Patents by Inventor Kenneth Richardson
Kenneth Richardson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050087253Abstract: A method and apparatus for filling a transmission at the transmission assembly plant including the steps of pumping fluid through the transmission entering at a first port and exiting through a second port, rotating the torque converter to purge trapped air, shifting the transmission, filling the transmission to a desired level and plugging the first and second ports. Through use of the method and apparatus of the present invention, the transmission is placed in a “road ready” condition and will not require additional fluid to be added in a top off operation at the vehicle assembly plant.Type: ApplicationFiled: October 27, 2003Publication date: April 28, 2005Inventors: Kenneth Richardson, David Mitchell
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Patent number: 6015825Abstract: The invention relates to compounds of the formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein Ar, Z and Het are as defined herein. The compounds of formula (I) possess activity as antifungal agents. The invention also relates to pharmaceutical compositions containing said compounds of formula (I) and to methods of treating fungal infections by administering said compounds of formula (I).Type: GrantFiled: December 19, 1997Date of Patent: January 18, 2000Assignee: Pfizer Inc.Inventors: Andrew Simon Bell, Michael Jonathan Fray, Alan Patrick Marchington, Kenneth Richardson, Peter Thomas Stephenson, Peter John Whittle
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Patent number: 5773443Abstract: The invention provides antifungal compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, whereinR is phenyl substituted by 1 to 3 substituents each independently selected from halo, --CF.sub.3 and --OCF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl;X is CH or N; andY is F or Cl.Type: GrantFiled: July 18, 1996Date of Patent: June 30, 1998Assignee: Pfizer Inc.Inventors: Stephen J. Ray, Kenneth Richardson
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Patent number: 5567817Abstract: The invention provides antifungal compounds of the formula: ##STR1## and pharmaceutical salts thereof, whereinR is phenyl substituted by 1 to 3 substituents each independently selected from halo, --CF.sub.3 and --OCF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl;X is CH or N; andY is F or Cl.Type: GrantFiled: May 1, 1995Date of Patent: October 22, 1996Assignee: Pfizer Inc.Inventors: Stephen J. Ray, Kenneth Richardson
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Patent number: 5541203Abstract: The invention provides antifungal compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by up to 3 substituents each independently selected from halo and trifluoromethyl;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is ##STR2## R.sup.3 is --S(O).sub.m R.sup.4 ; R.sup.4 is C.sub.1 -C.sub.4 alkyl; andm is 0, 1 or 2, together with pharmaceutical compositions containing, and processes and intermediates for preparing, said compounds.Type: GrantFiled: April 8, 1994Date of Patent: July 30, 1996Assignee: Pfizer Inc.Inventors: Andrew S. Bell, Kenneth Richardson, Peter J. Whittle
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Patent number: 5364938Abstract: The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, whereinR is phenyl optionally substituted by 1 to 3substituents each independently selected from halo and CF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; and"Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, CN, NO.sub.2, NH.sub.2, --NH(C.sub.1 -C.sub.4 alkanoyl) or --NHCO.sub.2 (C.sub.1 -C.sub.4 alkyl).Type: GrantFiled: March 4, 1993Date of Patent: November 15, 1994Assignee: Pfizer Inc.Inventors: Roger P. Dickinson, Kenneth Richardson
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Patent number: 5278175Abstract: The invention provide antifungal compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by 1 to 3 substituents each independently selected from halo, --CF.sub.3 and --OCF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl;X is CH or N; andY is F or Cl.Type: GrantFiled: October 5, 1992Date of Patent: January 11, 1994Assignee: Pfizer Inc.Inventors: Stephen J. Ray, Kenneth Richardson
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Patent number: 5206364Abstract: The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; and"Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, CN, NO.sub.2, NH.sub.2, --NH(C.sub.1 -C.sub.4 alkanoyl) or --NHCO.sub.2 (C.sub.1 -C.sub.4 alkyl).Type: GrantFiled: March 4, 1992Date of Patent: April 27, 1993Assignee: Pfizer Inc.Inventors: Roger P. Dickinson, Kenneth Richardson
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Patent number: 5149814Abstract: Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R.sup.3 is lower alkyl; Y is 1,4-phenylene and X is 2-alkylimidazopyridyl.Type: GrantFiled: September 11, 1991Date of Patent: September 22, 1992Assignee: Pfizer IncInventors: Kelvin Cooper, Michael J. Fray, Kenneth Richardson, John Steele
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Patent number: 5120747Abstract: Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl(C.sub.1 -C.sub.4)alkoxy, fluoro(C.sub.1 -C.sub.4)alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano, or is phenyl fused to a dioxole ring;R.sup.1 and R.sup.2 are each independently H or C.sub.1 -C.sub.6 alkyl, or R.sup.1 and R.sup.2 together complete a pyrrolidinyl, piperidino, morpholino, piperazinyl, N-(C.sub.1 -C.sub.4 alkyl)piperazinyl or N-(C.sub.2 -C.sub.4 alkanoyl)-piperazinyl group;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl and R.sup.1 is CN, C.sub.3 -C.sub.7 cycloalkyl, aryl, heteroaryl or a C.sub.1 -C.sub.4 alkyl group substituted by one or more substituents selected from C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, aryl or heteroaryl;Z is selected from C.sub.1 -C.sub.6 alkoxy, aryl(C.sub.1 -C.sub.Type: GrantFiled: May 1, 1990Date of Patent: June 9, 1992Assignee: Pfizer Inc.Inventors: Kelvin Cooper, Michael Fray, Kenneth Richardson, John Steele
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Patent number: 5116844Abstract: The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; and"Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, CN, NO.sub.2, NH.sub.2, --NH(C.sub.1 -C.sub.4 alkanoyl) or --NHCO.sub.2 (C.sub.1 -C.sub.4 alkyl).Type: GrantFiled: August 11, 1989Date of Patent: May 26, 1992Assignee: Pfizer Inc.Inventors: Roger P. Dickinson, Kenneth Richardson
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Patent number: 5070205Abstract: Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R.sup.3 is lower alkyl; Y is 1,4-phenylene and X is a benzimidazol-1-yl.Type: GrantFiled: May 1, 1990Date of Patent: December 3, 1991Assignee: Pfizer Inc.Inventors: Melvin Cooper, Michael J. Fray, Kenneth Richardson, John Steele
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Patent number: 5063237Abstract: Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl(C.sub.1 -C.sub.4)alkoxy, fluoro(C.sub.1 -C.sub.4)alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano, or is phenyl fused to a dioxole ring;R.sup.1 and R.sup.2 are each independently H or C.sub.1 -C.sub.6 alkyl, or R.sup.1 and R.sup.2 together complete a pyrrolidinyl, piperidino, morpholino, piperazinyl, N-(C.sub.1 -C.sub.4 alkyl)piperazinyl or N-(C.sub.2 -C.sub.4 alkanoyl)-piperazinyl group;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl and R.sup.1 is CN, C.sub.3 -C.sub.7 cycloalkyl, aryl, heteroaryl or a C.sub.1 -C.sub.4 alkyl group substituted by one or more substituents selected from C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, aryl or heteroaryl;Z is selected from C.sub.1 -C.sub.6 alkoxy, aryl(C.sub.1 -C.sub.Type: GrantFiled: May 1, 1990Date of Patent: November 5, 1991Assignee: Pfizer Inc.Inventors: Kelvin Cooper, Michael J. Fray, Kenneth Richardson, John Steele
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Patent number: 5047548Abstract: Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof, wherein R is 5-chloro-2-pyridyl, or phenyl optionally substituted by one to three substituents, each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; R.sup.1 is CN, CSNH.sub.2 or CONR.sup.2 R.sup.3 where either(a) R.sup.2 is H or certain alkyl groups and R.sup.3 is H or certain alkyl, substituted alkyl, aralkyl, phenyl or cycloalkyl groups, or(b) R.sup.2 and R.sup.3 taken together with the nitrogen atom to which they are attached form a nitrogen heterocyclic group, optionally containing an oxygen atom or NR.sup.4 group, as a ring member and R.sup.4 is H, C.sub.1 -C.sub.4 alkyl; C.sub.2 -C.sub.4 alkanoyl or (C.sub.1 -C.sub.4 alkoxy)carbonyl;R.sup.5 and R.sup.6 are each H or CH.sub.Type: GrantFiled: January 27, 1988Date of Patent: September 10, 1991Assignee: Pfizer Inc.Inventors: Kenneth Richardson, Geoffrey E. Gymer
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Patent number: 5023258Abstract: The invention provides triazole antifungal compounds of the formula: ##STR1## wherein R is either (a) a phenyl group optionally substituted with 1 to 3 substituents, each selected independently from halo and CF.sub.3 ; or(b) a 5-chloropyridin-2-yl group; and R.sup.Type: GrantFiled: June 20, 1989Date of Patent: June 11, 1991Assignee: Pfizer Inc.Inventors: Geoffrey E. Gymer, Subramaniyan Narayanaswami, Kenneth Richardson
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Patent number: 4992447Abstract: Compounds of the formula ##STR1## where R.sup.1 is lower alkyl, R.sup.2 is chlorophenyl, Y is alkylene, X is heterocyclic and Z is a fused ring are useful as antiinflammatory and antiallergy agents.Type: GrantFiled: May 8, 1989Date of Patent: February 12, 1991Assignee: Pfizer Inc.Inventors: Kelvin Cooper, Peter E. Cross, Michael J. Fray, Kenneth Richardson
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Patent number: 4992454Abstract: Triazole antifungal agents of the formula ##STR1## where R is 5-chloropyrid-2-yl or phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; and R.sup.1 is H or CH.sub.3 ; and their O-esters, O-ethers and pharmaceutically and agriculturally acceptable salts. The compounds are useful as human and agricultural antifungal agents.Type: GrantFiled: February 27, 1984Date of Patent: February 12, 1991Assignee: Pfizer Inc.Inventor: Kenneth Richardson
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Patent number: 4963560Abstract: The invention provides compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by halo;R.sup.1 is C.sub.1 -C.sub.4 alkyl;is hydrogen, C.sub.5 -C.sub.7 cycloalkyl, benzyl or C.sub.1 -C.sub.4 alkyl, said C.sub.1 -C.sub.4 alkyl group being optionally substituted by cyano, trimethylsilyl or C.sub.1 -C.sub.3 alkoxy; and"Het" is ##STR2## wherein R.sup.3 is hydrogen or methyl. The compounds are useful in the treatment of allergic, inflammatory and hypersecretory conditions, and circulatory shock, stroke and thrombosis.Type: GrantFiled: September 12, 1989Date of Patent: October 16, 1990Assignee: Pfizer Inc.Inventors: Kelvin Cooper, Michael J. Fray, Kenneth Richardson, John Steele
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Patent number: 4960782Abstract: Triazoles of the formula ##STR1## where R is phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, or R is 5-chloro-pyrid-2-yl; and R.sup.1 is H, CH.sub.3 or F; and their pharmaceutically and agriculturally acceptable salts. The compounds are useful as human and agricultural fungicides.Type: GrantFiled: October 23, 1989Date of Patent: October 2, 1990Assignee: Pfizer Inc.Inventors: Geoffrey E. Gymer, Kenneth Richardson
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Patent number: 4935430Abstract: Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl (C.sub.1 -C.sub.4) alkoxy, fluoro (C.sub.1 -C.sub.4) alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano, or is phenyl fused to a dioxole ring;R.sup.1 and R.sup.2 are each independently H or C.sub.1 -C.sub.6 alkyl, or R.sup.1 and R.sup.2 together complete a pyrrolidinyl, piperidino, morpholino, piperazinyl, N-(C.sub.1 -C.sub.4 alkyl) piperazinyl or N-(C.sub.2 -C.sub.4 alkanoyl)-piperazinyl group;orR.sup.2 is H or C.sub.1 -C.sub.4 alkyl and R.sup.1 is CN, C.sub.3 -C.sub.7 cycloalkyl, aryl, heteroaryl or a C.sub.1 -C.sub.4 alkyl group substituted by one or more substituents selected from C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, aryl or heteroaryl;Z is selected from C.sub.1 -C.sub.6 alkoxy, aryl (C.sub.1 -C.sub.Type: GrantFiled: September 29, 1988Date of Patent: June 19, 1990Assignee: Pfizer Inc.Inventors: Kelvin Cooper, Michael J. Fray, Kenneth Richardson, John Steele