • Jongent et al., “The Proton therapy system for the NPTC: Equipment Description and Progress report,” Nuclear Instruments and methods in physics research, 1996, Section B, 113(1): 522-525.
  • Jongen et al., “The proton therapy system for MGH's NPTC: equipment description and progress report,” Bulletin du Cancer/Radiotherapie, Proceedings of the meeting of the European Heavy Particle Therapy Group, 1996, 83 (Suppl. 1):219-222.
  • Kanai et al., “Three-dimensional Beam Scanning for Proton Therapy,” Nuclear Instruments and Methods on Physic Research, Sep. 1, 1983, The Netherlands, 214(23):491-496.
  • Karlin et al., “Medical Radiology” (Moscow), 1983, 28, 13.
  • Karlin et al., “The State and Prospects in the Development of the Medical Proton Tract on the Synchrocyclotron in Gatchina,” Med. Radiol., Moscow, 28(3):28-32 (Mar. 1983) (German with English Abstract on end of page 32).
  • Kats and Druzhinin, “Camparison of Methods for Irradiation Prone Patients,” Atomic Energy, Feb. 2003, 94(2):120-123.
  • Kats and Onosovskii, “A Simple, Compact, Flat System for the Irradiation of a Lying Patient with a Proton Beam from Different Direction,” Instruments an Experimental Techniques, 1996, 39(1):132-134.
  • Kats and Onosovskii, “A Planar Magnetooptical Systems for the Irradiation of a Lying Patient with a Proton Beam from Various Directions,” Instruments and Experimental Techniques, 1996, 39(1):127-131.
  • Khoroshkov et al., “Moscow Hospital-Based Proton Therapy Facility Design,” Am. Journal Clinical Oncology: CCT, Apr. 1994, 17(2):109-114.
  • Kim and Blosser, “Optimized Magnet for a 250 MeV Proton Radiotherapy Cyclotron,” Cyclotrons an Their Applications 2001, May 2001, Sixteenth International Conference, pp. 345-347.
  • Kim and Yun, “A Light-Ion Superconducting Cyclotron System for Multi-Disciplinary Users,” Journal of the Korean Physical Society, Sep. 2003, 43(3):325-331.
  • Kim et al., “Construction of 8T Magnet Test Stand for Cyclotron Studies,” IEEE Transactions on Applied Superconductivity, Mar. 1993, 3(1):266-268.
  • Kim et al., “Design Study of a Superconducting Cyclotron for Heavy Ion Therapy,” Cyclotrons and Their Applications 2001, Sixteenth International Conference, May 13-17, 2001, pp. 324-326.
  • Kim et al., “Trim Coil System for the Riken Cyclotron Ring Cyclotron,” Proceedings of the 1997 Particle Accelerator Conference, IEEE, Dec. 1981, vol. 3, pp. 214-235 OR 3422-3424, 1998.
  • Kim, “An Eight Tesla Superconducting Magnet for Cyclotron Studies,” Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy, 1994, 138 pages.
  • Kimstrand, “Beam Modelling for Treatment Planning of Scanned Proton Beams,” Digital Comprehensive Summaries of Uppsala dissertations for the Faculty of Medicine 330, Uppsala Universitet, 2008, 58 pages.
  • Kishida and Yano, “Beam Transport System for the RIKEN SSC (II),” Scientific Papers of the Institute of Physical and Chemical Research, Dec. 1981, 75(4):214-235.
  • Koehler et al., “Range Modulators for Protons and Heavy Ions,” Nuclear Instruments and Methods, 1975, vol. 131, pp. 437-440.
  • Koto and Tsujii, “Future of Partical Therapy,” Japanese Journal of Cancer Clinics, 2001, 47(1):95-98 [Lang.:Japanese], English Abstract (http://sciencelinks.jp/j-east/article/200206/000020020601A0511453.php).
  • Kraft et al., “Hadrontherapy in Oncology,” U. Amaldi and Larrsson, editors Elsevier Science, 1994, 390 pages.
  • Krevet et al., “Design of a Strongly Curved Superconducting Bending Magnet for a Compact Synchrotron Light Source,” Advances in Cryogenic Engineering, 1988, vol. 33, pp. 25-32.
  • Laisne et al., “The Orsay 200 MeV Synchrocyclotron,” IEEE Transactions on Nuclear Science, Apr. 1979, NS-26(2):1919-1922.
  • Larsson et al., Nature 1958 , 182:1222.
  • Larsson, “Biomedical Program for the Converted 200-MeV Synchrocyclotron at the Gustaf Werner Institute,” Radiation Research, 1985, 104:S310-S318.
  • Lawrence et al., “Heavy particles in acromegaly and Cushing's Disease,” in Endocrine and Norendocrine Hormone Producing Tumors (Year Book Medical Chicago, 1973, pp. 29-61.
  • Lawrence et al., “Successful Treatment of Acromegaly: Metabolic and Clinical Studies in 145 Patients,” The Journal of Clinical Endocrinology and Metabolism, Aug. 1970, 31(2), 21 pages.
  • Lawrence et al., “Treatment of Pituitary Tumors,” (Excerpta medica, Amsterdam/American Elsevier, New York, 1973, pp. 253-262.
  • Lawrence, Cancer, 1957, 10:795.
  • Lecroy et al., “Viewing Probe for High Voltage Pulses,” Review of Scientific Instruments USA, Dec. 1960, 31(12):1354.
  • Lin et al., “Principles and 10 Year Experience of the Beam Monitor System at the PSI Scanned Proton Therapy Facility”, Center for Proton Radiation Therapy, Paul Scherrer Institute, CH-5232, Villigen PSI, Switzerland, 2007, 21 pages.
  • Linfoot et al., “Acromegaly,” in Hormonal Proteins and Peptides, edited by C.H. Li, 1975, pp. 191-246.
  • Literature Keyword Search, Jan. 24, 2005, 98 pages.
  • Livingston et al., “A Capillary ion source for the cyclotron,” Review Science Instruments, Feb. 1939, 10:63.
  • Mandrillon, “High Energy Medical Accelerators,” EPAC 90, 2nd European Particle Accelerator Conference, Jun. 12-16, 1990, 2:54-58.
  • Marchand et al., “IBA Proton Pencil Beam Scanning: an Innovative Solution for Cancer Treatment,” Proceedings of EPAC 2000, Vienna, Austria, 3 pages.
  • Marti et al., “High Intensity Opeation of a Superconducting Cyclotron,” Proceedings of the 14the International Conference, Cyclotrons and Their Applications, Oct. 1995, pp. 45-48 (Oct. 1995).
  • Martin, “Operational Experience with Superconducting Synchrotron Magnets” Proceedings of the 1987 IEEE Particle Accelerator Conference, Mar. 16-19, 1987, vol. 3 of 3:1379-1382.
  • Meote et al., “ETOILE Hadrontherapy Project, Review of Design Studies” Proceedings of EPAC 2002, 2002, pp. 2745-2747.
  • Miyamoto et al., “Development of the Proton Therapy System,” The Hitachi Hyoron, 79(10):775-779 (1997) [Lang: Japanese], English abstract (http://www.hitachi.com/rev/1998/revfeb98/rev4706.htm).
  • Montelius et al., “The Narrow Proton Beam Therapy Unit at the Svedberg Laboratory in Uppsala,” ACTA Oncologica, 1991, 30:739-745.
  • Moser et al., “Nonlinear Beam Optics with Real Fields in Compact Storage Rings,” Nuclear Instruments & Methods in Physics Research/Section B, B30, Feb. 1988, No. 1, pp. 105-109.
  • Moyers et al., “A Continuously Variable Thickness Scatterer for Proton Beams Using Self-compensating Dual Linear Wedges” Lorna Linda University Medical Center, Dept. of Radiation Medicine, Lorna Linda, CA, Nov. 2, 1992, 21 pages.
  • National Cancer Institute Funding (Senate-Sep. 12, 1992) (www.thomas.loc.gov/cgi-bin/query/z?r102:S21SE2-712 (2 pages).
  • Nicholson, “Applications of Proton Beam Therapy,” Journal of the American Society of Radiologic Technologists, May/Jun. 1996, 67(5): 439-441.
  • Nolen et al., “The Integrated Cryogenic—Superconducting Beam Transport System Planned for MSU,” Proceedings of the 12th International Conference on High-Energy Accelerators, Aug. 1983, pp. 549-551.
  • Norimine et al., “A Design of a Rotating Gantry with Easy Steering for Proton Therapy,” Proceedings of EPAC 2002, 2002, pp. 2751-2753.
  • Ogino, Takashi, “Heavy Charged Particle Radiotherapy-Proton Beam”, Division of Radiation Oncology, National Cancer Hospital East, Kashiwa, Japan, Dec. 2003, 7 pages.
  • Okumura et al., “Overview and Future Prospect of Proton Radiotherapy,” Japanese Journal of Cancer Clinics, 1997, 43(2):209-214 [Lang.: Japanese].
  • Okumura et al., “Proton Radiotherapy” Japanese Journal of Cancer and Chemotherapy, 1993, 10. 20(14):2149-2155 [Lang.: Japanese].
  • Outstanding from Search Reports, “Accelerator of Polarized Portons at Fermilab,” 2005, 20 pages.
  • Paganetti et al., “Proton Beam Radiotherapy—The State of the Art,” Springer Verlag, Hidelberg, ISBN 3-540-00321-5, Oct. 2005, 36 pages.
  • Palmer and Tollestrup, “Superconducting Magnet Technology for Accelerators,” Annual Review of Nuclear and Particle Science, 1984, vol. 34, pp. 247-284.
  • Patent Assignee and Keyword Searches for Synchrocyclotron, Jan. 25, 2005, 78 pages.
  • Pavlovic, “Beam-optics study of the gantry beam delivery system for light-ion cancer therapy,” Nuclear Instruments and Methods in Physics Research, Section A, Nov. 1997, 399(2):439-454(16).
  • Pedroni and Enge, “Beam optics design of compact gantry for proton therapy” Medical & Biological Engineering & Computing, May 1995, 33(3):271-277.
  • Pedroni and Jermann, . “SGSMP: Bulletin 3/2002 Proscan Project, Progress Report on the PROSCAN Project of PSI” [online] retrieved from www.sgsmp.ch/protA23.htm, Mar. 2002, 5 pages.
  • Pedroni et al., “A Novel Gantry for Proton Therapy at the Paul Scherrer Institute,” Cycloctrons and Their Applications 2001: Sixteenth International Conference. AIP Conference Proceedings, 2001, 600:13-17.
  • Pedroni et al., “The 200 MeV proton therapy project at the Paul Scherrer Institute: Conceptual design and Practical Realization,” Medical Physics, Jan. 1995, 22(1):37-53.
  • Pedroni, “Accelerators for Charged Particle Therapy: Performance Criteria from the User Point of View,” Cyclotrons and their Applications, Proceedings of the 13th International Conference, Jul. 6-10, 1992, pp. 226-233.
  • Pedroni, “Latest Developments in Proton Therapy” Proceedings of EPAC 2000, 2000, pp. 240-244.
  • Pedroni, “Status of Proton Therapy: results and future trends,” Paul Scherrer Institute, Division of Radiation Medicine, 1994, 5 pages.
  • Peggs et al., “A Survey of Hadron Therapy Accelerator Technologies,” Particle Accelerator Conference, Jun. 25-29, 2007, 7 pages.
  • Potts et al., “MPWP6-Therapy III: Treatment Aids and Techniques” Medical Physics, Sep./Oct. 1988, 15(5):798.
  • Pourrahimi et al., “Powder Metallurgy Processed Nb3Sn(Ta) Wire for High Field NMR magnets,” IEEE Transaction on Applied Superconductivity, Jun. 1995, 5(2):1603-1606.
  • Prieels et al., “The IBA State-of-the-Art Proton Therapy System, Performances and Recent Results,” Application of Accelerators in Research and industry—Sixteenth Int'l. Conf., American Institute of Physics, Nov. 1-5, 2000, 576:857-860.
  • Rabin et al., “Compact Designs for Comprehensive Proton Beam Clinical Facilities,” Nuclear Instruments & Methods in Physics Research, Apr. 1989, Section B, vol. 40-41, Part II, pp. 1335-1339.
  • Research & Development Magazine, “Proton Therapy Center Nearing Completion,” Aug. 1999, 41(9):2 pages, (www.rdmag.com).
  • Resmini, , “Design Characteristics of the K=800 Superconducting Cyclotron at M.S.U.,” Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, IEEE Transaction on Nuclear Science, vol. NS-26, No. 2, Apr. 1979, 8 pages.
  • RetroSearch “Loma Linda University Beam Compensation,” Jan. 21, 2005, 60 pages.
  • RetroSearch “Loma Linda University, Bam Compensation Foil Wedge,” Jan. 21, 2005, 15 pages.
  • Rifuggiato et, al., “Status Report of the LNS Superconducting Cyclotron” Nukleonika, 2003, 48:S131-S134, Supplement 2.
  • Rode, “Tevatron Cryogenic System,” Proceedings of the 12th International Conference on High-energy Accelerators, Fermilab, Aug. 11-16, 1983, pp. 529-535.
  • Salzburger et al., “Superconducting Synchrotron Magnets Supraleitende Synchrotronmagnete,” Siemens A.G., Erlangen (West Germany). Abteilung Technische Physik, Report No.: BMFT-FB-T-75-25, Oct. 1975, p. 147, Journal Announcement: GRAI7619; STAR1415, Subm-Sponsored by Bundesmin. Fuer Forsch. U. Technol. In German; English Summary.
  • Schillo et al., “Compact Superconducting 250 MeV Proton Cyclotron for the PSI Proscan Proton Therapy Project,” Cyclotrons and Their Applications 2001, Sixteenth International Conference, 2001, pp. 37-39.
  • Schneider et al., “Nevis Synchrocyclotron Conversion Program—RF System,” IEEE Transactions on Nuclear Science USA, Jun. 1969, ns 16(3):430-433.
  • Schneider et al., “Superconducting Cyclotrons,” IEEE Transactions on Magnetics, vol. MAG-11, No. 2, Mar. 1975, New York, pp. 443-446.
  • Schreuder et al., “The Non-orthogonal Fixed Beam Arrangement for the Second Proton Therapy Facility at th National Accelerator Centre,” Application of Accelerators in Research and Industry, American Institute o Physics, Proceedings of the Fifteenth International Conference, Nov. 1998, Part Two, pp. 963-966.
  • Schreuder, “Recent Developments in Superconducting Cyclotrons,” Proceedings of the 1995 Particle Accelerator Conference, May 1-5, 1995, vol. 1, pp. 318-321.
  • Schubert and Blosser, “Conceptual Design of a High Field Ultra-Compact Cyclotron for Nuclear Physics Research,” Proceedings of the 1997 Particle Accelerator Conference, May 12-16, 1997, vol. 1, pp. 1060-1062.
  • Schubert, “Extending the Feasibility Boundary of the Isochronous Cyclotron,” Dissertation submitted to Michigan State University, 1997, Abstract http://adsabs.harvard.edu/abs/1998PhDt. . . .147S.
  • Shelaev et al., “Design Features of a Model Superconducting Synchrotron of JINR,” Proceedings of the 12th International Conference on High-energy Accelerators, Aug. 11-16, 1983, pp. 416-418.
  • Shintomi et. al, “Technology and Materials for the Superconducting Super Collider (SSC) Project,” [Lang.:Japanese], The Iron and Steel Institute of Japan 00211575, 78(8): 1305-1313, 1992, http://ci.nii.ac.jp/naid/110001493249/en/.
  • Sisterson, “World Wide Proton Therapy Experience in 1997,” The American Institute of Physics, Applications of Accelerators in Research and Industry, Proceedings of the fifteenth International Conference, Part Two, Nov. 1998, pp. 959-962.
  • Sisterson, “Clinical use of Proton and ion beams from a world-wide perspective,” Nuclear Instruments and Methods in Physics Research, Section B, 1989, 40-41:1350-1353.
  • Slater et al., “Developing a Clinical Proton Accelerator Facility: Consortium-Assisted Technology Transfer,” Conference Record of the 1991 IEEE Particle Accelerator Conference: Accelerator Science and Technology, vol. 1, May 6-9, 1991, pp. 532-536.
  • Slater et al., “Development of a Hospital-Based Proton Beam Treatment Center,” International Journal of Radiation Oncology Biology Physics, Apr. 1988, 14(4):761-775.
  • Smith et al., “The Northeast Proton Therapy Center at Massachusetts General Hospital” Journal of Brachytherapy International, Jan. 1997, pp. 137-139.
  • Snyder and Marti, “Central region design studies for a proposed 250 MeV proton cyclotron,” Nuclear Instruments and Methods in Physics Research, Section A, 1995, vol. 355, pp. 618-623.
  • Soga, “Progress of Particle Therapy in Japan,” Application of Accelerators in Research and Industry, American Institute of Physics, Sixteenth International Conference, Nov. 2000, pp. 869-872.
  • Spiller et al., “The GSI Synchrotron Facility Proposal or Acceleration of High Intensity Ion and Proton Beams” Proceedings of the 2003 Particle Accelerator Conference, May 12-16, 2003, vol. 1, pp. 589-591.
  • Stanford et al., “Method of Temperature Control in Microwave Ferroelectric Meansurements,” Sperry Microwave Electronics Company, Clearwater, Florida, Sep. 19, 1960, 1 page.
  • Tadashi et al., “Large superconducting super colloder (SSC) in the planning and materials technology,” 1992, 78(8):1305-1313, The Iron and Steel Institute of Japan 00211575.
  • Takada, “Conceptual Design of a Proton Rotating Gantry for Cancer Therapy,” Japanese Journal of Medical Physics, 1995, 15(4):270-284.
  • Teng, “The Fermilab Tevatron,” Coral Gables 1981, Proceedings, Gauge Theories, Massive Neutrinos, and Proton Decay, 1981, pp. 43-62.
  • The Journal of Practical Pharmacy, 1995, 46(1):97-103 [Japanese].
  • Tilly et al., “Development and verification of the pulsed scanned proton beam at The Svedberg Laboratory in Uppsala,” Phys. Med. Biol., 2007, 52:2741-2754.
  • Tobias et al., Cancer Research, 1958, 18, 121 (1958).
  • Tom, “The Use of Compact Cyclotrons for Producing Fast Neutrons for Therapy in a Rotatable Isocentric Gantry,” IEEE Transaction on Nuclear Science, Apr. 1979, 26(2):2294-2298.
  • Toyoda, “Proton Therapy System”, Sumitomo Heavy Industries, Ltd., 2000, 5 pages.
  • Trinks et al., “The Tritron: A Superconducting Separated-Orbit Cyclotron,” Nuclear Instruments and Methods in Physics Research, Section A, 1986, vol. 244, pp. 273-282.
  • Tsuji, “The Future Methods and Progress of Proton Beam Radiotherapy,” Journal of Japanese Society for Therapeutic Radiology and Oncology, 1994, 6(2):63-76.
  • Umegaki et al., “Development of an Advance Proton Beam Therapy System for Cancer Treatment” Hitachi Hyoron, 2003, 85(9):605-608 [Lang.: Japanese], English Abstract, http://www.hitachi.com/ICSFiles/afieldfile/2004/06/01/r2003_04_104.pdf or http://www.hitachi.com/rev/archive/2003/2005649_12626.html (full text) [Hitachi, 52(4), Dec. 2003].
  • Umezawa et al., “Beam Commissioning of the new Proton Therapy System for University of Tsukuba,” Proceedings of the 2001 Particle Accelerator Conference, vol. 1, Jun. 18-22, 2001, pp. 648-650.
  • van Steenbergen, “Superconducting Synchrotron Development at BNL,” Proceedings of the 8th International Conference on High Energy Accelerators CERN 1971, 1971, pp. 196-198.
  • van Steenbergen, “The CMS, a Cold Magnet Synchrotron to Upgrade the Proton Energy Range of the BNL Facility,” IEEE Transactions on Nuclear Science, Jun. 1971, 18(3):694-698.
  • Vandeplassche et al., “235 MeV Cyclotron for MGH's Northeast Proton Therapy Center (NPTC): Present Status,” EPAC 96, Fifth European Partical Accelerator Conference, vol. 3, Jun. 10-14, 1996, pp. 2650-2652.
  • Vorobiev et al., “Concepts of a Compact Achromatic Proton Gantry with a Wide Scanning Field”, Nuclear Instruments and Methods in Physics Research, Section A., 1998, 406(2):307-310.
  • Vrenken et al., “A Design of a Compact Gantry for Proton Therapy with 2D-Scanning,” Nuclear Instruments and Methods in Physics Research, Section A, 1999, 426(2):618-624.
  • Wikipedia, “Synchrotron” http://en.wikipedia.org/wiki/Synchrotron (originally visited Oct. 6, 2005, revisited Jan. 28, 2009), 7 pages.
  • Written Opinion in PCT Application No. PCT/US2007/001628, dated Feb. 18, 2008, 11 pages.
  • Wu, “Conceptual Design and Orbit Dynamics in a 250 MeV Superconducting Synchrocycloton,” Ph. D. Dissertation, Michigan State University, Department of Physics and Astronomy, 1990, 172 pages.
  • York et al., “Present Status and Future Possibilities at NSCL-MSU,” EPAC 94, Fourth European Particle Accelerator Conference, pp. 554-556, Jun. 1994.
  • York et al., “The NSCL Coupled Cyclotron Project—Overview and status,” Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Jun. 1998, pp. 687-691.
  • Yudelev et al., “Hospital Based Superconducting Cyclotron For Neutron Therapy: Medical Physics Perspective,” Cyclotrons and their applications 2001, 16th International Conference. American Institute of Physics Conference Proceedings, vol. 600, May 13-17, 2001, pp. 40-43.
  • Zherbin et al., “Proton Beam Therapy at the Leningrad Synchrocyclotron (Clinicomethodological Aspects and Therapeutic Results)”, Aug. 1987, 32(8):17-22, (German with English Abstract on pp. 21-22).
  • Ofice action with English translation from Taiwanese application No. 097144546 issued Oct. 25, 2013 (27 pages).
  • Tilly, et al., “Development and verification of the Pulsed scanned proton beam at the Svedberg Laboratory in Uppsala”, Physics in Medicine and Biology, Phys. Med. Biol. 52, pp. 2741-2454, 2007.
  • Voluntary amendment filed in Canadian Application No. 2707075 on Oct. 13, 2013 (8 pages).
  • Response with English translation to office action dated Oct. 25, 2013 in Taiwanese Application No. 097144546, filed on Mar. 28, 2014 (34 pages).
  • European Search Report issued in European Application No. 08856764.9 on Jun. 4, 2014 (3 pages).
  • Response with English translation to Japanese Office action filed Mar. 1, 2012 in Japanese Application No. 2007-522777 (14 pages).
  • Office Action with English translation from Japanese Application No. 2007-522777 mailed Oct. 4, 2011 (15 pages).
  • European Search Report from European Application No. 10175751.6 mailed Nov. 18, 2010 (8 pages).
  • Response to examination search report filed in European Application No. 05776532.3 on Dec. 20, 2011 (14 pages).
  • European Communication issued in European Application No. 05776532.3 mailed Jun. 10, 2011 (10 pages).
  • Office action with English Translation issued in Chinese Application No. 201010581384.2 on Nov. 10, 2011 (19 pages).
  • Voluntary amendment filed in Canadian Application No. 2,574,122 on Jul. 26, 2010 (16 pages).
  • Voluntary amendment filed in Canadian Application No. 2,574,122 on Nov. 5, 2010 (15 pages).
  • Response with English translation to Chinese Office action filed in Chinese Application No. 200880125832.9 on Dec. 16, 2013 (12 pages).
  • Voluntary Amendment filed in Canadian Application No. 2707075 on Oct. 18, 2013 (8 pages).
  • Canadian office action from corresponding Canadian application No. 2574122 dated Aug. 14, 2014 (6 pages).
Patent History
Patent number: RE48047
Type: Grant
Filed: Feb 9, 2017
Date of Patent: Jun 9, 2020
Assignee: Mevion Medical Systems, Inc. (Littleton, MA)
Inventors: Alan Sliski (Lincoln, MA), Kenneth Gall (Somerville, MA)
Primary Examiner: Angela M Lie
Application Number: 15/429,078
Classifications
Current U.S. Class: Cyclotrons (313/62)
International Classification: H05H 15/00 (20060101); H05H 13/02 (20060101);