Abstract: Aspects of the present disclosure relate to methods for making tampons including primary absorbent members and secondary absorbent members. In some configurations, the tampons may be constructed with a primary absorbent member formed by a primary absorbent pad in a rolled configuration. In some configurations, the tampons may be constructed with a primary absorbent member formed by first and second primary absorbent pads positioned in a crossing configuration.

Abstract: An online concierge system receives orders from users identifying items and a warehouses from which the items are obtained. The online concierge system displays groups of one or more orders to shoppers, allowing a shopper to select a group of orders for fulfillment. When selecting groups of orders to display to shoppers, the online concierge system accounts for costs for fulfilling different groups and displays groups having costs satisfying one or more criteria, while maintaining one or more restrictions on times to fulfill orders. The online concierge system trains a selection prediction model to predict an amount of time for a shopper to select a group of orders and determines an estimated fulfillment time for the group from the predicted amount of time. Accounting for the predicted selection time allows the online concierge system to identify a larger number of groups for which costs of fulfillment are determined.

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.

Abstract: An online concierge system receives information describing the progress of a picker servicing a batch of existing orders and predicts a first likelihood the picker will finish servicing the batch within a threshold amount of time based on the picker's progress and information describing the batch. If the first likelihood exceeds a threshold likelihood, the system accesses a machine learning model trained to predict a second likelihood the picker will accept a batch of new orders for servicing while servicing the batch of existing orders. The system applies the model to inputs including a set of attributes of the picker and the picker's progress to predict the second likelihood. The system matches batches of new orders with pickers based on the second likelihood and sends one or more requests to service one or more batches matched with the picker to a client device associated with the picker.

Abstract: An online concierge system receives information describing the progress of a picker servicing a batch of existing orders and a service request for an order. The system identifies picker attributes of the picker and order attributes of the order and each existing order of the set and accesses a machine learning model trained to predict a likelihood the picker will accept an add-on request to add the order to the batch of existing orders. To predict the likelihood, the system applies the model to the picker attributes, the progress of the picker, and the order attributes. The system determines a cost associated with sending the add-on request to the picker based on the likelihood and assigns the order to a set of orders based on the cost. The system sends the add-on request to the picker responsive to determining the order is assigned to the batch of existing orders.

Abstract: Aspects of the present disclosure relate to methods for making tampons including primary absorbent members and secondary absorbent members. In some configurations, the tampons may be constructed with a primary absorbent member formed by a primary absorbent pad in a rolled configuration. In some configurations, the tampons may be constructed with a primary absorbent member formed by first and second primary absorbent pads positioned in a crossing configuration.

Abstract: The present disclosure provides nectin-4 antibody drug conjugates and pharmaceutical compositions thereof, and methods of using for the treatment of cancer.

Abstract: An online concierge system generates a set of candidate estimated times of arrival (ETAs) for delivery of a set of items being purchased by a user. Each candidate ETA is scored by using a machine-learned model to estimate values for different criteria of interest, such as likelihood of acceptance of the ETA, cost of delivery of the items to the user, and the like. The values for the different criteria may be combined to generate the overall score for a candidate ETA. One or more of the highest-scoring ETAs are selected and provided to the user, who may then approve one of the ETAs for use with delivery of the user's set of items.

Abstract: Aspects of the present disclosure relate to methods for making tampons including primary absorbent members and secondary absorbent members. In some configurations, the tampons may be constructed with a primary absorbent member formed by a primary absorbent pad in a rolled configuration. In some configurations, the tampons may be constructed with a primary absorbent member formed by first and second primary absorbent pads positioned in a crossing configuration.

Abstract: The present disclosure relates to apparatuses and methods for making tampons including primary and secondary absorbent members. During assembly, primary absorbent members, a continuous length of secondary absorbent members, and a continuous cord are advanced in a machine direction. Leading edges of the primary absorbent members are separated from each other in the machine direction by a pitch distance. Discrete secondary absorbent members are cut from the continuous length of secondary absorbent members. Leading edges of the discrete secondary absorbent members are also separated from each other in the machine direction by the pitch distance. The continuous cord is positioned on the secondary absorbent members. And a secondary absorbent member is positioned in contact with a primary absorbent member. A thread is combined with the continuous cord, the secondary absorbent member, and the primary absorbent member.

Abstract: Techniques are disclosed relating to methods that include training, by a new profile process executing on a computer system, a contrastive loss function to identify fraudulent images associated with a particular entity. The new profile process may receive new profile information that includes a new profile image and a new profile identifier and compare the new profile identifier to one or more existing profile identifiers. In response to determining that one or more existing profile identifiers satisfy a threshold identifier metric, a particular neural network, using the contrastive loss function, may compare the new profile image to one or more existing profile images corresponding to the one or more existing profile identifiers. The new profile process may determine, using the comparing, whether the new profile information is a possible fake profile of a legitimate profile.

Abstract: Methods and apparatus for managing models for classification of online users are disclosed. An example method includes determining a segment associated with a received impression, determining whether the received impression includes an indication that the received impression is the result of a conversion associated with the segment, determining a current ratio of converted to non-converted impressions associated with a classification model associated with the segment, determining a difference between the current ratio and a target ratio, and storing an indication of the received impression for use in at least one of training or updating a classification model associated with the segment when: (a) the difference does not meet a threshold or (b) counting the received impression in the ratio would reduce the difference.

Abstract: The present invention relates to novel cGAS inhibitor compounds, having a formula of: to pharmaceutical compositions comprising the compounds, and to methods of using the compounds and compositions to treat certain pathological conditions such as immune-mediated diseases.

Abstract: The present disclosure relates to apparatuses and methods for making tampons including primary and secondary absorbent members. During assembly, primary absorbent members, a continuous length of secondary absorbent members, and a continuous cord are advanced in a machine direction. Leading edges of the primary absorbent members are separated from each other in the machine direction by a pitch distance. Discrete secondary absorbent members are cut from the continuous length of secondary absorbent members. Leading edges of the discrete secondary absorbent members are also separated from each other in the machine direction by the pitch distance. The continuous cord is positioned on the secondary absorbent members. And a secondary absorbent member is positioned in contact with a primary absorbent member. A thread is combined with the continuous cord, the secondary absorbent member, and the primary absorbent member.

Abstract: Aspects of the present disclosure relate to methods for making tampons including primary absorbent members and secondary absorbent members. In some configurations, the tampons may be constructed with a primary absorbent member formed by a primary absorbent pad in a rolled configuration. In some configurations, the tampons may be constructed with a primary absorbent member formed by first and second primary absorbent pads positioned in a crossing configuration.

Abstract: An online concierge system accesses and applies a model to predict likelihoods of acceptance of a service request for an order by pickers. The system accesses timespan distributions for accepted service requests and identifies sets of pickers based on the order. Based on the likelihoods and distributions, the system generates simulated responses of the sets of pickers to the service request and trains an additional model based on attributes of the order, the simulated responses, and information associated with corresponding sets of pickers. The system receives a new order, identifies additional sets of pickers based on the new order, and applies the additional model to predict responses of the additional sets of pickers to an additional service request for the new order. Based on the predicted responses and a delivery time associated with the new order, a minimum number of pickers to send the additional service request is determined.

Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.

Abstract: A tampon including a pledget, a wicking member disposed in direct contact with the pledget, and a withdrawal cord is disclosed. The wicking member is non-coaxially arranged with respect to the withdrawal cord.

Abstract: Disclosed herein are liquid cleansing compositions comprising: a. from about 90 percent by volume to about 99 percent by volume of a base liquid soap; b. from about 0.2 percent by volume to about 1.5 percent by volume Citronella oil; c. from about 0.05 percent by volume to about 1.0 percent by volume Peppermint oil; d. from about 0.1 percent by volume to about 1.0 percent by volume Eucalyptus oil; e. from about 0.1 percent by volume to about 1.0 percent by volume Sandalwood oil; f. from about 0.1 percent by volume to about 1.0 percent by volume Lemon oil; and g. from about 0.25 percent by volume to 2.5 percent by volume of an abrasive material, wherein the combined volume percent value of all components does not exceed 100 wt. %, and all volume percent values are based on the total volume of the composition.