Abstract: A method for producing 4-borono-L-phenylalanine and its intermediates is provided. The method is for producing a substituted phenyl compound represented by formula (II) from a substituted phenyl compound represented by formula (I). The method comprises a first step in which the compound represented by formula (I) reacts with a linear or branched C1-C10 alkylmagnesium halide in the presence of a metal halide; and a second step in which a boronic acid ester or boronic acid amide reacts with the compound obtained in said first step. The method also can comprise a step of deprotecting the compound of formula (II) obtained in the second step.

Abstract: An electrostatic chuck 10 includes a dielectric substrate 100 including a placement surface and a base plate 200 which is joined to the dielectric substrate 100 and which has formed therein a coolant flow path 400 through which a coolant flows. The coolant flow path 400 includes a first flow path 410 and a second flow path 420 connected in series to each other. The second flow path 420 is formed in a position on the dielectric substrate 100 side relative to the first flow path 410 in a direction perpendicular to the placement surface.

Abstract: An electrostatic chuck 10 includes a dielectric substrate 100 which includes a first part 101 including a placement surface and a second part 102 which protrudes from an outer circumferential edge of the first part 101 further towards an outer circumferential side, an internal electrode 140 provided inside the second part 102, a feed terminal 160 provided in a position which is not overlapped with the internal electrode 140 in top view, and a bypass portion 150 which is provided inside the dielectric substrate 100 and electrically connects the feed terminal 160 and the internal electrode 140.

Abstract: To curb deterioration in image quality due to ghost light caused by reflection. An imaging lens includes a lens group with at least one aspherical lens that forms an optical image of an object on an imaging surface curved concavely toward an object side. The lens surface closest to an imaging surface side in the lens group, is aspherical, and a sign of surface power is not inverted with increasing distance from an optical axis. The final surface tilts toward an object side with increasing distance from the optical axis. The imaging lens satisfies 0.1<BF/f<0.3 when a distance on the optical axis from a vertex on the optical axis of the final surface to a position of a maximum image height of the imaging surface is denoted by BF, and a focal length of the entire imaging lens is denoted by f.

Abstract: Imaging of, with height reduction, a high-quality image with a maximum angle of view of 90 degrees or larger is realized. A lens group forms an optical image of an object on a curved imaging surface. The maximum angle of view is 90 degrees or larger. When a first imaging height half angle of view is 40 degrees and is denoted by Yw, a second imaging height that is a half of the maximum angle of view is denoted by Y, a total optical length is denoted by TL, a focal length of the entire imaging lens is denoted by f, and a focal length of the lens closest to the object is denoted by f1, the following are satisfied: 0.27?(Yw/Y)2?0.7, 0.3?TL/2Y?0.695, ?0.35?f/f1?0.73. The present technology can be applied to an ultrawide-angle camera or the like.

Abstract: Conditions necessary for antibodies to human PD-1 to have agonist activity are searched and an optimized agonist antibody is provided based on the conditions and used as a therapeutic for human inflammatory diseases. An agonist antibody to human PD-1 or a functional fragment thereof, wherein the antibody or a functional fragment thereof binds to domain #7 of human PD-1 as shown in SEQ ID NO: 9 is provided.

Abstract: An operation device for a vehicle transmission is configured to include: a base bracket that is fixed to a vehicle body of a vehicle; a slider lever that is slidably supported by the base bracket and includes a shift knob; and a main gear, which is rotatably supported by the base bracket and includes gear teeth at an outer circumferential portion, to which an end portion of a shift wire of the vehicle transmission is connected at a position separated from a gear support shaft of the base bracket, the slider lever including a rack gear that is formed along a sliding direction of the slider lever and is engaged with the gear teeth of the main gear, and gear change of the transmission being performed by causing the main gear to rotate with sliding of the slider lever and pushing and pulling the shift wire.

Abstract: Provided are new compounds that can have the property of being specifically taken up into cancer cells. In the present invention, novel 4-borono-phenylalanine derivatives, borono-phenylalanine derivatives having a heterocyclic skeleton, borono-phenylalanine derivatives having a fused ring structure, or pharmaceutically acceptable salts thereof are prepared. These compounds have the property of being taken up specifically by LAT1 and thus easily taken up specifically by cancer cells in the evaluation of LAT1 and LAT2 selective uptake, and can be conveniently used for neutron capture therapy and the like. A typical example is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A method for producing 4-borono-L-phenylalanine and its intermediates is provided. The method is for producing a substituted phenyl compound represented by formula (II) from a substituted phenyl compound represented by formula (I). The method comprises a first step in which the compound represented by formula (I) reacts with a linear or branched C1-C10 alkylmagnesium halide in the presence of a metal halide; and a second step in which a boronic acid ester or boronic acid amide reacts with the compound obtained in said first step. The method also can comprise a step of deprotecting the compound of formula (II) obtained in the second step.

Abstract: An object of the present invention is to provide a method of producing an alkene using a solvent that has little decrease in production rate over time and is easy to recover and recycle. The method of producing an alkene, which solves the problem, includes: a step of contacting a solution containing an alcohol having three or more carbon atoms and a hydroxide of an alkali metal and/or an alkaline earth metal with a halogenated alkane.

Abstract: An operation device for a vehicle transmission is configured to include: a base bracket that is fixed to a vehicle body of a vehicle; a slider lever that is slidably supported by the base bracket and includes a shift knob; and a main gear, which is rotatably supported by the base bracket and includes gear teeth at an outer circumferential portion, to which an end portion of a shift wire of the vehicle transmission is connected at a position separated from a gear support shaft of the base bracket, the slider lever including a rack gear that is formed along a sliding direction of the slider lever and is engaged with the gear teeth of the main gear, and gear change of the transmission being performed by causing the main gear to rotate with sliding of the slider lever and pushing and pulling the shift wire.

Abstract: A novel use of agonist to PD-1 is developed. Provided is a pharmaceutical composition for treating or preventing Th2-mediated diseases, the composition comprising an effective amount of a PD-1 agonist.

Abstract: A touch sensor in which an increase in manufacturing processes is suppressed and which can be provided inexpensively is obtained. A touch sensor (1) has a structure in which resistance membranes (12A, 12B) and membranes (13A, 13B) made of pressure sensitive ink are formed on predetermined places of a film (11), two parts (11A, 11B) on which the resistance membranes (12A, 12B) are formed are interfolded so that the resistance membranes (12A, 12B) face each other, two parts (11C, 11D) on which the membranes (13A, 13B) are formed are interfolded so that the membranes (13A, 13B) face each other, and the interfolded two parts are further interfolded.

Abstract: The present invention is to provide a method of producing an alkene that can further enhance the yield of an alkene, a reaction product, the method including bringing a gaseous halogenated alkane into contact with an alkaline aqueous solution in the presence of a phase-transfer catalyst. The objective above is achieved by a method of producing an alkene comprising bringing in the presence of a phase-transfer catalyst a liquid phase containing an alkaline aqueous solution and a water-insoluble solvent into contact with a gas phase containing a halogenated alkane that is soluble in the water-insoluble solvent.

Abstract: In a heat treatment method for obtaining a bearing ring for an annular roller bearing whose thickness changes in an axial direction, the heat treatment method includes (A) applying a quenching process to a work which is annular, made of high carbon chromium bearing steel, and having a thickness changing in an axial direction, (B) applying a tempering process to the work which is quenched to entirely soak the work in cooling liquid and inductively heat the work in a state that the work is soaked in the cooling liquid, and (C) applying a finishing process to the work which is tempered.

Abstract: An injector arrangement structure includes an air cleaner which is arranged at a rear side of an engine for a vehicle, a rear suspension which extends vertically at the rear side of the engine, and a first injector which is attached to the air cleaner. The air cleaner includes an outlet tube configuring a clean side of the air cleaner. The rear suspension and the outlet tube overlap each other in a side view. A partition wall dividing an intake passage vertically is provided inside the outlet tube. The first injector is attached from a lower side of the outlet tube so as to inject fuel toward the partition wall.

Abstract: Provided is a transmission which eliminates torque loss during gear shift and with which the processing of components can be simplified. An axial force is generated in a protrusion by means of a first portion during gear shift from a low gear to a high gear, and when a low-speed transmission gear and a clutch ring separate from each other, a high speed transmission gear and the clutch ring interlock. Since relative movement of the protrusion in a neutral direction is suppressed by means of a first retaining portion during coasting, gear disengagement whereby the transmission gears and the clutch ring separate from each other can be suppressed. Since the first retaining portion can be formed in a first wall when providing a groove portion, an increase in the component processing workload can be suppressed.

Abstract: A technique enabling downsizing of an image forming apparatus is provided. A cleaning unit 13 attachable to and detachable from an apparatus main body of an image forming apparatus 100 that forms an image on a recording material 12 is provided, with this cleaning unit 13 including: a photosensitive drum 1; and a cleaning frame body 14 that supports the photosensitive drum 1 and that includes an opening 14c through which laser light 3c for exposing the photosensitive drum 1 can pass, wherein the opening 14c is configured such that a width of the opening 14c in a scanning direction in an irradiation range of the light for exposing the photosensitive drum 1 becomes greater toward a side of the photosensitive drum 1 from a side of a light source of light for exposing the photosensitive drum 1.

Abstract: The present invention is to provide a method of producing an alkene that can further enhance the yield of an alkene, a reaction product, the method including bringing a gaseous halogenated alkane into contact with an alkaline aqueous solution in the presence of a phase-transfer catalyst. The objective above is achieved by a method of producing an alkene comprising bringing in the presence of a phase-transfer catalyst a liquid phase containing an alkaline aqueous solution and a water-insoluble solvent into contact with a gas phase containing a halogenated alkane that is soluble in the water-insoluble solvent.

Abstract: An optical tweezers device includes: an acquisition unit which acquires basic movement information indicating a movement of a stage; a conversion unit which converts the movement of the stage indicated by the basic movement information into a movement of a particle being trapped and generates converted movement information indicating the movement of the particle; and a distance calculation unit which determines a distance between the particle being trapped by the laser beam and a focal point of the lens. The conversion unit generates the converted movement information by correcting the movement of the particle using the distance determined by the distance calculation unit.